Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism by Felix Pfister, Lucas R. Carnell, Lisa Löffler, Philipp Boosz, Niels Schaft, Jan Dörrie, René Stein, Malte Lenz, Erdmann Spiecker, Christian M. Huber, Sami Haddadin, Carola Berking, Christoph Alexiou, Christina Janko

“…Importantly, SPIONs suppressed cytokine release in the loaded CAR‐T cells, shifting the cell death phenotype in the tumor cells from pyroptosis to apoptosis. …”
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Colorimetric aptasensor coupled with a deep-learning-powered smartphone app for programmed death ligand-1 expressing extracellular vesicles by Adeel Khan, Adeel Khan, Haroon Khan, Nongyue He, Zhiyang Li, Heba Khalil Alyahya, Yousef A. Bin Jardan

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Combination of Anti-programmed Cell Death Protein 1 and Antiangiogenesis Displaying a Response Disparity between Pulmonary and Nonpulmonary Metastases by Bing-Syuan Chung, Peng-Chan Lin, Shang-Hung Chen, Yu-Min Yeh

“…Targeting the vascular endothelial growth factor-mediated immune suppression is a strategy to overcome the resistance of anti-programmed cell death protein 1/programmed death-ligand 1 (anti-PD-1/PD-L1) therapy. …”
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MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies by Bu-Fu Tang, Wang-Ting Xu, Shi-Ji Fang, Jin-Yu Zhu, Rong-Fang Qiu, Lin Shen, Yang Yang, Qiao-You Weng, Ya-Jie Wang, Jia-Yi Ding, Xiao-Jie Zhang, Wei-Qian Chen, Li-Yun Zheng, Jing-Jing Song, Biao Chen, Zhong-Wei Zhao, Min-Jiang Chen, Jian-Song Ji

“…Methods The RFA treatment in hepatocellular carcinoma (HCC) tumor models in vivo, was analyzed by RNA sequencing technology. The heat treatment in vitro for HCC tumor cells was also constructed to explore the mechanism after RFA treatment in tumor cells. …”
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Assessing the relationship between the distress levels in patients with irreversible terminal delirium and the good quality of death from the perspective of bereaved family by Pei Zhou, Cheng Tang, Jingyi Wang, Chunhua Zhang, Jun Zhong

Subjects: “…Good quality of death…”
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Moral distress, attitude toward death, and palliative care core competencies among ICU nurses: a cross-sectional study by Mengyun Peng, Qin Guan, Xiaoling Zhu

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Analysis of the correlation between the serum triglyceride glucose index and the risk of death in patients on maintenance hemodialysis: a retrospective cohort study by Xiaokeng Chi, Shuxin Chen, Zhe Huang, Rong Zhou, Zhicheng Su, Qiujun Mai, Yilin Xu, Jianxin Wan

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Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models by Andrea Mancini, Alessandro Colapietro, Loredana Cristiano, Alessandra Rossetti, Vincenzo Mattei, Giovanni Luca Gravina, Giovanni Luca Gravina, Héctor Perez-Montoyo, Marc Yeste-Velasco, Jose Alfon, Carles Domenech, Claudio Festuccia

“…Both actions converge to induce autophagy-mediated cell death. ABTL0812 anticancer efficacy was studied in vivo using subcutaneous and orthotopic intra-brain xenograft tumor models. …”
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Loss of p53 impairs death receptor expression and confers resistance to CD19 CAR T-cell therapy in BCP-ALL by Willem P. J. Cox, Noël M. M. Dautzenberg, Linde Dekker, Tesa Klenovsek, Annelisa M. Cornel, Marliek van Hoesel, Dorette S. van Ingen Schenau, Reno S. Bladergroen, Roland P. Kuiper, Laurens T. van der Meer, Friso G. Calkoen, Stefan Nierkens, Frank N. van Leeuwen

“…Moreover, expression analysis in cell lines and xenografts demonstrated that loss of p53 abrogates the expression of the death receptors Fas and death receptor 5 (DR5), both implicated in CAR T cytotoxicity. …”
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ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury by Xuechan Bi, Min Li, Yiming Guo, Mengyao Hu, Yujie Chen, Ni Lian, Sihan Chen, Min Li, Heng Gu, Xu Chen

“…Cell Death and Disease…”
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Polarization of alcohol consumption or coding changes as the cause of the increase in 100% alcohol-attributable deaths in Lithuania during the COVID-19 pandemic by Jürgen Rehm, Robertas Badaras, Ahmed S. Hassan, Shannon Lange, Alexander Tran, Mindaugas Stelemekas, Huan Jiang

Subjects: “…100% alcohol-attributable deaths…”
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Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma by Soo Yeon Kim, Miaolu Tang, Stephen Y. Chih, Jessica Sallavanti, Yan Gao, Zhiqiang Qiu, Hong-Gang Wang, Wei Li

“…Cell Death and Disease…”
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Certain Death: Mike Flanagan’s Gothic Antidote to Traumatic Memory and Other Enlightenment Hang-Overs in <i>Doctor Sleep</i> by Erik Bond

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Estimating degradation of strength of neat PEEK and PEEK-CF laminates under cyclic loading by mechanical hysteresis loops by Alexey Bogdanov, Alexander Eremin, Mikhail Burkov, Sergey Panin, Pavel Lyubutin

“…A DIC-based method was employed for assessing the fatigue induced degradation of mechanical properties of neat polyetheretherketone (PEEK) and its laminated composite reinforced with unidirectional carbon fibers. …”
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Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity by Karine Andreau, Melanie Leroux, Aida Bouharrour

“…These atmospheric pollutants have been incriminated in deleterious health effects by numerous epidemiological and in vitro studies. …”
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Updating the Earth remote sensing software for the detection of thermal anomalies by S. A. Zolotoy, I. B. Strashko, Dz. S. Kotau, I. M. Nestsiarovich, V. V. Rouba, Dz. V. Valakhovich

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Enhancing the Health-Promoting Effects of Tomato Fruit for Biofortified Food by Assunta Raiola, Maria Manuela Rigano, Roberta Calafiore, Luigi Frusciante, Amalia Barone

“…Consumption of tomato fruits, like those of many other plant species that are part of the human diet, is considered to be associated with several positive effects on health. Indeed, tomato fruits are an important source of bioactive compounds with known beneficial effects including vitamins, antioxidants, and anticancer substances. …”
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