TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6 by Sheng Luo, Wenjin Wang, Jingfang Feng, Rui Li

“…The present work is aimed at revealing TEX10 expression and biological function within urinary bladder carcinoma and elucidating the potential mechanisms. Results showed that TEX10 is abundant in urinary bladder carcinoma, and its protein level was related to poor disease-free survival in a positive manner. …”
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YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders by Aderonke O. Ajongbolo, Aderonke O. Ajongbolo, Sigrid A. Langhans

“…Such non-canonical regulation of YAP/TAZ includes well-known growth factor signaling pathways such as the epidermal growth factor receptor (EGFR)/ErbB family, Notch, and Wnt signaling as well as cell-cell adhesion, cell-matrix interactions and mechanical cues from a cell’s microenvironment. This puts YAP/TAZ at the center of a complex signaling network capable of regulating developmental processes and tissue regeneration. …”
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Analysis of Unsteady Flow Characteristics of Centrifugal Pump under Part Load Based on DDES Turbulence Model by Tang Xin, Liu Zhili, Zhao Meng, Yang Haotian, Jiang Wei, Wang Yuchuan, Chen Diyi

“…To better reveal the mechanism of the rotor-stator interference between the impeller and the guide vane and the evolution process of the stall vortex under the part-load conditions, numerical simulation is carried out based on the DDES turbulence model, which can better capture vortex structure. …”
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PENGARUH PENGGUNAAN KOLEKTOR PLAT DATAR PADA PENGERING PADI TIPE DRUM DRYER by Nur Hidayati, Iskandar Ridwan

“…This drum dryer also utilizes mechanical energy from the gasoline engine so that it can rotate the drum. …”
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Construction of Pickering Double Emulsions Based on Xanthan Gum/Lysozyme Nanoparticles: Structure, Stability, and Co-Encapsulation of Epigallocatechin Gallate and β-Carotene by Yongpeng Yin, Denglin Luo, Lala Li, Xingguo Li, Mengyao Kang, Bakht Ramin Shah, Xianling Wei, Wei Xu

“…Therefore, in this study, W₁/O/W₂ Pickering double emulsions (PDEs) were prepared by a two-step emulsification method using polyglycerol polyricinoleate (PGPR) and xanthan gum/lysozyme nanoparticles (XG/Ly NPs) as lipophilic and hydrophilic emulsifiers, respectively. The regulation mechanism of the performance of PDEs by XG/Ly NPs was investigated, and the ability of the system to co-encapsulate epigallocatechin gallate (EGCG) and β-carotene was evaluated. …”
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Influence of Bidirectional Impact Loading on Anomalously Low-Friction Effect in Block Rock Media by Liping Li, Weijun Li, Jupeng Tang, Jiaqing Lv

“…Finally, this study denotes that it is great significance to investigate the bidirectional impact loading in order to capture the mechanism of anomalously low-friction effect.…”
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Muscle parameters in men and oxidative stress markers by Michał Pietruszewski, Judyta Nowak-Kornicka, Agnieszka Żelaźniewicz, Bogusław Pawłowski

“…The results suggest that testosterone-driven traits like handgrip strength or muscle mass may not necessarily incur oxidative stress costs in healthy young men, possibly due to effective compensatory antioxidant mechanisms. Factors like lifestyle, diet, and genetic predisposition, which were not controlled in this study, could also influence the observed outcomes and should be included in future research.…”
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Synaptic transistor implementing potentiation or depression via field distribution modulation of dual dielectric layers by single-polarity pulsed voltage stimuli by Jieun Kim, Jung Wook Lim, Chohyeon Park, Chaerin Yu, Jaehee Lee

“…Understanding and simulating the synaptic plasticity mechanisms of the human brain are crucial for advancing neuromorphic computers for artificial intelligence (AI) and humanoid applications. …”
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Utilization of bauxite residue as fine aggregate for the development of structural concrete: An approach towards sustainable construction materials by Gali Kusumanjali, S. Tejas, Amit Chatterjee, Dinakar Pasla

“…In the second phase, a wide spectrum of concrete consisting of 20 % optimum BR content as fine aggregates (BRC20 concrete) with a w/c ratio ranging from 0.3 to 0.8 was developed, and their mechanical and long-term performance was investigated. …”
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Identification of key regulators in pancreatic ductal adenocarcinoma using network theoretical approach. by Kankana Bhattacharjee, Aryya Ghosh

“…The disease's development involves complex interactions among immunological, genetic, and environmental factors, yet its molecular mechanism remains elusive. A major challenge in understanding PDAC etiology lies in unraveling the genetic profiling that governs the PDAC network. …”
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Hsa_circ_0003220 Drives Chemoresistance of Human NSCLC Cells by Modulating miR-489-3p/IGF1 by Shaofeng Xia, Chenliang Wang

“…For the purpose of the mechanism study, hsa_circ_0003220 knockdown substantially reduced IGF1 expression via miR-489-3p sponging, reducing chemoresistance in PR NSCLC cells. …”
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Early and delayed STAT1-dependent responses drive local trained immunity of macrophages in the spleen by Aryeh Solomon, Noa Bossel Ben-Moshe, Dotan Hoffman, Sébastien Trzebanski, Dror Yehezkel, Leia Vainman, Mihai G Netea, Roi Avraham

“…While the differentiation of hematopoietic stem cells (HSCs) and reprogramming of bone marrow (BM) progenitors are well-established mechanisms underpinning durable TI protection, remodeling of the cellular architecture within the tissue during TI remains underexplored. …”
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Engineered ipilimumab variants that bind human and mouse CTLA-4 by Brett Robison, SJ Diong, Anusha Kumar, Thomas M. Moon, Olin Chang, Bryant Chau, Christine Bee, Ishita Barman, Arvind Rajpal, Alan J. Korman, Sean West, Pavel Strop, Peter S. Lee

“…These cross-reactive ipilimumab variants may facilitate improved translatability and future mechanism-of-action studies for anti-CTLA-4 targeting in murine models.…”
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Investigation and Optimization of The Effect of Anhydrous Borax Mineral on The Vickers Hardness and Indentation Modulus Values of Iron Material by Talha Tunahan Kesemenli, Şenol Şahin, Ayşegül Bodur Yılmaz

“…In the productions carried out using Taguchi experimental design method, AHB additive ratio, and sintering temperature parameters were selected as control parameters that were thought to affect the physical and/or mechanical properties of the Fe/AHB composite materials. …”
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Entrepreneurial strategies for sustainable growth: a deep dive into cloud-native technology and its applications by T. A. Alka, Aswathy Sreenivasan, M. Suresh

“…The policymaker's and enterprises' focus and actionable intervention are necessary for developing mechanisms to solve the barriers of regulatory compliance, lack of skilled manpower, data security, privacy issues, and upfront investment for entrepreneurial success.…”
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CAFs-released exosomal CREB1 promotes cell progression and immune evasion in thyroid cancer via the positive regulation of CCL20 by Chen Zheng, Hu Hei, Yifei Zhai, Wenbo Gong, Runfang Zhang, Songtao Zhang

“…Currently, we aimed to explore the molecular mechanism of exosome-associated CREB1 and C-C motif chemokine ligand 20 (CCL20) in TC.Methods The mRNA and protein levels were examined via RT-qPCR and western blot. …”
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Ancient Stone Inscription Image Denoising and Inpainting Methods Based on Deep Neural Networks by Haoming Zhang, Yue Qi, Xiaoting Xue, Yahui Nan

“…To further improve the denoising results, an image inpainting model with the coherent semantic attention mechanism is introduced to recover some effective information removed by the former denoising model as much as possible. …”
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Structural and functional connectivity coupling as an imaging marker for bone metastasis pain in lung cancer patients by Jiahui Zheng, Chengfang Wang, Xiaoyu Zhou, Yu Tang, Lin Tang, Yong Tan, Jing Zhang, Hong Yu, Jiuquan Zhang, Daihong Liu

“…Understanding these changes could provide valuable insights into the neural mechanisms underlying cancer pain.…”
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Studies on the alleviating effect of Bifidobacterium lactis V9 on dextran sodium sulfate-induced colitis in mice by Xiaoyan Duan, Xiaoyan Duan, Xiaoyan Duan, Xiaoyan Duan, Rilige Wu, Jianbo Li, Jianbo Li, Zeya Li, Yanqi Liu, Ping Chen, Bangmao Wang, Bangmao Wang, Bangmao Wang

“…We aimed to investigate the potential mechanisms by which Bifidobacterium lactis V9 (V9) alleviated colitis in a dextran sodium sulfate-induced colitis model mice.MethodsMice were induced to develop colitis by drinking DSS solution to induce colitis. …”
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The cognitive critical brain: Modulation of criticality in perception-related cortical regions by Xingyu Liu, Xiaotian Fei, Jia Liu

“…In conclusion, our study provides empirical evidence from the domain of perception supporting the cognitive critical brain hypothesis that modulating the criticality of subsystems within the brain's hierarchical and modular organization may be a fundamental mechanism for achieving diverse cognitive functions.…”
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