IUPHAR review: Targeted therapies of signaling pathways based on the gut microbiome in autism spectrum disorders: Mechanistic and therapeutic applications by Abdullah Al Mamun, Peiwu Geng, Shuanghu Wang, Chuxiao Shao, Jian Xiao

“…The discussion shows the potential of customized microbiome-based therapeutics and the integration of multi-omics methods to understand the underlying mechanisms. Moreover, the review explores the intricate relationship between gut microbiota and ASD, aiming to develop innovative therapies that utilize the gut microbiome to improve the clinical outcomes of ASD patients. …”
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IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome by Min Guo, Rui Yan, Hongmei Yao, Liqin Duan, Meng Sun, Zheng Xue, Yongping Jia

“…Then, overexpression and inhibition of IRF-1 was performed in macrophages from patients with ACS to explore the possible role and mechanism of IRF-1 involvement in macrophage pyroptosis. …”
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Investigating the Influence of Raw and Treated Coconut Fibre Obtained from Agricultural Residue on the Strength and Durability Characteristics of High-Strength Concrete by Gervany Hurlich Mboungou Londe, John Nyiro Mwero, Christopher Kanali, Sylvester Ochieng Abuodha

“…The study evaluated the mechanical and durability characteristics of HSC reinforced with raw and processed coconut fibres (CFR-HSC). …”
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Enhancing Africa’s agriculture and food systems through responsible and gender inclusive AI innovation: insights from AI4AFS network by Nicholas Ozor, Joel Nwakaire, Alfred Nyambane, Wentland Muhatiah, Cynthia Nwobodo

“…Key recommendations include establishing robust policy frameworks, strengthening capacity-building efforts, and securing sustainable funding mechanisms to support long-term AI adoption. This work provides the global community, policymakers, and stakeholders with critical insights on establishing ethical, responsible, and inclusive AI practices that can be adapted to similar agricultural contexts worldwide, contributing to sustainable food systems on an international scale.…”
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Evaluation of the Drug-Resistant Tuberculosis (DR-TB) management component under the National Tuberculosis Elimination Program (NTEP) in Kerala, India, 2021-22 by Raman Swathy Vaman, Madhanraj Kalyanasundaram, Malu Mohan, Narayana Pradeepa, Manoj V. Murhekar

“…Conclusion: Prioritizing the establishment of a district DR-TB treatment center and sputum transport mechanism, posting a clinical psychologist dedicated to counseling patients on therapy, and training all categories of staff on DR-TB management guidelines will significantly contribute to improving program outcomes.…”
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Educational Paradigm of Academic Writing by L. V. Dudnik, T. S. Putilovskaya

“…The aim of the article is to make an overview of these aspects in order to show how academic writing can be incorporated in the existing higher educational curricula, in particular the foreign language course, and to design an effective didactic mechanism of academic writing acquisition. The authors formulate the major principles of organising and implementing the training process, the most important being the competence-and-activity-based approach to teaching, relying on the competence-based model of academic writing worked out by the authors and applying the step-bystep strategy of training. …”
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Estudio de dosificaciones en laboratorio para pavimentos porosos de hormigón Laboratory study of mixture proportioning for pervious concrete pavement by Javier Castro, Hernán de Solminihac, Carlos Videla, Bonifacio Fernández

“…The results allow a good characterization of these mixtures both mechanical and hydraulic behavior. Reliationships between void contents, infiltration rate and flexural strength were found.…”
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United Nations - African Union Cooperation In Conflict Prevention, Peacekeeping and Peacebuildin by L. I. Romadan, V. A. Shagalov

“…In the article the main mechanisms and methods that are used by the United Nations and the African Union to hold peacekeeping operations are analyzed in details. …”
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Kindergarten teachers’ emotional intelligence and surface acting: the chain mediating effects of self-efficacy and work engagement by Shucun Sun, Zhonglian Yan, Caixia Sun

“…Additionally, self-efficacy and work engagement have chain mediating effects in the relationship between kindergarten teachers’ emotional intelligence and surface acting.ConclusionThe research findings reveal the influencing mechanism of kindergarten teachers’ emotional intelligence on surface acting, providing a theoretical basis and practical implications for understanding and promoting the reasonable use of surface acting by kindergarten teachers in the Chinese context.…”
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Fine mapping and expression characteristics analysis of male-sterile gene BrRNR1 in Chinese cabbage (Brassica rapa L. ssp. pekinensis) by Meihui Xue, Jiahang Li, Ruiqi Liao, Junjie Xu, Mingwei Zhou, Runpeng Yao, Zhiyong Liu, Hui Feng, Shengnan Huang

“…Conclusion Our study is the first to characterize the function of BrRNR1 gene associated with male sterility and lays a foundation for exploring the molecular mechanism of anther abortion caused by the mutation in BrRNR1 gene of Chinese cabbage.…”
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Expression pattern of Calbindin-D28k, NeuN proteins, ATOH1 and EN2 genes in the human fetal cerebellum by Phanindra Prasad Poudel, Arnab Ghosh, Chacchu Bhattarai, Saman Pradhan, Nirmal Panthi, Dela Singh Joshi, Shanti Khadka, Sandhya Kumari, Guruprasad Kalthur, R. Vani Lakshmi, Sneha Guruprasad Kalthur

“…Understanding the expression patterns of key genes involved in these processes during various stages of fetal development can provide valuable insights into the complex mechanisms of cerebellar development. This study aims to investigate the expression patterns of Calbindin-D28k, NeuN (neuronal nuclease), ATOH1 (Atonal homolog 1), and EN2 (Engrailed -2) in the human fetal cerebellum. …”
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What drives farmers’ behavior under climate change? Decoding risk awareness, perceived impacts, and adaptive capacity in northern Italy by Sandra Ricart, Claudio Gandolfi, Andrea Castelletti

“…Farmers blend adaptive measures, including climate services and insurance, with preventive mechanisms like reducing fertilizer use, rotating and diversifying crops, and introducing soil conservation techniques. …”
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Molecular evidence for the efficacy of PBM therapy in the treatment of oral lichen planus by Maria Zaharieva Mutafchieva, Milena Nenkova Draganova, Plamen Ivanov Zagorchev, Reem Hanna, Georgi Tomchev Tomov

“…At the molecular level, PBM is likely to recover the impaired cell cycle mechanisms and keratinocyte proliferation.…”
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Economic Boycott from the Islamic Law Perspective: A Post-Tūfān al-ʾAqṣā Case Study by Naim Hank

“…The data in question claims that the companies did not face a significant financial loss due to the boycott after the Tūfān al-ʾAqṣā. However, a control mechanism to verify this data could not be determined. …”
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Airway Inflammation and the Pathogenesis of Asthma by Paul M O'Byrne

“…An improved understanding of the precise mechanisms by which airway inflammation is initiated, propagates and causes airway damage will hopefully allow more precise treatment strategies to he developed for asthma than currently exist.…”
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TEMPO-oxidized cellulose fiber from spent coffee ground: Studying their properties as a function of particle size by Hooriyeh Rahmani Khoshk, Marzieh Moeenfard

“…The applicability of cellulose and its derivatives is greatly depends on their attributes such as aspect ratio, morphology, surface chemistry, crystallinity, as well as their thermal and mechanical properties. However, these attributes can alter according to the utilized raw material, size classifications, extraction techniques, or fibrillation methods. …”
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The Response of the miRNA Profiles of the Thyroid Gland to the Artificial Photoperiod in Ovariectomized and Estradiol-Treated Ewes by Zizhen Ren, Wei Wang, Xiaoyun He, Mingxing Chu

“…The photoperiod has been considered to be a key environmental factor in sheep reproduction, and some studies have shown that the thyroid gland plays an important role in mammalian reproduction, but the molecular mechanism is still unclear. In this study, we used the artificial-light-controlled, ovariectomized, and estradiol-treated model (OVX + E2 model); healthy and consistent 2–3-year-old Sunite multiparous ewes were collected; and thyroids were collected for testing, combined with RNA-seq technology and bioinformatics analysis, to analyze the effects of different photoperiods (long photoperiod treatment for 42 days, LP42; short photoperiod treatment for 42 days, SP42; SP42 transferred to LP42, SPLP42) on the variations in the miRNA profiles of the thyroid gland. …”
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Optimization of Barrier Pillar Design in Longwall Mining with Top Coal Caving in Spontaneous Combustion Coal Seam by Qiang Fu, Ke Yang, Qinjie Liu, Shuai Liu, Xiang He, Xin Lyu

“…The theoretical model of the coal pillar along the gob-side entry shows that its instability is related to density of overlying strata, physical and mechanical parameters of coal body, dip angle of coal seam and weak face, and buried depth and mining width of working face. …”
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Association between weekend catch-up sleep and hypertension of the United States population from 2017 to 2020: a cross-sectional study by Yan Luo, Qingyuan Li, Qingyuan Li, Tong Feng, Shasha Meng, Shasha Meng, Ran Duan, Ran Duan

“…Future longitudinal studies are needed to confirm these findings and clarify the mechanisms underlying the relationship between WCS and hypertension risk.…”
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15q23 Gain in a Neonate with a Giant Omphalocele and Multiple Co-Occurring Anomalies by Hui-Fang Zhou, Christopher J. O’Conor, Chiraag Gangahar, Louis P. Dehner

“…Further study of the function of GLCE and other genes might lead to a better understanding of the molecular mechanism of omphalocele.…”
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