Exploring aspects of mentoring for black and minoritised healthcare professionals in the UK: a nominal group technique study by Vimal Sriram, Anita Atwal, Elizabeth A McKay

“…This model provides a mechanism for supporting and mentoring BME workers in healthcare for career advancement.…”
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CONCEPTUALIZING ENVIRONMENTAL POLICY: AN ANALYSIS OF RUSSIAN AND INTERNATIONAL LEGISLATION IN THE CONTEXT OF ENSURING ENVIRONMENTAL SECURITY IN THE ARCTIC by Elena M. Klyuchnikova, Vladimir A. Masloboev, Vladimir V. Dyadik, Andrey V. Masloboev, Natalia V. Dyadik, Anastasia N. Chapargina

“…A hierarchical framework was used for comparison, analyzing the content of environmental legislation in terms of concepts, objectives, policy directions, and implementation mechanisms. The novelty of the approach lies in its consideration of the socio-cultural factors underpinning the environmental concepts that shape each nation’s environmental policy. …”

p38/JNK Is Required for the Proliferation and Phenotype Changes of Vascular Smooth Muscle Cells Induced by L3MBTL4 in Essential Hypertension by Chaowei Hu, Kun Zuo, Kuibao Li, Yuanfeng Gao, Mulei Chen, Roumu Hu, Ye Liu, Hongjie Chi, Hongjiang Wang, Yanwen Qin, Xiaoyan Liu, Jiuchang Zhong, Jun Cai, Xinchun Yang, Jing Li

“…Yet, little evidence has been reported whether p38/JNK contributed directly to L3MBTL4-induced vascular remodeling and exploring the potential mechanism of L3MBTL4 in vascular smooth muscle cells (VSMCs). …”
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Dye adsorption on fish scale biosorbent from tannery wastewater by Md. Abul Hashem, Forhad Ahammad, Bishwajit Chandra Das, Eshtiyaq Tauhid Enan, Modinatul Maoya, Mohammad Jakir Hossain Khan, Md. Mukimujjaman Miem

“…The dye removal efficiency was evaluated by monitoring the biosorbent dose, settling time, stirring time, and temperature effect. The dye adsorption mechanism was characterized using Freundlich and Langmuir’s regression models. …”
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Biodegradable Mg alloy modified with bioactive exosomes for cardiovascular stent application by Ya-chen Hou, Jing-an Li, Chang Cao, Chang Su, Zhen Qin, Ge Zhang, Jia-cheng Guo, Jun-nan Tang, Jin-ying Zhang, Shao-kang Guan

“…In addition, the MgF2-PDA/exosome coating also improved the adhesion, proliferation, CD31 expression and nitric oxide (NO) release of vascular endothelial cells (ECs), all of which contribute to the surface endothelialization. And the mechanism experiments showed the exosome released from the coating uptake by the ECs and assemble around the lysosome and mitochondria, and the released rate of the exosome on the coating is around 5 to 7 days, indicating excellent multi-functions of MgF2-PDA/exosome coating in cardiovascular stent.…”
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The Integration of Multimodal Networks: The Generalized Modal Split and Collaborative Optimization of Transportation Hubs by Yifei Cai, Jun Chen, Da Lei, Jiang Yu

“…A hybrid genetic search with advanced diversity control (HGSADC) is developed to solve the bilevel model, where the exploration of the search space is expanded using the biased fitness function and diversification mechanism. The solution properties of the hybrid MSA and HGSADC are demonstrated in two modified nine-node networks. …”
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Analysis of the Outer Contour Characteristics of Roadway Forming under the Influence of Cutting Head Vibration by Zhixiang Liu, Shuai Wang, Miao Xie, Chunxue Xie

“…Considering that the trajectory of the cutting head of the longitudinal axis roadheader directly affects the surface morphology of the roadway, the formation mechanism of the outer profile of the roadway obtained by the cutting head is analyzed, and the dynamic model of the cutting part was constructed. …”
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Kinetic Aspects of Ethylene Glycol Degradation Using UV-C Activated Hydrogen Peroxide (H₂O₂/UV-C) by Timur Fazliev, Mikhail Lyulyukin, Denis Kozlov, Dmitry Selishchev

“…Air purging the reaction mixture at 1000 cm³ min⁻¹ increases the EG mineralization rate up to two times because the simultaneous action of UV-activated H₂O₂ and O₂ (H₂O₂ + O₂/UV-C) leads to a synergistic effect, especially at low EG:H₂O₂ ratios. The kinetics and mechanism of EG degradation are discussed on the basis of the concentration profiles of ethylene glycol and intermediate products.…”
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Light quality‐dependent roles of REVEILLE proteins in the circadian system by Cassandra L. Hughes, Yuyan An, Julin N. Maloof, Stacey L. Harmer

“…Overall, our results suggest that the RVEs have separable functions in plant growth and circadian regulation and that they are involved in blue light‐specific circadian signaling via a novel mechanism.…”
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Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonists for the treatment of obesity and diabetes mellitus by Alexander C. Martins, Beatriz G. de la Torre, Fernando Albericio

“…In this paper, the authors address all the GLP-1RA options developed to date, covering their mechanisms of action, efficacy, and chemical structures, among other aspects.…”
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Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a viciou... by Yin Jin, Apostolia Topaloudi, Sudhanshu Shekhar, Guangxin Chen, Alicia Nicole Scott, Bryce David Colon, Petros Drineas, Chris Rochet, Peristera Paschou

“…Post-GWAS analyses illuminate the functional and biological mechanisms underlying AD and reveal sex-specific differences. …”
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Weak acid and pepsin reflux induce laryngopharyngeal mucosal barrier injury: A rabbit-model-based study. by Chenjie Hou, Liqun Zhou, Yujin Zheng, Ting Chen, Renyou Hu, Jingyi Zheng, Chaofeng Liu, Yaqi Liu

“…<h4>Objective</h4>Using rabbit models, this study simulated the laryngopharynx's response to the synergistic effects of various acidic reflux environments and pepsin to investigate the response mechanism underlying weak acid reflux and pepsin in the mucosal barrier injury of laryngopharyngeal reflux.…”
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GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway by Shao Xie, Shao Xie, Jiahai Ding, Zhaohao Wang, Hengliang Shi, Zheng-Quan Yu

“…Understanding the molecular mechanisms underlying glioma initiation and progression and identifying potential therapeutic targets for gene therapy are crucial for improving patient outcomes. …”
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MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial by Mrinal Gounder, Melissa Johnson, Rebecca S. Heist, Geoffrey I. Shapiro, Sophie Postel-Vinay, Frederick H. Wilson, Elena Garralda, Gerburg Wulf, Caroline Almon, Salah Nabhan, Elia Aguado-Fraile, Peng He, Mathilde Romagnoli, Mohammad Hossain, Rohini Narayanaswamy, Amel Sadou-Dubourgnoux, Michael Cooper, Vasileios Askoxylakis, Howard A. Burris, Josep Tabernero

“…Our data provide preliminary evidence of clinical activity and proof-of-mechanism for MAT2A inhibition.…”
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Facile synthesis of size-tunable L-carnosine-capped silver nanoparticles and their role in metal ion sensing and catalytic degradation of p-nitrophenol by Akash Kumar, Ridhima Chadha, Abhishek Das, Nandita Maiti, Rayavarapu Raja Gopal

“…Further optimization and research are needed to expand their environmental applications and to understand their interaction mechanisms with various contaminants.…”
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Experimental Investigation of Chemical Flooding Using Nanoparticles and Polymer on Displacement of Crude Oil for Enhanced Oil Recovery by Imran Akbar, Hongtao Zhou, Wei Liu, Muhammad Usman Tahir, Asadullah Memon, Ubedullah Ansari, Fengzhang Lv

“…In this work, the effects of nanosuspensions (KY-200) and polymer gel HPAM (854) on oil recovery and water cut were studied in the view of EOR techniques and their results were compared. The mechanism of nanosuspensions transportation through the sand pack was also discussed. …”
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Gene expression signatures between Limia perugiae (Poeciliidae) populations from freshwater and hypersaline habitats, with comparisons to other teleosts. by Elizabeth J Wilson, Nick Barts, John L Coffin, James B Johnson, Carlos M Rodríguez Peña, Joanna L Kelley, Michael Tobler, Ryan Greenway

“…Our analyses of gill gene expression revealed potential molecular mechanisms underlying salinity tolerance in this species, including the enrichment of genes involved in ion transport, maintenance of chemical homeostasis, and cell signaling in the hypersaline population. …”
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DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer by Rashmi R. Joshi, Sk Imran Ali, Amanda K. Ashley

“…The nonhomologous end-joining (NHEJ) pathway is one mechanism to repair DNA double strand breaks, and proteins involved in NHEJ may also regulate DNA replication. …”
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Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related Tumorigenesis via Modulating Macrophages by Yanxia Fu, Jun Li, Mengdi Li, Junfeng Xu, Zheng Rong, Fangli Ren, Yinyin Wang, Jianqiu Sheng, Zhijie Chang

“…Indeed, HUC-MSCs dramatically ameliorated the disease symptoms and pathological changes of DSS-induced colitis mice. We deciphered the mechanism that HUC-MSCs inhibited tumorigenesis through reducing the proportion of macrophages, which were decreased in the mice suffered from AOM/DSS-induced colon cancer. …”
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Unusual Presentation of Type 1 Idiopathic Macular Telangiectasia by Zaïnab Bentaleb Machkour, Philippe Denis, Laurent Kodjikian

“…The description of more cases of bilateral type 1 IMT should be helpful to more precisely define the pathophysiologic mechanism that could be different from a localized Coats’ disease of the macula area.…”
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