The American Society of Pain and Neuroscience (ASPN) Guidelines and Consensus on the Definition, Current Evidence, Clinical Use and Future Applications for Physiologic Closed-Loop... by Pope JE, Deer TR, Sayed D, Antony AB, Bhandal HS, Calodney AK, Chakravarthy K, Costandi S, Diep J, Durbhakula S, Fishman MA, Gilligan C, Goree JH, Guirguis M, Hagedorn JM, Hunter CW, Kallewaard JW, Kapural L, Lam CM, Li S, Mayrsohn B, Nijhuis H, Nikolic S, Petersen EA, Poree LR, Puri SK, Reece DE, Rosen SM, Russo MA, Shah JM, Staats PS, Verrills P, Vu CM, Levy RM, Mekhail N

“…Appreciating the dynamic nature of electrical modulation of the nervous system from the epidural space, the goal has been consistent, reliable, and therapeutic neural activation of the spinal cord. This has proven to be extremely difficult. …”
Get full text

Helicobacter pylori: ¿lo tratamos de acuerdo a las evidencias? by Marcos Félix Osorio Pagola

“…--[endif] --> <p class="MsoNormal"><span lang="ES">.<br /></span></p>…”
Get full text

HHO–LSSVM prediction model of blast casting muck pile morphology based on Gaussian distribution by Ning MA, Li MA, Yinda LI, Tianxiang LI, Sen YANG, Fuming LIU, You ZHOU, Xiaomin WANG, Qifeng ZHANG, Mengbo LI

“…And the Gaussian distribution model combined with the HHO–LSSVM algorithm was used to predict the shape of the blast casting muck pile, compare the accuracy of the LSSVM, Particle Swarm Optimization (PSO) optimized Least Squares Support Vector Machine, and Genetic Algorithm (GA) optimized BP neural network models, at the same time, compare the predicted blast casting muck pile morphology with the actual blasting muck pile morphology. …”
Get full text

The Impact of Acute Aerobic Exercise on General and Food-Related Inhibitory Function Among Young Adults with Obesity: An Event-Related Potential (ERP) Study by Chun Xie, Tao Huang, Yingying Wang, Peisi Wang, Yanxia Chen, Jiali Qian, Guozhuang Chen, Kun Wang

“…Moreover, reduced N2 amplitudes and No-go accuracy in response to food stimuli compared to non-food stimuli indicate a diminished ability to allocate attentional and neural resources to manage food-related conflicts. …”
Get full text

Diagnostic Capability of Pattern Electroretinogram and Three Circumpapillary Retinal Nerve Fiber Layer Thickness Circle Diameter Scans in Glaucoma Suspects by Tirsi A, Tsai J, Abizadeh A, Kacaj D, Procyk O, Gliagias V, Leung N, Yang H, Park SC, Tello C

“…Circumpapillary retinal nerve fiber layer thickness (RNFLT) was measured using spectral domain OCT in 49 eyes from 26 patients (36 normal, 13 GS) in three circle diameters (3.5, 4.1, and 4.7 mm). …”
Get full text

Evaluation of clinical, laboratory, radiographical and histopathological characteristics in patients with spinal tuberculosis in the context of HIV infection: An analysis of 52 pat... by J Scherer, M Locketz, S Castelein, R Dunn, M Held, F Thienemann

“…To assess differences in means between the two groups, an independent samples t-test was used for normally distributed continuous data, and a χ2 test for categorical data. …”
Get full text

The impact of the objective state and self-esteem of health on academic performance in senior students of medical and humanitarian specialties, taking into account various environm... by V. V. Kuznetsov, K. V. Kosilov

“…Chronic morbidity among senior medical and humanitarian students is high (comorbidity index 1.5–1.7), but the total self-assessment of the quality of life associated with health is 59–62 points and falls within the normal range of values. Thus, despite the high level of chronic somatic pathology, students generally positively assess their physical and psychological status.…”
Get full text

Effects of isometric contraction training on hypertensive patients: A Systematic Review by Yuan Hao Dong

“…Moreover, studies have shown that 43.1% of the population have normal high blood pressure, with an estimated number of 4.35. …”
Get full text

Exploring Web-Based Support for Suicidal Ideation in the Scottish Population: Usability Study by Heather McClelland, Rory C O'Connor, Laura Gibson, Donald J MacIntyre

“…The website included resources (eg, videos from lived experience and written guidance about how to respond to someone who may be experiencing suicidal thoughts) to help reduce distress, normalize experiences, and challenge distressing thoughts. …”
Get full text

Cause-Effect Relationships between Painful TMD and Postural and Functional Changes in the Musculoskeletal System: A Preliminary Report by Adam Andrzej Garstka, Monika Brzózka, Aleksandra Bitenc-Jasiejko, Roman Ardan, Helena Gronwald, Piotr Skomro, Danuta Lietz-Kijak

“…Nevertheless, dental procedures still very rarely include comprehensive diagnostics and procedures aimed at the normalization of the locomotor system related to TMD. …”
Get full text

The gut–kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity by Cong Han, Ran-ran Gao, Le Zhou, Wei Li

“…This study aimed to verify the ameliorative effects of AS-IV on CICN and further explore the mechanisms underlying the modulation of the “gut–transcriptome–metabolome coexpression network” by AS-IV within the context of the “gut–kidney axis” to improve CICN.MethodsFive groups of 40 mice were studied: a normal group (N, olive oil), a model group (M, CsA, 30 mg kg-−1 d−1), a low-dose AS-IV group (CsA + AS-IV, 30 mg kg−1 d−1 + 10 mg kg−1 d−1), a high-dose AS-IV group (CsA + AS-IV, 30 mg kg−1 d−1 + 20 mg kg−1 d−1), and a valsartan group (CsA + Val, 30 mg kg−1 d−1 + 10 mg kg−1 d−1). …”
Get full text

Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…Carcinoembryonic antigen (CEA) is an attractive target due to its high expression in many tumors, particularly gastrointestinal cancers, while limited expression in normal adult tissues. In our previous clinical study, we reported a 70% disease control rate with no severe side effects using a humanized CEA-targeting CAR-T cell. …”
Get full text

Crocin improves post-thaw quality, fertility-associated gene expression and fertilization potential of buffalo bull sperm by Amjad Riaz, Ghulam S. Khan, Muhammad Zahid Tahir, Muhammad Yasir Zahoor, Hifz-ul-Rahman Hifz-ul-Rahman

“…Computer-assisted semen analysis, Normal Apical Ridge assay, Rhodamine 123, Acridine orange, and Propidium iodide staining were used to assess sperm motility parameters, acrosome integrity, mitochondrial membrane potential, DNA integrity, and viability, respectively. …”
Get full text

Accelerating CO₂ Outgassing in the Equatorial Pacific from Satellite Remote Sensing by Yiwu Shang, Jingyuan Xi, Yi Yu, Wentao Ma, Shuangling Chen

“…We found that during the very strong El Niño events (1997/1998, 2015/2016), both <i>p</i>CO₂sw and FCO₂ showed a significant decrease of 41–58 μatm and 0.5–0.8 mol·m⁻²·yr⁻¹ in the eastern equatorial Pacific, yet they remained at normal levels in the western equatorial Pacific. In contrast, during the very strong La Niña events (1999/2000, 2007/2008, and 2010/2011), both <i>p</i>CO₂sw and FCO₂ showed a strong increase of 40–48 μatm and 1.0–1.4 mol·m⁻²·yr⁻¹ in the western equatorial Pacific, yet with little change in the eastern equatorial Pacific. …”
Get full text

Machine Learning-Based Alzheimer’s Disease Stage Diagnosis Utilizing Blood Gene Expression and Clinical Data: A Comparative Investigation by Manash Sarma, Subarna Chatterjee

“…A deep learning (DL) classifier was used to identify the stages—cognitive normal (CN), mild cognitive impairment (MCI), and Alzheimer’s disease (AD)/dementia. …”
Get full text

Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer by Meng Ye, Guojie Xu, Liming Zhang, Zhihui Kong, Zhenhua Qiu

“…MTHFR, a key enzyme in folate metabolism, has been widely studied in relation to neural tube defects and hypertension, but its role in colorectal cancer remains underexplored. …”
Get full text

Drug-induced autoimmune-like hepatitis: A disproportionality analysis based on the FAERS database. by Wangyu Ye, Yuan Ding, Meng Li, Zhihua Tian, Shaoli Wang, Zhen Liu

“…Positive signal drugs were identified using Proportional Reporting Ratio (PRR), Reporting Odds Ratio (ROR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayesian Geometric Mean (EBGM). …”
Get full text

Comprehensive treatment of the macular edema in patients with retinal vein occlusion and hemostasis system disturbances by T.V. Shelkovnikova, Kh.P. Takhchidi, G.V. Vavin, N.Yu. Barkova, N.Yu. Shishlyannikova

“…<br> <b>Results</b>: in all patients with RVO and ME before and after comprehensive treatment, deviations from the normal hemostasis parameters and endothelial dysfunction of von Willebrand factor, activated protein C, VIII factor, VEGF were detected. …”
Get full text

Neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios and systemic immune-inflammation index in patients with post-traumatic stress disorder by Gözde Yontar, Elif Aktan Mutlu

“…Neutrophil and platelet levels of PTSD patients were significantly higher than controls although both groups’ values were in normal range. Moreover, NLR, PLR and SII were significantly higher in PTSD group. …”
Get full text

Risk Factors for Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction: Multicenter Retrospective Cohort Study by Yanqi Kou, Shicai Ye, Yuan Tian, Ke Yang, Ling Qin, Zhe Huang, Botao Luo, Yanping Ha, Liping Zhan, Ruyin Ye, Yujie Huang, Qing Zhang, Kun He, Mouji Liang, Jieming Zheng, Haoyuan Huang, Chunyi Wu, Lei Ge, Yuping Yang

“…A total of 7 ML algorithms—logistic regression, k-nearest neighbors, support vector machine, decision tree, random forest (RF), extreme gradient boosting, and neural networks—were trained using 10-fold cross-validation. …”
Get full text