Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective... by Itske Fraterman, Lucia Sacchi, Henk Mallo, Valentina Tibollo, Savannah Lucia Catherina Glaser, Stephanie Medlock, Ronald Cornet, Matteo Gabetta, Vitali Hisko, Vadzim Khadakou, Ella Barkan, Laura Del Campo, David Glasspool, Alexandra Kogan, Giordano Lanzola, Roy Leizer, Manuel Ottaviano, Mor Peleg, Konrad Śniatała, Aneta Lisowska, Szymon Wilk, Enea Parimbelli, Silvana Quaglini, Mimma Rizzo, Laura Deborah Locati, Annelies Boekhout, Lonneke V van de Poll-Franse, Sofie Wilgenhof

“…HRQoL data were measured with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 at baseline (T0), 3 months (T1), and 6 months (T2) after start of treatment. Mixed effects linear regression models were used to compare HRQoL between the 2 groups over time. …”
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Identifying Digital Markers of Attention-Deficit/Hyperactivity Disorder (ADHD) in a Remote Monitoring Setting: Prospective Observational Study by Heet Sankesara, Hayley Denyer, Shaoxiong Sun, Qigang Deng, Yatharth Ranjan, Pauline Conde, Zulqarnain Rashid, Philip Asherson, Andrea Bilbow, Madeleine J Groom, Chris Hollis, Richard J B Dobson, Amos Folarin, Jonna Kuntsi

“…We focus on features derived from (1) Active App (mean and SD of questionnaire notification response latency and of the time interval between questionnaires), (2) Passive App (daily mean and SD of response time to social and communication app notifications, the SD in ambient light during phone use, total phone use time, and total number of new apps added), and (3) a wearable device (Fitbit) (daily steps taken while active on the phone). Linear mixed models and td ResultsGroup differences were significant for 5 of the 10 variables. …”
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Recent Developments to the ANSWERS® Monte Carlo Codes MONK® and MCBEND® by Fildes Jessica, Richards Simon, Bird Adam, Cox Andrew, Fry Timothy, Hanlon David, Jones Brian, Long David, Tantillo Francesco, Wright George, Hiles Richard

“…Improvements to the physics include stochastic mixing of bound thermal scattering data, Doppler broadening rejection correction, improved support for low temperature analyses in MONK, and modelling of photonuclear reactions in MCBEND. …”
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Longitudinal analysis of lifestyle risk factors, nutrition status and drivers of food choice among urban migrants in Ulaanbaatar, Mongolia, and Almaty, Kazakhstan: a formative stud... by Sabri Bromage, Shamil Tazhibayev, Xin Zhou, Chang Liu, Enkhtsetseg Tserenkhuu, Oksana Dolmatova, Munkhbat Khishignemekh, Leyla Musurepova, Wusigale, Soninkhishig Tsolmon, Enkhjargal Tsendjav, Davaasambuu Enkhmaa, Rajesh Kumar Rai, Bayarmaa Enkhbat, Bilige Menghe, Davaasambuu Ganmaa

“…Trends were analysed using mixed-effects models and qualitatively compared within and between cities. …”
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How do palliative care doctors recognise imminently dying patients? A judgement analysis by Nicola White, Priscilla Harries, Adam JL Harris, Victoria Vickerstaff, Philip Lodge, Catherine McGowan, Ollie Minton, Christopher Tomlinson, Adrian Tookman, Fiona Reid, Patrick Stone

“…Phase II: participants gave a probability of death within 72 hours (0%–100%). A mixed model regression analysis was completed using the percentage estimate as the outcome and the patient information included in the vignettes as the predictors.Results The mean Brier score of all participants was 0.237 (95% CI 0.235 to 0.239). …”
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Taking a partnership approach to embed physical activity in local policy and practice: a Bradford District case study by Jennifer Hall, Elliot Lever, Nathan Dawkins, Emma Young, Jamie Crowther, Rachel Williams, John Pickavance, Sally Barber, Andy Daly-Smith, Anna Chalkley, On behalf of the wider JU:MP team

“…The aim of this study was to examine ‘what works’, and identify factors underpinning change, focused on work to embed physical activity in local policy and practice in Bradford, UK. Methods A mixed-methods case study approach involved collecting data from cross-sectoral stakeholders directly or indirectly engaged in the physical activity agenda in Bradford over a period of three years (2021–2024). …”
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Anti-sperm Antibody Positivity in Men with Varicocele: A Systematic Review and Meta-Analysis by Marco Falcone, Kadir Bocu, Hakan Keskin, Jesus Fernando Solorzano Vazquez, Ravi Banthia, Tara Mahendran, Muslim Dogan Deger, Vinod Kv, Preto Mirko, Ahmed M. Harraz, Ramadan Saleh, Rupin Shah, Ashok Agarwal

“…Results: Out of 151 abstracts identified during the initial screening, 6 articles met the inclusion criteria and were included in the meta-analysis. Using mixed antiglobulin reaction (MAR) assay, 61 out of the 153 (39.8%) patients with varicocele tested positive for ASA in their ejaculates as compared to 22 out of the 129 control subjects (17%, OR=4.34 [95% CI: 1.09–17.28]; p=0.04). …”

Percutaneous Mitral Valve Repair versus Optimal Medical Therapy in Patients with Functional Mitral Regurgitation: A Systematic Review and Meta-Analysis by Muhammad Uzair Lodhi, Muhammad Shariq Usman, Tariq Jamal Siddiqi, Muhammad Shahzeb Khan, Muhammad Arbaz Arshad Khan, Safi U. Khan, Intekhab Askari Syed, Mustafa Rahim, Srihari S. Naidu, Rami Doukky, Mohamad Alkhouli

“…Secondary endpoints were 30-day mortality and cardiovascular mortality and HF hospitalizations, at maximum follow-up. Studies including mixed cohort of degenerative and functional MR were allowed initially but were excluded in a secondary sensitivity analysis for each of the study’s end points. …”
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Achieving equiaxed and lamellar TiAl alloys via cold-cathode electron beam additive manufacturing with dual-wire synergistic control by Yilei Shi, Shuili Gong, Haiying Xu, Wei Chen, Zhuang Wang, Guang Yang, Xin Liu, Bojin Qi

“…The results show that the cold-cathode electron beam heat source under low vacuum and the co-molten pool mode reduce aluminum evaporation and promote element mixing through layer-by-layer temperature control and remelting. …”
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Protocol for a process evaluation: face-to-face physiotherapy compared with a supported home exercise programme for the management of musculoskeletal conditions: the REFORM trial by David Wong, Catherine Sherrington, Manuela L Ferreira, Christopher G Maher, Hueiming Liu, Joshua R Zadro, Lisa A Harvey, Hannah G Withers, Joanne V Glinsky, Jackie Chu, Matthew D Jennings, Alison J Hayes, Ian J Starkey, Blake A Palmer, Lukas Szymanek, Jackson J Cruwys, Kitty Duong, Anne Barnett, Matthew J Tindall, Barbara R Lucas, Tara E Lambert, Deborah A Taylor

“…These two frameworks will be broadly used to guide this process evaluation using a mixed-methods approach. For example, qualitative data will be derived from interviews with patients, healthcare professionals and stakeholders, and quantitative data will be collected to determine the cost and feasibility of providing supported home exercise programmes. …”
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Hydrocarbon generation, expulsion, and retention characteristics of the Permian Fengcheng shale and Lucaogou shale in the Junggar Basin: implications for the exploration of lacustr... by Wenjun He, Zhiming Li, Zhiming Li, Zhiming Li, Changrong Li, Changrong Li, Jinyi He, Jinyi He, Jinyi He, Junying Leng, Junying Leng, Junying Leng, Zhongliang Sun, Zhongliang Sun, Zhongliang Sun, Deguang Liu, Sen Yang

“…Exploration of the Fengcheng shale should focus on lithofacies assemblages, the dolomitic mixed rock-shale assemblages in the shore-shallow lake facies represent the primary exploration target. …”
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Effectiveness of advanced cardiovascular life support in hyperkalemic cardiac arrest: A randomized experimental study in pigs by Najmiddin Mamadjonov, Wan Young Heo, Kyung Woon Jeung, Yong Hun Jung, Hyoung Youn Lee, Seok Jin Ryu, Byung Kook Lee, Yong Soo Cho, Tag Heo

“…Hemodynamic, echocardiographic, and brain tissue oxygen tension measurements were obtained during advanced cardiovascular life support and compared using linear mixed-effects models. Two animals developed massive hemothorax associated with cardiopulmonary resuscitation and were excluded from further analysis. …”
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Approaches to implementing and financing primary health care in Kenya: a case of seven counties by Janette Karimi, Salim Hussien, Elizabeth Wangia, Mercy-Irene Kimani, Mohamud Mohamed, Melissa Wanda, Rosemarie Muganda, Rachel Ndirangu, Daniel Mwai, Mercy Wanjala, Fadhila Richter

“…This scholarly article delineates the outcomes of an investigative assessment reviewing the current state and trajectory of PHC implementation, focusing on the PCN implementation, and analyzing PHC financing modalities in 7 counties in Kenya.MethodsThis study employed a mixed-methodological approach to gather data from seven counties; Garissa, Nyeri, Makueni, Vihiga, Kisumu, Nakuru, and Mombasa. …”
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Early sST2 Liberation after Implantation of a Left Ventricular Assist Device in Patients with Advanced Heart Failure by Philipp Opfermann, Elisabeth Simader, Alessia Felli, Michele Bevilacqua, Caroline Holaubek, Martin Dworschak, Mohamed Mouhieddine, Daniel Zimpfer, Jan Hendrik Ankersmit, Barbara Steinlechner

“…We compared the kinetics of IL-6, sST2, and IL-33 release in survivors with those of nonsurvivors using mixed model two-way analysis of variance for repeated measures. …”
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Features of the functioning of the hypothalamic-pituitary-thyroid axis in mice with Lewis carcinoma on the background of induced hyperthyroidism by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, I. V. Neskubina, E. I. Surikova, A. I. Shikhlyarova, L. K. Trepitaki, M. A. Gusareva, I. A. Udalenkova, E. O. Vasilieva, N. D. Cheryarina, V. V. Pozdnyakova

“…The experimental model was mixed-sex mice of the C57BL/6 line with subcutaneously transplanted LLC on the background of induced hyperthyroidism (main group). …”
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Genesis of Dolomite in Middle Permian Maokou Formation in Eastern Sichuan: Constraints from In Situ Geochemistry, Sr-Mg Isotopes, and Fluid Inclusions by Yanxia Jiang, Xianfeng Tan, Chengjiang Zhang, Wei Jiang, Jia Wang, Long Luo, Dongping Tan, Wei Wang, Zhifu Xiong

“…The hydrothermal fluid stage is related to the movement of the Emeishan Large Igneous Province, which was made up of basaltic magmatic fluids mixing with the surface water. The hydrothermal fluid mainly migrated upwards along structural fractures or faults and filled in structural fractures, occurring in the Late Permian to Middle-Late Triassic.…”
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Associations between brominated flame retardants exposure and non-alcoholic fatty liver disease: Mediation analysis in the NHANES by Yulan Cheng, Jingyi Su, Xiangdong Wang, Ruiyao Huang, Zixuan Zhao, Kai Tian, Tianxiang Gu, Xiaoke Wang, Lin Chen, Xinyuan Zhao

“…Conclusions: Our findings offer evidence for single and mixed associations of BFRs and NAFLD in ordinary US adults. …”
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Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the pro... by Zeyu Li, Guoying Wang, Joseph M. Braun, Xiumei Hong, Giehae Choi, Shawn P. O’Leary, Chang Ho Yu, Colleen Pearson, William G. Adams, Zhihua (Tina) Fan, Jessie P. Buckley, Xiaobin Wang

“…The exposure-outcome associations were evaluated with linear and modified Poisson mixed-effects regression for individual PFAS and Bayesian kernel machine regression and quantile-based g-computation models for PFAS mixture. …”
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The Petrogenesis of the Permian Podong Ultramafic Intrusion in the Tarim Craton, Western China: Constraints from C-He-Ne-Ar Isotopes by Mingjie Zhang, Pengyu Feng, Tong Li, Liwu Li, Juerong Fu, Peng Wang, Yuekun Wang, Zhongping Li, Xiaodong Wang

“…The δ13C of CO2 and CH4 suggested the magmatic volatile of the mantle mixed with the volatiles of thermogenic and crustal origins. …”
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Effects of the maternal and child health handbook and other home-based records on mothers’ non-health outcomes: a systematic review by Akira Shibanuma, Masamine Jimba, Rogie Royce Carandang, Jennifer Lisa Sakamoto, Ekaterina Yarotskaya, Milana Basargina, Mika Kondo Kunieda

“…While home-based records positively affected communication within the household, we observed mixed effects on communication between mothers/caregivers and healthcare providers. …”
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