A pre-clinical MRI-guided all-in-one focused ultrasound system for murine brain studies by Tarana Parvez Kaovasia, Sarah Duclos, Dinank Gupta, Kourosh Kalayeh, Mario Fabiilli, Douglas C. Noll, Jonathan Sukovich, Aditya Pandey, Zhen Xu, Timothy L. Hall

“…Abstract This paper describes the design and initial proof-of-concept of a single pre-clinical transcranial focused ultrasound (FUS) system capable of performing histotripsy (mechanical ablation), hyperthermia, blood-brain barrier opening (BBBO), sonodynamic therapy, or neuromodulation in a murine brain. …”
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CD8+T cells and monocytes were associated with brain alterations in human immunodeficiency virus-infected individuals with cognitive impairment by Xin Zhang, Zhen Li, Jiahao Ji, Yundong Ma, Guangqiang Sun, Xue Chen, Ling Zhang, Tong Zhang, Yulin Zhang, Yang Zhang

“…Cognitive impairment (CI) continues to be a concern for people living with HIV-1 (PLWH) in the era of antiretroviral therapy (ART), yet the underlying mechanisms remain unclear. We aimed to elucidate the structural and functional brain alterations and peripheral immune profile of PLWH with CI, as well as the correlation between them. …”
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Unlocking the Potential of RNA Sequencing in COVID-19: Toward Accurate Diagnosis and Personalized Medicine by Heba M. Saad Eldien, Abdulrahman H. Almaeen, Ahmed Abo El Fath, Ahmed E. Taha, Rehab Ahmed, Hassabelrasoul Elfadil, Helal F. Hetta

“…It allows for the differentiation between asymptomatic and symptomatic individuals and sheds light on the immune response mechanisms that contribute to disease progression. In critically ill patients, RNAseq has been crucial for identifying key genes that may predict patient outcomes, guiding therapeutic decisions, and assessing the long-term effects of the virus. …”
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DDX3 participates in miRNA biogenesis and RNA interference through translational control of PACT and interaction with AGO2 by Ming‐Chih Lai, Yen‐Ling Yu, Chiao‐Nung Chen, Jau‐Song Yu, Hsin‐Yuan Hung, Shih‐Peng Chan

“…Emerging evidence suggests that DDX3 plays a vital role in tumorigenesis and cancer progression, however, its underlying mechanism is still not fully understood. Here, we showed that the control of PACT by DDX3 is conserved in human cells and Caenorhabditis elegans. …”
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Observation of a rare beta decay of the charmed baryon with a Graph Neural Network by The BESIII Collaboration

“…Abstract The beta decay of the lightest charmed baryon $${\Lambda }_{c}^{+}$$ Λ c + provides unique insights into the fundamental mechanism of strong and electro-weak interactions, serving as a testbed for investigating non-perturbative quantum chromodynamics and constraining the Cabibbo-Kobayashi-Maskawa (CKM) matrix parameters. …”
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Infectivity in full-term placenta of Zika viruses with different lipid profiles by Eva Mazzetto, Alessio Bortolami, Davide Bovo, Matteo Stocchero, Elisa Mazzacan, Alessandra Napolitan, Valentina Panzarin, Maria Rosa Tran, Gianpiero Zamperin, Adelaide Milani, Andrea Fortin, Michela Bigolaro, Paola Pirillo, Matteo Pagliari, Claudia Zanardello, Giuseppe Giordano, Maria Teresa Gervasi, Eugenio Baraldi, Calogero Terregino, Carlo Giaquinto, Francesco Bonfante

“…While many studies have focused on understanding ZIKV pathogenesis during pregnancy, the viral mechanisms affecting fetal development remain largely unclear. …”
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Eliminating Postoperative Nausea and Vomiting in Outpatient Surgery with Multimodal Strategies including Low Doses of Nonsedating, Off-Patent Antiemetics: Is “Zero Tolerance“ Achie... by Susan J. Skledar, Brian A. Williams, Manuel C. Vallejo, Patricia L. Dalby, Jonathan H. Waters, Ronald Glick, Michael L. Kentor

“…Rescue therapy consists of avoiding unnecessary repeat doses of drugs acting by the same mechanism: haloperidol 2 mg i.v. (antidopaminergic) is prescribed for patients pretreated with cyclizine or promethazine 6.25 mg i.v. …”
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Exploring the Therapeutic Potential of Cannabidiol in U87MG Cells: Effects on Autophagy and NRF2 Pathway by Laura Giannotti, Benedetta Di Chiara Stanca, Francesco Spedicato, Daniele Vergara, Eleonora Stanca, Fabrizio Damiano, Luisa Siculella

“…In conclusion, low-dose CBD makes U87MG cells more vulnerable to cytotoxic effects, reducing cell viability and mitochondrial dynamics while increasing autophagic flux and redox systems. This explains the mechanisms by which glioma cells respond to CBD treatment. …”
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Sociodemographic characteristics, occupational characteristics, motivational factors, and job satisfaction among primary health service practitioners by Di Liu, Huanyan Wang, Wenlin Zhang, Peixuan Chen, Yuqing Lin, Yujin Xie, Mingyang Zou, Debao Li, Ming Fang, Bingjie Hu, Lei Shi

“…Establishing scientific and reasonable research on the incentive mechanism at grassroots medical institutions can help stabilize the team, enhance staff satisfaction and work performance, and optimize human resource utilization.…”
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The Role of Community Police in Crime Prevention and Control for the Effective Management by Rachel Nimma Ndakotsu

“…Tables, frequency and percentages were used to describe the responses from respondents, which shows that 3.56% was targeted sample from the population, out of 46 of the respondents, representing 29.5% described community policing as very effective mechanism of crime prevention in the study area. As well out of 45 respondents, 28 of the respondents representing 62.22% agreed quality information determined police response on crime prevention, this implies that community policing is an appropriate tool for crime prevention. …”
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NCHD handover in the acute mental health setting: a quality improvement initiative implementing an electronic handover tool by Karen O’Connor, Stelios Naxakis, Megan Wafer, Syeda Gardezi, Aamina Sadia, Rimsha Mujahid

“…Continuous training, feedback mechanisms and further refinement of the handover tool are essential for long-term success. …”
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Comparative transcriptome analysis on candidate genes involved in lipid biosynthesis of developing kernels for three walnut cultivars in Xinjiang by Wenqiang Wang, Hao Wen, Qiang Jin, Wenjun Yu, Gen Li, Minyu Wu, Hongjin Bai, Lirong Shen, Cuiyun Wu

“…In order to explore the biosynthesis molecular mechanism of oil accumulation and fatty acid (FA) synthesis in walnut, the samples at different development periods of three walnut cultivars, ‘Zhipi’ (ZP), ‘Xinwu 417’ (W417) and ‘Xinwen 81’ (W81) were collected for transcriptomic analysis. …”
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Research on multi-granularity password analysis based on LLM by Meng HONG, Weidong QIU, Yangde WANG

“…Password-based authentication has been widely used as the primary authentication mechanism.However, occasional large-scale password leaks have highlighted the vulnerability of passwords to risks such as guessing or theft.In recent years, research on password analysis using natural language processing techniques has progressed, treating passwords as a special form of natural language.Nevertheless, limited studies have investigated the impact of password text segmentation granularity on the effectiveness of password analysis with large language models.A multi-granularity password-analyzing framework was proposed based on a large language model, which follows the pre-training paradigm and autonomously learns prior knowledge of password distribution from large unlabelled datasets.The framework comprised three modules: the synchronization network, backbone network, and tail network.The synchronization network module implemented char-level, template-level, and chunk-level password segmentation, extracting knowledge on character distribution, structure, word chunk composition, and other password features.The backbone network module constructed a generic password model to learn the rules governing password composition.The tail network module generated candidate passwords for guessing and analyzing target databases.Experimental evaluations were conducted on eight password databases including Tianya and Twitter, analyzing and summarizing the effectiveness of the proposed framework under different language environments and word segmentation granularities.The results indicate that in Chinese user scenarios, the performance of the password-analyzing framework based on char-level and chunk-level segmentation is comparable, and significantly superior to the framework based on template-level segmentation.In English user scenarios, the framework based on chunk-level segmentation demonstrates the best password-analyzing performance.…”
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O-GlcNAc transferase mediates O-GlcNAcylation of NLRP3 regulates pyroptosis in spinal cord injury by Zhichao Zeng, Xuqiang Liao, Xinjian Zhao

“…Discussion and conclusion: This study preliminarily proved that the mechanism of OGT mediated O-GlcNAcylation of NLRP3 participates in the action of pyroptosis in SCI. …”
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Employing Decorative Composition Between Originality and Contemporary in Furniture Designs by Mohammed Hassan Al-Hilo, Lilian Ali Ajaj

“…while the goal of the research is embodied in revealing the mechanism of employing decorative composition between originality and contemporary in furniture designs. …”
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A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients by Beatriz Bernal-Bermúdez, Beatriz Bernal-Bermúdez, Beatriz Bernal-Bermúdez, Alicia Martínez-López, Alicia Martínez-López, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Teresa Martínez-Menchón, Teresa Martínez-Menchón, Teresa Martínez-Menchón, Pablo Mesa-del-Castillo, Pablo Mesa-del-Castillo, Pablo Mesa-del-Castillo, María L. Cayuela, María L. Cayuela, María L. Cayuela, Victoriano Mulero, Victoriano Mulero, Victoriano Mulero, Diana García-Moreno, Diana García-Moreno

“…Our results demonstrate the potential of this model to further understand AGS pathological mechanisms and to identify novel therapeutic drugs by HTS.…”
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Normal Ranges of Left Atrial Strain and 3D Echocardiographic Volume Measurements in Türkiye by Özden Seçkin Göbüt, Serkan Ünlü, Burcu Cihan Talay

“…Speckle tracking echocardiography makes it possible to evaluate the physio-mechanics of the LA method and threedimensional echocardiography have been shown to provide robust calculations of LA volume. …”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…Abstract V-set and immunoglobulin domain-containing 4 (VSIG4) positive tumor-associated macrophage (VSIG4+ TAM) is an immunosuppressive subpopulation newly identified in aggressive cancers. However, the mechanism how VSIG4+ TAMs mediate immune evasion in aggressive cancers have not been fully elucidated. …”
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Advances in Nucleic Acid Drugs and Gene Therapies based on Animal Models of Duchenne Muscular Dystrophy by LIU Siyu, LAI Yuezhao, GUO Wenting, CHEN Xuejin

“…This review briefly outlines the pathological mechanisms and genetic characteristics of DMD before delving into recent progress in therapeutic strategies, with a particular focus on nucleic acid drugs (including antisense oligonucleotides for exon skipping therapy and translation readthrough inducers) and gene therapy approaches (including gene replacement therapy and gene editing). …”
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Multi-channel spatio-temporal graph attention contrastive network for brain disease diagnosis by Chaojun Li, Kai Ma, Shengrong Li, Xiangshui Meng, Ran Wang, Daoqiang Zhang, Qi Zhu

“…Moreover, temporal dependencies across windows are captured by integrating feature embeddings through a self-attention mechanism, and the inter-window recurrent contrastive constraint is devised to extract higher-order spatio-temporal topological features. …”
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