Identification and validation of TSPAN13 as a novel temozolomide resistance-related gene prognostic biomarker in glioblastoma. by Haofei Wang, Zhen Liu, Zesheng Peng, Peng Lv, Peng Fu, Xiaobing Jiang

“…Functional enrichment and mutation analyses were conducted to explore the underlying mechanisms of the risk score and its relationship with immune cell infiltration levels in GBM. …”
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Clinical Holistic Medicine: Treatment of Physical Health Problems Without a Known Cause, Exemplified by Hypertension and Tinnitus by Søren Ventegodt, Mohammed Morad, Isack Kandel, Joav Merrick

“…Believing in the treatment and not giving up on your patient, and moving forward in the treatment with the patient himself is the ultimate goal, even when you yourself do not understand the mechanism fully. This will force you to develop your own competence and is, in essence, what makes an outstanding holistic physician.…”
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Multiple low-dose radiation ameliorates type-2 diabetes mellitus via gut microbiota modulation to activate TLR4/MyD88/NF-κB pathway by Lijing Qin, Rongrong Liu, Zhen Jia, Weiqiang Xu, Li Wang, Hongyuan Tian, Xinru Lian, Wen Li, Yali Qi, Huan He, Zhicheng Wang

“…However, the underlying mechanisms remain unclear. Methods In this study, T2DM model was established using high fat diet combined with streptozocin (STZ) injection in C57BL/6 mice, and then exposed to multiple 75 mGy LDR every other day for one month. …”
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Association of cognitive reserve with stroke outcome: a protocol for a systematic review by Laura Gallucci, Roza M Umarova

“…Introduction The concept of cognitive reserve (CR) was introduced to account for individual differences in the clinical manifestation of neurodegenerative diseases. Though several mechanisms and risk factors are shared between neurodegeneration and stroke, the effect of CR on poststroke functional outcome has been poorly addressed. …”
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Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease by Tristan Gabriel-Segard, Margherita Boltri, Mathilde Barrau, Catherine Massoubre, Stéphane Paul, Xavier Roblin

“…<b>Conclusions:</b> To tackle the question of fatigue in IBD, research should consider investigating the biological mechanisms implicating intestinal physiopathology of IBD in the impairment of brain structure involved in motivation. …”
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Understanding the affinity of Cyphos Nitrate for Zr(IV) over other metal ions present in simulated high level liquid waste compositions by Alok Rout, S. Sriram, N. Ramanathan

“…The efficient extraction of Zr(IV) without any additional ligand in IL phase by adopting simple complexation mechanism infers the novelty of [P66614][NO3]. High asymmetricity and bulkiness of IL cation enables more freedom to its anion (NO3-) to coordinate with Zr(IV), thereby realizing high extraction factors as compared to other ILs having different cations (or anions). …”
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Genetic Types and Main Control Factors of Microfractures in Tight Oil Reservoirs of Jimsar Sag by Xiangye Kong, Jianhui Zeng, Xianfeng Tan, Haowei Yuan, Dan Liu, Qun Luo, Qianyou Wang, Rusi Zuo

“…Microfracture formation mechanisms differed depending on lithology, and microfractures were found to develop most in dolomite and dolomitic siltstones and least in mudstone. …”
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Corporate genome screening India (CoGsI) identified genetic variants association with T2D in young Indian professionals by Shah Fahad Husami, Tavleen Kaur, Love Gupta, Garima Rastogi, Lakhvinder Singh, Pooja Meena, Indu Sharma, Hemender Singh, Varun Sharma

“…Present findings provide insights into mechanisms underlying T2D manifestation in corporate professionals due to genetics interacting with occupational stress and urban lifestyles.…”
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Preparing controlled low strength materials with cement-treated construction waste clay improved by sodium hexametaphosphate. by Chenhao Li, Tinglong Xie, Jianwen Ding, Jian Tang, Mengying Gao

“…The influence of additive content on the mechanical and microstructural properties of cement-treated clay-based CLSM was analyzed. …”
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PharmaLLM: A Medicine Prescriber Chatbot Exploiting Open-Source Large Language Models by Ayesha Azam, Zubaira Naz, Muhammad Usman Ghani Khan

“…PharmaLLM incorporates a multi-modal input/output mechanism, supporting both text and speech, to enhance accessibility. …”
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Recombinant SpTransformer proteins bind to specific sites on sea urchin phagocytes and modulate SpTransformer gene expression and immune responsiveness by Ryley S. Crow, Leon Grayfer, L. Courtney Smith

“…Their varied functions enable a robust immune response while also providing a unique modulatory mechanism by which response levels are controlled and adjusted to the level of the foreign threat. …”
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Graphene oxide scaffolds promote functional improvements mediated by scaffold-invading axons in thoracic transected rats by Marta Zaforas, Esther Benayas, Raquel Madroñero-Mariscal, Ana Domínguez-Bajo, Elena Fernández-López, Yasmina Hernández-Martín, Ankor González-Mayorga, Elena Alonso-Calviño, Eduardo R. Hernández, Elisa López-Dolado, Juliana M. Rosa, Juan Aguilar, María C. Serrano

“…Additionally, behavioral tests evidence that these scaffolds play an important role in whole-body mechanical stabilization (postural control) proved by the absence of scoliosis, a higher trunk stability and a larger cervico-thoraco-lumbar movement range in rGO-implanted rats.…”
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Experimental Investigation of Dispersant on Dynamics of Impact of Al₂O₃ Nanofluid Droplet by Dandan Liang, Ruichao Guo, Zichun Sun, Haizhen Zhao, Guohua Qin, Yongxin Zhang

“…This study can provide theoretical basis and specific guidance for experimental characterization of UAVs’ electronic devices based on the mechanism of nanofluid droplet impact on the wall.…”
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Effect of crude extract and polysaccharides derived from Fucus spiralis on radish plants Raphanus sativus L. agrophysiological traits under drought stress by Safaa Er-rqaibi, Karim Lyamlouli, Houda El Yacoubi, Mohammed El Mehdi El Boukhari

“…Overall, F. spiralis extracts interacted through several mechanisms using various compounds to mitigate the negative effects of drought stress on radish plants. …”
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Comparative Analysis of Roadway Reinforcement Effects Based on Fluid-Solid Coupling in the Fractured Zone of Water-Rich Fault by Jihua Zhang, Yun Dong, Yadong Chen, Yang Jiang, Huasheng Sun, Yuqing Fan, Chun Wang

“…In this paper, the 15107 mining roadway built by Yuxing coal mine in such a fault zone was used as a case study to determine the water content of the surrounding rocks and a fault zone using the transient electromagnetic method (TEM). Also, the mechanics characteristics of such rocks in both saturated and unsaturated states were analyzed, a computational model for fluid-solid coupling in the water-rich fault fracture zone was established, and the permeability coefficient of the rocks under both shield support and bolt-grouting support was compared, along with analyzing the changes in pore pressure, fissure water velocity, and characteristics of deformation in the surrounding rocks. …”
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Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K/AKT/mTOR signaling pathway by Zhengguo Qiu, Jianbing Ma, Xiaqing Zhang, Mingna Jiao, Liqiang Zhi

“…However, the synergistic effects of EA and TG in CIRI and the underlying mechanism have not been demonstrated. Methods: Rats were subjected to middle cerebral artery occlusion (MCAO) surgery and reperfusion (MCAO/R) to establish a CIRI model. …”
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Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance by Santiago Rodríguez de Córdoba, Andrea Reparaz, Daniel Sanchez, Sheila Pinto, Lucia Juana Lopez, Héctor Martin Merinero, Iria Calvete, Julian Perez-Perez, Sydney S. Jellison, Yuzhou Zhang, Richard J. H. Smith, Inmaculada Moreno, Mercedes Dominguez

“…The specific regions of FH targeted by FHAAs correlate with the pathogenic mechanism of the associated disease. In aHUS, FHAAs target the C-terminus, thereby impacting FH ability to recognize cell surfaces. …”
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Drought resistance of introgressive spring common wheat lines with genetic material of tall wheatgrass by L. Ya. Plotnikova, A. T. Sagendykova, S. P. Kuzmina

“…Introgressive lines with T. ponticum genetic material are valuable for breeding spring common wheat cultivars with various drought-adaptation mechanisms.…”
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Animal cognition (reasoning) in the light of genetic ideas by I. I. Poletaeva, O. V. Perepelkina, Z. A. Zorina

“…The data obtained show the intricate connection between the mouse ability to solve the problem and the processes of anxiety, which in turn looks as non-uniform by its nature and mechanisms. The data from experiments performed in classical genetics should be combined with the new knowledge concerning the role of single genes determining animal behavior.…”
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Immune status improvement in piglets through the use of interferon-containing products during specific prevention of porcine pleuropneumonia by A. G. Shakhov, L. Yu. Sashnina, V. A. Prokulevich, Yu. Yu. Vladimirova, M. I. Adodina

“…In order to improve the effectiveness of preventive vaccination, various immunomodulators that differ in their origin and mechanism of action are used. The paper presents the results of the study of the effect of such products as biferon-S and prostimul containing species-specific recombinant interferons on the immune status of piglets during specific prevention of porcine pleuropneumonia. …”
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