Islet Transplantation Reverses Podocyte Injury in Diabetic Nephropathy or Induced by High Glucose via Inhibiting RhoA/ROCK/NF-κB Signaling Pathway by Chongchu Huang, Yi Zhou, Hongjian Huang, Yushu Zheng, Lijun Kong, Hewei Zhang, Yan Zhang, Hongwei Wang, Mei Yang, Xiaona Xu, Bicheng Chen

“…Abnormal signaling pathways play a crucial role in the mechanisms of podocyte injury in diabetic nephropathy. …”
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A simplified version of the method of calculation of multilayer composite rods according to the theory of A.R. Rzhanitsyn by V. V. Filatov, Thi Linh Quyen Hoang

“…The influence of various parameters (geometric and mechanical characteristics of layers, shear stiffness of seams) on the operation of simplified models is studied. …”
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General Theoretical Provisions of Forensic Psychology by O. M. Tsilmak

“…It has been noted that forensic psychology is an independent branch of legal psychology that studies psychological patterns and mechanisms of the development of processes and phenomena that arise during the performance of judicial activity. …”
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EDUCATIONAL COWORKING AS A NEW ORGANIZATION FORMAT OF EDUCATIONAL SPACE OF SUPPLEMENTARY VOCATIONAL EDUCATION by Galina A. Ignatyeva, Oksana V. Tulupova, Andrey S. Molkov

“…Based on the comparative analysis of mechanisms of coworking in economics, sociology and business education key characteristics of a model of educational co-working space are highlighted. …”
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Effect of Carbonation on the Leachability of Solidified/Stabilized Lead-Contaminated Expansive Soil by Fusheng Zha, Congmin Liu, Bo Kang, Long Xu, Chengbin Yang, Chengfu Chu, Chuang Yu, Wei Zhang, Jiwen Zhang, Zhenghong Liu

“…After semidynamic leaching, leaching indexes such as the effective diffusion coefficient (De), leachability index (Lx), and slope (rc) were used to reveal the ion leaching mechanism. The results indicated that the amount of Pb2+ and Ca2+ leached out under different pH conditions increased after carbonation, which confirmed that carbonate on solidified/stabilized lead (Pb) had a negative impact. …”
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Detectability of Emission from Exoplanet Outflows Calculated by pyTPCI, a New 1D Radiation-hydrodynamic Code by Riley Rosener, Michael Zhang, Jacob L. Bean

“…We calculate the eclipse depths and signal-to-noise ratios (SNRs) of these lines for a 10 m class telescope with a high-resolution spectrograph, taking into account appropriate line broadening mechanisms. We show that the most detectable spectral lines tend to be the 589 nm Na i doublet and the 1083 nm metastable helium triplet. …”
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Identification of blood transcriptome modules associated with suicidal ideation in patients with major depressive disorder by Min Wang, Hailin Xiang, Jinxue Wei, Yikai Dou, Yushun Yan, Yue Du, Huanhuan Fan, Liansheng Zhao, Rongjun Ni, Xiao Yang, Xiaohong Ma

“…Although there are many transcriptomic studies on postmortem brain tissue related to suicidal behavior, the blood transcriptional mechanisms of suicidal ideation (SI) remain unknown. …”
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Global, regional, and national burden of anxiety disorders during the perimenopause (1990–2021) and projections to 2035 by Ying Zhang, Ting-Ting Hu, Yong-Ran Cheng, Zhi-Fen Zhang, Jun Su

“…Abstract Purpose Perimenopause is associated with an increased risk of anxiety disorders, largely due to hormonal changes affecting the body’s regulatory feedback mechanisms. This study aims to provide a comprehensive analysis of the global burden of anxiety disorders among perimenopausal women. …”
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Investigation of the Effects of Fosfomycin in Kidney Damage Caused by CLP-Induced Sepsis by Ilknur Esen Yildiz, Tolga Mercantepe, Ilkay Bahceci, Medeni Arpa, Sule Batcik, Yasin Yildiz, Levent Tumkaya

“…These findings suggest that fosfomycin may have a protective effect on kidney damage caused by CLP-induced sepsis. The potential mechanisms underlying this protection include the modulation of inflammation, reduction of oxidative stress, and inhibition of apoptosis.…”
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Systems biology analysis of the WOX5 gene and its functions in the root stem cell niche by E. A. Oshchepkova, N. A. Omelyanchuk, M. S. Savina, T. Pasternak, N. A. Kolchanov, E. V. Zemlyanskaya

“…To this end, we performed a phylogenetic analysis on 62 publicly available WOX5 amino acid sequences, generalized published data about WOX5 expression domain in Arabidopsis and other species and its role in development, integrated the results of experiments on identification of primary and secondary targets for this transcription factor. Data on possible mechanisms of direct and indirect regulation of WOX5 expression were discussed. …”
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Cross Layer Optimization and Simulation of Smart Grid Home Area Network by Lipi K. Chhaya, Paawan Sharma, Adesh Kumar, Govind Bhagwatikar

“…To prevail over this effect, frame aggregation is used in combination with RTS and fragmentation mechanisms. The results show that this combination notably improves network performance. …”
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Fluid structure Interaction analysis for rupture risk assessment in patients with middle cerebral artery aneurysms by Jozsef Nagy, Wolfgang Fenz, Stefan Thumfart, Julia Maier, Zoltan Major, Harald Stefanits, Maria Gollwitzer, Johannes Oberndorfer, Nico Stroh, Michael Giretzlehner, Michael Sonnberger, Andreas Gruber, Philip-Rudolf Rauch, Matthias Gmeiner

“…To address this limitation, we applied Fluid-Structure Interaction (FSI) analysis, an integrative approach that simulates the dynamic interplay between hemodynamics and wall mechanics, offering a more comprehensive risk assessment. …”
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Porous Multiphase Microcharacteristics Research of New Cement-Based Grouting Material Concretion by Wei Xie, Junwu Xia, Linli Yu, Hongfei Chang

“…Four types of water-cement ratio (W/C ratio) NCG concretions were systematically researched on the solid-phase composition, microscopic morphology, nanoscale pore characteristics and micron-scale multiphase microscopic characteristics through SEM, TGA-DSC, BET, MIP, and 3D-XRM in combination with hydration reaction mechanism. The NCG concretion is characterized as a spatial network structure formed by dendritic or columnar ettringite (AFt) crystals, filled with calcium silicate hydrate gel (C–S–H) and aluminum gel (AH3). …”
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Characterization and evaluation of the cytotoxic, antioxidant, and anti-human lung cancer properties of copper nanoparticles green-synthesized by fennel extract following the PI3K/... by Tao Huang, KaiLi Ma, Yihua Wang

“…In summary, these findings illustrated the mechanisms behind the therapeutic effect of CuNPs, thus making them good targets for the NSCLC treatment. …”
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Increased Growth Differentiation Factor 15 Levels Are Associated with HIV-Associated Neurocognitive Impairment: A Pilot Study by Ali Boustani, Mary K. Ford, Jacqueline R. Kulbe, Anna E. Laird, Leeann Shu, Matthew Spencer, Bryant Avalos, Kyle C. Walter, Ronald J. Ellis, Jerel Adam Fields

“…<b>Conclusions</b>: The findings indicate that GDF15 may play a role in the pathogenesis of HIV-associated NCI, possibly through neuroinflammatory mechanisms. The strong association between GDF15 levels and cognitive impairment severity suggests its potential as a biomarker for the early detection and monitoring of NCI in PWH.…”
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Changes in RNA Splicing: A New Paradigm of Transcriptional Responses to Probiotic Action in the Mammalian Brain by Xiaojie Yue, Lei Zhu, Zhigang Zhang

“…Elucidating the gene regulatory mechanisms underlying the gut–brain axis is critical for uncovering novel gut–brain interaction pathways and developing therapeutic strategies for gut bacteria-associated neurological disorders. …”
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Rituximab (monoclonal anti-CD20 antibody) induced posterior reversible encephalopathy syndrome (PRES): A case report and literature review by Praveen K. Sharma, MD, Sanjaykanth Balachandar, MBBS, Michael Antony Vikram, MBBS, Pujitha Duvooru Sukumar, MD

“…More studies are necessary to clarify the pathophysiological mechanisms causing the PRES produced by Rituximab and to improve therapeutic approaches.…”
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Early Reciprocal Effects in a Murine Model of Traumatic Brain Injury and Femoral Fracture by Katharina Ritter, Kirsten Jung, Christopher Dolderer, Dominik Appel, Christine C. Oswald, Ulrike Ritz, Michael K. E. Schäfer

“…However, early reciprocal effects and mechanisms have been barely investigated. To address this issue, C57BL/6N mice were subjected to either the controlled cortical impact (CCI) model of TBI, fracture of the left femur (FF), combined injury (CCI+FF), or sham procedure. …”
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Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment by Sandra H. P. Farsky, Luís Roberto C. Gonçalves, José M. Gutiérrez, Adriana P. Correa, Alexandra Rucavado, Philippe Gasque, Denise V. Tambourgi

“…The venom of the snake Bothrops asper, the most important poisonous snake in Central America, evokes an inflammatory response, the mechanisms of which are not well characterized. The objectives of this study were to investigate whether B. asper venom and its purified toxins – phospholipases and metalloproteinase – activate the complement system and the contribution of the effect on leucocyte recruitment. …”
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MicroRNA-4735-3p Facilitates Ferroptosis in Clear Cell Renal Cell Carcinoma by Targeting SLC40A1 by Cairong Zhu, Zhiquan Song, Zhen Chen, Tianqi Lin, Haili Lin, Zhenqiang Xu, Fen Ai, Shijiao Zheng

“…The present study was aimed at investigating the role and underlying mechanisms of microRNA-4735-3p (miR-4735-3p) in ccRCC. …”
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