Formulation of Salam (Syzygium polyanthum (wight) walp) Leaves Ethanolic Extract Matrix Patch and Its Evaluation by Dian Eka Ermawati, Novi Andriani, Ulfa Afrinurfadhilah Darojati

“…For topical anti-inflammatory, a matrix patch has a delivery mechanism that drugs pass through in the skin in a controlled for an extended period. …”
Get full text

Feeding Behavior of Mice under Different Food Allocation Regimens by Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

“…The findings help elucidate potential evolutionary aspects that help maintain social cohesion while providing insights into potential mechanisms underlying socially anxious behavior.…”
Get full text

Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association by Amy Rebecca Bentley, Ayo P. Doumatey, Guanjie Chen, Hanxia Huang, Jie Zhou, Daniel Shriner, CongQing Jiang, Zhenjian Zhang, Guozheng Liu, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Benjamin A. Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Clement Adebamowo, Albert Amoah, Joseph Acheampong, Adebowale Adeyemo, Charles N. Rotimi

“…Notably, these findings suggest that the unexplained mechanism by which APOL1 affects kidney-disease risk may involve HDLc.…”
Get full text

Investigating the effect of mindfulness training for stress management in military training: the relationship between the autonomic nervous system and emotional regulation by Seho Lee, Jin Hyung Kim, Hakseung Kim, Sung Ha Kim, Sung Soo Park, Chang Woo Hong, Ki Tae Kwon, Seung Hun Lee, Kyoung Soo Kim, Hoon Choi, Jung Bin Kim, Dong-Joo Kim

“…Our findings provide insight into the neural mechanisms behind MT-induced stress reduction from the perspective of neuromodulation.…”
Get full text

Cyanidin-3-O-Glucoside Modulates the In Vitro Inflammatory Crosstalk between Intestinal Epithelial and Endothelial Cells by Daniela Ferrari, Francesco Cimino, Deborah Fratantonio, Maria Sofia Molonia, Romina Bashllari, Rossana Busà, Antonella Saija, Antonio Speciale

“…We demonstrated that selective inhibition of the NF-κB pathway in epithelial cells represents the main mechanism by which C3G exerts these protective effects. …”
Get full text

mTOR downregulation promotes anti-inflammatory responses via the CCL3-CCR5 axis in hypoxic retinopathy by Tae Kwon Moon, Im Kyeung Kang, Kyoung Jin Lee, Ji Hyun Kim, Hee Jong Kim, A. Reum Han, Ha-Na Woo, Joo Yong Lee, Jun-Sub Choi, Keerang Park, Heuiran Lee

“…Previously, we demonstrated that AAV2-shmTOR, effective across distinct species, holds therapeutic promise by modulating the activated mTOR pathway, yet its mechanisms for reducing inflammation remain largely unexplored. …”
Get full text

Antioxidant therapy for infertile couples: a comprehensive review of the current status and consideration of future prospects by Ramadan Saleh, Ramadan Saleh, Hassan Sallam, Hassan Sallam, Mohamad AlaaEldein Elsuity, Mohamad AlaaEldein Elsuity, Sulagna Dutta, Sulagna Dutta, Pallav Sengupta, Ahmed Nasr

“…In this review, we discuss the role of AOXs in the management of infertile couples, focusing on their biological mechanisms, potential adverse effects, therapeutic efficacy, and clinical applications in improving reproductive outcomes in both natural conception and medically assisted reproduction. …”
Get full text

Exploring the influence of pregnancy on cognitive function in women: a systematic review by Jana Younis, Malak Bleibel, Jad El Masri, Ali Ismail, Linda Abou‑Abbas

“…Conclusion Future efforts should prioritize uncovering the underlying mechanisms driving these cognitive changes during pregnancy and consider developing targeted interventions. …”
Get full text

5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation by Jinque Luo, Jinque Luo, Xin Li, Xin Li, Li Zhang, Li Zhang, Meijing Deng, Jieyang Zhao, Jinghuan Zhang, Wenyu Tang, Qinghua Guo, Ling Wang

“…Additionally, NF-κB pathway activation significantly diminished the inhibition of the NLRP3 inflammasome by 5-DR.DiscussionOur findings highlight the therapeutic potential of 5-DR as a promising candidate for treating LPS-induced ALI, offering insights into its underlying mechanism that targets NLRP3 inflammasome-mediated inflammation.…”
Get full text

JK-1, a useful erythroleukemic cell line model to study a controlled erythroid differentiation from progenitors to terminal erythropoiesis by Sylvain Metral, Sandrine Genetet, Benoît Gamain, Isabelle Mouro-Chanteloup

“…Abstract New hematopoietic cell models have recently emerged through immortalization of CD34 cells to study and understand various molecular mechanisms of erythropoiesis. Here, we characterize the JK-1 CML-derived cell line, previously shown to spontaneously differentiate without cytokines. …”
Get full text

A structural genomics approach to investigate Dystrophin mutations and their impact on the molecular pathways of Duchenne muscular dystrophy by Abdelbaset Mohamed Elasbali, Farah Anjum, Osama A. AlKhamees, Waleed Abu Al-Soud, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan

“…Six substitutions (N26H, N26K, G47W, D98G, G109A, and G109R) were predicted to decrease protein solubility and were located in minimally frustrated regions, potentially compromising Dystrophin functionality and contributing to DMD pathogenesis.ConclusionThis study provides novel insights into the molecular mechanisms of DMD, highlighting specific mutations that disrupt Dystrophin’s solubility and function. …”
Get full text

Facilitation of Tumor Stroma-Targeted Therapy: Model Difficulty and Co-Culture Organoid Method by Qiu-Shi Feng, Xiao-Feng Shan, Vicky Yau, Zhi-Gang Cai, Shang Xie

“…Tumor stroma, representing the non-cancerous and non-cellular composition of the tumor microenvironment (TME), plays a crucial role in oncogenesis and progression, through its interactions with biological, chemical, and mechanical signals. This review aims to analyze the challenges of stroma mimicry models, and highlight advanced personalized co-culture approaches for recapitulating tumor stroma using patient-derived tumor organoids (PDTOs). …”
Get full text

β-Carboline Alkaloids and Essential Tremor: Exploring the Environmental Determinants of One of the Most Prevalent Neurological Diseases by Elan D. Louis, Wei Zheng

“…A small number of studies have explored several of the biological correlates of exposure to harmane in ET patients. Studies of the mechanisms of this putative elevation of harmane in ET have explored the role of increased dietary consumption, finding weak evidence of increased exogenous intake in male ET cases, and other studies have found initial evidence that the elevated harmane in ET might be due to a hereditarily reduced capacity to metabolize harmane to harmine (7-methoxy-1-methyl-9H-pyrido[3,4-β]-indole). …”
Get full text

Azimuthal asymmetries in lepton and heavy-quark pair production in UPCs by Daniël Boer, Luca Maxia, Cristian Pisano

“…In particular, this leads to a feed-in mechanism among harmonics of different orders, which in principle generates harmonics of all (even) orders. …”
Get full text

Research Progress on the Relationship between Peripheral Somatosensory Neurons and Autism Spectrum Disorder by ZHUANG Wanyu, HONG Yu, LIN Dong, HUANG Longsheng

“…However, due to the diversity of clinical manifestations of ASD, differences in different pathogenic genes and pathogenesis, and the high diversity of sensory interneurons in the spinal dorsal horn, the next step still needs to be in-depth study on the application of peripheral somatosensory neurons in ASD, and further clarify its internal mechanism.…”
Get full text

L’émergence d’une sexualité juvénile hors mariage chez les jeunes de Sidi Ifni (Maroc) by Leila Boufraioua

“…However, dating relationships are becoming a new stage for them to understand the mechanisms that leading to the decline of celibacy and to the rise of sexual relations outside marriage. …”
Get full text

Oxidative stress-driven enhanced iron production and scavenging through Ferroportin reorientation worsens anemia in antimony-resistant Leishmania donovani infection. by Souradeepa Ghosh, Krishna Vamshi Chigicherla, Shirin Dasgupta, Yasuyuki Goto, Budhaditya Mukherjee

“…Understanding these mechanisms is crucial for managing LD-R-infections and their associated complications like severe anemia, and may also provide valuable mechanistic insights into understanding drug unresponsiveness developed in other intracellular pathogens that rely on host iron.…”
Get full text

Hygrothermal aging behavior of regenerated cellulose fiber-reinforced polyamide 5.10 composites by Celia Katharina Falkenreck, Jan-Christoph Zarges, Hans-Peter Heim

“…Furthermore, a strong association between aging and moisture content was demonstrated, which corresponds with the resulting mechanical properties. An influence of the inhomogeneous saturation of the PA5.10 on the molecular chain splitting processes could also be shown. …”
Get full text

How Can the Protection of Important Agricultural Heritage Sites Contribute to the Green Development of Agriculture: Evidence from China by Li Mo, Song Chen, Shenwei Wan, Lei Zhou, Shiyuan Wang

“…Additionally, a mediating effect model was used to test the potential mechanism. The specific conclusions are as follows: firstly, the protection of agricultural heritage sites has a significant positive effect on the green development of agriculture; secondly, the protection of agricultural heritage sites can advance the agricultural industrial structure, increase the land transfer rate, strengthen the construction of new agricultural management organisations, enhance financial investment in supporting, and promote green technology innovation. …”
Get full text

Legal Regulation of Interaction of Security Service of Ukraine with Civil Society in Counteracting Terrorism by A. Yu. Helzhynskyi

“…In response to these threats, the state creates protective mechanisms, increasing the level of protection of the population, since this is one of its main tasks. …”
Get full text