Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Our findings highlight clinically relevant immune signatures that enhance our understanding of aging-related diseases and could guide future research into new treatments, offering translational insights into human health and aging. …”
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Photoreduction of CO2 to Formic Acid in Aquatic Phase Using Layer Double Hydroxide (LDH) Catalyst by Jenny Rizkiana, Dzaky Auliardi, Aghietyas Choirun Az Zahra, Francesco Thadeo, Wibawa Hendra Saputera, Tatang Hernas Soerawidjaja, Hary Devianto

“…The increasing accumulation of CO2, the primary greenhouse gas (GHG), in the Earth's atmosphere has caused significant environmental problems and adverse climate change. Photoreduction offers promising method to convert CO2 into high value chemical compounds, such as formic acid, which can serve as a hydrogen carrier. …”
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Winter wheat yield responses to growing degree days: Long-term trends and adaptability in major producing areas of China by Ziyang Liu, Davide Cammarano, Xiaojun Liu, Yongchao Tian, Yan Zhu, Weixing Cao, Qiang Cao

“…This study provides crucial insights into current challenges and offers a foundation for future research on yield forecasting under varying climate scenarios.…”
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Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin by Prastika Krisma Jiwanti, Dewi Kartika Azizah Sukardi, Anis Puspita Sari, Mai Tomisaki, Siti Wafiroh, Sri Hartati, Arramel, Yew Hoong Wong, Pei Meng Woi, Joon Ching Juan

“…Consequently, the SPE modified with rGO-SnO2 nanocomposite emerges as a highly promising and effective tool for precise and sensitive CIP measurement, offering unparalleled performance metrics and opening avenues for enhanced environmental and health monitoring.…”
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Clinical Utility of Combined Tissue and Plasma Next-Generation Sequencing in Patients With Advanced, Treatment-Naïve NSCLC by Helena Bote-de Cabo, MD, Marco Siringo, MD, Esther Conde, MD, PhD, Susana Hernández, PhD, Fernando López-Ríos, MD, PhD, Alicia Castelo-Loureiro, MD, Esther García-Lorenzo, MD, Javier Baena, MD-PhD, Mercedes Herrera, MD, Ana Belén Enguita, MD, Yolanda Ruano, PhD, Jon Zugazagoitia, MD, PhD, Luis Paz-Ares, MD, PhD

“…The addition of orthogonal biopsy (tissue to liquid, or liquid to tissue) offered no relevant clinical value in cases with ESCAT I or II targetable drivers already detected by one method. …”
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Innovative determination of phytohormones in Aloe vera by Muhammad K. Hakeem, Meera Maraqa, Sampath K. Elangovan, Sampath K. Elangovan, Esam Eldin Saeed, Ajay Kumar Mishra, Khaled M. Hazzouri, Iltaf Shah, Iltaf Shah, Khaled M. A. Amiri

“…The results underscore the significant role of ABA, I3AA, SA, and GA in the plant's hormonal profile, offering a valuable tool for the analysis of phytohormonal content in Aloe vera and other plant species. …”
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Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy by Jianyao Zeng, Yan Sun, Yan Sun, Yuan Fang, Xiaodie Wang, Qian Huang, Pingjing Zhang, Meiqi Shao, Pei Wang, Jingbo Cheng, Meng Di, Tao Liu, Qijun Qian, Qijun Qian, Qijun Qian

“…Furthermore, LCG CAR-T cells modulated pro-inflammatory cytokine release, thereby reducing in vivo inflammatory responses and surpassing the effects observed with unmodified CAR-T cells.ConclusionsCollectively, our results demonstrate the high safety and efficacy of non-viral, low CpG Passer transposon CAR-T cells, offering new avenues for improving CAR-T cell efficacy while minimizing in vivo inflammation.…”
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The MyFlex-ζ Foot: A Variable Stiffness ESR Ankle-Foot Prosthesis by Johnnidel Tabucol, Vera G. M. Kooiman, Marco Leopaldi, Ruud Leijendekkers, Giacomo Selleri, Marcello Mellini, Nico Verdonschot, Magnus Oddsson, Raffaella Carloni, Andrea Zucchelli, Tommaso M. Brugo

“…Overall, these findings suggest MyFlex-<inline-formula> <tex-math notation="LaTeX">$\zeta $ </tex-math></inline-formula> offers adaptability and performance improvements over traditional ESR feet. …”
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Development of a multi-laboratory integrated predictive model for silicosis utilizing machine learning: a retrospective case-control study by Guo-kang Sun, Yun-hui Xiang, Lu Wang, Pin-pin Xiang, Zi-xin Wang, Jing Zhang, Ling Wu

“…It is cheap, sensitive, specific, and preliminarily offers a potential strategy for the large-scale screening of silicosis.…”
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Acupuntura urbana en bordes de ciudad: ejercicios en Arequipa y Bogotá by Carlos Zeballos Velarde, Carlos Mario Yory García, Eliana Chui Choque, Linda Zuluaga Laguna

“…Zonas que, marcadas por situaciones de fragmentación y de precariedad física y social, inciden negativamente en las condiciones de habitabilidad, gobernabilidad, productividad y conectividad de la ciudad. El caso peruano ofrece una metodología que integra las nociones de catálisis urbana, construcción social del hábitat y diseño participativo. …”
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Sustainable foam glass property prediction using machine learning: A comprehensive comparison of predictive methods and techniques by Mohamed Abdellatief, Leong Sing Wong, Norashidah Md Din, Ali Najah Ahmed, Abba Musa Hassan, Zainah Ibrahim, G. Murali, Kim Hung Mo, Ahmed El-Shafie

“…By achieving the most precise predictions with minimal error distributions, the GPR model offers actionable insights into FG design. These findings enable the optimization of FG production by providing reliable tools for predicting and controlling porosity and CS, reducing material waste, enhancing product quality, and streamlining manufacturing processes. …”
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Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction by Hongjian Zhou, Zhipeng Xu, Chun Jiang, Qiuyue Wu, Chuanyue Zhang, Zhenyu Liu, Xiaoxue Zhang, Weiwei Li, Yujia Pang, Jing Zhang, Wenju Pan, Min Chen, Xinyi Xia

“…This study not only provides new insights for further research into IR-induced damage and spermatogenic disorders caused by other factors, but also offers potential therapeutic strategies for developing radioprotective agents in cancer radiotherapy.…”
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Noninvasive prenatal diagnosis (NIPD) of non-syndromic hearing loss (NSHL) for singleton and twin pregnancies in the first trimester by Huanyun Li, Shaojun Li, Zhenhua Zhao, Lingrong Kong, Xinyu Fu, Jingqi Zhu, Jun Feng, Weiqin Tang, Di Wu, Xiangdong Kong

“…Moreover, it provides a novel and advanced diagnostic approach for families at high risk of NSHL during pregnancy, offering earlier detection, enhanced safety, and improved accuracy.…”
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Comparative effectiveness of buprenorphine-naloxone versus methadone for treatment of opioid use disorder: a population-based observational study protocol in British Columbia, Cana... by Lawrence C McCandless, Malcolm Maclure, M Eugenia Socías, Evan Wood, Paul Gustafson, Robert W Platt, Bohdan Nosyk, Sander Greenland, Micah Piske, Trevor Thomson, Emanuel Krebs, Natt Hongdilokkul, Julie Bruneau, M Ehsan Karim, Judith I Tsui

“…We will determine the effectiveness of buprenorphine/naloxone vs methadone using intention-to-treat and per-protocol analyses—the former emulating flexible-dose trials and the latter focusing on the comparison of the two medication regimens offered at the optimal dose. Sensitivity analyses will be used to assess the robustness of results to heterogeneity in the patient population and threats to internal validity.Ethics and dissemination The protocol, cohort creation and analysis plan have been approved and classified as a quality improvement initiative exempt from ethical review (Providence Health Care Research Institute and the Simon Fraser University Office of Research Ethics). …”
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An autonomous navigation method for orchard mobile robots based on octree 3D point cloud optimization by Hailong Li, Hailong Li, Hailong Li, Kai Huang, Kai Huang, Yuanhao Sun, Yuanhao Sun, Xiaohui Lei, Xiaohui Lei, Quanchun Yuan, Quanchun Yuan, Jinqi Zhang, Xiaolan Lv, Xiaolan Lv

“…Three-dimensional (3D) LiDAR is crucial for the autonomous navigation of orchard mobile robots, offering comprehensive and accurate environmental perception. …”
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The effects of psychosocial aftercare following pediatric chronic pain treatment withstand the coronavirus disease 2019 pandemic: long-term outcomes of a randomized controlled tria... by Lisa-Marie Rau, Meltem Dogan, Gerrit Hirschfeld, Markus Blankenburg, Michael C. Frühwald, Rosemarie Ahnert, Sarah Braun, Ursula Marschall, Boris Zernikow, Julia Wager

“…Psychosocial aftercare (PAC) offered for 6 months after IIPT can improve treatment outcomes for up to 12 months. …”
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Evaluating the impact of roof rainwater harvesting on hydrological connectivity and urban flood mitigation by Quang-Oai Lu, Reza Bahramloo, Jesús Rodrigo-Comino, Jun Wang, Ali Talebi, Quynh Thi Phuong Tran, Afshin Ghahramani, Mehdi Sepehri

“…Roof rainwater harvesting is a form of low impact development that offers an effective solution for mitigating urban flooding, particularly in densely populated metropolitan areas. …”
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Monitoring changes of forest height in California by Samuel Favrichon, Jake Lee, Yan Yang, Yan Yang, Ricardo Dalagnol, Ricardo Dalagnol, Fabien Wagner, Le Bienfaiteur Sagang, Le Bienfaiteur Sagang, Sassan Saatchi, Sassan Saatchi, Sassan Saatchi

“…Height showed distinct spatial variations across forest types offering quantitative and spatial information to evaluate forest conditions. …”
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Person-based design and evaluation of MIA, a digital medical interview assistant for radiology by Kerstin Denecke, Daniel Reichenpfader, Dominic Willi, Karin Kennel, Harald Bonel, Harald Bonel, Knud Nairz, Nikola Cihoric, Damien Papaux, Hendrik von Tengg-Kobligk

“…In this paper, we propose leveraging conversational agents to realize a medical interview assistant to facilitate medical history taking, while at the same time offering patients the opportunity to ask questions on the examination.MethodsMIA, the digital medical interview assistant, was developed using a person-based design approach, involving patient opinions and expert knowledge during the design and development with a specific use case in collecting information before a mammography examination. …”
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Effects of Limosilactobacillus reuteri on gastrointestinal microbiota, muscle fiber formation and meat quality of Sunit sheep by Ting Liu, Chenlei Wang, Mirco Corazzin, Taiwu Zhang, Maoqin Zhai, Yue Zhang, Qiaoge Zhang, Xin Zhao, Ye Jin, Lina Sun

“…In conclusion, supplementation with L. reuteri may affect muscle fiber characteristics, enhance intestinal health, and facilitate carbohydrate digestion of Sunit sheep. This study offers novel insights into the use of feed additives for improving meat quality.…”
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