Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment by Hanan Seddiek, Mira Hanna, Amany Elsayed Mohamed Hamoud, Marawan Abd Elbaset, Ahmed M. A. Akabawy, Mohamed Zakaria Kotb, Mohamed Mansour Khalifa

“…So, we aimed to use iron chelator as a new strategy based on an anti-ferroptotic mechanism and to evaluate its neuroprotective effect against polyneuropathy in Cisplatin-treated rats. …”
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The impact of oxidative balance on all-cause and cause-specific mortality in US adults and cancer survivors: evidence from NHANES 2001–2018 by Juan Wu, Yingdong Han, Menghui Yao, He Zhao, Zhikai Li, Tiange Xie, Yun Zhang, Xuejun Zeng

“…Abstract Background Oxidative stress is a crucial pathophysiological mechanism in chronic diseases and mortality. While individual oxidative markers have been studied, the comprehensive impact of oxidative balance on mortality risks remains unclear, particularly among cancer survivors. …”
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MHC Class 1 and PDL-1 Status of Primary Tumor and Lymph Node Metastatic Tumor Tissue in Gastric Cancers by Ibrahim Halil Erdogdu

“…MHC-1 downregulation is most frequently observed in the tumor escape mechanism of cancer cells from the immune system. MHC-1 downregulation with increased PDL-1 expression of cancer cells has an important role in immune escape. …”
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An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors by Russell J. Schilder, Drew Rasco, Manish R. Sharma

“…Tyrosine kinase inhibitors (TKIs) targeting ALK have improved disease outcomes, but resistance mechanisms are common. This first-in-human trial evaluates ESK-440, a dual inhibitor of ALK and focal adhesion kinase, as a novel strategy for cancers with resistance to ALK-targeting TKIs. …”
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Legal Status of the Accounting Chamber of Ukraine: Current State and Perspectives of Development by L. V. Borets, Ya. O. Arbych

“…The emphasis has been placed on the fact that the mechanism for bringing officials of the Accounting Chamber to disciplinary responsibility is not regulated at a high level. …”
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Total flavonoids isolated from Eucommia ulmoides can alleviate bone loss and regulate intestinal microbiota in ovariectomized rats by Baocang Yin, Baocang Yin, Mingzhen Yang, Mingzhen Yang, Bowen Wang, Bowen Wang, Yun Zhang, Yun Zhang, Ningli Li, Ningli Li, Qin Li, Yingying Li, Cory J. Xian, Tiejun Li, Tiejun Li, Yuankun Zhai, Yuankun Zhai

“…Modern pharmacological research has proved that E. ulmoides could prohibit the occurrence of osteoporosis and arthritis.AimTo investigate the effect and action mechanism of total flavonoids isolated from the leaves of E. ulmoides (TFEL) on bone loss in ovariectomized (OVX) rats, and to study its effect on intestinal flora.Materials and methodsThe 3-month-old female rats were randomly divided into six groups: sham operation group, OVX model group, estradiol group, TFEL low (TFEL-L) (50), mid (-M) (100) and high (-H) (200 mg/kg/d) dose groups. …”
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An Integrated Electricity–Gas–Heat Energy System Based on the Synergy of Long- and Short-Term Energy Storage by Min Zhang, Jinhao Wang, Huiqiang Zhi, Jun Zhao, Xiao Chang, Shifeng Zhang, Xiangyu Guo, Tengxin Wang

“…Firstly, an adaptive noise integration empirical modal decomposition method based on the optimization improvement of the grey wolf algorithm is designed for the power allocation strategy of the hybrid energy storage system; secondly, for the electric–gas system, an energy management strategy for the hybrid electric–gas energy storage system, taking into account the operating characteristics of the alkaline electrolyzer, is proposed in order to strengthen the complementary mechanism between electric energy storage and gas energy storage. …”
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Honeypot defense and transmission strategy based on offensive and defensive games in vehicular networks by Jie YI, Tengfei CAO, Shuai GAO, Jianqiang HUANG

“…With the rapid development of the Internet of Vehicles, service providers can efficiently provide caching services for vehicle users by deploying 5G base station-type RSUs adjacent to vehicles.However, due to the presence of malicious attackers, the controlled base station is turned to be malicious for the purpose of identity forgery attack.When messages are sent in the name of malicious base stations to interfere with the communication link between vehicles and the trusted base stations, it is easy to cause serious driving safety problems.To solve the above problem, an efficient transmission and honeypot defense strategy was proposed, which was based on the offensive and defensive game in the Internet of Vehicles to reduce the risk of identity forgery attacks and improve the security of data transmission.The interaction between trusted base stations and malicious base stations in the Internet of Vehicles scenario was modeled as an attack-defense game model.On this basis, trusted base stations and honeypot base stations were jointly used as defenders to defend against malicious attacks.Then, the trusted base station and the malicious base station, as the two sides of the offensive and defensive game, chose their respective strategies to construct a model of the benefit function of both sides.Combined with the vehicle delay feedback mechanism, the defender and the malicious base station dynamically adjusted their respective strategies.By adjusting the interaction between the honeypot base station and the vehicle, and also the degree of IP randomization, the overall benefit of the defender was effectively improved.Besides, the optimal solution was obtained by using the mixed strategy Nash equilibrium theory.Simulation experimental results show that the proposed strategy can improve the secure transmission performance of the Internet of Vehicles service in the presence of malicious attackers, and the defender’s expected benefit is improved by 48.9% and the data transmission delay is reduced by 57.1% compared to the no-honeypot defense scheme.…”
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Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance by Tianming Qiu, Yu Zhi, Jingyuan Zhang, Ningning Wang, Xiaofeng Yao, Guang Yang, Liping Jiang, Li Lv, Xiance Sun

“…Even though apoptosis plays a pivotal role in arsenic-induced islet β-cell dysfunction, the explicit underlying mechanisms remain elusive. Here, we have identified that the SET-Rac1 signaling pathway is instrumental in the apoptosis and dysfunction of islet β-cells induced by NaAsO2. …”
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Octreotide in Intestinal Lymphangiectasia: Lack of a Clinical Response and Failure to Alter Lymphatic Function in a Guinea Pig Model by S Makhija, P-Y vod der Weid, J Meddings, SJ Urbanski, PL Beck

“…In conclusion, in this case, octreotide failed to induce a clinical response and laboratory studies showed that octreotide did not alter lymphatic function. Thus, the mechanisms by which octreotide induced clinical responses in the cases reported elsewhere in the literature remain unclear, but the present study suggests that it does not appear to act via increasing lymphatic pumping.…”
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PS1-11aop: Probing the Mass-loss History of a Luminous Interacting Supernova Prior to Its Final Eruption with Multiwavelength Observations by Adaeze L. Ibik, Maria R. Drout, Raffaella Margutti, David Matthews, V. Ashley Villar, Edo Berger, Ryan Chornock, Kate D. Alexander, Tarraneh Eftekhari, Tanmoy Laskar, Ragnhild Lunnan, Ryan J. Foley, David Jones, Dan Milisavljevic, Armin Rest, Daniel Scolnic, Peter K. G. Williams

“…Luminous interacting supernovae (SNe) are a class of stellar explosions whose progenitors underwent vigorous mass loss in the years prior to core collapse. While the mechanism by which this material is ejected is still debated, obtaining the full density profile of the circumstellar medium (CSM) could reveal more about this process. …”
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Application of Gel Method Ba2TiSi2O8 Ferroelectric Thin Film in Contemporary Handicraft Three-Dimensional Fiber Art Works by Zhe Li

“…It shows that the Ba2TiSi2O8 structured flexible film has good temperature stability at about 80°C, and the contemporary handicraft three-dimensional fiber art work based on ferroelectric film not only has a good economic mechanism but also has its flexibility and beauty increased by 80%.…”
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Pan-caspase inhibitor protects against noise-induced hearing loss in a rodent model by Maria Fernanda Yepes, Kayla Minesinger, Federica M. Raciti, Maria Camila Salazar, Suhrud M. Rajguru, Suhrud M. Rajguru, Suhrud M. Rajguru

“…BackgroundDespite the high prevalence of noise-induced hearing loss (NIHL), no effective treatments exist currently. Underlying mechanisms behind NIHL include elevated reactive oxygen species and inflammation, all which ultimately lead to cellular apoptosis. …”
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Development of the relationship between visual selective attention and auditory change detection by Yuanjun Kong, Xuye Yuan, Yiqing Hu, Bingkun Li, Dongwei Li, Jialiang Guo, Meirong Sun, Yan Song

“…Our one recent study has shown a positive correlation between the event-related potential (ERP) amplitudes associated with visual selective attention (posterior contralateral N2) and auditory change detection (mismatch negativity) in adults, suggesting an intimate relationship and potential shared mechanism between visual selective attention and auditory change detection. …”
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New paradigm for auditory paired pulse suppression. by Nobuyuki Takeuchi, Shunsuke Sugiyama, Koji Inui, Kousuke Kanemoto, Makoto Nishihara

“…Sensory gating is a mechanism of sensory processing used to prevent an overflow of irrelevant information, with some indexes, such as prepulse inhibition (PPI) and P50 suppression, often utilized for its evaluation. …”
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Solving the maximum cut problem using Harris Hawk Optimization algorithm. by Md Rafiqul Islam, Md Shahidul Islam, Pritam Khan Boni, Aldrin Saurov Sarker, Md Asif Anam

“…Crossover and refinement operators are used to modify the fitness of the hawk in such a way that they can provide precise results. A mutation mechanism along with an adjustment operator has improvised the outcome obtained from the updated hawk. …”
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Competition between microstructure and defect in multiaxial high cycle fatigue by F. Morel, R. Guerchais, N. Saintier

“…The so-called Kitagawa effect can be interpreted as a competition between the crack initiation mechanisms governed either by the microstructure or by the defect. …”
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Partially unraveling mechanistic underpinning and weight loss effects of time-restricted eating across diverse adult populations: A systematic review and meta-analyses of prospecti... by Duc Tran Quang, Nguyen Di Khanh, Linh Le Cu, Huyen Nguyen Thi Hoa, Chi Vu Thi Quynh, Quang Phan Ngoc, Thuy Bui Thi

“…This study aimed to evaluate the effects of TRE on weight loss in three adult populations using pre- and post-intervention analyses while also investigating its underlying mechanism. A systematic search was conducted across four databases (PubMed, Web of Science, Scopus, and the CENTRAL) up until January 28, 2024, specifically focusing on prospective studies that examined the efficacy of TRE in achieving weight loss. …”
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Dendrobium officinale flowers flavonoids enriched extract protects against acute ethanol-induced gastric ulcers via AMPK/PI3K signaling pathways by Zhiyu Zhang, Hualing Xie, Mohamed A. Farag, Zhenhao Li, Qingping Wu, Ping Shao

“…In this study, protective effects and possible action mechanisms of D. officinale flowers’ flavonoid enriched extract (DOFF) were assessed against gastric ulcer. …”
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Cross-Community Question Relevance Prediction for Stack Overflow and GitHub by Song Yu, Bugao Jiang, Danni Zhang, Zhifang Liao

“…The question-and-answer community’s mechanism for recommending related questions helps users discover more content relevant to their current problems, expediting issue resolution. …”
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