Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans by Mariano A. Aufiero, Li-Yin Hung, De'Broski R. Herbert, Tobias M. Hohl

“…We found that Mpeg1−/− mice generated on a mixed C57BL/6J-DBA/2 background exhibited enhanced survival, reduced lung fungal burden, and greater neutrophil fungal killing activity compared to wild-type C57BL/6J (B6) mice, suggesting that Perforin-2 may impair antifungal immune responses. …”
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Challenges and opportunities for assessing trends of amphibians with heterogeneous data – a call for better metadata reporting by Klaus Henle, Reinhard A. Klenke, M. Benjamin Barth, Annegret Grimm-Seyfarth, Diana E. Bowler

“…We assessed the effects of data processing decisions to infer absences, the use of survey method information and the statistical model (generalised linear mixed-effect occurrence model [GLMM] versus occupancy-detection model) and compared the trends with expert opinions (Red Lists). …”
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Evaluation of a pilot family planning educational seminar and subsequent attitudes towards family planning among Muslim communities in Tanzania. by Alexandra A Cordeiro, Hajirah Gumanneh, Aneth Nzali, Valencia J Lambert, Amina Yussuph, Albert Kihunrwa, Yassin Mchondo, Ramadhan Mtita, Hidaya Yahaya, Samuel E Kalluvya, Joyce Wamoyi, Mehrunisha Suleman, Jennifer A Downs, Agrey H Mwakisole

“…This study employed a mixed-methods approach to pilot-test a one-day educational seminar about social, medical, and theological aspects of FP. …”
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Predictive Clinical Factors of Pain-Related Quality of Recovery Following Elective Gastrointestinal and Hepato-Pancreato-Biliary Surgery: An Observational Study in Norway by Bergestuen L, Hagen M, Kisa S

“…Data were collected using QoR-15NO upon admission for surgery and on the first postoperative day, and surgery severity was classified using the Surgical Outcome Risk Tool. A linear mixed model and multivariate linear regression were used to investigate associations between postoperative scores and possible predictive clinically relevant factors.Results: The results of this study showed that postoperative pain was significantly associated with age, gender, severity of surgery, and changes from pre- to postoperative status. …”
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Influence of High School Socioeconomic Status on Athlete Injuries during the COVID-19 Pandemic: An Ecological Study by Garrett Bullock, Albert Prats-Uribe, Charles Thigpen, Heather Martin, Beverly Loper, Ellen Shanley

“…Injury incidence proportion with 95% confidence interval (95% CI) was calculated for each academic year. Mixed effects negative binomial models with robust errors were performed to assess the association between the incidence proportion ratio and high school median household income. …”
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Development and validation of the Multimorbidity Treatment Burden Questionnaire (MTBQ) by Daisy Gaunt, Chris Salisbury, Mei-See Man, Katherine Chaplin, Polly Duncan, Mairead Murphy

“…Objective To develop and validate a new scale to assess treatment burden (the effort of looking after one’s health) for patients with multimorbidity.Design Mixed-methods.Setting UK primary care.Participants Content of the Multimorbidity Treatment Burden Questionnaire (MTBQ) was based on a literature review and views from a patient and public involvement group. …”
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Use of Subsurface Geology in Assessing the Optimal Co-Location of CO2 Storage and Wind Energy Sites by I. de Jonge-Anderson, J. R. Underhill

“…The Rotliegend Group reservoir (Leman Sandstone Formation) is a mixed aeolian/fluvial succession with variable thickness (25 m–80 m), high net-to-gross (0.9–1.0), moderate average porosity (9%–17%) and fair-average permeability (>1 mD). …”
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Assessment of satisfaction of using socially marketed health consumables at government settings among beneficiaries in a rural area of Hooghly District, West Bengal by Aditi Sur, Bobby Paul, Lina Bandyopadhyay, Monalisha Sahu, Rivu Basu, Ankush Banerjee

“…Materials and Methods: A community-based, Mixed-Methods study (Convergent parallel design) was done in the service area of the Rural Health Unit and Training Centre (RHU&TC), Singur of Hooghly district, West Bengal, between January 2023 and December 2023, where the quantitative component was carried out by face-to-face interview among 150 beneficiary household respondents selected by two-stage cluster sampling; and qualitative component was done by 4 Key informant interviews (KII) among healthcare personnel (medical officer, public health nurse, pharmacist). …”
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Optimal exercise dose on Body Mass Index (BMI) in children and adolescents with overweight and obesity: a systematic review and bayesian model-based network meta-analysis by Zan Huang, Gang Sun, Jiayu Li, Bin Zhang, Guangping Lai, Hongwei Jing, Yulan Zhou

“…High-intensity interval training demonstrated a significant reduction in BMI (MD = -1.33, 95% CrIs - 2.01 to -0.66), followed by combined exercise (MD = -1.25, 95% CrIs − 1.93 to -0.61), moderate-intensity continuous training (MD = -1.09, 95% CrIs - 1.73 to -0.45), and mixed aerobic exercise (MD = -1.05, 95% CrIs - 1.67 to -0.42). …”
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Protocol for prognosticating PPD using EEG changes during labor pain by uterine contractions: a prospective cohort study in the first stage of labor by Yan Wang, Wan-Ying He, Chang’ an A. Zhan, Shi-Lei Pan, Wen Wu, Feng-Xian Li, Hong-Fei Zhang

“…The connections between PPD severity and EEG measurements as a function of time will be assessed using linear mixed-effects models. Maternal age, parity, and whether oxytocin is used during labor, all have an impact on the incidence of PPD, hence a stratified analysis will be carried out. …”
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Human and entomological determinants of malaria transmission in the Lihir Islands of Papua New Guinea: A cross-sectional study. by Pere Millat-Martínez, Michelle Katusele, Bernadine Kasian, Elias Omera, Esther Jamea, Lina Lorry, Aina Casellas, Dan Ouchi, Chilaka Wali, Sylvia Raulo, Arthur Elizah, Peter Kaman, Absalom Dau, Muker Sakur, Lemen Kilepak, Siub Yabu, Nelson Koata, John Kave, Michael Toa, Christopher Urakusie, Charles Kongs, Frank Kisba, Moses Laman, Oriol Mitjà, William Pomat, Quique Bassat, Stephan Karl, Bàrbara Baro

“…P. vivax accounted for 37.1% of infections, P. falciparum for 34.6%, P. malariae for 3.0%, P. ovale 0.2%, and mixed infections for 24.5%. Prevalence (qPCR) varied across geographic areas, from 8.5% in the mine-impacted zone (MIZ) to 27.0% in the non-MIZ. …”
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Hydrochemical Characteristics and Evolution Mode of Cold Seeps in the Qiongdongnan Basin, South China Sea by Zhifeng Wan, Chongmin Chen, Jinqiang Liang, Wei Zhang, Wei Huang, Pibo Su

“…The concentrations of trace elements and their ratios to Cl- in the bottom seawater were high at the stations with cold seeps, suggesting the mixing of other fluids rich in those elements. Biochemical reactions may also have caused the chemical anomalies. …”
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Remote symptom monitoring with patient-reported outcomes and nudges during lung cancer immunotherapy in China (PRO-NET): protocol for a randomised controlled trial by Ping He, Yanan Luo, Zhenyu Shi, Yiqi Xia, Xiaolong Guan

“…Differences in HRQoL between the groups will be compared using general linear mixed model, accounting for potential confounding.Ethics and dissemination The study was approved by the Institutional Review Board of the Peking University protocol on 21 July 2024 (No. …”
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The Restoration Effect of Degraded Grassland Depends on the Response of Species Root Distribution to Resource Availability by Yiming Zhao, Hui Li, Fei Peng, Dabu Xilatu, Qing Chen, Shan Lin

“…The purpose of this study is to explore a method to distinguish the response of various plant root architectures to the resource availability in a mixed ecosystem in situ. Field experiments were conducted using isotope techniques in conjunction with a specialized experimental design at a semiarid grassland location featuring heavily grazed (HG) and moderately grazed (MG) grassland sites with different dominant species. …”
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Charting the course: Insights into EMR usability from Australian clinicians – A national survey by Sheree Lloyd, Abraham Oshni Alvandi, Yasmine Probst, Jeremy Roach, Richard Olley, Christopher Bain

“…Although 63% agreed it is easy to obtain necessary patient information, 45% disagreed that entering and documenting data is quick and smooth. There were mixed responses regarding the EMR system's role in preventing medication errors, with 50% agreeing that it helps prevent errors and 27% disagreeing. …”
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CHRONOTYPE AND DAILY FUNCTIONING OF PATIENTS WITH DIFFERENT MOTOR SUBTYPES OF PARKINSON DISEASE by A.D. Shkodina, M. Bardhan, K.A. Tarianyk, M. Yu. Delva

“…The examined patients were divided into 3 groups according to the motor subtype of PD: group 1 (n = 38) - patients with PD subtype with the predominance of postural instability and gait disorders (PIGD); group 2 (n = 26) - patients with PD subtype with the predominance of tremor and mixed subtype; control group (n = 30) - conditionally healthy individuals without CNS lesions. …”
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Population pharmacokinetics of iruplinalkib in healthy volunteers and patients with solid tumors by Guihong Yang, Yimei Wang, Huimin Zhao, Ziyi Jiang, Shansong Zheng, Mingjing Ge, Meimei Si, Xiaoyan Kang

“…Data were analyzed using non‐linear mixed‐effects modeling. Iruplinalkib plasma concentrations were best described by a two‐compartment model with first‐order absorption and first‐order elimination. …”
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Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with... by Enrique S. Nuñez-del-Arco, Renzo A. Agurto-García, Rodrigo M. Carrillo-Larco, J. Jaime Miranda, Antonio Bernabe-Ortiz

“…Crude and adjusted linear mixed models were used to assess the associations of interest, and coefficients (β) and 95% confidence intervales (95% CI) were reported. …”
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ALGORITHMIC THINKING IN HIGHER EDUCATION: DETERMINING OBSERVABLE AND MEASURABLE CONTENT by Marian Byrka, Andrii Sushchenko, Volodymyr Luchko, Galina Perun, Victoria Luchko

“…The purpose of this study is to identify, clarify, and categorize algorithmic thinking content in observable and measurable knowledge, skills, and abilities statements (KSAs). The study is a mixed-methods type of development research carried out in 4 stages: 1) extraction of the KSA statements from the extant scientific literature related to algorithmic thinking; 2) design of The Algorithmic Thinking Content Survey (ATCS) based on the five steps Universal Sequence of an Algorithm Development (USAD); 3) administration of the ATCS on a wide variety of educational professionals (N = 117); 4) data analysis aimed to obtain the content of algorithmic thinking in observable and measurable KSA statements. …”
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Relationships between diabetes distress and biomarkers in people with type 1 diabetes mellitus by V.I. Pankiv, T.Yu. Yuzvenko, G.P. Mykhalchyshyn

“…Perceived stress, diabetes distress, morning salivary cortisol, inflammatory biomarkers, and hemoglobin A1c (HbA1c) were measured in this quantitative, cross-sectional phase of a larger, mixed methods research. People with T1DM completed self-report surveys, provided blood and salivary samples to examine effect sizes of relationships among variables of interest. …”
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