Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping by Hannah L. Cornman, Martin P. Alphonse, Arbor Dykema, Alexander L. Kollhoff, Kevin K. Lee, Jaya Manjunath, Emily Z Ma, Varsha Parthasarathy, Junwen Deng, Thomas Pritchard, Anusha Kambala, Melika Marani, Kayla A. Parr, Javid P. Mohammed, Madan M. Kwatra, Jay H. Bream, Won Jin Ho, Shawn G. Kwatra

“…This study highlights a novel form of erythroderma with concomitant Th2 and Th17 dysregulation and introduces a minimally invasive peripheral blood-based immunophenotyping platform that offers a personalized medicine approach to the management of systemic inflammatory diseases.…”
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The Silent Threat of Human Metapneumovirus: Clinical Challenges and Diagnostic Insights from a Severe Pneumonia Case by Rubens Carmo Costa-Filho, Felipe Saddy, João Luiz Ferreira Costa, Leandro Reis Tavares, Hugo Caire Castro Faria Neto

“…The development of vaccines, such as the IVX-A12 in phase II trials, offers hope for targeted prevention, underscoring the need for further research and therapeutic innovations.…”
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Application of three-dimensional printing in the planning and execution of aortic aneurysm repair by Harshank Patel, Paul Choi, Jennifer C. Ku, Rosemary Vergara, Rafael Malgor, Dhiren Patel, Yong Li

“…This review examines the application of 3D printing and AI in complex aortic aneurysm repair, highlighting current clinical trends.MethodsAn exhaustive literature review was performed using keywords such as “3D printing,” “Artificial intelligence,” “Thoracoabdominal aneurysm,” “Abdominal aortic aneurysm,” “Aortic arch aneurysm,” “Endovascular repair,” and “Open repair” in PubMed and Google Scholar indexes up to June 2022.ResultsThis analysis included seven studies: four focused on 3D-printed phantoms for endovascular repair of various aortic pathologies (aortic arch, thoracoabdominal aorta, juxtarenal and pararenal aorta), one on open thoracoabdominal aneurysm repair using 3D-printed models for graft construction, and two on the use of convolutional neural networks, an AI-based technology, for the pre-processing of aortic computed tomography angiography images.ConclusionThe application of 3D printing and AI-based image pre-processing in the planning of complex aortic aneurysms offers several benefits, including enhanced patient and trainee education, more accurate fenestration placement, reduced surgical time and complications, and decreased surgeon stress.…”
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Enhancing maize seed resistance to chilling stress through seed germination and surface morphological changes using high voltage electrostatic field by Yao Lu, Yaoyao Li, Qian Peng, Xiangyun Sun, Qinglu Yang, Zhanhua Song, Fuyang Tian, Yinfa Yan, Mochen Liu

“…Optimal HVEF treatment resulted in cell wall expansion, enhanced fiber elasticity, reduced interstitial spaces, and swollen cells, indicating improved hydrophilicity and protease activity. This study offers valuable insights into the mechanisms by which HVEF improves seed performance under low-temperature stress.…”
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Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta‐analysis and genome‐wide association studie... by Jie Tian, Caiyang Liu, Guanchu Liu, Chunjian Zuo, Huanwen Chen

“…Collectively, this review offered a comprehensively referenced information with cumulative evidence of associations between genetic polymorphisms and EC and ESCC risk.…”
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A comprehensive review on alpha-lipoic acid delivery by nanoparticles by Navid Mosallaei, Amirhossein Malaekeh-Nikouei, Setayesh Sarraf Shirazi, Javad Behmadi, Bizhan Malaekeh-Nikouei

“…Each nanoparticulate system offers unique advantages, such as improved stability, sustained release, enhanced bioavailability, and targeted delivery. …”
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Emerging antifungal resistance in Trichophyton mentagrophytes: insights from susceptibility profiling and genetic mutation analysis by Yakun Shao, Jin Shao, Sybren de Hoog, Paul Verweij, Lin Bai, Riina Richardson, Malcolm Richardson, Zhe Wan, Ruoyu Li, Jin Yu, Yinggai Song

“…Together, these findings highlight a growing prevalence of antibiotic resistance among Trichophyton and identify potential target genes for new therapies, underscoring the need for ongoing monitoring and offering directions for novel therapeutics.…”
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El Trabajo Interdisciplinar de Módulo como herramienta para el desarrollo de competencias transversales by Leire Ugalde, Elena Bernaras, Eider Rodríguez, Ane Odria

“…El desarrollo de competencias transversales se erige como clave para ello y los trabajos interdisciplinares de módulo pueden ofrecer el escenario propicio para su logro. Esta investigación presenta los resultados obtenidos en el desarrollo de seis competencias transversales a través de la aplicación del módulo “Diversidad en la Escuela” en el segundo curso del Grado de Educación Primaria de la Universidad del País Vasco (UPV/EHU). 113 estudiantes respondieron a un cuestionario, tanto antes como después de realizar el módulo, donde se les preguntaba acerca de su percepción sobre estas competencias. …”
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Process, dynamics and bioeffects of acoustic droplet vaporization induced by dual-frequency focused ultrasound by Yubo Zhao, Yi Feng, Liang Wu

“…Importantly, dual-frequency combinations such as 1.5 MHz + 3 MHz (fundamental and second harmonic), which exhibit a higher Degree of Nonlinearity (DoN) can extend bubble lifespan, offering a potential pathway to the efficacy of ultrasound treatments.…”
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Developments and clinical experiences in collagenase chemonucleolysis for lumbar disc herniation: a narrative review by Hao Zhang, Chi Zhang, Lin Li, Ming-liang Hu, Jian-ning Zhao, Zhang Zheng, Wen-feng Ding

“…While chemonucleolysis offers advantages such as minimal invasiveness and cost-effectiveness, its complexity necessitates a multidisciplinary approach. …”
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Defect Detection in Concrete Structures Based on Characteristics of Hammer Reaction Force and Apparent Stiffness of Concrete by Koki Shoda, Jun Younes Louhi Kasahara, Qi An, Atsushi Yamashita

“…The impact method detects defects by analyzing characteristic reaction forces generated when striking areas with internal cavities, offering the advantage of being unaffected by acoustic noise and not requiring direct sensor contact. …”
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Numerical modeling of the long-term poromechanical performance of a deep enhanced geothermal system in northern Québec by Saeed Vadiee, Biao Li, Jasmin Raymond, Mafalda M. Miranda

“…These findings provide valuable insights into the long-term safety and behavior of geothermal reservoirs, offering important implications for future geothermal energy development and management strategies.…”
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Effects of long-term adapted physical training on functional capacity and quality of life in older adults with Parkinson's disease by Oussama Gaied Chortane, Elmoetez Magtouf, Wael Maktouf, Sabri Gaied Chortane

“…Although physical activity is considered a therapeutic treatment to slow the progression of the disease, it is considered to be an effective non-pharmacological adjuvant to medication to improve the symptom management.MethodsThe training program was offered for all the participants (N = 50) in three non-consecutive sessions per week for 60 minutes and a total duration of 12 to 16 months. …”
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Socio-spatial vulnerability index of type 2 diabetes mellitus in Mexico in 2020 by Enríque Ibarra-Zapata, Darío Gaytán-Hernández, Yolanda Terán-Figueroa, Verónica Gallegos-García, Carmen del Pilar Suárez-Rodríguez, Sergio Zarazúa Guzmán, Omar Parra Rodríguez

“…This method proves to be robust and offers a technical-scientific basis for guiding T2DM prevention strategies and actions using a spatial/epidemiological approach. …”
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PPARG/SPP1/CD44 signaling pathway in alveolar macrophages: Mechanisms of lipid dysregulation and therapeutic targets in idiopathic pulmonary fibrosis by Ganggang Li, Yuwei Zhang, Huanyu Jiang, Xuanyu Wu, Yanwei Hao, Yuchen Su, Yutong Zou, Wenjia Xian, Fei Wang, Quanyu Du

“…Moreover, network pharmacology analysis identified several herbal compounds that target PPARG, offering potential therapeutic opportunities. In conclusion, these findings highlight the critical role of lipid metabolism in IPF and present novel molecular targets for the development of future therapeutic strategies.…”
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Evaluating combinations of rainfall datasets and optimization techniques for improved hydrological predictions using the SWAT+ model by Mahesh R. Tapas, Randall Etheridge, Thanh-Nhan-Duc Tran, Manh-Hung Le, Brian Hinckley, Van Tam Nguyen, Venkataraman Lakshmi

“…The combination of the GPM IMERG dataset and the GLUE method proved most effective, offering valuable guidance for selecting optimal datasets and methods to enhance prediction accuracy in complex watersheds.…”
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Comparative Accuracies of Models for Drag Prediction During Geomagnetically Disturbed Periods: A First Principles Model Versus Empirical Models by R. L. Walterscheid, M. W. Chen, C.‐C. Chao, S. Gegenheimer, J. Cabrera‐Guzman, J. McVey

“…The empirical models are at present more practical for operational purposes, but the TIEGCM, developed as a research model, with a greater focus on operational use offers the potential for improved utility during stressing conditions.…”
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Design of a wasp-inspired biopsy needle capable of self-propulsion and friction-based tissue transport by Jette Bloemberg, Suzanne van Wees, Suzanne van Wees, Vera G. Kortman, Aimée Sakes

“…Future iterations should aim to reduce the outer diameter while maintaining tissue yield. The design offers a promising new avenue for wasp-inspired medical tools, potentially enhancing early pancreatic cancer detection, thus reducing healthcare costs and patient complications.…”
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Mechanisms and Production Enhancement Effects of CO₂/CH₄ Mixed Gas Injection in Shale Oil by Xiangyu Zhang, Qicheng Liu, Jieyun Tang, Xiangdong Cui, Shutian Zhang, Hong Zhang, Yinlong Lu, Xiaodong Dong, Hongxing Yan, Mingze Fu, Yuliang Su, Zheng Chen

“…In both matrix and fractured cores, the recovery rates achieved with mixed gases were 36.9% and 58.6%, respectively, demonstrating improved production compared to single-component gases. This research offers a theoretical foundation and novel insights into shale oil development.…”
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Segmental ischemia and indocyanine green navigation: impact on perioperative parameters in laparoscopic vs. open partial nephrectomy by R.M. Molchanov, O.O. Honcharuk, G.G. Khareba, O.B. Blyuss, R.V. Duka

“…Laparoscopic partial nephrectomy offers advantages in preserving renal function and minimizing estimated Glomerular Filtration Rate decline compared to open partial nephrectomy. …”
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