RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melan... by Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Restuan Lubis, Manuel Philip, Florian Rambow, Alexander Roesch, Michael Flaig, Susanne Horn, Raphael Stoll, Fang Zhao, Annette Paschen, Bert Klebl, Ian D. Hickson, Dirk Schadendorf, Matthias Mann, Iris Helfrich

“…RECQL4, a RecQ‐like helicase, plays a central role in DNA replication and repair as part of the DNA damage response, a pathway implicated in enhancing efficacy of immune checkpoint inhibitor (ICI) therapies. …”
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ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway by Jing-Yu Hou, Hao Wu, Shuang-Mei Li, Xiao-Jing Li, Shu-Jun Yang, Xu-Xiang Chen, Chang-Qing Zhou, Hui-Bao Long, Hai-Dong Wu, Jia-Ying Fu, Ya-Jie Guo, Tong Wang

“…ELA pretreatment effectively heightened the homing capacity of BMSCs to the site of myocardial injury and their proficiency in repairing myocardial damage in vivo. Transcriptome sequencing revealed upregulation of Exo70 in ELA pretreated BMSCs, which promoted F-actin polymerization and migration. …”
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The prolonged health sequelae “of the COVID-19 pandemic” in sub-Saharan Africa: a systematic review and meta-analysis by Melsew Setegn Alie, Getayeneh Antehunegn Tesema, Getayeneh Antehunegn Tesema, Gossa Fetene Abebe, Desalegn Girma

“…It is crucial for individuals who have recovered from COVID-19 to receive careful follow-up care to assess and reduce any potential organ damage and maintain their quality of life.Systematic review registrationClinicaltrial.gov, identifier CRD42024501158.…”
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Impaired Mitochondrial Bioenergetics Function in Pediatric Chronic Overlapping Pain Conditions with Functional Gastrointestinal Disorders by Gisela Chelimsky, Pippa Simpson, Liyun Zhang, Doug Bierer, Steve Komas, Balaraman Kalyanaraman, Thomas Chelimsky

“…Environmental and oxidative stressors can damage the mitochondrial respiratory chain. The known low-grade inflammation in COPC could, therefore, impact the respiratory chain and theoretically account for the disabling fatigue so often voiced by patients. …”
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Rainwater and fog harvesting from solar panels by I. Alazzam, K. Shatanawi, R. Al-Weshah

“…This method of rainwater and fog harvesting can be effectively applied to solar power plants which are widely spread in Jordan for use in solar panel cleaning, agriculture, groundwater recharge, and reducing stormwater discharge to assess and manage the risk of environmental damage. Rainwater and fog harvesting systems offer a higher level of efficiency and cost-effectiveness compared to other methods, especially when seamlessly integrated into the infrastructure of solar power plants. …”
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Safeguarding in Sport: The Performative Compliance of International Sports Federations by Carole Gomez, Lucie Schoch

“… Introduction For decades, cases of sexual abuse and harassment of athletes have been ignored or minimised due to silence, collusion, fear of reputational damage and ignorance (Mountjoy, 2016). Sports authorities have often avoided or shown reluctance to address these issues (Brackenridge, 1994; Lang & Hartill, 2016). …”
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Iron(III)–Quercetin Complex: In Vivo Acute Toxicity and Biodistribution of Novel MRI Agent by Innuan P, Kongkarnka S, Thongtharb A, Kantapan J, Dechsupa N

“…Acute toxicity studies showed no mortality, morbidity, or significant biochemical changes, with histopathology confirming no irreversible organ damage. Pharmacokinetics revealed peak blood iron content at 1.1 hours post-administration and clearance within 24 hours. …”
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Identifikasi Pertumbuhan Jamur Aspergillus Sp pada Roti Tawar yang Dijual di Kota Padang Berdasarkan Suhu dan Lama Penyimpanan by Dina Khaira Mizana, Netty Suharti, Arni Amir

“…Jamur merupakan mikroorganisme utama yang berperan penting dalam proses pembuatan dan pembusukan roti. …”
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Hurricane Effects on a Shallow Lake Ecosystem and Its Response to a Controlled Manipulation of Water Level by Karl E. Havens, Kang-Ren Jin, Andrew J. Rodusky, Bruce Sharfstein, Mark A. Brady, Therese L. East, Nenad Iricanin, R. Thomas James, Matthew C. Harwell, Alan D. Steinman

“…We treated this operation as a whole ecosystem experiment, and assessed ecological responses using data from an existing network of water quality and submerged plant monitoring sites. …”
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Endothelial Dysfunction and Oxidative Stress in Patients with Severe Coronary Artery Disease: Does Diabetes Play a Contributing Role? by Alexandra Maria Boieriu, Cezar Dumitrel Luca, Carmen Daniela Neculoiu, Alina Bisoc, Diana Țînț

“…Diabetes is a pathological state associated with endothelial damage and enhanced oxidative stress. This study evaluated endothelial dysfunction and oxidative stress in patients with severe coronary artery disease (CAD) undergoing coronary artery bypass graft (CABG) surgery, comparing those with and without type 2 diabetes mellitus (T2DM). …”
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Metformin Ameliorates Ulcerative Colitis Through Inhibiting NLRP3 Inflammasome Activation by Cao R, Jing J, Ma Y, Qi W, Huang X, Zhang C, Lu Z, He J, Wang G, Ma Y, Zhang H

“…Furthermore, in vitro, bone marrow-derived macrophages (BMDMs) selected to clarify the role of Met on NLRP3 inflammasome activation and the underlying mechanisms.Results: In vivo, Met could significantly inhibit the development of UC, characterized by decreased DAI, increased body weight and colorectal length, and the repair of damaged tissue. Met could also block macrophage infiltration and subsequently reduced the level of IL-1β, NLRP3, and Caspase-1 in the colorectal tissue, which were mainly expressed by macrophages. …”
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Mechanism of Exogenous Silicon in Enhancing Cold Stress Tolerance in <i>Solanum lycopersicum</i> L. Seedlings: Insights from Resistance and Quality Indicators by Fan Zhang, Yihong Zhao, Yuanbo Zhang, Yu Shi, Leiping Hou, Abid Khan, Ruixing Zhang, Yi Zhang

“…This study explores whether exogenous Si fertilizer can effectively alleviate the stress of low temperature and cold damage on tomato plant growth, fruit yield, and quality. …”
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Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

“…The safety profile was consistent with previous reports.DiscussionDeep longitudinal immunophenotyping, analysis of transcriptional changes, reduction in cells expressing pro-inflammatory cytokines, along with the marker of neuroaxonal damage provide novel and innovative evidence of CladT rebalancing the immune system towards a more homeostatic and less pathogenic state.Clinical Trial Registrationhttps://clinicaltrials.gov/study/, identifier NCT03364036.…”
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Neural Network and Hybrid Methods in Aircraft Modeling, Identification, and Control Problems by Gaurav Dhiman, Andrew Yu. Tiumentsev, Yury V. Tiumentsev

“…These are semi-empirical models that combine in the resulting network structure both empirical data on the behavior of an object and theoretical knowledge about its nature. …”
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Elucidating the Role of HIF-1&alpha;/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study by Zhao HW, Liu ST, Wang XJ, Zhang XM, Ma X

“…Hui-Wei Zhao,1 Shu-Tai Liu,2 Xiang-Jin Wang,1 Xue-Mei Zhang,1 Xiang Ma1 1Department of Periodontology, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai, 264000, People’s Republic of China; 2Department of Periodontology, Shenzhen Stomatology Hospital, Shenzhen, 518000, People’s Republic of ChinaCorrespondence: Xiang Ma, Department of Periodontology, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, 148 North Road, YanTai, People’s Republic of China, Email MaXiang900218@163.comBackground and Objective: Periodontitis is a chronic inflammatory disease caused by dental plaque accumulation, leading to damage of periodontal tissues and potential tooth loss. …”
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It is time to tackle psychological determinants of obesity and eating disorders by Pietro Crescenzo

“…In the USA, prevalence of obesity was 39.8% and affected about 93.3 million of adults in 2015~2016 [6]. In Europe, recent data showed overweight affects 30-70% and obesity affects 10-30% of adults [7]. …”
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The Fake History: Soviet Totalitarianism and the Memory of the Guerrilla War by Bernardas Gailius

“…After the restoration of Lithuanian independence in 1990, the Soviet quasi-historical culture collapsed together with the regime. However, the damage was already done. The real historical culture did not form. …”
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Proinflammatory Tear Cytokines in Human Adenoviral Keratoconjunctivitis and Clinical Eye Severity by Santacruz Valdés C, Ponce-Rosas ER, Jimenez-Martinez MC

“…Animal models have provided insight into the role of the innate immune system in clinical damage, but the human immune response at the ocular surface remains poorly understood. …”
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Experimental study and model prediction of the influence of different factors on the mechanical properties of saline clay by Hui Cheng, Lingkai Zhang, Chong Shi, Pei Pei Fan

“…Canal water leakage exacerbates the salt expansion traits of such soil, damaging canal slope lining structures. To investigate the mechanical properties of saline clay, this study conducted indoor tests, including direct shear, compression, and permeation tests, and scanning electron microscopy (SEM) analysis of soil samples from typical sites. …”
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Impact of Methotrexate and 7‐Hydroxymethotrexate Exposure on Renal Toxicity in Pediatric Non‐Hodgkin Lymphoma by Hao Bing, Yi Ma, Jiamin Xu, Qixian Ling, Yanlong Duan, Libo Zhao

“…Method A total of 280 plasma concentration data (140 for MTX and 140 for 7‐OHMTX) for 60 pediatric patients with non‐Hodgkin lymphoma (NHL) were prospectively collected. …”
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