Menopausal Hormone Therapy: Its Role in the Prevention of Cardiovascular Diseases and the Risk of Breast Cancer in Women by Tam Thai Thanh Tran, Thu Minh Phung, Anh Thi Mai Do, Quynh Tran Mai Ly, Tin Hoang Nguyen

“…Objective: This review was conducted to explain how menopausal hormone therapy (MHT) benefits cardiovascular diseases (CVDs) and how to control the risk of breast cancer. Mechanism: Estrogen deficiency, altered energy homeostasis, adipocyte changes, inflammation, and insulin resistance are responsible for the development of metabolic syndrome and CVDs. …”
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Chelate compounds and their use for correction of trace element deficiencies in livestock (review) by A. G. Koshchaev, N. E. Gorkovenko, A. V. Kosykh, D. V. Antipova

“…The scientific rationale is given for the use of amino acids and organic acids as organic carriers of metal, vitamin and other compounds. The mechanism of biological action of chelate compounds and the pathogenesis of trace element deficiencies in animals are considered, while the advantages of chelate compound use in microelementoses therapy and prevention are specified.…”
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Transcriptional and Posttranscriptional Regulations of the HLA-G Gene by Erick C. Castelli, Luciana C. Veiga-Castelli, Layale Yaghi, Philippe Moreau, Eduardo A. Donadi

“…The HLA-G promoter region is different from the classical class I promoters, mainly because (i) it lacks regulatory responsive elements for IFN-γ and NF-κB, (ii) the proximal promoter region (within 200 bases from the first translated ATG) does not mediate transactivation by the principal HLA class I transactivation mechanisms, and (iii) the presence of identified alternative regulatory elements (heat shock, progesterone and hypoxia-responsive elements) and unidentified responsive elements for IL-10, glucocorticoids, and other transcription factors is evident. …”
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Mineralization Potential of Electrospun PDO-Hydroxyapatite-Fibrinogen Blended Scaffolds by Isaac A. Rodriguez, Parthasarathy A. Madurantakam, Jennifer M. McCool, Scott A. Sell, Hu Yang, Peter C. Moon, Gary L. Bowlin

“…Mineralized electrospun Fg scaffolds without PDO were not mechanically stable after 5 days in SBF, but had superior mineralization capabilities which produced a thick bone-like mineral (BLM) layer throughout the scaffolds. 50 : 50 : 0 scaffolds incubated in either r-SBF for 5 days or c-SBF for 14 days produced scaffolds with high mineral content and individual-mineralized fibers. …”
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Impact of sleep deprivation on colon cancer: Unraveling the KynA-P4HA2-HIF-1α axis in tumor lipid metabolism and metastasis by Zuojie Peng, Jia Song, Wenzhong Zhu, Haijun Bao, Yuan Hu, Yongping Shi, Xukai Cheng, Mi Jiang, Feifei Fang, Jinhuang Chen, Xiaogang Shu

“…Furthermore, HILPDA was screened by transcriptomics, and its potential mechanism was explored through ChIP, co-IP, ubiquitination experiments, phenotyping experiments, etc. …”
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Therapeutic potential of boric acid as a local drug delivery agent in periodontitis: a comprehensive systematic review and meta-analysis by Reham Abdel-Fatah, Ghada A. Elhusseiny, Wafaa Saleh

“…These findings underscore the potential of boric acid as a valuable addition to periodontal therapy, demanding further investigation to reveal its precise mechanisms and optimize clinical application.…”
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Climate adaptation and resilience of biofiltration as a low-cost technological solution for water treatment – A critical review by Adedamola Adesomi Ali, Oliver Terna Iorhemen, Ronald W. Thring

“…It highlights several conventional water treatment methods and discusses their insufficiencies in treating emerging contaminants. The mechanisms through which biofiltration removes contaminants as well as the key parameters that influence biofiltration such as biofilter media, types of microorganisms, temperature, pH, nutrients supply, etc and the dominant microbes present in biofilters were reviewed. …”
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The Clinical Impact of Vascular Endothelial Growth Factor/Receptor (VEGF/R) Inhibitors on Voice by Christina Hui Lee Ng, Edward J. Damrose

“…To describe the preliminary laryngeal findings in patients undergoing chemotherapy with VEGF/R inhibitors, and to describe possible mechanisms of their effect on vocal fold function. Methods. …”
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Effects of fertilizer application on the bacterial community and weathering characteristics of typical purple parent rocks by Xuan Wang, Xuan Wang, Jixia Zhao, Chunpei Li, Chunpei Li, Limei Deng, Limei Deng, Rongyang Cui, Rongyang Cui, Tao Zhou, Tao Zhou, Zakir Hussain, Zakir Hussain, Gangcai Liu

“…IntroductionRock weathering is a fundamental process that shapes Earth’s topography, soil formation, and other surface processes. However, the mechanisms underlying the influence of fertilizer application on weathering remain poorly understood, especially with respect to bacterial intervention.MethodsIn this study, purple parent rocks from Shaximiao Group (J2s) and Penglaizhen Group (J3p) were selected to investigate the effects of fertilizer application on the bacterial community and weathering characteristics of these rock by leaching experiment.ResultsThe results revealed that: fertilizer application, especially when at high levels, greatly altered the abundance, diversity and composition of the bacterial community in weathered products. …”
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Synthesis, Characterization, and Application of Fe2O3 Nanophotocatalyst for the Treatment of Various Pollutants in Aqueous Phase: A Systematic Review by Aya Khalaf, Duaa Abu-Dalo, Ehab AlShamaileh

“…It covers the application of Fe2O3 nanoparticles in the treatment of water and wastewater and the mechanisms of solar photodegradation of iron oxide (Fe2O3) photocatalysts. …”
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Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain? by Yanyuan Du, Yaoyuan Li, Jieqing Hu, Ruiying Fang, Yuming Liu, Liu Cai, Ying Song, Susu Ma, Jin Gao, Hanyue Zhang, Baihui Li, Hongtai Xiong, Huibo Yu, Shenglei Yang, Shuduo Zhu, Honggang Zheng

“…Additionally, rTMS shows promise in improving cancer-related fatigue, anxiety, depression, and cognitive dysfunction, which can indirectly reduce cancer pain. The analgesic mechanisms of rTMS include inhibiting nociceptive signal transmission in the spinal cord, modulating hemodynamic changes in brain regions, and promoting endogenous opioid release. …”
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Ventilación natural: estudio aerodinámico mediante CFD de extractores pasivos y captadores de viento Natural ventilation: CFD aerodynamic study about passive extractor and windcatc... by José Sanchez, José Manuel Salmerón, Francisco José Sanchez, Servando Alvarez, José Luis Molina

“…The purpose of the article is to analyze the aerodynamics of windcatchers and wind-extractors by means of computational fluid mechanics, optimizing the geometries of these elements, and giving a simplified model as a result of the work, so as to include it in the aeraulic calculation of the buildings' air conditioning systems. …”
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PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting by Izabela Wojtkowska, Andrzej Tysarowski, Katarzyna Seliga, Janusz A. Siedlecki, Zbigniew Juraszyński, Milosz Marona, Lidia Greszata, Anna Skrobisz, Karol Kaminski, Robert Sawicki, Janina Stępińska

“…Genetic research has elucidated molecular mechanisms of heart failure (HF). Peroxisome proliferator-activated receptors (PPARs) seem to be important in etiology of HF. …”
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Concept, Framework, and Data Model for Geographical Soundscapes by Xiu Lu, Guannan Li, Xiaoqing Song, Liangchen Zhou, Guonian Lv

“…They cannot study the relationship between the elements related to the sound source or explore the interaction mechanism between the sound and geographical environments. …”
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Pluripotency of Dental Pulp Cells and Periodontal Ligament Cells Was Enhanced through Cell-Cell Communication via STAT3/Oct-4/Sox2 Signaling by Zhengjun Peng, Lu Liu, Wenyu Zhang, Xi Wei

“…Further research on the mechanism of the related signaling pathways was investigated by overexpression/silence of STAT3, ChIP, the dual-luciferase reporter assay, and EMSA. …”
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The guanine nucleotide exchange factor DOCK5 negatively regulates osteoblast differentiation and BMP2-induced bone regeneration via the MKK3/6 and p38 signaling pathways by Ju Ang Kim, Soomin Im, Jiwon Lim, Jung Min Hong, Hye Jung Ihn, Jong-Sup Bae, Jung-Eun Kim, Yong Chul Bae, Eui Kyun Park

“…Moreover, DOCK5 inhibition by C21 in WT mice enhanced BMP2-induced subcutaneous ectopic bone formation. The mechanism responsible for enhanced bone formation induced by DOCK5 inhibition may involve the suppression of Rac1 under TAK1, accompanied by the activation of MKK3/6 and p38 induced by BMP2. …”
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Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats by Vijay K. Bharti, R. S. Srivastava, H. Kumar, S. Bag, A. C. Majumdar, G. Singh, S. R. Pandi-Perumal, Gregory M. Brown

“…The present data suggest that F can induce oxidative stress in liver, heart, and kidney of female rats which may be a mechanism in F toxicity and these adverse effects can be ameliorated by buffalo (Bubalus bubalis) epiphyseal proteins and melatonin by upregulation of antioxidant defense system of heart, liver, and kidney of rats.…”
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Molecular assessment of splicing variants in a cohort of patients with inborn errors of immunity: methodological approach and interpretation remarks by Laura Miguel Berenguel, Carla Gianelli, Carla Gianelli, Carla Gianelli, Elisabet Matas Pérez, Teresa del Rosal, Ana Méndez Echevarría, Ángel Robles Marhuenda, Marta Feito Rodríguez, Maria Teresa Caballero Molina, Maria Teresa Caballero Molina, Lorena Magallares García, Brenda Sánchez Garrido, Samantha Hita Díaz, Luis Allende Martínez, Luis Allende Martínez, Pilar Nozal Aranda, Pilar Nozal Aranda, Pilar Nozal Aranda, Carmen Cámara Hijón, Carmen Cámara Hijón, Carmen Cámara Hijón, Eduardo López Granados, Eduardo López Granados, Eduardo López Granados, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, María Bravo García-Morato, María Bravo García-Morato, María Bravo García-Morato

“…BackgroundSplicing is the molecular mechanism to produce mature messenger RNA (mRNA) before its translation into protein. …”
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Brain Hemodynamic Intermediate Phenotype Links Vitamin B12 to Cognitive Profile of Healthy and Mild Cognitive Impaired Subjects by Luca Cecchetti, Giada Lettieri, Giacomo Handjaras, Andrea Leo, Emiliano Ricciardi, Pietro Pietrini, Silvia Pellegrini, The Train the Brain Consortium

“…Vitamin B12, folate, and homocysteine are implicated in pivotal neurodegenerative mechanisms and partake in elders’ mental decline. Findings on the association between vitamin-related biochemistry and cognitive abilities suggest that the structural and functional properties of the brain may represent an intermediate biomarker linking vitamin concentrations to cognition. …”
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The theoretical cognition and research paradigm of land system science by LONG Hualou, CHEN Kunqiu, ZHENG Yuhan, ZHANG Yingnan

“…The research paradigm of land system science has gradually transformed from knowledge and phenomenon description to the simulation and prediction of complex land systems, which emphasizes the integration of multidisciplinary theories and methods as well as understanding the local-distant coupled interactions of land systems based on the integrated multiscale analysis of expanding boundaries, and focuses on the construction of large-scale quantitative land system models to provide comprehensive and dynamic integrated analysis, prediction and simulation of its dynamic mechanisms, integrated effects and future scenarios and risks, and appeals for an opening scientific collaboration in the era of big data.…”
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