Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…The combination of CM272 with immunotherapy offers a novel, effective treatment strategy for PDAC.…”
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Vers la conservation intégrée des gibbons à favoris blancs by Brice Lefaux, Camille Coudrat

“…Le gibbon à favoris blanc du Nord (Nomascus leucogenys) est un des 25 primates les plus menacés au monde, classé en danger critique d’extinction sur la liste rouge de l’IUCN. …”
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Molecular characterization, DNA fingerprinting and genetic diversity analysis of Nepalese rice landraces using SSR markers by Bal Krishna Joshi, Nancy Shrestha, Rakshya Pokhrel, Raju Chaudhary

“…However, local landraces in these collections are explored on a very limited scale for novel genetic variations. The availability of wild relatives of Oryza sativa has increased interest in understanding the genetic makeup of Nepalese rice landraces. …”
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Optimal joint production and green investment decisions of green credit financing under uncertain demands by Zhiping Yu, Xin Feng

“…Green credit financing (GCF) is a specialized financial service offered by banks, aimed at incentivizing borrowers to engage in environmentally sustainable investments, and thus promote sustainable development. It is worth noting that in the practical economic environment, the ability of enterprises to adapt their production and green investment decisions to unforeseen market demand is critical for their green credit financing. …”
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UNA EXPERIENCIA PEDAGÓGICA PARA EL DESARROLLO DE LA ORALIDAD A TRAVÉS DE LA CORPORALIDAD Y LA LÚDICA DRAMÁTICA by Benítez Mosquera Carlos Andrés, Herrera Torres Wilder Duban

“…De cara a esta problemática se genera una investigación que buscó aportar una mirada rigurosa de la lúdica dramática como estrategia y didáctica alternativa que potencie la competencia comunicativa de la oralidad, para tal efecto, los planteamientos teóricos se abordan desde tres ejes: la oralidad, el teatro y la lúdica dramática, para ello, en la oralidad se retoman los planteamientos de Walter Ong (1987), Justo Morales (1997) y Noam Chomsky (1965); en el teatro se trabaja las teorías de Stanislavski (2014) y Bertolt  Brecht (1948) y la lúdica dramática se asume desde los planteamientos de Verónica García (1996), Pedro Zavala ( 2009) y Andrés Vicente (2015). …”
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Network analyses of brain tumor multiomic data reveal pharmacological opportunities to alter cell state transitions by Brandon Bumbaca, Jonah R. Huggins, Marc R. Birtwistle, James M. Gallo

“…For example, the transcription factor TFAP2A can be seen to promote a transition from the NPC-like to the MES-like state. Such protein nodes and the associated signaling pathways provide potential drug targets that can be further tested in vitro and support cell state-directed (CSD) therapy.…”
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Cramér-Rao Bound Analysis of Spatial Effects in 2D TOA Localization With Directive Antennas by Imran Moez Khan, Xuezhi Wang, William Moran, Wayne S. T. Rowe

“…In both of these cases, observability emerges from the directional noise introduced by non-isotropic antenna radiation patterns. …”
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Active Control Optimization for Minimizing the Dynamic Response of Functionally Graded Plate by M. E. Fares, M. Kh. Elmarghany, Doaa Atta

“…The influence of through-the-thickness normal strain effect on the accuracy of the obtained results is illustrated. …”
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Citrus Sudden Death in Brazil by Stephen H. Futch, M. J. Beretta, Kenneth S. Derrick

“…The disease was first reported in the northern part of the citrus production area located in the state of Minas Gerais and has since spread into the northern part of Sao Paulo State, which is the largest citrus-producing state in Brazil. …”
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L’appropriation culturelle dans le secteur de la mode by Clara Gavelli

“…The difficulties of extending this model to this type of creation, as well as the economic and cultural stakes underlying the notion of cultural appropriation, invite us to reconsider not only our symbolic representations, but also our legal relationships with things that surround us.…”
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El Instituto Latinoamericano de Estudios Críticos Animales como proyecto decolonial by Iván Darío Ávila Gaitán

“…Finalmente se esbozan unas líneas orientadas a poner de manifiesto la potencia infraestructural del ILECA para hacer resonar mundos, comunidades o sociedades tecno-bio-físicas en movimiento (compuestas por humanos y no humanos), y para repensar las nociones de crítica y animalidad.…”
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On Some Recent Developments in Ulam's Type Stability by Nicole Brillouët-Belluot, Janusz Brzdęk, Krzysztof Ciepliński

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De parias à victimes. Mobilisations féministes sur la prostitution en France et au Canada (1880-1920) by Yolande Cohen

“…The reglementation of prostitution in Europe was actively contested by abolitionists, while tolerance was met by temperance movements requiring its prohibition in North America. The comparative analysis of French and Canadian National Council of Women’s proposals show that they had an important influence in the adoption of reglementarist laws in both countries, reducing the distance between their legislations. …”
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Problems of developing a strategic planning methodology for regional socio-economic systems by A. G. Ataeva

“…The peculiarities of the region have been have been disclosed as an open complex system, occupying an intermediate level in the public administration system, characterized by a non-linear development and informational openness of management.The complex nature of a region affects the fact, that a regional strategy is a mechanism for coordinating the long-term interests of various stakeholders of a territory. …”
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A Green Demand-Responsive Airport Shuttle Service Problem with Time-Varying Speeds by Ming Wei, Binbin Jing, Jian Yin, Yang Zang

“…Since this task is an NP-hard problem, a heuristic-based nondominated sorting genetic algorithm (NSGA-II) is also presented to find Pareto optimal solutions in a reasonable amount of time. …”
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Evaluation of the penetration depth of Guttaflow bioseal and Bioceramic sealers using scanning electron microscope (in vitro study). by Razawa Kareem Saeed

“…Result: Independent sample t-test shows that the difference between the penetration depth of guttaflow bioseal and bioceramic sealers are non-significant while the ANOVA test shows that the difference between the three sections of the root is highly significant for both sealer, coronal section shows the best result for Guttaflow bioseal while middle section for Bioceramic shows the best result of penetration. …”
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Rimonabant: From RIO to Ban by Amir H. Sam, Victoria Salem, Mohammad A. Ghatei

“…However, the drug was quickly withdrawn due to the emergence of significant side effects—notably severe mood disorders. This paper provides a brief overview of the Rimonabant story and places the recent spate of FDA rejections of other centrally acting weight loss drugs entering Phase 3 trials in this context.…”
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Mathematical model of penetration of cylindrical electromagnetic fields with axial symmetry through the plane screen from permalloy by V. Т. Erofeenko

“…For solution simplification of the boundary-value problem as a result of exclusion value the entering in nonlinear equation second-order infinitesimal, nonlinear task is transformed into linear task. …”
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Pathological variants in HPV-independent vulvar tumours by Sanja A. Farkas, Alvida Qvick, Gisela Helenius, Gabriella Lillsunde-Larsson

“…The top 10 frequently mutated genes in HPV-indepentent tumors were TP53, POLE, PTCH1, BRCA2, CREBBP, NOTCH2, ARID1A, CDKN2A, MSH2, and NOTCH1. Three fusion genes were detected; TBL1XR1(1)::PIK3CA(2) (n = 2) and NF1(5)::PSMD11(2) (n = 1). …”
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Role of Endoscopy in the Investigation of Upper Gastrointestinal Symptoms in HIV-Infected Patients by C Mel Wilcox

“…Although processes can be identified, a diagnosis is less likely in patients who present with nausea and vomiting or nonspecific abdominal pain. By tailoring the use of endoscopy to the presenting symptoms and CD4 lymphocyte count, the diagnostic benefit can be increased.…”
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