Integration of histone modification-based risk signature with drug sensitivity analysis reveals novel therapeutic strategies for lower-grade glioma by Jingyuan Wang, Shuai Yan

“…This integrated approach offers a promising framework for improving LGG patient care through molecular-based risk assessment and treatment selection.…”
Get full text

Assessment of Technology Readiness in Norwegian Older Adults With Long-Term Health Conditions Receiving Home Care Services: Cross-Sectional Questionnaire Study by Sverre Bergh, Jūratė Šaltytė Benth, Lisbeth Dyrendal Høgset, Britt Rydjord, Lars Kayser

“…Participants in cluster 4 (n=16) had the lowest scores in the eHealth Literacy Questionnaire scales in the READHY instrument and should be offered nondigital services or would need extensive management support. …”
Get full text

The accumulation of harmful genes within the ROH hotspot regions of the Tibetan sheep genome does not lead to genetic load by Lixia Sun, Chao Yuan, Tingting Guo, Yaqin Bai, Zengkui Lu, Jianbin Liu

“…Conclusions This study provides a comprehensive and precise genomic analysis and interpretation of Tibetan sheep, offering theoretical basis for genetic breeding and evolution in Tibetan sheep.…”
Get full text

Computational Analysis of an Ammonia Combustion System for Future Two-Stroke Low-Speed Marine Engines by Jose R. Serrano, Ricardo Novella, Héctor Climent, Francisco José Arnau, Alejandro Calvo, Lauge Thorsen

“…The production and combustion of green ammonia do not generate carbon dioxide, offering a promising avenue for substantial reductions in greenhouse gas (GHG) emissions from a well-to-wake perspective. …”
Get full text

Integrating Remote Sensing and Soil Features for Enhanced Machine Learning-Based Corn Yield Prediction in the Southern US by Sayantan Sarkar, Javier M. Osorio Leyton, Efrain Noa-Yarasca, Kabindra Adhikari, Chad B. Hajda, Douglas R. Smith

“…Unlike prior studies that focus mainly on county-level or controlled laboratory-scale areas, this study targets a production-scale area, better representing real-world agricultural conditions and offering more practical relevance for farmers. Therefore, the objective of our study was to determine the best combination of vegetation indices and abiotic factors for predicting corn yield in a rain-fed, production-scale area, identify the most suitable corn growth stage for yield estimation using machine learning, and identify the most effective machine learning model for corn yield estimation. …”
Get full text

Relative Fat Mass and Physical Indices as Predictors of Gallstone Formation: Insights From Machine Learning and Logistic Regression by Deng L, Wang S, Wan D, Zhang Q, Shen W, Liu X, Zhang Y

“…The model developed in this study offers clinicians a valuable tool for identifying critical prognostic factors, facilitating personalized patient monitoring and tailored management.Keywords: gallstones, atherogenic index of plasma, national health and nutrition examination survey, cross-sectional studies, risk factor, machine learning…”
Get full text

Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis by Linsa Zhou, Qiang Zhou, Qian Guo, Peng Lai, Chen Rui, Wanqing Li, Xuemei Chen, Yue Zhuo, Xiaoping Zhong, Sen Lin

“…Methods The Gene Expression Omnibus (GEO) database was used to obtain differential genes for CM and normal skin, and the Genome-Wide Association Studies (GWAS) analysis offered summary-level melanoma data for CM. Mendelian randomization (MR) analyses were used to examine the correlated linkage between CM and sun-exposed skin genes. …”
Get full text

Photon-counting detector CTA to assess intracranial stents and flow diverters: an in vivo study with ultrahigh-resolution spectral reconstructions by Frederic De Beukelaer, Sophie De Beukelaer, Laura L. Wuyts, Omid Nikoubashman, Mohammed El Halal, Iliana Kantzeli, Martin Wiesmann, Hani Ridwan, Charlotte S. Weyland

“…Relevance statement PCD-CTA offers the opportunity to reduce the need for invasive angiography serving as follow-up examination after intracranial stent (ICS) or flow diverter (FD) implantation. …”
Get full text

Take five: about the beat and the bar of annual and 5-year periodic national forest inventories by Jean-Daniel Bontemps, Olivier Bouriaud

“…Conclusions The review evidences that a core sampling design principle, used to simultaneously operate annual and 5-year periodic forest inventory, has given rise to a diversity of implementation options. While it offers an original benchmark for any survey transition toward an annual frequency, it demonstrates the absence of a standardized framework. …”
Get full text

Tilrettelegging på eksamen for studenter med funksjonsnedsettelser by Kari Eldby Rygg, Liv Ingrid Aske Håberg, Beate Farstad

“…Både på nettsidene og i intervjuene kommer det frem at studenter med dysleksi får tilbud om flere tiltak for tilrettelegging på eksamen enn studenter med ASD eller ADHD. …”
Get full text

Association between fibrinogen-to-albumin ratio and bone metabolism markers (β-CTX and P1NP) in Chinese individuals with osteoporotic fracture: a cross-sectional investigation by Li-long Feng, Ke Lu, Chong Li, Min-zhe Xu, Yao-wei Ye, Yi Yin, Hui-qiang Shan

“…The study may provide a novel clinical implication by introducing FAR as a potential reference indicator for assessing bone health, offering a cost-effective and conveniently obtainable biomarker to monitor inflammation to improve bone metabolism in the treatment of osteoporosis.…”
Get full text

Cross-agency working when conducting a pragmatic RCT for older victims of crime: our experiences and lessons learned by Marc Serfaty, Jessica Satchell, Gloria K. Laycock, Chris R. Brewin, Marta Buszewicz, Gerard Leavey, Vari M. Drennan, Jonathan Cooke, Anthony Kessel

“…Conducting research within an existing busy clinical service was challenging, but the COVID-19 pandemic demonstrated the acceptability and feasibility of offering online therapy to older victims. Conclusion SNT screening was an effective way to identify distressed victims, but service demands question whether it is viable for working police staff and the delivery of the therapy proved challenging in the context of a traditional RCT. …”
Get full text

Exploratory study of patients’ and carers’ preferences for postdischarge surgical wound monitoring using survey and interviews by Keith Wilson, Nigel Westwood, Catherine Wloch, Pauline Harrington, Luke J Rogers, Judith Tanner, Gavin Murphy, Colin S Brown, Jeremy Dearling, Ricky Vaja, Melissa Rochon, Lyn Brierley Jones

“…Digital surgical wound monitoring offers these benefits and is acceptable to patients.Trial registration number ISRCTN13950775; Post-results.…”
Get full text

Wind speed and direction on predicting wind energy availability for a sustainable ecosystem by B. Baranitharan, D. Sivakumar, M. Perarul Selvan

“…This research has the potential to significantly reduce the amount of environmentally hazardous energy sources used to meet societal requirements. This study offers a trustworthy technique for assessing wind direction and speed, which helps design sustainable wind power plants, construct engineering curricula, and estimate clean, environmentally friendly energy sources.…”
Get full text

Combining a Risk Factor Score Designed From Electronic Health Records With a Digital Cytology Image Scoring System to Improve Bladder Cancer Detection: Proof-of-Concept Study by Sandie Cabon, Sarra Brihi, Riadh Fezzani, Morgane Pierre-Jean, Marc Cuggia, Guillaume Bouzillé

“…With this second data set, the combination of both models obtained areas under the curve of 0.82 on the training set and 0.83 on the test set, demonstrating the value of combining risk factor–based and image-based models. This combination offers a higher associated risk of cancer than VisioCyt alone for all classes, especially for low-grade bladder cancer. …”
Get full text

Integrating the A2DS2 Score with 24-Hour ASPECTS and red cell distribution width for enhanced prediction of stroke-associated pneumonia following intravenous thrombolysis: model de... by Sarawut Krongsut, Nat Na-Ek, Atiwat Soontornpun, Niyada Anusasnee

“…Conclusions The combined A2DS2-MFP calculation showed superior performance, enabling early SAP detection and improving survival outcomes. This novel model offers a practical tool for resource-limited settings, supporting better SAP risk stratification and clinical management.…”
Get full text

Integration of machine learning and experimental validation to identify the prognostic signature related to diverse programmed cell deaths in breast cancer by Longpeng Li, Longpeng Li, Jinfeng Zhao, Yaxin Wang, Zhibin Zhang, Wanquan Chen, Jirui Wang, Yue Cai

“…The mRNA expression levels of seven genes were upregulated in clinical cancer tissues.ConclusionPCDRS can be used as a biomarker to assess the prognosis and treatment response of BRCA patients, which offers novel insights for prognostic monitoring and treatment personalization of BRCA patients.…”
Get full text

Profiles of physician follow-up care, correlates and outcomes among patients affected by an incident mental disorder by Marie-Josée Fleury, Louis Rochette, Zhirong Cao, Guy Grenier, Victoria Massamba, Alain Lesage

“…Results Five profiles were identified: Profiles 2 and 5 (64%) offered low mental health (MH) outpatient follow-up care, while the others dispensed higher MH follow-up care. …”
Get full text

iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis by Jingyu Zhao, Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu

“…Its MIC against Cryptococcus was over eight times lower than conventional AmB, significantly reducing fungal burden in the mouse brain and lowering serum inflammatory factors.ConclusionThe iPSC-Exo/AmB complex is a promising therapeutic strategy that enhances AmB efficacy while reducing toxicity, offering new hope for treating CM and other refractory fungal infections of the central nervous system.…”
Get full text

Indications, Surgical Technique and Outcomes of Laparoscopic Splenectomy: A Retrospective Descriptive Study from Srinagar, India by Mushtaq Chalkoo, Mudasir Habib, Ashiq Hussain Raina, Firdous Hamid, Sajad Nazir Malla, Imtiyaz Ahmad Malik

“…Introduction: Laparoscopic splenectomy has become the preferred approach because it offers several advantages over traditional open surgery, including smaller incisions, decreased postoperative pain, reduced blood loss and shorter hospital stays. …”
Get full text