Chronic Gastroesophageal Reflux Dysregulates Proteostasis in Esophageal Epithelial CellsSummary by Kodisundaram Paulrasu, Ravindran Caspa Gokulan, Wael El-Rifai, Zhibin Chen, Jianwen Que, Timothy C. Wang, Olivier G. Boutaud, Karoline Briegel, Sergey I. Dikalov, Monica T. Garcia-Buitrago, Alexander I. Zaika

“…Surgical model of esophageal reflux injury and L2-IL1β transgenic mice were used to investigate the mechanisms of protein misfolding and aggregation. Results: Our studies demonstrate that gastroesophageal reflux causes protein misfolding and aggregation that is associated with severity of GERD. …”
Get full text

Thermodynamic Properties of γ- and δ-Lactones: Exploring Alkyl Chain Length Effect and Ring-Opening Reactions for Green Chemistry Applications by Ana L. R. Silva, Gastón P. León, Vladimír Lukeš, Erik Klein, Maria D. M. C. Ribeiro da Silva

“…Finally, the thermochemistry of individual steps of lactone ring opening and successive decarboxylation mechanism, including the identification of transition states, was studied using the M06-2X/6-311++G(d,p) approach.…”
Get full text

Progress of CCL20-CCR6 in the airways: a promising new therapeutic target by Ya -Jing Li, Wan-Li Geng, Chen-Chen Li, Jia-Hao Wu, Fei Gao, Yong Wang

“…Despite the promising research prospects surrounding the CCL20-CCR6 chemokine axis, the precise mechanisms underlying its action in respiratory diseases remain largely elusive. …”
Get full text

Study on the Adhesion Properties of Raw Coal and Adhesive Clogging Characteristics of Underground Coal Bunkers by Chongyang Jiang, Lianguo Wang, Zhiyuan Pan, Jiaxing Guo, Shuai Wang

“…Based on these, we obtained the influence patterns of various factors, such as coal bunker convergence angle, coal storage height, and coal moisture content, on the coal particle flow pattern, bunker wall pressure, and adhesive clogging distribution characteristics of the coal bunker during the discharge process, thereby revealing the mechanisms underlying the adhesive clogging phenomenon. …”
Get full text

Mapping dynamic regulation of gene expression using single-cell transcriptomics and application to complex disease genetics by Hanna Abe, Phillip Lin, Dan Zhou, Douglas M. Ruderfer, Eric R. Gamazon

“…As an application, we show that the approach detects known and new genes associated with schizophrenia and enables insights into context-dependent disease mechanisms. We provide a genomic resource from a phenome-wide application of our models to more than 1,500 phenotypes from the UK Biobank. …”
Get full text

Tennis Assistance Technology Based on Dynamic Time Warping Algorithm by Penggang Wang, Pengpeng Zhang, Guanxi Fan

“…Compared with the experimental group that does not use normalization, support vector mechanism node detection, sparse matrix, and second-order stepping mode, there is a significant improvement in performance. …”
Get full text

Seismic Damage Prediction Method for Lining Structures Based on the SEDR Principle by Q. Zheng, C. L. Xin, Y. S. Shen, Z. M. Huang, B. Gao

“…This method can be used to predict the seismic damage of lining structures and provide a reference for the research of the damage mechanism of tunnels.…”
Get full text

Practical considerations for DNA sensing using Faradaic electrochemical impedance spectroscopy on ENIG PCB electrodes by Shruti Ahuja, Avani Kulkarni, Richa Pandey, Kiran Kondabagil, Siddharth Tallur

“…We also present preliminary results for utilizing this sensing mechanism to detect E. coli from wastewater samples.…”
Get full text

De Novo Donor-Specific HLA Antibody Development and Peripheral CD4+CD25high Cells in Kidney Transplant Recipients: A Place for Interaction? by Josefina Alberu, Maria Inés Vargas-Rojas, Luis E. Morales-Buenrostro, Jose C. Crispin, Roxana Rodríguez-Romo, Norma O. Uribe-Uribe, Gabriel Carrasco, Diana Gómez-Martín, Jorge Alcocer-Varela

“…Additional inhibitory mechanisms participating earlier in DSA development after KT deserve to be sought.…”
Get full text

Patent Analysis in the Grain Storage Sector by DU Shang-qiu, CUI Peng-cheng

“…China should establish a technology transfer mechanism centered on enterprises, with active participation from universities and research institutes, fostering shared benefits and risks. …”
Get full text

Regolith-Rich PEEK Composite Bricks: Steps Towards Space-Ready Lunar Construction Materials by Roberto Torre, Carlo Giovanni Ferro, Lorenzo Bono, Aidan Cowley

“…The study investigates key processing parameters and evaluates the effects of vacuum processing and temperature testing on mechanical properties. The research also evaluates the effects of vacuum processing and temperature testing to assess the material’s performance under lunar conditions. …”
Get full text

Circular RNA ITCH Is a Tumor Suppressor in Clear Cell Renal Cell Carcinoma Metastasis through miR-106b-5p/PDCD4 Axis by Ping Gao, Yong Huang, Yanmei Hou, Qian Li, Haimei Wang

“…Downregulation circ-ITCH promoted cell migration, but overexpressing circ-ITCH inhibited cell migration and invasion in OSRC-2 and SW839 cells. Mechanism investigations claimed that circ-ITCH exerted its metastasis-inhibitory activity via sponging miR-106b-5p and regulating the expression of PDCD4. …”
Get full text

The association between perceived social support and self-management behaviors in adolescents and young adults with inflammatory bowel disease: the chain mediating role of basic ps... by Yangfan Zhu, Yangfan Zhu, Yueyue Chen, Yuman Tang, Xin Zhang, Qiao Shen, Fei Li, Hao Wang, Xianlan Zheng

“…Self-management behaviors were demonstrated to enhance remission and quality of life, yet the mechanisms influencing self-management behaviors remained under-explored. …”
Get full text

PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling by Qinghui Zhang, Shihao Xiang, Qingqian Liu, Tao Gu, Yongliang Yao, Xiaojie Lu

“…This study was aimed at investigating the role of PPARγ in hypoxia-induced hepatic fibrogenesis and its possible mechanism. Methods. Rats used for CCl4-induced hepatic fibrosis model were exposed to hypoxia for 8 hours each day. …”
Get full text

The effect of high temperature deformation on the austenite reversion transformation and η-Ni3Ti precipitation behavior in a Ti–Mo maraging steel by Chih-Yuan Chen, Iting Chiang, Yung-Chang Kang

“…Via microstructural characterization analysis and mechanical properties tests, the present study primarily focused on exploring the effect of hot deformation strain on the phase transformation behavior in Ti–Mo precipitation hardening stainless steels (PHSSs). …”
Get full text

Temperature and Stress Evaluation during Three Different Phases of Friction Stir Welding of AA 7075-T651 Alloy by Kareem N. Salloomi, Furat I. Hussein, Sanaa N. M. Al-Sumaidae

“…In addition, asymptotic V shape with high gradient temperature value in the weld nugget region after the full plunging was distinguished. Mechanical stresses and related plastic deformations generated, while achieving the FSW samples were evaluated in addition to the tool reaction force and heat generated to protect against tool failure.…”
Get full text

Genetic Variant of C-5434T REN Enhancer on Serum Renin Levels and Binding Pattern of Signal Transducers and Activators Transcription 3 by Imama Maslahah, Mohammad Saifur Rohman, Nashi Widodo, Agustina Tri Endharti, Didik Utomo

“…Genetic variant C-5434T of REN enhancer contributed to renin gene transcription and serum renin regulation. However, the mechanism associated with the transcription level changes remains unknown, and only a few reports exist that discussed serum renin levels on C-5434T of REN. …”
Get full text

Impact of heat stress on growth and physiological parameters of soybean varieties at the seedling stage by Bashir Hassan, Samanhudi, Parjanto, Setyawati Andriyana, Komariah, Senge Masateru, Rahayu Muji, Salma Fathin Tilmiidzah

“…This study provides valuable insights into soybean heat stress tolerance mechanisms and identifies promising genetic resources for breeding heat-resilient cultivars in Indonesia. …”
Get full text

TIM‐4 increases the proportion of CD4+CD25+FOXP3+ regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL‐6 secretion by Ziyao Wang, Zerong Xie, Yu Mou, Ruiman Geng, Chen Chen, Nengwen Ke

“…TIM‐4 influences the differentiation of Treg by inhibiting IL‐6 secretion in pancreatic cancer cells and facilitates the proliferation of pancreatic cancer in mice. Additionally, the mechanism may be through the CD8+ effector T cells (CD8+Tc). …”
Get full text

Smart Integrated Decentralization Strategies of Solar Power System in Buildings by Syed Muhammad Kashif Shah, Tanzeel Ur Rasheed, Hafiz Muhammad Ali

“…The proposed system is a collaborative sharing integrated decentralized solar system that credits sunlight-based energy framework proprietors for the power they add to different buildings due to the collaborative sharing mechanism at Rs.10 per kWh. This low-cost electricity is available at your doorstep that you can share according to the collaborative sharing basis that will not range any certain variable. …”
Get full text