Dependencia de la gasolina. Presentación de un caso. by Ariel Acosta González, Milaidi Milian Martínez, Amalia González Pestana

“…La revisión de la bibliografía, así como la consulta con el Instituto Nacional de Toxicología, no reportó evidencias de caso similar publicado en Cuba.</p> <p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify; line-height: normal;"><span style="font-size: 12pt;"> </span></p>…”
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Pien Tze Huang Attenuates Neuro-inflammatory Injury in BV2 Microglial Cells Induced by Lipopolysaccharide via Inhibition of TLR4/MAPK Signaling Pathway by Zhenwei HUANG, Qing ZHANG, Lili HUANG, Xiaoqin ZHANG, Mingqing HUANG

“…Then the protein expression of TLR4, ERK1/2, p-ERK1/2, p38, p-p38, JNK, p-JNK, COX-2, iNOS in BV2 microglial cells were detected by Western blot.Results:1) The result of MTT assay showed that PZH at 0.05-0.15 mg/mL concentration and LPS at 100 ng/mL concentration had no significant cytotoxicity on BV2 microglial cells (<italic>P</italic>&gt; 0.05).2) The result of ELISA showed that the secretion of IL-6 was significantly increased in BV2 microglial cells induced by LPS compared with the normal control group (<italic>P</italic>&lt; 0.001); compared with the LPS group, different concentrations of PZH significantly decreased the expression level of IL-6 in LPS-induced BV2 microglial cells (<italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01).3) The result of RT-qPCR showed that the transcriptional levels of IL-1β(<italic>P</italic>&lt; 0.001), IL-6(<italic>P</italic>&lt; 0.001) and TNF-α(<italic>P</italic>&lt; 0.01) were significantly increased after the induction of LPS compared with normal controal group; different concentrations of PZH significantly inhibited the LPS-induced IL-1β(<italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.001), IL-6(<italic>P</italic>&gt; 0.05, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.001) and TNF-α(<italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.001) mRNA upregulation.4) The result of Western blot showed that PZH significantly inhibited the LPS-induced TLR4/MAPK signaling pathway activation, and decreased the protein expressions of TLR4(<italic>P</italic>&gt; 0.05, <italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.05), p-ERK1/2(<italic>P</italic>&gt; 0.05, <italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01), p-p38(<italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.01), COX-2(<italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.001) and iNOS(<italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.01, <italic>P</italic>&lt; 0.01), but not p-JNK.Conclusion:PZH can significantly improve the LPS-induced neuro-inflammatory injury, which may be related to the inhibition of the activation of TLR4/MAPK signaling pathway.…”
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Julius Kruopis – the pioneer of applied statistics in Lithuania by Vilijandas Bagdonavičius, Vydas Čekanavičius, Rūta Levulienė, Pranas Vaitkus

“…In contrast, the accuracy of normal approximation to discrete random variables is measured in weaker uniform metric only. …”
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Methodology for the Positive Voices 2022 Survey of People With HIV Accessing Care in England, Wales, and Scotland: Cross-Sectional Questionnaire Study by Janey Sewell, Carole Kelly, Adamma Aghaizu, Hannah Kitt, Annegret Pelchen-Matthews, Veronique Martin, Amal Farah, Colette Smith, Alison Brown, Clare Humphreys, Alex Sparrowhawk, Valerie Delpech, Alison Rodger, Fiona Lampe, Meaghan Kall

“… BackgroundDue to advances in treatment, HIV is now a chronic condition with near-normal life expectancy. However, people with HIV continue to have a higher burden of mental and physical health conditions and are impacted by wider socioeconomic issues. …”
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Design of an improved model using federated learning and LSTM autoencoders for secure and transparent blockchain network transactions by R. Vijay Anand, G. Magesh, I. Alagiri, Madala Guru Brahmam, Balamurugan Balusamy, Chithirai Pon Selvan, Haya Mesfer Alshahrani, Masresha Getahun, Ben Othman Soufiene

“…So, by training the autoencoder on normal transaction data, the system can alert transactions with high reconstruction errors, meaning real-time anomalies. …”
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Assessment of hemodynamic disturbances and impaired ventricular filling in asymptomatic fontan patients: A 4D flow CMR study by Li-Wei Hu, Xiaodan Zhao, Shuang Leng, RongZhen Ouyang, Qian Wang, Ai-Min Sun, Yi-Man Liu, Wei Dong, Liang Zhong, Yu-Min Zhong

“…The parameters of FSV normalized to the ventricular end-diastolic volume (KEiEDV) were found to be significantly lower in Fontan patients (all P < 0.05). …”
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Enhancing semantical text understanding with fine-tuned large language models: A case study on Quora Question Pair duplicate identification. by Sifei Han, Lingyun Shi, Fuchiang Rich Tsui

“…In our previous study, we developed a Siamese Convolutional Neural Network (S-CNN) that achieved an F1 score of 82.02% (95% C.I.: 81.83%-82.20%). …”
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The role of ultrasound combined with water bath in the establishment of animal models of rat urethral stricture by Xiaojian Ye, Xianjing Lin, Yehui Chen, Rongquan Xu, Jiawei Zhou

“…Ultrasonographic assessment revealed significant differences in urethral echogenicity between the normal group and the surgical group, with noticeable changes in urethral morphology post-injury. …”
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The effect of training intervention based on health belief model on self-care behaviors of women with gestational diabetes mellitus by Fatemeh Mohammadkhah, Amirhossein Kamyab, Babak Pezeshki, Samira Norouzrajabi, Ali Khani Jeihooni

“…The data were analyzed using SPSS 24, Kolmogorov-Smirnov tests (for normal distribution of data), independent t-test, paired t-test, chi-2 test, and descriptive statistics (P &lt; 0.05).ResultsThe mean age of the participants in the intervention group and control group was 32.45 ± 4.82 and 33.16 ± 4.69, respectively. …”
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Evaluating the effects of time-restricted eating on overweight and obese women with polycystic ovary syndrome: A randomized controlled trial study protocol. by Hui Liu, Fuliang Shangguan, Fen Liu, Yu Guo, Huixi Yu, Hanbing Li, Yinhua Su, Zhongyu Li

“…Statistical analysis will include the Anderson-Darling test for normality, T-test/Wilcoxon test based on distribution, mixed-effects models for assessing time/group effects, Cox model for time-to-event analysis, repeated ANOVA for change analysis, and sensitivity analysis. …”
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Common pathogenic aspects of diabetic retinopathy and nephropathy. Kidney transplantation and the course of diabetic retinopathy by I.V. Vorobyeva, L.K. Moshetova, A.V. Pinchuk, Е.V. Bulava, E.P. Delver, A.A. Belogurov

“…However, one-third of patients develop diabetic nephropathy in normal albuminuria. Degradation products of glomerular filtration barrier are thought to be perspective biomarkers of early diabetic nephropathy. …”
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Effectiveness and safety of percutaneous endoscopic debridement and drainage for spinal infections: a systematic review and meta-analysis by Guozhong Zhou, Xiaorong Liu, Zhi Liang, Xuesong Chen, Chao Song

“…Subgroup analyses demonstrated a significantly lower reoperation rate in the group that discontinued antibiotics based on a normal CRP than in the fixed-duration group (2.7% [95% CI 0.3–7.7%] vs 20.1% [95% CI 14.5–26.3%], p = 0.0002). …”
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Misdiagnosis and analysis of clinical characteristics in patients with giant cystic pheochromocytoma/paraganglioma by Yue Zhang, Bo Zhou

“…The misdiagnosis and mistreatment characteristics of PPGLs were as follows: female (50%); median age, 51 years; normal blood pressure; greater mass effect at onset; larger tumors; median time to diagnosis extension, 180 days; and misdiagnosed disease, which was mainly tumors of adjacent organs, the digestive system, the cardiovascular system, the urinary system, the nervous system, or the endocrine system. …”
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Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia by Olga Plisko, Jana Žodžika, Irina Jermakova, Inta Liepniece-Karele, Jeļena Eglīte, Dace Rezeberga

“…The aim of the study was to assess an association between HLA-DQA1*; DQB1*; DRB1* allele’s genetic variants between women with cervical precancerous lesions and healthy controls in Latvia.Materials and methods: From January until April 2017 we enrolled 84 consecutive patients referred for colposcopy to Riga East University Hospital (Latvia) due to abnormal cervical cytology results. 57 women who came for a regular check-up and had normal cytology smears were included in the control group. …”
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POST OTİSTİK İKTİSAT: İKTİSAT EĞİTİMİ VE NEOKLASİK İKTİSAT ELEŞTİRİSİ by Yılmaz Aydın

“…Başka bir ifadeyle, Neoklasik Teori, geliştirildiği dönemden itibaren kısa süreli kriz dönemi hariç günümüze kadar “normal bilim” olma özelliğini korumuştur. Literatürde oldukça geniş yer bulan eleştirilere rağmen Neoklasik teori ve bu teorinin çağdaş versiyonları iktisat eğitiminde, özellikle lisans düzeyinde, neredeyse geçerli tek yaklaşım olarak okutulmaktadır. …”
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Delusions of Glass Under Skin: An Unusual Case of Somatic-Type Delusional Disorder Treated with Olanzapine by Nicholas Comardelle, Amber Edinoff, Juliana Fort

“…Cognitive screening testing was normal, and a physical exam showed several areas of excoriation on the hands and arms bilaterally, a removed left thumbnail, and a thin frame (BMI: 18.02). …”
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Diagnostic accuracy of drooling, reluctance, oropharynx, others, and leukocytosis score as a predictor of mortality and complications following acute corrosive ingestion by Fawaz Poonthottathil, Soorya Suresh, Jamshed Nayer, Praveen Aggarwal

“…The majority of our patients had normal to Zargar grade 1 injury to the stomach and esophagus. …”
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Photobiomodulation preconditioning for oral mucositis prevention and quality of life improvement in chemotherapy patients: a randomized clinical trial by Marwa Khalil, Omar Hamadah, Maher Saifo

“…Regarding Late Effects in Normal Tissue (LENT-SOMA) scale, there was a statistically significant difference between the three groups studied (p = 0.037). …”
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Desórdenes abióticos asociados con palmas ornamentales en la Ciudad de México by Dionicio Alvarado Rosales, Luz de Lourdes Saavedra-Romero, Alejandra Almaraz-Sánchez, Andrés Quezada-Salinas, Silvia Edith García-Díaz, Sergio Aranda-Ocampo, Carlos Fredy Ortiz-García, Armando Equihua-Martínez, José Abel López-Buenfil, Roberto Quintero-Campos

“…Por palma, se midió el diámetro normal a 1.30 m sobre el nivel del suelo, altura total y ancho del camellón de plantación, y en los nueve transectos de longitud variable, también se colectaron muestras de suelo de las palmas con diferente categoría de salud y se determinó el grado de compactación del suelo (bajo o alto). …”
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TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury by Shubhayu Bhattacharyay, Florian D. van Leeuwen, Erta Beqiri, Cecilia A. I. Åkerlund, Lindsay Wilson, Ewout W. Steyerberg, David W. Nelson, Andrew I. R. Maas, David K. Menon, Ari Ercole, the CENTER-TBI investigators and participants

“…We developed the TILTomorrow modelling strategy, which leverages recurrent neural networks to map a token-embedded time series representation of all variables (including missing values) to an ordinal, dynamic prediction of the following day’s five-category therapy intensity level (TIL(Basic)) score. …”
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