Endogenous Estrogen Influences Predator Odor-Induced Impairment of Cognitive and Social Behaviors in Aromatase Gene Deficiency Mice by Yaner Gao, Lei Ma, Feng Gao, Zuoli Sun, Zhengrong Zhang, Yuhong Li, Rena Li

“…While women are more vulnerable than men to depression and anxiety, it is unclear whether endogenous estrogens are responsible for the underlying sex-specific mechanisms. In this study, the aromatase gene heterozygous (Ar+/-) mice were used as an endogenous estrogen deficiency model and age- and sex-matched wild type mice (WT) as controls to study the predator odor 2,3,5-trimethyl-3-thiazoline- (TMT-) induced short- and long-term cognitive and social behavior impairments. …”
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Potential Functions and Causal Associations of GNLY in Primary Open-Angle Glaucoma: Integration of Blood-Derived Proteome, Transcriptome, and Experimental Verification by Wang D, Pu Y, Gao X, Zeng L, Li H

“…Dangdang Wang,1,2,* Yanyu Pu,1,2,* Xi Gao,1,2 Lihong Zeng,1,2 Hong Li1,2 1Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Chongqing Key Laboratory for the Prevention and Treatment of Major Blinding Eye Diseases, Chongqing Eye Institute, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Li, Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China, Email lihong@hospital.cqmu.edu.cnPurpose: Genome-wide association studies (GWAS) have identified multiple genetic loci associated with primary open-angle glaucoma (POAG). However, the mechanisms by which these loci contribute to POAG progression remain unclear. …”
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Multi-omics analyses identify gut microbiota-fecal metabolites-brain-cognition pathways in the Alzheimer’s disease continuum by Han Zhao, Xia Zhou, Yu Song, Wenming Zhao, Zhongwu Sun, Jiajia Zhu, Yongqiang Yu

“…Conclusion Aside from elucidating the underlying mechanism whereby gut microbiota dysbiosis is linked to AD, our findings may contribute to groundwork for future interventions targeting the microbiota-metabolites-brain-cognition pathways as a therapeutic strategy in the AD continuum.…”
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Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract by Ji Shi, Xiaohang Ren, Jia Wang, Xiaofeng Wei, Bonan Liu, Tianzhu Jia

“…However, the underlying mechanism of this method remains elusive. The compounds monotropein, rubiadin, and rubiadin 1-methyl ether are the major effective components of Morinda officinalis How. …”
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Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…These findings provide new insights into the complex mechanisms underlying RPE-EMT and PVR pathogenesis, with implications for rational strategies for potential therapeutic applications in PVR by targeting RPE-EMT.…”
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A bird's eye view of the mental health systems in India by Satish Suhas, Banavaram A. Arvind, Gautham M. Sukumar, Pradeep S. Banandur, Lakshmi P. Nirisha, Channaveerachari N. Kumar, Vivek Benegal, Girish N. Rao, Mathew Varghese, Gopalkrishna Gururaj, NMHS National Collaborators Group

“…Conclusion: MHSA, as conducted within the framework of NMHS, emerges as a dependable, valid, and holistic mechanism for documenting mental health systems in India. …”
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Resveratrol Alleviates NEFA-Induced Oxidative Damage in Bovine Mammary Epithelial Cells by Restoring Mitochondrial Function by Longwei Sun, Junpeng Huang, Xiangyang Dou, Zhenyu Dong, Yuan Li, Shujing Tan, Ran Yu, Chengmin Li, Weiguo Zhao

“…This study aimed to investigate the antioxidant effects and underlying molecular mechanisms of RES in NEFA-challenged BMECs. The results showed that RES ameliorated NEFA-induced oxidative damage by upregulating antioxidant enzyme expression and reducing malondialdehyde (MDA) and reactive oxygen species (ROS). …”
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Peculiarities of criminal radicalism determination among prisoners sentenced to imprisonment by P. Yu. Danylchenko

“…It has been proved that the stratification and normative elements of criminal and prison subculture determine both the system of social and status hierarchy in the criminal environment in general and among convicts in particular, and the mechanisms of forced identification and inclusion in this system. …”
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TREM-1 and TREM-2 Expression on CD14+ Cells in Bronchoalveolar Lavage Fluid in Pulmonary Sarcoidosis and Hypersensitivity Pneumonitis in the Context of T Cell Immune Response by M. Suchankova, J. Urban, M. Ganovska, E. Tibenska, K. Szaboova, E. Tedlova, F. Sandor, I. Majer, M. Bobovcak, I. Jonner, B. Konig, M. Bucova

“…The aim of the study was to analyse TREM-1 and TREM-2 expression to identify further molecular mechanisms participating in the immunopathogenesis of sarcoidosis and HP. …”
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Econometric Analysis of Macroeconomic to Age-Specific Mortality Rate in Malaysia: Evidence from Panel Data by Robiaatul Adawiah Edrus, Zailan Siri, Mohd Azmi Haron, Muhammad Aslam Mohd Safari, Mohammed K. A. Kaabar

“…The present study aims to contribute to the development of an effective support mechanism by rectifying Malaysia’s socioeconomic inequalities in order to mitigate the COVID-19 increase in mortality rate. …”
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Characterization of H460R, a Radioresistant Human Lung Cancer Cell Line, and Involvement of Syntrophin Beta 2 (SNTB2) in Radioresistance by Chang-Nim Im, Byeong Mo Kim, Eun-Yi Moon, Da-Won Hong, Joung Whan Park, Sung Hee Hong

“…H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.…”
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The Influence of Lifestyle Modifications on Cardiovascular Outcomes in Older Adults: Findings from a Cross-Sectional Study by Mohammed Almutairi, Ashwaq A. Almutairi, Abdulaziz M. Alodhialah

“…This study examines the combined effects of these behaviors on cardiovascular outcomes and their mediating mechanisms. <b>Methods:</b> A cross-sectional study was conducted among older adults (aged ≥ 60 years) in Riyadh, Saudi Arabia. …”
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A De Novo Mutation in ACTC1 and a TTN Variant Linked to a Severe Sporadic Infant Dilated Cardiomyopathy Case by Jose G. Acuña-Ochoa, Norma A. Balderrábano-Saucedo, Ana C. Cepeda-Nieto, Maria Y. Alvarado-Cervantes, Vianca L. Ibarra-Garcia, Daniel Barr, Matthew J. Gage, Ryan Pfeiffer, Dan Hu, Hector Barajas-Martinez

“…Computational 3D modeling of the mutated proteins showed electrostatic and conformational shifts of cardiac actin compared to wild-type version, as well as changes in the stability of the compact/folded states of titin that normally contributes to avoid mechanic damage. In conclusion, our findings suggest a likely pathogenic de novo mutation in ACTC1 in coexpression of a TTN variant as possible causes of an early onset of a severe DCM and premature death. …”
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Counteracting Mobbing in Labor Legal Relations by V. V. Honcharuk

“…The Constitution of Ukraine recognizes the honor and dignity of a man as the main value, but the current Ukrainian legislation does not provide any mechanism to combat mobbing in labor relations. …”
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Placental Vascular Malperfusion in Pregnancies With Congenital Heart Disease by Nour Rahnama, MD, Arthur Colson, MD, PhD, Pamela Baldin, MD, PhD, Agnès Pasquet, MD, PhD, Damien Gruson, MD, PhD, David Vancraeynest, MD, PhD, Christophe Beauloye, MD, PhD, Frédéric Debiève, MD, PhD, Sophie Pierard, MD, PhD

“…While the underlying mechanisms remain unclear, previous studies have identified maternal vascular malperfusion (MVM) in their placentas. …”
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STUDY ON FAILURE OF TRACTOR DOUBLE-CAVITY FUEL TANK BASED ON MEASURED LOAD by ZHANG ZongYang, XIE ShuangShuang, WANG Kai, BING Tao, SUN ShiTao, WANG LiTai

“…Based on the analysis of the mechanical properties of fuel , the main reason for the failure of the double-cavity tank wasthat the solid partition receives too much impact force due to the insufficient sloshing damping provided by single damping baffle. …”
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Gallic acid alleviates exercise-induced muscle damage by inhibiting mitochondrial oxidative stress and ferroptosis by Likai Yu, Di Tian, Zishan Su, Li Zhang, Shaobo Guo, Wenhui Zhu, Yuan Fang, Peimin Wang, Nongshan Zhang

“…However, its function and mechanism in skeletal muscle injury remain unclear. …”
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Abnormal Circadian Modification of Aδ-Fiber Pathway Excitability in Idiopathic Restless Legs Syndrome by Catello Vollono, Giacomo Della Marca, Elisa Testani, Anna Losurdo, Daniela Virdis, Diana Ferraro, Valerio Brunetti, Paolo M. Rossini, Domenica Le Pera, Salvatore Mazza, Massimiliano Valeriani

“…A likely pathogenetic mechanism is a central dopaminergic dysfunction. The exact role of pain system is unclear. …”
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From Waste to Innovation: A Circular Economy Approach for Tissue Engineering by Transforming Human Bone Waste into Novel Collagen Membranes by Lorena Gallego, Kimberly Harvey, Marta Pevida, Luis García-Consuegra, Olivia García-Suárez, Álvaro Meana, María Alvarez-Viejo, Luis Junquera

“…The purpose of the study is to manufacture a novel human-purified type I collagen membrane from bone remnants typically discarded during the processing of cortico-cancellous bones in tissue banks and to evaluate its mechanical properties and effectiveness in regenerating bone-critical mandibular defects in rabbits. …”
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Study on the Tribological Behavior of Laser Surface Texturing on Silicon Nitride Ceramic Under Water Lubrication by Hong-Jian Wang, Jing-De Huang, Bo Wang, Yang Zhang, Jin Wang

“…The friction and wear mechanisms are also discussed in this study.…”
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