Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway by Lili Wu, Chunfeng Liang, Xuemei Huang, Xiujun Deng, Jiming Jiang, Zuojie Luo

“…In this study, we aimed to determine whether salubrinal (Sal), a selective activator of eukaryotic translation initiation factor 2 (eIF2α), can induce apoptosis of human adrenocortical carcinoma (ACC) cell via activating the PERK/eIF2α/ATF4 signaling pathway, and the potential mechanisms of this action were explored. The ACC cell lines, including SW-13 and NCI–H295 R, were used. 3-(4,5)-Dimethylthiazol(-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay, cell scratch experiments, flow cytometry, and JC-1 staining assays were performed to detect the cell viability, cell migration, and cell apoptosis. …”
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The impact of bariatric surgery on gut microbiota: a bibliometric analysis of research trends and scientific contributions by Shuaichang Gong, Xiabiao Zhang, Xiabiao Zhang, Xiaoliang Chen, Ping Wan, Longfei Zhou, Jun Zhang

“…Our findings suggest that future research will likely focus on the effects of bariatric surgery on gut microbiota and its biological mechanisms, the role of gut microbiota in the weight loss process, and the development of combined treatments based on gut microbiota.…”
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Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma by Dandan Gao, Yang Lv, Fei Hong, Dong Wu, Ting Wang, Gongzhizi Gao, Zujie Lin, Ruoyu Yang, Jinsong Hu, Aili He, Pengyu Zhang

“…Further, the deficiency of PRDX6 promoted MM cell lines (RPMI 8226, MM.1S, and U266) apoptosis significantly. Mechanically, PRDX6 serves as an anti-oxidative enzyme, and its deficiency led to over-accumulation of reactive oxygen species (ROS), resulting in oxidative stress, following the activation of MAPK signaling pathway, which manifested as phosphorylation of JNK and p38. …”
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Improved Constraints on the Vertical Profile of CH4 at Jupiter’s Mid- to High Latitudes, Using IRTF-TEXES and SOFIA-EXES Spectroscopy by James A. Sinclair, Thomas K. Greathouse, Rohini S. Giles, Matthew Richter, Maisie Rashman, Curtis de Witt, Julianne Moses, Vincent Hue, Pablo Rodríguez-Ovalle, Thierry Fouchet, Ananyo Bhattacharya, Bilal Benmahi, Glenn S. Orton, Leigh N. Fletcher, Patrick G. J. Irwin

“…We therefore conclude that the region poleward of the northern MAE is, at times, subject to enhanced vertical transport resulting from auroral energy deposition. The exact mechanisms responsible for the enhanced vertical transport in Jupiter's auroral regions are uncertain: time-dependent circulation modeling of Jupiter's polar atmosphere is required to better understand this phenomenon. …”
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Stories of taking part in Everyday Life Rehabilitation - A narrative inquiry of residents with serious mental illness and their recovery pathway by Rosaline Bezerra Aguiar, Maria Lindström

“…Future research should further explore effective strategies and mechanisms to promote personal recovery and to reduce the stigma associated with SMI.…”
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BMP9 induces postnatal zonal stratification of immature articular cartilage through reconfiguration of the existing collagen framework by Miles Anderson-Watters, Ilyas M. Khan

“…These data suggest a possible mechanism whereby MMP3 induces proteoglycan turnover and depolymerises collagen fibrils enabling them to undergo spatial reorganisation. …”
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Syndecan-1: A Review on Its Role in Heart Failure and Chronic Liver Disease Patients’ Assessment by Radu-Stefan Miftode, Ionela-Lăcrămioara Şerban, Amalia-Stefana Timpau, Ionela-Larisa Miftode, Adriana Ion, Ana-Maria Buburuz, Alexandru-Dan Costache, Irina-Iuliana Costache

“…In this review, we review the mechanisms by which syndecan-1 exerts its effects and the possible perspectives opened by its use as a dual cardio-hepatic biomarker.…”
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PermGuard: A Scalable Framework for Android Malware Detection Using Permission-to-Exploitation Mapping by Arvind Prasad, Shalini Chandra, Mueen Uddin, Taher Al-Shehari, Nasser A. Alsadhan, Syed Sajid Ullah

“…The framework’s resilience is tested against adversarial attacks, demonstrating its ability to withstand attempts to bypass or deceive detection mechanisms and enhance overall security. Designed for scalability, PermGuard can handle large and continuously growing datasets, making it suitable for real-world applications. …”
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An effective video captioning based on language description using a novel Graylag Deep Kookaburra Reinforcement Learning by M. Gowri Shankar, D. Surendran

“…The residual convolved dual sparse graph attention network then generates detailed and contextually rich language descriptions by applying dual sparse attention mechanisms and residual convolutions. Finally, hybrid graylag and kookaburra optimization refine the captioning process, producing comprehensive and precise textual descriptions of the video content. …”
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Excessive copper induces lignin biosynthesis in the leaves and roots of two citrus species: Physiological, metabolomic and anatomical aspects by Xin Zhou, Xing Xiong, Fei Lu, Wenqing Shi, Yu Zhou, Ningwei Lai, Li-Song Chen, Zeng-Rong Huang

“…The findings from the present study increased our understanding of lignin biosynthesis in Cu-stressed citrus species, which would provide a theoretical basis for the citrus Cu-tolerant mechanisms.…”
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Screening key genes for intracranial aneurysm rupture using LASSO regression and the SVM-RFE algorithm by Qi Wu, Chunli Yang, Cuilan Huang, Zhiying Lin

“…This study explored the molecular mechanism and potential targets of IA rupture through bioinformatics methods.MethodsThe gene expression matrices of GSE13353, GSE122897, and GSE15629 were downloaded. …”
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Features of dry eye syndrome treatment by E.A. Egorov

“…In the case of DES, a decrease in secretion of tear fluid leads to an inflammatory reaction in eye tissues and peripheral nerve corruption, which brings to a feeling of dryness and pain in the eye. A triggering mechanism can be both inflammation and oxidative stress, which occurs when a balance between production of active oxygen species and antioxidant defense factors is disturbed. …”
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A New Approach to Non-Invasive Microcirculation Monitoring: Quantifying Capillary Refill Time Using Oximetric Pulse Waves by Yuxiang Xia, Xinrui Wang, Zhe Guo, Xuesong Wang, Zhong Wang

“…The intraclass correlation coefficient was 0.995 in Group A, and the <i>p</i>-value was greater than 0.05 in Group B. (4) Conclusions: The non-invasive monitoring of microcirculation has been rendered both rapid and effective, thus paving the way for the further mechanization and standardization of this process. The CRT, when measured using the capillary refill time meter test machine, demonstrated consistent and reproducible results, both when assessed by different researchers and when evaluated across varying measurement sets.…”
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Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4+ T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated L... by Chao Gao, Shiguan Wang, Xiaoyu Xie, Pierluigi Ramadori, Xinying Li, Xiaoyu Liu, Xue Ding, Jinyuan Liang, Bowen Xu, Yawei Feng, Xueying Tan, Haoran Wang, Yan Zhang, Haiyan Zhang, Tingguo Zhang, Ping Mi, Shiyang Li, Cuijuan Zhang, Detian Yuan, Mathias Heikenwalder, Peng Zhang

“…Background &amp; Aims: The immunological mechanisms underpinning the pathogenesis of alcoholic-associated liver disease (ALD) remain incompletely elucidated. …”
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Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19 by Yongzhi Lu, Qi Yang, Ting Ran, Guihua Zhang, Wenqi Li, Peiqi Zhou, Jielin Tang, Minxian Dai, Jinpeng Zhong, Hua Chen, Pan He, Anqi Zhou, Bao Xue, Jiayi Chen, Jiyun Zhang, Sidi Yang, Kunzhong Wu, Xinyu Wu, Miru Tang, Wei K. Zhang, Deyin Guo, Xinwen Chen, Hongming Chen, Jinsai Shang

“…However, the mutations causing drug resistance have been observed in RdRp and 3CLpro from SARS-CoV-2, which makes it necessary to develop antivirals with novel mechanisms. Through the application of a structure-based drug design (SBDD) approach, we discover a series of novel potent non-covalent PLpro inhibitors with remarkable in vitro potency and in vivo PK properties. …”
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Characterization of squash polysaccharide and the anti-diabetic effect on type 2 diabetic rat revealed by urine metabolomics analysis by Li Liang, Fuming Zhang, Quanhong Li, Baoguo Sun, Yuyu Zhang, Robert J. Linhardt

“…Thus, the metabolomics and SPR approach were proved to be a promising tool in exploring the anti-diabetes effects of SPS and provided a deep understanding of the mechanisms.…”
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Enhanced silk production and pupal weight in Bombyx mori through CRISPR/Cas9-mediated circadian Clock gene disruption. by Daniel J Brady, Alessio Saviane, Matteo Battistolli, Irene Varponi, Federica Barca, Kunihiro Shiomi, Silvia Cappellozza, Federica Sandrelli

“…Future research should focus on elucidating the molecular mechanisms driving these phenotypes and determining whether they result from circadian clock functions or pleiotropic effects of B. mori Clk. …”
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Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss by Jiali Liu, Haisen Peng, Yuehui Liu, Chunhua Li, Wen Xie

“…This study explored the therapeutic effects of growth differentiation factor 6 (GDF6) overexpression-induced MSCs (MSCs-GDF6) on age-related hearing loss (ARHL) and its underlying mechanisms. …”
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Investigating male factors and their relationships with reproductive health outcomes: a case-control study protocol for Towards Optimal Fertility, Fathering, and Fatherhood studY (... by Fabian Yap, See Ling Loy, Yin Bun Cheung, Jerry Kok Yen Chan, Keith Godfrey, Chee Wai Ku, Jun Wei Pek, Melissa D/O Tharmalingam Durgahshree, Melinda Chan, Yie Hou Lee

“…This study aims to investigate the male contribution to fertility and explore the underlying biological mechanisms. Specifically, we aim to (1) identify male factors associated with successful pregnancy, (2) develop a fertility index incorporating modifiable factors for both males and females to predict pregnancy rate and (3) explore the relationship of male modifiable factors with semen parameters and molecular characteristics.Methods and analysis We will conduct an unmatched case-control study involving 240 couples with impaired male fertility (cases) and 240 couples with normal male fertility (controls). …”
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The double-edged sword effect of conscientiousness on the work engagement of medical staff in Chinese public hospitals by Hui Sun, Xuelu Hua, Shibing Wu, Ling Sun

“…Conscientiousness has a significant impact on the work engagement of medical staff, but the mechanism between the two is not yet clear.ObjectiveThis study examined the double-edged sword effect of conscientiousness on medical staff work engagement, with a particular focus on exploring the mediating effects of thriving at work (TAW) and workload, as well as the moderating effect of perceived insider status (PIS).MethodsThe study sample was drawn from four public hospitals in the Jiangsu Province, Shanghai City, and Zhejiang Province. …”
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