Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y glo... by Mieke Van Hemelrijck, Salvatore Grisanti, Avinash Aujayeb, Martin Forster, Giannis Mountzios, Andrea Napolitano, Bruno Vincenzi, Joachim G J V Aerts, Marina Garassino, Valter Torri, Solange Peters, Alex Friedlaender, Alfredo Addeo, Giuseppe Lo Russo, Roberto Ferrara, Diego Signorelli, Alessandro Russo, So Yeon Kim, Jarushka Naidoo, Scott Gettinger, Heather Wakelee, Martin Sebastian, Mark Awad, Abdul Rafeh Naqash, Alessio Cortellini, Raffaele Giusti, Michele De Tursi, Federica Zoratto, Marco Russano, Rita Chiari, Biagio Ricciuti, Andrea De Giglio, Alain Gelibter, Giuseppe Tonini, Amin H Nassar, Alessandra Curioni-Fontecedro, Eleni Karapanagiotou, Emilio Bria, Jack Bell, Paolo Bironzo, Joao V Alessi, Alessandro Morabito, David J Pinato, Francesco Passiglia, Carlo Genova, Francesca Mazzoni, Alessandro Inno, Francesco Grossi, Luca Cantini, Lorenza Landi, Luigi Della Gravara, Margarita Majem, Uma Mukherjee, Federica Biello, Alessandro Leonetti, Annalisa Guida, Marianna Macerelli, Gabriele Minuti, Giulio Metro, Thomas Newsom-Davis, Eleni Josephides, Andrea Camerini, Elisa Roca, David O’Reilly, Mingjia Li, Laura Mezquita, Teresa Gorría, Claudia A M Fulgenzi, Lauren Young, Joel W Neal, Javier Baena, Francesco Pantano, Jacobo Rogado, Mary Jo Fidler, Teresa Beninato, Federica Pecci, Alessandro Di Federico, Kazuki Takada, Leonardo Brunetti, Talal El Zarif, Laura Moliner, Alberto Servetto, Sukumar Kalvapudi, Sai Yendamuri, Edoardo Garbo, Giuseppina Rita Di Fazio, Monica Loza, Ritujith Jayakrishnan, Michele Montrone, Nichola O Awosika, Bartlomiej Tomasik, Maximilian Rost, Isabelle Monnet, Francesco Agustoni, Artur Katz, Dwight Hall Owen, Michele Ghidini, Armida D’Incecco, Gianpaolo Spinelli, Monica Verrico, Manuel Dupont, Rafael Di Marco Barros, Diego Luigi Cortinovis, Chiara Bennati, Frank Aboubakar Nana, Anne-Marie Dingemans, Taher Abu Hejleh

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Architecture et réfection des aqueducs d’Orléans/Cenabum (Loiret) by Julien Courtois, Mathilde Noël, Franck Verneau

“…Because of its status as a commercial centre with a river port and a bridge crossing the Loire, the town benefited from public facilities typical of Gaul, including public baths. …”
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Impact of Duodopa on Quality of Life in Advanced Parkinson's Disease: A UK Case Series by T. Foltynie, C. Magee, C. James, G. J. M. Webster, A. J. Lees, P. Limousin

“…In this study, we describe the outcome of 12 PD patients with PD related complications started on LCIG, with respect to their quality of life measured by a disease specific validated scale—the PDQ39, together with diaries recording time spent “On,” “Off,” “Dyskinetic,” or “Asleep.” …”
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Easy, fast and reproducible Stochastic Cellular Automata with chouca by Génin, Alexandre, Dupont, Guillaume, Valencia, Daniel, Zucconi, Mauro, Ávila-Thieme, M. Isidora, Navarrete, Sergio A., Wieters, Evie A.

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A catalogue of land-based adaptation and mitigation solutions to tackle climate change by Maria Vincenza Chiriacò, Claudia Dămătîrcă, Sara Abd Alla, Sara Barilari, Rebeca Biancardi Aleu, Tommaso Brazzini, Tiago Capela Lourenço, Carlotta Annamaria de Carolis Villars, Suzie Durand, Giulio Di Lallo, Ricardo Encarnação Coelho, Océane Espin, Noelia Ferreras-Alonso, Giulia Galluccio, Daniel Ganszky, Sofie Hellsten, Gema Hernández-Moral, Jane Ihrfors, Iphigenia Keramitsoglou, Chris T. Kiranoudis, Attila Nemethy, Robert Oakes, Jesús Ortuño Castillo, Amandine Valérie Pastor, Patricia Pérez-Ramirez, Iván Ramos-Diez, Panagiotis Sismanidis, Chiara Trozzo, Chiara De Notaris

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Diagnostic Accuracy Of Spectral Doppler Ultrasound In Diagnosis Of Malignant Breast Lesions Taking Histopathology As Gold Standard by Mehwish Tabassum, Rabia Waseem, Manal Niazi, Zainab Riaz, Hamna Shakil, Wajeeha Anam

“…Each patient was subject to spectral Doppler ultrasound using a high-resolution unit with a linear array probe centred at 7.5MHz. The findings were interpreted by a consultant radiologist for the presence or absence of malignant breast lesions. …”
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A Comparison of the Celiacomesenteric Trunk in the Caribbean with Global Prevalence Calculated by a Systematic Review by Shamir O. Cawich, Maurice Fortune, Rahul Deshpande, Michael Gardner, Neil Pearce, Peter Johnson, Vijay Naraynsingh

“…Typically, the celiac trunk and superior mesenteric artery branch off separately from the anterior aspect of the abdominal aorta. …”
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Real-world clinical validation of the Qatar pre-diabetes risk score: a cross-sectional study by Mohamed Ahmed Syed, Narjiss Sallahi, Abduljaleel Abdullatif Zainel, Halima None Bensmail, Abdelilah Arredouani

“…HbA1c test revealed that 21.9% of the 797 subjects had pre-diabetes (HbA1c between 5.7% and 6.5%) while 3.3% had undiagnosed diabetes (HbA1c≥ 6.5%). Using a PRISQ cut-off of 16, PRISQ sensitivity exceeded 90% in all subgroups of individuals aged 40 years and above, regardless of ethnicity. …”
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Use of computerised adaptive testing to reduce the number of items in patient-reported hip and knee outcome scores: an analysis of the NHS England National Patient-Reported Outcome... by Jose Maria Valderas, Andrew D Toms, Jonathan Peter Evans, Christopher Gibbons

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The iGains4Gains model guides irrigation water conservation and allocation to enhance nexus gains across water, food, carbon emissions, and nature by Bruce Lankford, Nafn Amdar, Matthew McCartney, Tafadzwanashe Mabhaudhi

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Hierarchizing multi-scale environmental effects on agricultural pest population dynamics: a case study on the annual onset of Bactrocera dorsalis population growth in Senegalese or... by Caumette, Cécile, Diatta, Paterne, Piry, Sylvain, Chapuis, Marie-Pierre, Faye, Emile, Sigrist, Fabio, Martin, Olivier, Papaïx, Julien, Brévault, Thierry, Berthier, Karine

“…These results suggest that favourable microclimate conditions could provide refuges for small BD  populations that could survive, with little or no reproduction, during the mango off-season and, then, recolonize neighbouring orchards at the beginning of the next mango season. …”
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Self-reported determinants for subjective financial distress: a qualitative interview study with German cancer patients by Eva Winkler, Katja Mehlis, Bastian Surmann, Wolfgang Greiner, Andrea Züger, Viktoria Mathies, Sophie Pauge, Luise Richter, Thomas Ernst, Natalja Menold

“…The self-reported determinants can be classified into material (savings, good salary, shared rent through shared living, employed partner, paid-off house, potential financial support from family and friends, work-related specifics, consumer restrictions, out-of-pocket-costs and anticipated financial changes), social (social support from friends and family), systemic (administrative hurdlers and insurance cover) and inner personal determinants (coping strategies, change of attitude, character traits).Conclusion Subjective financial distress depends not only on material but also on social, systemic and inner personal determinants. …”
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Modelling the health, financial protection and equity impacts of upscaling the ACT NOW early intervention breast cancer pilot program in the Philippines: an extended cost-effective... by Blake Angell, Stephen Jan, Mark Woodward, Sanne Peters, Merel Kimman, Alexander Chye, Nirmala Bhoo Pathy, Herdee Gloriane C Luna, Soledad B Lim, Helen Monaghan, Corazon A Ngelangel

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Real-world, feasibility study to investigate the use of a multidisciplinary app (Pulsara) to improve prehospital communication and timelines for acute stroke/STEMI care by Joosup Kim, Dominique A Cadilhac, Karen Smith, Ramesh Sahathevan, Stephen Bernard, Dion Stub, Voltaire Nadurata, Ernesto Oqueli, Thomas Kraemer, Chris F Bladin, Kathleen L Bagot, Michelle Vu, Grant Hocking, Tessa Coupland, Debra Pearce, Diane Badcock, Marc Budge, Wayne Pearce, Howard Hall, Ben Kelly, Angie Spencer, Pauline Chapman, Casey Hair

“…When Pulsara was used, patients were off ambulance stretcher faster for stroke (11(7, 17) vs 19(11, 29); p=0.0001) and STEMI (14(7, 23) vs 19(10, 32); p=0.0014). …”
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Intracranial pressure monitoring in patients with spontaneous onset of orthostatic headache by Linda D’Antona, Sanjay Cheema, Dwij Mehta, Fion Bremner, Laurence Dale Watkins, Ahmed Kassem Toma, Manjit Singh Matharu

“…The primary objective of this study was to determine the proportion of patients with spontaneous orthostatic headaches and normal diagnostic work-up who exhibited abnormal ICP monitoring results. Methods This single-centre, retrospective observational study was conducted at a tertiary referral centre specialising in SIH and CSF dynamics disorders. …”
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Overweight among Four-Year-Old Children in Relation to Early Growth Characteristics and Socioeconomic Factors by Jörgen Thorn, Maria Waller, Maria Johansson, Staffan Mårild

“…Overweight was defined by the BMI cut-offs established by IOTF. BMI values expressed as BMI standard deviation score (BMISDS) were used for analysis. …”
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MACEDONIAN NATIONAL INNOVATION SYSTEM – MAIN CHALLENGES by Radmil Polenakovik, Ivana Stankovska, Bojan R. Jovanovski

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MACEDONIAN NATIONAL INNOVATION SYSTEM – MAIN CHALLENGES by Radmil Polenakovik, Ivana Stankovska, Bojan R. Jovanovski

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Evaluating ecosystem multifunctionality in tree-based intercropping: a case study from southern Québec, Canada by David Rivest, Marc-Olivier Martin-Guay, Ève-Marie Hébert, Samuel Dulac, Alain Cogliastro, Audrey Maheu

“…Our results suggest that trade-offs between ES may occur at fine scales and be location-specific within TBI systems. …”
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La gestion de l’eau à Bibracte (Saône-et-Loire), avant et après la Conquête romaine by Laetitia Borau

“…Lastly, the management of run-off water and waste water seems to have been the main concern of the urban planners. …”
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