Mechanism of Swimming Exercise Intervention on Rats with Vascular Dementia Based on PERK/ATF4/CHOP Pathway by LIU Fang, LI Mengxing, WANG Yu, TANG Wei

“…Compared with the model group, the average escape latency of the swimming exercise group and the drug group were significantly shortened, and the number of platform crossing significantly increased (<italic>P</italic>&lt;0.05). (2) Neuron ultrastructure: in the model group, the number of organelles in the cytoplasm decreased, cytoplasmic matrix dissolution and vacuolization occurred, mitochondria cristae were broken and unclear, and neural fiber necrosis and dissolution were visible; compared with the model group, the swimming exercise group showed significant improvement in the structure of various organelles in the cytoplasm and the degree of vacuolar changes. (3) Expression levers of brain tissue PERK, ATF4, CHOP mRNA and protein: compared with the sham operation group, the expression levels of PERK, ATF4, CHOP mRNA, and protein in the hippocampal CA1 region of the model group significantly increased (<italic>P</italic>&lt;0.05); compared with the model group, the expression levels of PERK, ATF4, CHOP mRNA and protein in the hippocampal CA1 region of the swimming exercise group significantly decreased (<italic>P</italic>&lt;0.05).ConclusionSwimming exercise can protect brain tissue in rats with VD and improve their cognitive functions. …”
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Umbilical Cord Blood Bilirubin as a Predictor of Significant Hyperbilirubinemia Requiring Phototherapy among Full-term Healthy Neonates: A Prospective Study by Preethi B Patil, Prasanna Saka, Abhay K Chidananda

“…Clinical significance: Umbilical cord blood bilirubin measurement is a simple, economical, and non-invasive method to predict subsequent neonatal hyperbilirubinemia which can aid clinicians in early discharge of normal neonates and selective follow-up of high-risk infants.…”
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Characteristics and Associated Factors of Insomnia Among the General Population in the Post-Pandemic Era of COVID-19 in Zhejiang, China: A Cross-Sectional Study by Da M, Mou S, Hou G, Shen Z

“…Six machine learning models were employed to develop a predictive model for insomnia, namely logistic regression, random forest, neural network, support vector machine, CatBoost, and gradient boosting decision tree.Results: The study obtained 2769 and 1161 valid responses in T1 and T2, respectively. …”
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Plasma S100β is a predictor for pathology and cognitive decline in Alzheimer’s disease by Geetika Nehra, Bryan J. Maloney, Rebecca R. Smith, Wijitra Chumboatong, Erin L. Abner, Peter T. Nelson, Björn Bauer, Anika M. S. Hartz

“…The goal of this study was to assess markers for barrier dysfunction in postmortem tissue samples from research participants who were either cognitively normal individuals (CNI) or diagnosed with AD at the time of autopsy and determine to what extent these markers are associated with AD neuropathologic changes (ADNC) and cognitive impairment. …”
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The impact of the interaction between BDNF rs7103411 gene polymorphism and social activities on mild cognitive impairment in community-dwelling elderly adults by Zhenkun Tan, Junjiao Ping, Ying Zhang, Chuijia Kong, Jiali Luo, Xinxia Liu

“…The participants included 52 patients with Mild Cognitive Impairment due to Alzheimer’s Disease and 55 cognitively normal elderly adults control subjects. The two groups were matched based on gender, age, and education level. …”
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Dynamics of HDL-Cholesterol Following a Post-Myocardial Infarction Cardiac Rehabilitation Program by Carlos Bertolín-Boronat, Héctor Merenciano-González, Víctor Marcos-Garcés, María Luz Martínez-Mas, Josefa Inés Climent Alberola, Nerea Pérez, Laura López-Bueno, María Concepción Esteban-Argente, María Valls Reig, Ana Arizón Benito, Alfonso Payá Rubio, César Ríos-Navarro, Elena de Dios, Jose Gavara, Juan Sanchis, Vicente Bodi

“…A significant decrease in total cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) were noted, along with an increase in HDL-C (43.87 ± 9.18 vs. 39.8 ± 10.03 mg/dL, p < 0.001). Patients achieving normal HDL-C levels (>40 mg/dL in men and >50 mg/dL in women) significantly increased from 34.7% at admission to 52.9% the end of Phase 2. …”
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Petrophysical assessment of the Hammam Faraun, Matulla and Nubia Reservoirs in the Ashrafi Oil Field, Gulf of Suez by Mohammed Amer, Walid M. Mabrouk, Amr M. Eid, Ahmed Metwally

“…Also, the resulting structural interpretation reveals a series of normal faulted structures, including horsts, half-grabens, and step faults. …”
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IFN-<inline-formula><math display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> Maintains Immune Tolerance by Promoting M2 Macrophage Polarization... by Xinyu Feng, Cheng Yang, Ting Wang, Jinxin Zhang, Han Zhou, Bin Ma, Ming Xu, Ganzhen Deng

“…The results verified that IFN-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> significantly improved this mechanism and maintained normal pregnancy status in mice, but miR-30b-5p significantly reduced the M2 polarization by inhibiting SOCS1, which activated the NF-κB signaling pathway, and then leading to the failure of embryo implantation. …”
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LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK by Joanna Filipowska, Zelda Cisneros, Sneha S. Varghese, Nancy Leon-Rivera, Peng Wang, Randy Kang, Geming Lu, Yate-Ching Yuan, Hung-Ping Shih, Supriyo Bhattacharya, Sangeeta Dhawan, Adolfo Garcia-Ocaña, Nagesha Guthalu Kondegowda, Rupangi C. Vasavada

“…Lgr4cko mice exhibit normal glucose homeostasis but increased β-cell death in both sexes and decreased β-cell proliferation and maturation only in females. …”
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Clinical characteristics and prognosis of amyopathic dermatomyositis patients with interstitial lung disease: insights from a retrospective cohort by Yanan Ying, Tingting Wu, Long Wang, Yun Zhang, Yiming Yu, Zaichun Deng, Qunli Ding

“…Notably, 81.26% of patients with ADM-NSIP/OP had LDH levels above normal. The serum LDH levels could be used to distinguish patients with ADM-NSIP/OP (sensitivity: 73.91%, specificity: 82.64%). …”
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Comparing multi-texture fibrosis analysis versus binary opacity-based abnormality detection for quantitative assessment of idiopathic pulmonary fibrosis by Sebastian Nowak, Dominik Creuzberg, Maike Theis, Carmen Pizarro, Alexander Isaak, Claus C. Pieper, Julian A. Luetkens, Dirk Skowasch, Alois M. Sprinkart, Daniel Kütting

“…Opacity-based fibrotic lung (OFL) was measured by a second tool that performs a simpler binary classification of tissue into either normal or opacified lung and was originally developed for quantifying pneumonia. …”
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Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial by Aneal Khan, Dwayne L. Barber, William M. McKillop, C. Anthony Rupar, Christiane Auray‐Blais, Graeme Fraser, Daniel H. Fowler, Alexandra Berger, Ronan Foley, Armand Keating, Michael L. West, Jeffrey A. Medin

“…All blood pressures were in the normal range. Kidney symptoms were stabilized in all patients. …”
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Cross-sectional Study of EMG and EMG Rise During Fast and Slow Hamstring Exercises by Kasper Krommes, Markus Due Jakobsen, Thomas Bandholm, Lars Louis Andersen, Mette Zebis, Anthony Shield, Per Hölmich, Kristian Thorborg

“… # Purpose This cross-sectional study therefore aimed to compare the Nordic Hamstring curl with a conventional prone Leg Curl at different loads, and novel high velocity Hamstring Catches; in terms of peak normalized electromyographical activity (nEMG) and rate of electromyographic rise (RER) of Biceps Femoris long head, and angular velocity of the knee…”
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Radiotherapy-induced Hypothalamic-Pituitary axis dysfunction in adult Brain, head and neck and skull base tumor patients – A systematic review and Meta-Analysis by J.M.J. Paulissen, C.M.L. Zegers, R.M. Houben, D. Hofstede, M. Kars, H.M. van Santen, F.J.P. Hoebers, D.K.M. De Ruysscher, D.B.P. Eekers

“…Based on this knowledge, radiotherapy and follow-up of these patient groups should be standardized to establish a normal tissue complication probability (NTCP) model for the HPA.…”
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An Explainable Artificial Intelligence Text Classifier for Suicidality Prediction in Youth Crisis Text Line Users: Development and Validation Study by Julia Thomas, Antonia Lucht, Jacob Segler, Richard Wundrack, Marcel Miché, Roselind Lieb, Lars Kuchinke, Gunther Meinlschmidt

“…The Shapley Additive Explanations model identified language features predictive of SIBs, including self-reference, negation, expressions of low self-esteem, and absolutist language. ConclusionsNeural networks using large language model–based transfer learning can accurately identify SI and ASE. …”
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Effect of Spine Nerves Muscle Stimulation Combined with Scalp Acupuncture on Shoulder-hand Syndrome after Early Stroke by Huazhong YANG, Yongsheng ZHOU, Haipeng JIA, Qingjun YANG, Lingjuan RAO

“…The control group was treated with scalp acupuncture(The scalp movement area was needled and the midline of the vertex, anterior and posterior oblique line of the parietal of the healthy side were located according to the brain functional area)combined with conventional physiotherapy(included passive joint activity, neural booster and neuromuscular electrical stimulation therapy), 2 hours and 45 minutes per day, 5 days per week. …”
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Modeling future climate change impacts on sorghum (Sorghum bicolor) production with best management options in Amhara Region, Ethiopia by Adem Mohammed, Abebe Misganaw

“…The result of model calibration showed that the RMSE for anthesis, physiological maturity, grain yield, and above-ground biomass yield were 2 days, 2 days, 478 kg ha−1, and 912 kg ha−1, respectively with normalized nRMSE values of 2.74%, 1.6%, 13.42%, and 5.91%, respectively. …”
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Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, I. . A.s. Trukhmanov, Ye. K. Baranskaya, O. B. Dronova, O. V. Zayratyants, R. G. Sayfutdinov, A. A. Sheptulin, T. L. Lapina, S. S. Pirogov, Yu. A. Kucheryavy, O. A. Storonova, D. N. Andreyev

“…Prokinetic drugs promote recovery of a normal physiological state of the esophagus, controlling the pathogenic mechanisms of GERD, reducing the number of transient lower esophageal sphincter relaxations and improving esophageal clearance due to stimulation of the lower gastrointestinal motor function. …”
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Mycochemistry, antioxidant, anticancer activity, and molecular docking of compounds of F12 of ethyl acetate extract of Astraeus asiaticus with BcL2 and Caspase 3 by Swapan Kumar Ghosh, Koushik Pandey, Madhuparna Ghosh, Pradip Kumar Sur

“…After 24 h of treatment, the percentages of cell growth inhibition of HeLa, MCF-7, and A549 cell lines by highest concentration (1500 µg. mL− 1) of F12 were 92.03 ± 6.21 a, 90.38 ± 4.53a, and 87.51 ± 5.36a % respectively and the IC50 values were 701 ± 11.54, 728.71 ± 10.53, and 806.88 ± 11.52 µg. mL− 1 respectively but the growth of normal cell HEK 293T was inhibited slightly (3.0%). …”
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Development and Beta Validation of an mHealth-Based Hearing Screener (SRESHT) for Young Children in Resource-Limited Countries: Pilot Validation Study by Vidya Ramkumar, Deepashree Joshi B, Anil Prabhakar, James W Hall, Ramya Vaidyanath

“…In phase 2, a total of 55 children aged 0 to 6 years (31 normal hearing and 24 hearing impairment) underwent SRESHT screening for beta validation. …”
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