Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…Exploratory assessments of patients receiving ICI+chemotherapy (n=4369) observed more favorable rwOS only in TMB≥20.Conclusions Across >8000 patients treated with single-agent ICI, and within individual cancer types with sufficient power, elevated TMB based on the FDA-approved CDx was associated with more favorable rwOS compared with similar patients with lower TMB levels. …”
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Molecular and Transmission Characteristics of Mycobacterium Tuberculosis Strains Among College Students in Beijing, China by Cao X, Li X, Song Z, He P, Zhang R, Teng C, Sun Q, Wang X, Zhao B, Zhang Z, Zhao Y

“…Xiaolong Cao,1,2,* Xinyue Li,1,3,* Zexuan Song,4 Ping He,5 Ruiqing Zhang,1,3 Chong Teng,6 Qian Sun,2 Xue Wang,2 Bing Zhao,3 Zhiguo Zhang,7 Yanlin Zhao3 1National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People’s Republic of China; 2Outpatient Department, Beijing Changping Institute for Tuberculosis Prevention and Treatment, Beijing, 102200, People’s Republic of China; 3National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing, 102206, People’s Republic of China; 4Department of Clinical Laboratory, Children’s Hospital, Capital Institute of Pediatrics, Beijing, 100020, People’s Republic of China; 5Center for Infection Biology, School of Medicine, Tsinghua University, Beijing, 100084, People’s Republic of China; 6Tuberculosis Prevention and Control Department, Beijing Dongcheng District Center for Disease Control and Prevention, Beijing, 100050, People’s Republic of China; 7Hospital Management Office, Beijing Changping Mental Health Care Hospital, Beijing, 102202, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiguo Zhang, Beijing Changping Mental Health Care Hospital, Changping District, Beijing, 102202, People’s Republic of China, Email zhgzh8689@126.com Yanlin Zhao, National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Changping District, Beijing, 102206, People’s Republic of China, Email zhaoyl@chinacdc.cnBackground: College students are a crucial link in curbing the epidemic. …”
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Addressing racial and ethnic disparities in premature exits from permanent supportive housing among residents with substance use disorders by Talia J. Panadero, Sonya Gabrielian, Marissa J. Seamans, Lillian Gelberg, Jack Tsai, Taylor Harris

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Remote-sensing-based forest canopy height mapping: some models are useful, but might they provide us with even more insights when combined? by N. Besic, N. Picard, C. Vega, J.-D. Bontemps, L. Hertzog, J.-P. Renaud, J.-P. Renaud, F. Fogel, M. Schwartz, A. Pellissier-Tanon, G. Destouet, F. Mortier, F. Mortier, M. Planells-Rodriguez, P. Ciais

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Real-world outcomes in patients with melanoma brain metastasis: a US multisite retrospective chart review study of systemic treatments by Ning Ning, Sunandana Chandra, Andriy Moshyk, Divya Patel, Isabella C Glitza Oliva, Jennell Palaia, Leon A Sakkal, Natalia Han, Shardul Odak, Jordana K Schmier

“…Objective This study examined real-world treatment patterns and outcomes in patients with melanoma brain metastasis (MBM) treated with first-line immunotherapy consisting of nivolumab plus ipilimumab or anti-programmed death-1 (PD-1) monotherapy (nivolumab or pembrolizumab) or targeted therapy consisting of BRAF/MEK inhibitors.Design Retrospective chart review study.Setting Academic medical centres, community hospitals and private practice offices.Participants Included patients diagnosed with melanoma with brain metastasis in the USA.Outcome measures The statistical analysis was descriptive in nature. …”
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Polish Historiography of Polish - Lithuanian Union of 20th Century by Mečislovas Jučas

“…The "Bilateral Obligation" signed on October 20th, 1791, acknowledged the central offices to be in Warsaw, giving Lithuanians only participants' status. …”
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Climate change risks illustrated by the Intergovernmental Panel on Climate Change (IPCC) “burning embers” by P. Marbaix, P. Marbaix, P. Marbaix, A. K. Magnan, A. K. Magnan, A. K. Magnan, V. Muccione, V. Muccione, P. W. Thorne, Z. Zommers

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Protocol for a nested case-control study: identifying neuroimaging biomarkers for the progression of subclinical depression and qi-stagnation constitution to major depressive disor... by Jing Wang, Chengfeng Zhang, Yueqi Zhang, Yuanyuan Liu, Jingli Zhang, Xingwei Fang, Wangyang Xia, Yanzhao Xie, Zhongli Lan, Jinhui Wang, Jinhui Wang, Jinhui Wang, Jinhui Wang, Min Lu, Jun Chen, Jun Chen

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Iron⁃calcium⁃biochar enhanced sludge deep dewatering and sludge⁃based biochar preparation by JIAO Hongming, FU Liang*, ZHOU Yingying, WANG Xurong, ZHANG Leilei, Gao Yonglin, ZHOU Dandan

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Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies by Yizhou Zhang, Ruicheng Wei, Ge Song, Xinyi Yang, Mengli Zhang, Wei Liu, Aiying Xiong, Xuehan Zhang, Qianhao Li, Wan-Jen Yang, Chencheng Han, Rui Liu, Chen Hu, Qingyu Wang, Jun Zhu, Yongqiang Shan

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Bioinformatics combining machine learning and single-cell sequencing analysis to identify common mechanisms and biomarkers of rheumatoid arthritis and ischemic heart failure by Ziyi Sun, Jianguo Lin, Xiaoning Sun, Zhangjun Yun, Xiaoxiao Zhang, Siyu Xu, Jinlong Duan, Kuiwu Yao

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The impact of same‐day and rapid ART initiation under the Universal Health Coverage programme on HIV outcomes in Thailand: a retrospective real‐life cohort study by Sirinya Teeraananchai, David C. Boettiger, Cheewanan Lertpiriyasuwat, Rattaphon Triamwichanon, Patchara Benjarattanaporn, Nittaya Phanuphak

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High-time-cadence Spectroscopy and Photometry of Stellar Flares on M dwarf YZ Canis Minoris with the Seimei Telescope and TESS. I. Discovery of Rapid and Short-duration Prominence... by Yuto Kajikiya, Kosuke Namekata, Yuta Notsu, Hiroyuki Maehara, Bunei Sato, Daisaku Nogami

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A dehazing and enhancement algorithm for heterogeneous images of underground mining environments in coal mines by Xuhui ZHANG, Yanbin XIE, Wenjuan YANG, Chao ZHANG, Jicheng WAN, Zheng DONG, Yanqun WANG, Jie JIANG, Long LI

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Research on construction of public health system in China – a CiteSpace-based visualization analysis of studies published since the COVID-19 epidemic by Yuntong ZHAO, Ziyi PENG, Shuai DU, Wuqi QIU, Pei DONG, Ayan MAO

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Re-connecting ecosystems: Integrating coral reefs into monitoring of island restoration by Cassandra E. Benkwitt, Kalia S.I. Bistolas, Jayna L. DeVore, Simon Ducatez, Jazmín Prado Gómez, Rosalie Wright, Mayalen Zubia, Pierrick Harnay, Teva Beguet, Lisa M. Wedding, Deron E. Burkepile, Frank Murphy, Nicholas A.J. Graham, Rebecca Vega Thurber, Hannah E. Epstein

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Prospective multi-centre analysis of rural trauma team development training for medical trainees and traffic law enforcement professionals in Uganda: an interrupted time series stu... by Herman Lule, Micheal Mugerwa, Robinson Ssebuufu, Patrick Kyamanywa, Jussi P. Posti, Michael Lowery Wilson

“…Results A total of 500 participants including: 66 (13.2%) traffic police officers, 30 (6.0%) intern doctors, 140 (28.0%) fifth year and 264 (52.8%) third-year medical students were trained. …”
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Using Health Utility Index (HUI) for Measuring the Impact on Health-Related Quality of Life (HRQL) Among Individuals with Chronic Diseases by Frank Mo, Bernard C.K. Choi, Felix C.K. Li, Joav Merrick

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Real-World Efficacy and Safety of Avelumab Plus Axitinib in Metastatic Renal Cell Carcinoma: Results from the Ambispective RAVE-Renal Study by Ilya Tsimafeyeu, Vyacheslav Chubenko, Olga Baklanova, Alexey Kalpinskiy, Sufia Safina, Andrei Lebedinets, Vladislav Petkau, Elvira Parsadanova, Maria Turganova, Aleksei Shkurat, Natalia Tovbik, Elena Tkacheva, Yulia Anzhiganova, Olga Novikova, Varvara Bragina, Ruslan Zukov, Rashida Orlova

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Unpacking the benefits of black soldier fly frass fertilizer towards nematode suppression and potato production by Emmanuel O. Anedo, Emmanuel O. Anedo, Emmanuel O. Anedo, Dennis Beesigamukama, Benson Mochoge, Nicholas K. Korir, Solveig Haukeland, Solveig Haukeland, Xavier Cheseto, Moses Nyongesa, Patrick Pwaipwai, Sevgan Subramanian, Abdou Tenkouano, Betty Kibaara, Chrysantus M. Tanga

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