Real-life study on the effectiveness and safety of sofosbuvir/velpatasvir-based antiviral agents for hepatitis C eradication in Chinese patients by Jiayi Wang, Lingyao Du, Dongmei Zhang, Chen Zhou, Yilan Zeng, Miao Liu, Xing Cheng, Xiaona Song, Han Chen, Ning Han, Enqiang Chen, Hong Tang

“…Background: Hepatitis C virus (HCV) eradication with sofosbuvir/velpatasvir (SOF/VEL) represents a significant advancement, offering hope for eliminating the virus in diverse patient populations. …”
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Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models by Shohei Koyama, Yujiro Naito, John D Minna, David E Gerber, Ryan R Kowash, Manoj Sabnani, Laura T Gray, Qing Deng, Nusrat U A Saleh, Luc Girard, Kentaro Masahiro, Zhiqian Lucy Liu, Hemanta Baruah, Esra A Akbay

“…Tumor tissues from treated mice exhibit significantly increased immune cell infiltrates and activated NK cell populations.Conclusions Activating NK cells through MICA/B stabilization and inducing ADCC offers an alternative and potent therapy option in KL tumors. …”
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Unraveling landslide failure mechanisms with seismic signal analysis for enhanced pre-survey understanding by J.-M. Chang, J.-M. Chang, C.-M. Yang, W.-A. Chao, W.-A. Chao, C.-S. Ku, M.-W. Huang, M.-W. Huang, T.-C. Hsieh, C.-Y. Hung

“…This case study underscores the significance of remote and adjacent seismic stations in offering seismological-based landslide characteristics and a time vision of the physical processes of landslides, thereby assisting geologists in landslide observation and deciphering landslide evolution.…”
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Left atrial strain predicts paroxysmal atrial fibrillation recurrence after catheter ablation: a 1-year study using three-dimensional speckle-tracking echocardiography by Rui Zhang, He Li, Yan Wang, Tianle Yu, Jiacheng Li, Yumeng Wu, Zhiwen Yu, Cuixing Liang, Dan Yu, Li Xue

“…LASr, a predictive marker for the recurrence of PAF assists in the stratification of risk and contributes to informed treatment decisions, offering valuable points of reference.…”
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Impacto de Intar Radio, la primera emisora de radio online creada en España con IA by Concepción Gómez López

“…Los resultados obtenidos indican que, aun estando presente en plataformas digitales (www.radio.es), Intar Radio no ofrece contenidos bajo demanda, lo cual limita su competitividad frente a la radio convencional. …”
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Comparative transcriptome analysis reveals molecular mechanisms of resistance in Chinese cabbage to Plasmodiophora brassicae pathotype 11 by Yue Qiu, Yue Qiu, Yue Qiu, Jinhao Zhang, Jinhao Zhang, Chunju Deng, Chunju Deng, Jiasheng Yuan, Jiasheng Yuan, Bowen Wang, Bowen Wang, Han Meng, Han Meng, Mohamed Mohany, Liting Zeng, Liting Zeng, Lanfang Wei, Lanfang Wei, Waqar Ahmed, Guanghai Ji, Guanghai Ji

“…Therefore, our speculation revolves around the potential resistant mechanism of this variety, which inhibits the proliferation of P. brassicae in the roots via secondary metabolites, cell wall, and ROS and also regulates physiological mechanisms mediated by plant hormones such as ABA to adapt to adverse environmental conditions such as water scarcity induced by the pathogen.ConclusionThis study unveils the intricate defense mechanisms potentially activated within Chinese cabbage when confronted with P. brassicae pathotype 11, offering valuable insights for breeding programs and the development of novel strategies for managing clubroot disease in Brassica crops. …”
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System-Technology Co-Optimization for Dense Edge Architectures Using 3-D Integration and Nonvolatile Memory by Leandro M. Giacomini Rocha, Mohamed Naeim, Guilherme Paim, Moritz Brunion, Priya Venugopal, Dragomir Milojevic, James Myers, Mustafa Badaroglu, Marian Verhelst, Julien Ryckaert, Dwaipayan Biswas

“…In this article, we present a system-technology co-optimization (STCO) framework that interfaces with workload-driven system scaling challenges and physical design-enabled technology offerings. The framework is built on three engines that provide the physical design characterization, dataflow mapping optimizer, and system efficiency predictor. …”
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Enfoques epistemológicos que orientan la investigación de 4to. nivel by Omaira G. De Berríos, María Ysabel Briceño de Gómez

“…La orientación epistemológica ofrece como ventaja la ubicación de la fuente del “saber” en una investigación; según esta dimensión, en una investigación es necesaria una distinción gnoseológica, que implica el compromiso de exaltar la fuente del conocimiento que da sustento a la investigación que se trate. …”
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Análisis de microorganismos funcionales y su relación con parámetros fisicoquímicos del suelo en un bosque reservado by Guillermo Sales-Ordoñez, Casiano Aguirre-Escalante, Alberto Franco Cerna-Cueva, Doive Salvador Ortega-Silva, Víctor Ernesto Pérez-Hernández, Nicolas Walter Aguilar-Carazas, Manuel Emilio Reategui-Inga

“…Este estudio demuestra que la comprensión detallada de la microbiota del suelo puede ofrecer nuevas oportunidades para mejorar las prácticas agrícolas, especialmente en términos de gestión de la fertilidad del suelo y sostenibilidad ambiental. …”
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Dental and oral health assessments in the German National Cohort (NAKO) by Stefanie Samietz, Katrin Borof, Katrin Hertrampf, Ghazal Aarabi, Antonio Ciardo, Hannah Finke, Daniel Hagenfeld, Jan Kühnisch, Maurice Rütters, Sebastian-Edgar Baumeister, Stefan Lars Reckelkamm, Ti-Sun Kim, Thomas Kocher, Wolfgang Ahrens, Hermann Brenner, Carina Emmel, Beate Fischer, Amand Führer, Karin Halina Greiser, Jasmin Grischke, Kathrin Günther, Volker Harth, Stefanie Jaskulski, André Karch, Thomas Keil, Yvonne Kemmling, Alexander Kluttig, Lilian Krist, Oliver Kuss, Michael Leitzmann, Claudia Meinke-Franze, Karin B. Michels, Nadia Obi, Anette Peters, Nicole Pischon, Tobias Pischon, Sabine Schipf, Börge Schmidt, Henning Teismann, Stefan Rupf, Birte Holtfreter

“…As part of the Level 2 program that was offered to 20% randomly selected participants, each study centre selected one of three modules, one of them being the Level 2 oral examination. …”
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Um xamã yanomami frente ao discurso filosófico-sociológico da modernidade by Leno Francisco Danner, Julie Stéfane Dorrico Peres

“…En este texto, que busca tejer un diálogo entre la literatura y la filosofía-sociología, desarrollaremos un doble argumento, basado en una discusión entre la obra La caída del cielo: palabras de un chamán yanomami, de David Kopenawa y Bruce Albert, y la teoría filosófico-sociológica de la modernidad de Jürgen Habermas: i) el sello distintivo de la literatura indígena, en su género autobiográfico, consiste en la correlación fundamental entre historia personal y destino colectivo (en el nivel socio-cultural y ecológico-espiritual), dinamizada por y basada en el mito, de manera que tal correlación entre la identidad personal y el destino colectivo se ofrece como una clave de lectura epistemológica, estética, política, antropológica y ontológica para acceder al texto-praxis indígena; ii) ello permite deconstruir la visión idílica que la Europa moderna tiene sobre sí misma y su comprensión caricaturesca de las culturas, las epistemologías y los hombres primitivos (no modernos, pre-modernos - porque después de la modernidad no se tendría más nada, ya ella es el vértice de la evolución humana, en términos epistemológicos y ontológicos), en la que, en primer lugar, la modernidad sería racional, generando la individulización, la crítica, la emancipación y el universalismo, debido a la separación entre historia personal y destino colectivo, y en segundo lugar, la cultura tradicional no generaría racionalización ni crítica, ni emancipación ni universalismo, al ser marcada por la imbricación entre la historia personal y el destino colectivo mediado por el mito. …”
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Beyond identification of familial hypercholesterolemia: Improving downstream visits and treatments in a large health care system by Harin Lee, Tarun Kadaru, Ruth Schneider, Taylor Triana, Carol Tujardon, Colby Ayers, Mujeeb Basit, Zahid Ahmad, Amit Khera

“…As part of a QI program, random individuals from the registry deemed to possibly have FH were contacted via (1) MyChart message, (2) phone call, (3) letter, and/or (4) InBasket message to their PCP to notify them of the potential FH diagnosis, higher risk of ASCVD events, and offering referral to an FH specialist. Participants were contacted 1–4 times by one of these modalities. …”
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Contrastive learning with transformer for adverse endpoint prediction in patients on DAPT post-coronary stent implantation by Fang Li, Zenan Sun, Ahmed abdelhameed, Tiehang Duan, Laila Rasmy, Xinyue Hu, Jianping He, Yifang Dang, Jingna Feng, Jianfu Li, Yichen Wang, Tianchen Lyu, Naomi Braun, Si Pham, Michael Gharacholou, DeLisa Fairweather, Degui Zhi, Jiang Bian, Cui Tao

“…By delivering precise predictive insights at multiple time points, our method meets the current need for adaptive, personalized therapeutic strategies in cardiology, thereby offering substantial value in improving patient outcomes.…”
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GC/MS Fatty Acid Profile of Marine-Derived Actinomycetes from Extreme Environments: Chemotaxonomic Insights and Biotechnological Potential by Marlene B. Cunha, André F. Jorge, Maria João Nunes, Joana R. Sousa, Maria João Lança, Marco Gomes da Silva, Susana P. Gaudêncio

“…These findings highlight the metabolic versatility of actinomycetes, providing valuable insights into microbial chemotaxonomy and offering promising biochemical leads for the development of biofuel, nutraceutical, and antifungal agents. …”
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A historical introduction to the development of Language Teaching and Learning in Higher Education in England: Spanish as a case study by Matilde Gallardo Barbarroja, Nicola McLelland

“…En primer lugar, siguiendo un enfoque cronológico, se ofrece una visión general de los acontecimientos que marcaron el desarrollo de la enseñanza y el aprendizaje de lenguas desde el siglo XVI, mostrando el creciente interés en el estudio de las mismas por su valor cultural y no sólo puramente práctico, así como su paulatina incorporación al sistema educativo en escuelas y universidades. …”
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Comparative analysis of chloroplast genomes reveals molecular evolution and phylogenetic relationships within the Papilionoideae of Fabaceae by Qian Qin, Yanjing Dong, Jialong Chen, Bo Wang, Yuxin Peng, XinPeng Zhang, Xiaoyun Wang, Jinxiang Zeng, Guoyue Zhong, Shouwen Zhang, Xiaolang Du

“…Conclusion This study provides novel insights into the molecular evolution and phylogeny of Pap., offering a foundational resource for future taxonomic and evolutionary research.…”
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Implementing and evaluating the comprehensive integration of physical activity into a major health system: study design and protocol by Alex Ewing, Mark Stoutenberg, Jennifer L Trilk, Christopher Wichman, Paul A Estabrooks, John M Brooks, Meenu Jindal, James Rosemeyer, Leah M Schumacher, Lia K McNulty, Stephanie Eskuri, Frankie Bennett

“…In Phase I, adopting clinics will receive a standardised EIMG instructional video followed by EIMG activation, allowing providers to refer eligible patients to a 12-week evidence-informed PA programme offered at local community facilities. In Phase II, adopting clinics will receive a more in-depth EIMG onboard training. …”
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Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Conclusions: Both SD-OCT models provide reliable and consistent TRT measurements, with the New OCT offering marginally enhanced image quality. However, the reproducibility of the New OCT does not significantly outperform the Old OCT, supporting the use of both devices for accurate TRT assessment in clinical settings. …”
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BICULTIVO EN BIOFLOC DE CACHAMA BLANCA -Piaractus brachypomus- Y TILAPIA NILÓTICA -Oreochromis niloticus- ALIMENTADAS CON DIETAS DE ORIGEN VEGETAL by S. B. Brú-Cordero, V. M Pertúz-Buelvas, J. E. Ayazo-Genes, V. J. Atencio-García, S. C. Pardo-Carrasco

“…El desempeño productivo y los costos de producción permiten sugerir la viabilidad que ofrece el sistema biofloc para la producción de carne de pescado con alimento de 24% PB de origen vegetal.…”
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Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs by Siyuan Deng, Han Shao, Hongtao Shang, Lingjin Pang, Xiaomeng Chen, Jingyi Cao, Yi Wang, Zhao Zhao

“…<b>Conclusions:</b> The developed cPM, with enhanced endosomal escape capabilities, presents a promising strategy to improve the expression efficiency of delivered mRNAs. This approach offers a novel alternative strategy with no modifications to the inherent properties of mRNA-LNPs, preventing any unforeseeable changes in formulation characteristics. …”
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