Heme Oxygenase-1-Modified Bone Marrow Mesenchymal Stem Cells Combined with Normothermic Machine Perfusion Repairs Bile Duct Injury in a Rat Model of DCD Liver Transplantation via A... by Xuan Tian, Huan Cao, Longlong Wu, Weiping Zheng, Mengshu Yuan, Xiang Li, Hongli Song, Zhongyang Shen

“…The present study was aimed at exploring the repair effect of heme oxygenase-1- (HO-1-) modified BMMSCs (HO-1/BMMSCs) combined with normothermic machine perfusion (NMP) on bile duct injury after DCD liver transplantation and at revealing the underlying mechanisms. Rat livers were exposed to in situ warm ischemia for 30 min; then, NMP was performed through the portal vein for 4 h with BMMSCs, HO-1/BMMSCs, or neither before implantation. …”
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Dynamic alterations in spontaneous neural activity in patients with attention-deficit/hyperactivity disorder: A resting-state fMRI study by Rui Hu, Wei Du, Fan Tan, Yong Wu, Chun Yang, Weiwei Wang, Wen Chen, Yanwei Miao

“…The understanding of dALFF/dfALFF variability can contribute to the comprehension of neurophysiological mechanisms and potentially aid in the diagnosis of ADHD.…”
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<i>Weizmannia coagulans</i> BC99 Attenuates Oxidative Stress Induced by Acute Alcoholic Liver Injury via Nrf2/SKN-1 Pathway and Liver Metabolism Regulation by Ying Wu, Cheng Li, Yinyin Gao, Jie Zhang, Yao Dong, Lina Zhao, Yuwan Li, Shaobin Gu

“…This study investigated the protective mechanisms of <i>Weizmannia coagulans</i> BC99 against alcohol-induced oxidative stress using a dual model in rats and Caenorhabditis elegans. …”
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A comprehensive in silico analysis of structural and functional impacts of natural nonsynonymous SNPs in the ALDH2_HUMAN gene by Mehr Ali Mahmood Janlou

“…Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme involved in the metabolism of acetaldehyde to acetate through a coenzyme-dependent mechanism. Acetaldehyde exhibits a toxic effect, highlighting the necessity of ALDH2’s proper functioning to protect against diseases associated with aldehyde toxicity. …”
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Insights from the single-cell level: lineage trajectory and somatic-germline interactions during spermatogenesis in dwarf surfclam Mulinia lateralis by Yajuan Li, Huilan Wei, Xiaoting Dai, Lijing Zhang, Liangjie Liu, Xiaomei Chen, Tian Liu, Ya Shu, Yaxin Yang, Shi Wang, Zhenmin Bao, Lingling Zhang

“…However, a substantial gap remains in our understanding of the molecular mechanisms and key driver genes that underpin this process, particularly in invertebrates. …”
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The protective effect of coadministration of coenzyme Q10 and vitamin E on myopathy induced by simvastatin in rats by Omar Ammar Hashim, Intesar Tarik Numan, Nadia Hameed Mohammed

“…The study objective is to study the protective effect of CoQ10, vitamin E, and their combination to prevent simvastatin-induced skeletal muscle myopathy in rat models and explore possible mechanisms by measuring muscle biomarkers and histopathological changes. …”
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Application Study on Active Advanced Support Technology in Deep Roadway under Mine Goaf by Pengfei Jiang, Peng Xiao, Fanbao Meng, Suolin Jing, Jingkai Zhang, Ge Wang, Peng Zhao

“…To solve the problems of the rapid advance of the working face was delayed by complicated working procedure and high labor intensity, and the severe damage of roof bolt (anchor cable) induced by advanced hydraulic support, the deformation characteristics of surrounding rock, and the supporting principle of grouting truss anchor cable were analyzed theoretically by taking the roadway of 3_(down) coal seams 2326# working face in Sanhekou coal mine as the research object; then, the mechanical model of supporting structure of roadway under goaf was established. …”
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Doxycycline-integrated silk fibroin hydrogel: preparation, characterizations, and antimicrobial assessment for biomedical applications by Kranti Kiran Reddy Ealla, Chandra Sri Durga, Vikas Sahu, Neema Kumari, Jayachandran Venkatesan, Vishnu Priya Veeraraghavan, Pratibha Ramani, Kiran Kumar Bokara, Karthikeyan Ramalingam

“…Conclusions The findings suggest that SF-DH hydrogel showed sufficient mechanical strength, pore size, antimicrobial activity, and biocompatibility. …”
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EDUCATIONAL BUILDING PERFORMANCE EVALUATION PRACTICES AND PERCEPTIONS: A CASE OF FEDERAL UNIVERSITIES IN SOUTH EAST NIGERIA by K.C Okolie, W.M. Shakantu

“…The findings suggest that there appears to be an apparent lack of a systematic mechanism for measuring the success or performance of completed and occupied buildings in the universities. …”
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Mitochondrial dysfunction-driven AMPK-p53 axis activation underpins the anti-hepatocellular carcinoma effects of sulfane sulfur by Xue Zheng, Yuhua Luo, Rui Huo, Yiwen Wang, Youbang Chen, Mianrong Chen, Qi Zhao, Kexin Li, Hanyi Zhang, Xiaotong Li, Xiang Li, Hui Zhang, Zaopeng He, Li Huang, Chun-tao Yang

“…This study aimed to investigate the effects of PSCP on HCC and elucidate the underlying mechanisms. We utilized bioinformatics algorithms for clustering, function enrichment, feature screening and survival analysis on proteomic data from the Cancer Proteome Atlas (CPTAC) and transcriptomic data from the Cancer Genome Atlas (TCGA). …”
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Downregulation of hnRNPA1 inhibits hepatocellular carcinoma cell progression by modulating alternative splicing of ZNF207 exon 9 by Qi Ouyang, Qi Ouyang, Wenhui He, Yiping Guo, Lin Li, Ying Mao, Xiang Li, Shuanglin Xiang, Xiang Hu, Jun He

“…We identified that hnRNPA1 bound to ZNF207 and regulated its exon 9 skipping, influencing ZNF207 splicing and the PI3K/Akt/mTOR pathway, key regulators of cell growth and survival.ConclusionOur findings demonstrate that hnRNPA1 promotes HCC progression by regulating ZNF207 splicing and the PI3K/Akt/mTOR pathway. hnRNPA1-ZNF207 interaction represents a potential therapeutic target for HCC, providing insights into the molecular mechanisms underlying HCC progression.…”
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Molecular Dynamics Insights into Peptide-Based Tetrodotoxin Delivery Nanostructures by Shenghan Song, Xinyu Xia, Temair Shorty, Tongtong Li, Amy O. Stevens, Chao Zhao, Yi He

“…Despite the profound impact that the addition of a hydrophobic tail has on altering the release behavior of the original peptides, the atomic-level interactions and mechanisms underlying this phenomenon remain poorly understood. …”
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Target miRNA identification for the LPL gene in large yellow croaker (Larimichthys crocea) by Kalim Ullah, Aslam Hossain, Mingyue Cao, Liangyi Xue, Yajun Wang

“…Conversely, miR-891a was not concerned with this regulatory mechanism. Site-directed mutagenesis experiments elucidated the specificity of the interaction sequences. …”
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The Preparation of C-S-H Powder Seeds and Their Effect on the Early Hydration Performance of Cement Paste by Chunlong Huang, Yiren Wang, Zhongyuan Wei, Yong Yu

“…The hydration kinetics showed that the hydration of cement mixed with nucleating agents was not governed by a single reaction mechanism, but rather constitutes a complex, multi-component reaction process. …”
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The association between the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and delirium in ischemic stroke patients by Pangbo Wang, Pangbo Wang, Jing Huang, Liwei Xu, Rong Hu

“…Further prospective studies are needed to validate their association and to elucidate the underlying mechanisms.…”
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Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway by Baolong Li, Kaiming Yu, Xiongyao Zhou, Jialu Sun, Le Qi, Weiye Li, Tuo Yang, Weizhen Li, Ningning Wang, Xiaosong Gu, Shusen Cui, Rangjuan Cao

“…Abstract Neuropathic pain poses a significant clinical challenge, largely due to the incomplete understanding of its molecular mechanisms, particularly the role of mitochondrial dysfunction. …”
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Leishmania mexicana: Novel Insights of Immune Modulation through Amastigote Exosomes by Laura Enedina Soto-Serna, Mariana Diupotex, Jaime Zamora-Chimal, Adriana Ruiz-Remigio, José Delgado-Domínguez, Rocely Buenaventura Cervantes-Sarabia, Adriana Méndez-Bernal, Alma Reyna Escalona-Montaño, María Magdalena Aguirre-García, Ingeborg Becker

“…We conclude that aExo of L. mexicana are capable of decreasing microbicidal mechanisms of infected macrophages by inhibiting nitric oxide production, thereby enabling parasite survival. …”
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Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: an experimental insights by Aysegul Bulut, Goktug Senturk, Durmus Hatipoglu, Mehmet Burak Ates

“…However, more research is needed to determine the specific mechanism at the molecular level and offer therapeutic management suggestions.…”
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Dense integration of chlorocatechols crosslinked polyphenylene sulfide solid-state separator for Li metal-free batteries by Haitao Zhou, Lianlu Wan, Jiacheng Han, Jian-Chun Wu, Yihong Deng, Jie Gu, Huanggang Wang, Hongquan Gao, Zilong Su

“…By employing the dry electrode process, a PPS-based solid-state separator (PPS-SSS) is fabricated, featuring a thin profile (18±2 μm), a smoother surface, and a denser structure, significantly enhancing its mechanical properties. Moreover, the dense integration structure and chlorocatechol groups contribute to a higher Li+ transference number and more effectively inhibit the growth of Li dendrites. …”
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Changes of soil organic carbon and aggregate stability along elevation gradient in Cunninghamia lanceolata plantations by Xiaoqing Cao, Yuting Xu, Fei Wang, Zhili Zhang, Xiaoniu Xu

“…The physical protection of silt + clay fractions and the active carbon pools may be the main mechanisms for organic carbon preservation in the Dabie Mountains. …”
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