Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy by Chunhuan Jin, Xinyu Zhou, Minhui Xu, Hiroki Okanishi, Ryuichi Ohgaki, Yoshikatsu Kanai

“…These insights into nanvuranlat’s mechanism and metabolic impact provide essential information for understanding its clinical efficacy and advancing LAT1-targeted cancer therapies.…”
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Impact of sodium alginate hydrogel containing bacteriophage peptides that specifically bind to the EtCab protein on the inhibition of Eimeria tenella infection by Hang Chen, Wenjing Zhi, Bingrong Bai, Faisal R. Anjum, Zhipeng Jia, Rui Kong, Qiuju Liu, Biao Wang, Chunli Ma, Dexing Ma

“…Chickens were orally administered both microencapsulated and non-microencapsulated phages, and the protective effects against E. tenella infection were assessed. The binding mechanism of these peptides to the EtCab protein was investigated through in silico analysis. …”
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Unveiling Genital Tuberculosis: India’s hidden Infertility Epidemic by Yashvanthan VR, Angeline Grace G, Sujitha P, Ilam Ilaval T, Hariharan S

“…GTB primarily affects women of reproductive age but can also impact men, contributing to infertility through various pathophysiological mechanisms. Despite its prevalence, GTB remains a hidden epidemic due to limited awareness, diagnostic challenges, and systemic healthcare gaps. …”
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Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans. by Jeffrey Vedanayagam, Marion Herbette, Holly Mudgett, Ching-Jung Lin, Chun-Ming Lai, Caitlin McDonough-Goldstein, Stephen Dorus, Benjamin Loppin, Colin Meiklejohn, Raphaëlle Dubruille, Eric C Lai

“…However, relatively little is known about the molecular identity of meiotic drivers, their strategies of action, and mechanisms that can suppress their activity. Here, we present data from the fruitfly Drosophila simulans that address these questions. …”
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Natural enrichment of chromium and nickel in the soil surrounds the karst watershed by R.D.P. Astuti, A. Mallongi, A.U. Rauf

“…The Pangkep regency municipality must highlight the importance of strengthening environmental standards and monitoring mechanism as the priority to maintain a healthy environment.…”
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A quantum-optimized approach for breast cancer detection using SqueezeNet-SVM by Anas Bilal, Ali Alkhathlan, Faris A. Kateb, Alishba Tahir, Muhammad Shafiq, Haixia Long

“…SqueezeNet’s fire modules and complex bypass mechanisms extract distinct features from mammography images. …”
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Characterizing the deformation, failure, and water-conducting fractures evolution of shallow weakly cemented overburden under coal mining by Zhenhua Li, Yandong Zhang, Xuefeng Gao, Xuefeng Gao, Dan Ma, Dan Ma, Limin Fan, Guodong Li, Xiaolei Li, Min He, Zheng Cheng

“…Understanding the collapse mechanisms of shallow, multi-layered, weakly cemented overburden is key to safe and efficient coal mining in central and western China. …”
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DNA markers in oat breeding for crown rust resistance (a review) by A. V. Bakulina, N. V. Novoselova, L. S. Savintseva, G. A. Batalova

“…The review reveals the mechanisms of the A. sativa resistance to the fungus Puccinia coronata Corda f. sp. avenae Erikss. which causes crown rust disease. …”
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Pyrroloquinoline Quinone Administration Alleviates Allergic Airway Inflammation in Mice by Regulating the JAK-STAT Signaling Pathway by Zhihui Min, Jiebai Zhou, Ruolin Mao, Bo Cui, Yunfeng Cheng, Zhihong Chen

“…We sought to explore the effects of PQQ on allergic airway inflammation and reveal the underlying mechanisms. In vitro, the effects of PQQ on the secretion of epithelial-derived cytokines by house dust mite- (HDM-) incubated 16-HBE cells and on the differentiation potential of CD4+ T cells were investigated. …”
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Low-carbon cementitious composite incorporated with biochar and recycled fines suitable for 3D printing applications: hydration, shrinkage and early-age performance by Karol Federowicz, Krzysztof Cendrowski, Pawel Sikora

“….% of cement with either material accelerates the normalized heat flow, contributing to a quicker gain in mechanical properties. However, biochar increases shrinkage deformations within the first 12 hours, while recycled fines mitigate them. …”
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Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain by Darine Villela, Claudia K. Suemoto, Renata Leite, Carlos Augusto Pasqualucci, Lea T. Grinberg, Peter Pearson, Carla Rosenberg

“…CNVs represent a significant source of genetic variation in the human genome and have been implicated in several disorders and complex traits, representing a potential mechanism that contributes to neuronal diversity and the etiology of several neurological diseases and provides new insights into the normal, complex functions of the brain. …”
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Impact of Application of Multifunction Electrode (MFE) Pads on Cardiopulmonary Resuscitation Quality by Radosław Zalewski, Mateusz Puślecki, Łukasz Szarpak, Tomasz Kłosiewicz, Marek Dąbrowski, Bartłomiej Perek

“…Two 10-minute scenarios of SCA in the mechanism of ventricular fibrillation were analysed. …”
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Wpływ nowożytnego antropocentryzmu na relację człowieka do przyrody. Część pierwsza by Anita Ganowicz-Bączyk

“…The man was obliged even to dominate nature which was viewed as a complex of mathematical laws, a value-free mechanism determined by laws of nature. Contemporary view on nature and man was influenced also by philosophical views which on the one hand excluded man from nature (I. …”
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Numerical modelling of erosional landforms driven by offshore groundwater flow on siliciclastic continental margins: a conceptual approach by Shubhangi Gupta, Shubhangi Gupta, Aaron Micallef

“…Analysis of the coupling conditions highlights the multiplicative nature of the primary driving mechanisms (seepage-induced erosion and slope instability), suggesting a continuous transition between flow- and stress-controlled landforms. …”
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<i>Eugenia uniflora</i> Effects on the Depressive-like Behavior of MPTP-Exposed Female Rats: Apoptosis and α-Synuclein Modulation by Anne Suély Pinto Savall, Jhuly Dorneles De Mello, Eduarda Monteiro Fidelis, Vandreza Cardoso Bortolotto, Mustafa Munir Mustafa Dahleh, Gustavo Petri Guerra, Marina Prigol, Robson Puntel, Jean Ramos Boldori, Cristiane Casagrande Denardin, Tuane Bazanella Sampaio, Simone Pinton

“…<b>Conclusions:</b> These findings support PFEU’s potential as a neuroprotective agent for MPTP-induced depressive-like behavior in female rats, highlighting its molecular mechanisms.…”
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Investigation via morphological analysis of aluminium foams produced by replication casting by A. Boschetto, L. Bottini, F.Campana, L. Consorti

“…Foams and porous materials with cellular structure have many interesting combinations of physical and mechanical properties coupled with low specific weight. …”
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Review on Applications of System Dynamics Method in Regional Water Demand Prediction by QIN Huanhuan

“…Water resources are the most important basic natural resources for the sustainable development of the social economy,the controlling element of the ecological environment,and strategic economic resources.With the growth in population and economic development,regional water consumption is increasing,and the imbalance between the supply and demand of water resources has become the “bottleneck” restricting regional economic development.Water demand prediction is an important basis for the planning,management,and sustainable utilization of regional water resources,which involves complex factors such as economic,hydrological,meteorological,social,engineering,and technological factors as well as the industrial structure and industrial and agricultural development.The system dynamics method based on the feedback control theory has significant advantages in the dynamic change,causal mechanism analysis,quantitative analysis and simulation of a multi-factor coupled complex giant system.It has been widely used in the prediction of regional water demand.The system dynamics model of regional water demand prediction can decompose a complex social water use system into multiple interconnected and mutually constrained subsystems.It can clearly show the dynamic change process of water demand of each water use subsystem and obtain accurate prediction results of water demand.In this paper,firstly,the characteristics of the system dynamics method are briefly introduced.Then,the applications of this method in regional water demand are summarized and analyzed from four aspects,i.e.…”
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Principles of carbon catabolite repression in the rice blast fungus: Tps1, Nmr1-3, and a MATE-family pump regulate glucose metabolism during infection. by Jessie Fernandez, Janet D Wright, David Hartline, Cristian F Quispe, Nandakumar Madayiputhiya, Richard A Wilson

“…Carbon catabolite repression (CCR) is a global regulatory mechanism found in a wide range of microbial organisms that ensures the preferential utilization of glucose over less favourable carbon sources, but little is known about the components of CCR in filamentous fungi. …”
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Investigating the role of non-pharmaceutical interventions (NPI) during pandemics: COVID-19 as an example by Elaheh Abiri, Rasoul Raesi, Maryam Haji Ghasem Kashani

“…Conclusion In the near future, these findings may be helpful in the creation and execution of preventative initiatives and coping mechanisms.…”
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Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility by Sophie Debaenst, Tamara Jarayseh, Hanna De Saffel, Jan Willem Bek, Matthieu Boone, Ivan Josipovic, Pierre Kibleur, Ronald Y Kwon, Paul J Coucke, Andy Willaert

“…Validating causative genes and understanding their mechanisms remain challenging. We assessed a semi-high throughput zebrafish screening platform for rapid in vivo functional testing of candidate FBD genes. …”
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