A national study of choanal atresia in tertiary care centers in Canada – part I: clinical presentation by Josee Paradis, Agnieszka Dzioba, Hamdy El-Hakim, Paul Hong, Frederick K. Kozak, Lily H. P. Nguyen, Demitri Perera, Evan Jon Propst, Jennifer M. Siu, Monika Wojtera, Murad Husein, National Choanal Atresia Study Working Group

“…For the majority of patients (73.2%), the obstruction comprised mixed bony and membranous tissue, with only 10.5% presenting with a purely membranous obstruction. …”
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An Arctic Marine Source of Fluorescent Primary Biological Aerosol Particles During the Transition from Summer to Autumn at the North Pole by Julia Kojoj, Gabriel Pereira Freitas, Morven Muilwijk, Mats A. Granskog, Tuomas Naakka, Annica M. L. Ekman, Benjamin Heutte, Julia Schmale, Anderson Da Silva, Rémy Lapere, Louis Marelle, Jennie L. Thomas, Christian Melsheimer, Benjamin J. Murray, Paul Zieger

“…This relationship highlights the potential importance of biological sources of INPs in the formation of mixed-phase clouds during the central Arctic’s summer and early fall seasons. …”
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Association of exposure to multiple volatile organic compounds with ultrasound-defined hepatic steatosis and fibrosis in the adult US population: NHANES 2017–2020 by Wentao Shao, Wentao Shao, Pan Gong, Qihan Wang, Fan Ding, Weiyi Shen, Hongchao Zhang, Anhua Huang, Chengyu Liu

“…The study examined the relationship between urinary exposure biomarkers for 20 VOCs and liver health outcomes using multivariate logistic regression and Bayesian Kernel Machine Regression (BKMR) to evaluate the effects of both individual and mixed VOC exposures.ResultsMultivariate logistic regression analysis revealed that exposure biomarkers for acrolein and crotonaldehyde were positively associated with hepatic steatosis. …”
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The influence of Federal Regulations and community health indicators on community benefit spending by private nonprofit hospital in some States of the US: A retrospective longitudi... by Wael ELRAYES, David PALM, Fernando WILSON, Hongmei WANG, Jane MEZA, Robin HIGH, Valerie PACINO

“…Methods: A retrospective longitudinal study was used to estimate the relationship between county-level com- munity health indicators in one year and levels of spending on community health improvement initiatives in the consecutive year for 223 urban and rural counties in seven US states. A generalized linear mixed model with lagged community health indicators and included multiple covariates was used. …”
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From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair by Rajiv Borah, Daniel Diez Clarke, Jnanendra Upadhyay, Michael G. Monaghan

“…In this context, electrically conductive polymer (ECP)-based biomaterials offer unique advantages for nerve repair combining their flexibility, akin to traditional plastics, and mixed ionic-electronic conductivity, similar to ionically conductive nerve tissue, as well as their biocompatibility and ease of fabrication. …”
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Polymeric Multivalent Fc Binding Peptides‐Fabricated Clinical Compounding Bispecific Antibody Potentiates Dual Immunotherapy Targeting PD1 and CTLA‐4 by Zongyu Liu, Hongyu Chu, Weidong Zhao, Chenguang Yang, Tongjun Liu, Na Shen, Zhaohui Tang

“…The PD1/CTLA‐4 BsAb is prepared by mixing PLG‐Fc‐III‐4C with aPD1 and aCTLA‐4 in an aqueous solution for 3 h using the clinically optimal 3:1 proportion of aPD1 to aCTLA‐4. …”
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Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency by Laura Tarancon-Diez, Marianela Iriarte-Gahete, Pilar Sanchez-Mingo, Mª Ángeles Muñoz-Fernandez, Maria Luisa Navarro-Gomez, Yolanda M. Pacheco, Manuel Leal

“…Notable obesity-associated disturbances in iron metabolism are described and indicate a mixed ID among both, women and men. These findings highlight the importance of tailored interventions to correctly address ID in obese population.…”
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Impact of out-of-home nutrition labelling on people with eating disorders: a systematic review and meta-synthesis by Lucy Serpell, Dasha Nicholls, Ulrike Schmidt, Tom Jewell, Nora Trompeter, Fiona Duffy, Imogen Peebles, Emily Wadhera, Kate Chambers, Helen Sharpe, Ellen Maloney

“…Unpublished studies were searched for on Google Scholar and PsyArXiv.Eligibility criteria Studies were included if they assessed the impact of out-of-home nutrition labelling policies on individuals with eating disorders or disordered eating.Data extraction and synthesis 538 studies were screened, of which 16 studies met inclusion criteria.Results The reviewed studies included five experimental/quasi-experimental studies, five cross-sectional studies and six qualitative/mixed-methods studies. Across studies, eating disorder pathology was associated with noticing labels more frequently, paying more attention to caloric intake and more frequent behaviour changes due to caloric values. …”
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Evaluation of the cross-immunity between Mycobacterium tuberculosis and Mycobacterium abscessus in vitro by Da Xu, Yujie Gu, Guilian Li, Ruihuan Wang, Shiqi Xiao, Hongyang Duan, Jingwei Jiang, Xiuqin Zhao, Kanglin Wan, Xinyue He, Haican Liu, Yongliang Lou

“…The whole-cell proteins of Mycobacterium abscessus were lysed via ultrasonication and then were subcutaneously injected into BALB/c mice either alone or mixed with adjuvant for three times at a 10-day interval. …”
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Study on Viscosity Reducer Flooding Technology for Deep Low Permeability Extra Heavy Oil Reservoirs by Xiaopeng Cao, Zupeng Liu, Yong Yang, Shiming Zhang, Yahui Bu, Sen Wang, Yipu Liang, Qihong Feng

“…In this paper, core flooding experiment and microvisualization equipment were used to study the mechanism of improving the recovery of deep extra heavy oil by using water-soluble viscosity reducer; the realization of water-soluble viscosity reducer in numerical simulation was achieved by using nonlinear mixing rule; the reservoir numerical simulation model of water-soluble viscosity reducer displacement in test well group was established to optimize the development technical parameter of water-soluble viscosity reducer. …”
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Association of geriatric nutritional risk index with renal prognosis and all-cause mortality among older patients with chronic kidney disease: a secondary analysis of CKD-ROUTE stu... by Lei Chen, Mengyao Yan, Jie Li, Xue Zhao, Lu Zeng, Zhumei Gao, Hongli Jiang, Limin Wei

“…Associations between GNRI and clinical outcomes were estimated using Cox proportional hazards model analysis. Multivariable linear mixed regression models with random intercepts were used to assess the association between GNRI and estimated glomerular filtration rate (eGFR) decline per year.Results During the median follow-up period of 2.92 years, there were 123 (22.86%) CKD progression events, 44 (8.18%) deaths, and 76 (14.13%) cardiovascular events. …”
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Identification of Health Needs in Ukrainian Refugees Seen in a Primary Care Facility in Tenerife, Spain by Willian-Jesús Martín-Dorta, Cristo-Manuel Marrero-González, Eva-Lourdes Díaz-Hernández, Pedro-Ruymán Brito-Brito, Domingo-Ángel Fernández-Gutiérrez, Oxana-Migalievna Rebryk-De Colichón, Ana-Isabel Martín-García, Estrella Pavés-Lorenzo, María-Candelaria Rodríguez-Santos, Juan-Francisco García-Cabrera, Janet Núnez-Marrero, Alfonso-Miguel García-Hernández

“…Aim: To identify the health needs of Ukrainian refugees seen in primary care facilities in Tenerife, Canary Islands, Spain. Methods: A mixed-methods design was employed. Quantitative data were obtained through a descriptive analysis of health records, while qualitative data were collected via focus group interviews and thematic analysis of testimonies. …”
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A mind-body resilience intervention for emotional distress in cardiac arrest survivors and their informal caregivers – Recovering together after cardiac arrest: Protocol for an ope... by Danielle La Camera, Jonathan Elmer, Sarah M. Perman, Michael W. Donnino, Ona Wu, Robert A. Parker, Ana-Maria Vranceanu, Alexander M. Presciutti

“…We will integrate qualitative and quantitative data using explanatory-sequential mixed-methods. Discussion: We will use our findings to refine RT-CA content and study procedures. …”
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Genetic background of body reserves in laying hens through backfat thickness phenotyping by Bédère, Nicolas, Dupont, Joëlle, Baumard, Yannick, Staub, Christophe, Gourichon, David, Frédéric, Elleboudt, Le Roy, Pascale, Zerjal, Tatiana

“…To address these questions, hens from two lines under divergent selection for residual feed intake, were phenotyped for body weight, body composition traits (backfat, total fat volume, and blood adipokines levels), and egg number. Linear mixed models enabled to estimate variance components and calculate genetic parameters. …”
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Progression and mortality of patients with cystic fibrosis in China by Wangji Zhou, Yaqi Wang, Yanli Yang, Yanyan Sun, Chongsheng Cheng, Jinrong Dai, Shuzhen Meng, Keqi Chen, Yang Zhao, Xueqi Liu, Dingding Zhang, Song Liu, Weiguo Zhu, Yaping Liu, Kai-Feng Xu, Xinlun Tian

“…Compared to patients diagnosed with CF in childhood, adult-diagnosed patients exhibit a lower proportion of pancreatic exocrine insufficiency (25.0% vs. 77.8%, P = 0.001) and a higher body mass index (19.6 vs. 17.7 kg/m2, P = 0.045). According to the mixed-effects model, for patients ≤ 30 years of age at diagnosis, FEV1% predicted decreased 1.17% per year. …”
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Association between social activities and risk of COVID-19 in a cohort of healthcare personnel by Holly Shoemaker, Haojia Li, Yue Zhang, Jeanmarie Mayer, Michael Rubin, Candace Haroldsen, Morgan M. Millar, Per H. Gesteland, Andrew T. Pavia, Lindsay T. Keegan, Jessica Marie Cole, Egenia Dorsan, Matthew Doane, Kristina Stratford, Matthew Samore

“…Outcomes included self-reported SARS-CoV-2 infection (primary)and testing for SARS-CoV-2 (secondary). Mixed-effect logistic regression assessed the association between social behavior and outcomes, adjusting for baseline and time-dependent covariates. …”
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Feasibility and psychometric quality of smartphone administered cognitive ecological momentary assessments in women with metastatic breast cancer by Ashley M Henneghan, Emily W Paolillo, Kathleen M Van Dyk, Oscar Y Franco-Rocha, Soyeong Bang, Rebecca Tasker, Tara Kaufmann, Darren Haywood, Nicolas H Hart, Raeanne C Moore

“…Feasibility data were analyzed using mixed descriptive methods. Test-retest reliability was examined using intraclass correlation coefficients (ICCs) for each EMA, and Pearson's correlation were used to evaluate convergent validity between cognitive EMAs and baseline clinical cognitive and psychosocial variables. …”
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Dynamic changes in peripheral blood lymphocyte trajectory predict the clinical outcomes of sepsis by Dongkai Li, Jiahui Zhang, Wei Cheng, Guoyu Zhao, Xianli Lei, Yawen Xie, Na Cui, Hao Wang

“…This study aimed to apply latent class mixed modeling on longitudinal lymphocyte counts to uncover heterogeneous trajectory phenotypes in sepsis patients and assess their predictive value for clinical outcomes.ResultsFour lymphocyte trajectory phenotypes were identified in the retrospective cohort (n=2,149) and externally validated (n=2,388): high–declining (α, 3.8%), stable–medium (β, 69.3%), high–increasing (γ, 3.2%), and stable–low (δ, 23.8%). …”
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The importance of market signals in crop varietal development: lessons from Komboka rice variety by Mary Ng’endo, MaryLiza Kinyua, Lourine Chebet, Samuel Mutiga, Joseph Ndung’u, Oliver Nyongesa, Simon Njau, Ajay Panchbhai, Ruth Musila, Rosemary Murori

“…On the other hand, it has taken about seven years for Komboka to be appreciated by farmers, necessitating the need to understand farmer preferences when it comes to adopting a new improved variety. We used a mixed-method study approach by combining quantitative and qualitative data collected regionally and locally in both rainfed and irrigated ecologies. …”
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Protocol for the implementation evaluation of an integrated paediatric and primary care model: Strengthening Care for Children (SC4C) by Yvonne Zurynski, Susan Woolfenden, Peter D Hibbert, Harriet Hiscock, Raghu Lingam, Karen Wheeler, Michael Hodgins, Jade Burley, Rachel Pelly, Jane Le, Sonia Khano, Tammy Meyers Morris, Stephanie Germano

“…The purpose of this manuscript is to describe the pragmatic methods that will be used to capture implementation evaluation process and outcome data within this trial.Methods and analysis Our implementation evaluation will use a mixed methods design, with data collected in the intervention arm of the SC4C trial guided by a logic model developed using the Consolidated Framework for Implementation Research (CFIR) and Proctor and colleague’s taxonomy of implementation outcomes. …”
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