TMBocelot: an omnibus statistical control model optimizing the TMB thresholds with systematic measurement errors by Xin Lai, Shaoliang Wang, Xuanping Zhang, Xiaoyan Zhu, Yuqian Liu, Zhili Chang, Zhili Chang, Xiaonan Wang, Xiaonan Wang, Yang Shao, Yang Shao, Jiayin Wang, Yixuan Wang

“…TMBocelot utilizes a Bayesian approach based on the stationarity principle of Markov chains to implement an enhanced error control mechanism, utilizing moderately informative priors. …”
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Cost-effectiveness and budget impact of covering Burkitt lymphoma in children under Ghana’s National Health Insurance Scheme by Richmond Owusu, Dakota Pritchard, Lieke Fleur Heupink, Godwin Gulbi, Brian Asare, Ivy Amankwah, Joycelyn Azeez, Martha Gyansa-Lutterodt, Lydia Dsane-Selby, Ruby Aileen Mensah, William Omane-Adjekum, Francis Ruiz, Mohamed Gad, Justice Nonvignon, Lumbwe Chola, Ghana Health Technology Assessment Technical Working Group

“…Methods We developed a Markov model in Microsoft Excel to estimate the costs and effects of BL treatment when National Health Insurance Scheme (NHIS) was provided compared to the status quo where NHIS does not cover care for childhood cancer. …”
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Historical and projected forest cover changes in the Mount Kenya Ecosystem: Implications for sustainable forest management by Brian Rotich, Abdalrahman Ahmed, Benjamin Kinyili, Harison Kipkulei

“…Explanatory factors of LULC change (slope, aspect, population density, proximity to rivers, roads, and towns) were used to project LULC for 2035 using Cellular Automata and Markov Chain Analysis (CA-MCA).Six LULC types (open forest, closed forest, cropland, bareland, built-up, shrubland and grassland) were successfully classified with accuracies exceeding 82.5% and Kappa coefficients above 0.77. …”
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La longévité des nids, un paramètre essentiel pour la détermination de la taille des populations de grands singes : Cas de bonobos dans la Réserve de Faune de Lomako-Yokokala en Ré... by Valentin Omasombo Wotoko, Aurélien Besnard, Claude Miaud, Jean Malekani, Julien Punga

“…Les estimations sont de 86 jours avec les méthodes de type Capture-Marquage-Recapture et de 79 jours avec la méthode usuelle des chaînes de Markov. Dans les deux cas les intervalles de confiance des estimations sont relativement larges et ne devraient pas être négligées dans l’estimation des tailles de population comme c’est fréquemment le cas.…”
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Predictive modeling to evaluate long-term treatment effectiveness of darvadstrocel in patients with complex perianal fistulas in Crohn’s disease by Chitra Karki, Gary Hantsbarger, Erika Turkstra, Elisabetta Fenu, Ken Genenz, Inmaculada Gilaberte, Julián Panés

“…Predictive statistical models extrapolated clinical outcomes beyond observed follow-up using parametric curves, which were implemented into a semi-Markov model to obtain the number of patients in remission. …”
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Forecasting stroke and stroke-driven dementia in a rapidly ageing population: a model-based analysis of alternative projection scenarios for Ireland by Anne Hickey, Eithne Sexton, Frances Horgan, Kathleen E Bennett, Ronan Collins, Martin O'Flaherty, Suzanne Timmons, Chris Macey, David J. Williams

“…This study aims to evaluate scenarios for future trends in stroke age-specific incidence and case fatality, and estimate their impact on projected stroke and poststroke dementia prevalence in Ireland.Design This is an epidemiological modelling study based on a probabilistic Markov model. We extrapolated trends in age-specific stroke incidence and case fatality from 1990 to 2019 and applied these to 2016 to 2046. …”
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Initial Diagnostic Strategies for Helicobacter Pylori in Patients With Bleeding Peptic Ulcers Undergoing Endoscopy: A Cost-Effectiveness Analysis by Michael G. Artin, Josephine Soddano, Sheila D. Rustgi, Zainab Aziz, Francesca Lim, Jeong Yun Yang, Myles A. Ingram, John T. Nathanson, John Y. Kao, Chin Hur

“…Methods: We developed a Markov cohort model to compare the following 6 H. pylori testing strategies: no testing, histology, rapid urease test, stool antigen test, urea breath test (UBT), and serology. …”
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Wound-healing activity of solvent fractions and antiinflammatory activity of crude extract and solvent fractions of Acokanthera schimperi Schweinf (Apocynaceae) leaves in mice mode... by Workineh Woldeselassie Hammeso, Tesfaye Yimer, Getnet Tadege, Wakuma Wakene Jifar, Dejen Nureye

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Integrated Assessment of the Quality of Functioning of Local Electric Energy Systems by Waldemar Wójcik, Petro Lezhniuk, Cezary Kaczmarek, Viacheslav Komar, Iryna Hunko, Nataliia Sobchuk, Laura Yesmakhanova, Zhazira Shermantayeva

“…The integral indicator of the functioning of complex systems is based on a combination of the theory of Markov processes and the criterion method of similarity theory. …”
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Prevalence of intestinal parasites and Helicobacter pylori co-infection in people with gastrointestinal symptoms in Africa: a systematic review and meta-analysis by Yenesew Mihret Wondmagegn, Getu Girmay, Gashaw Azanaw Amare, Muluneh Assefa, Mebratu Tamir, Zufan Yiheyis Abriham, Abebaw Setegn

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Prevalence of depressive symptom and its associated factors among epilepsy patients in Amhara region, Ethiopia: cross-sectional study by Sintayehu Simie Tsega, Yilkal Abebaw Wassie, Alebachew Ferede Zegeye, Mekdes Kiflu, Sisay Maru Wubante, Kennean Mekonnen, Birhaneslasie Gebeyehu Yazew, Birye Dessalegn Mekonnen, Yeshambel Andargie Tarekegn

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Lifetime quality of life and cost consequences of delays in endovascular treatment for acute ischaemic stroke: a cost-effectiveness analysis from a Singapore healthcare perspective by Mayank Goyal, Weiyi Ni, Deidre Anne De Silva, Yu Li Ng, Kelvin Tan, Wolfgang G Kunz

“…This study determined the impact of EVT treatment delay on cost effectiveness of EVT in the Singapore healthcare setting.Design A short-term decision tree and long-term Markov health state transition model was constructed. …”
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A novel model-based meta-analysis to indirectly estimate the comparative efficacy of two medications: an example using DPP-4 inhibitors, sitagliptin and linagliptin, in treatment o... by Yan Gong, James Rogers, Christian Friedrich, Sanjay Patel, Alexander Staab, Jorge Luiz Gross, Daniel Polhamus, William Gillespie, Brigitta Ursula Monz, Silke Retlich

“…Comparison of two oral dipeptidyl peptidase (DPP)-4 inhibitors, sitagliptin and linagliptin, for type 2 diabetes mellitus (T2DM) treatment was used as an example.Design Systematic review with MBMA.Data sources MEDLINE, EMBASE, http://www.ClinicalTrials.gov, Cochrane review of DPP-4 inhibitors for T2DM, sitagliptin trials on Food and Drug Administration website to December 2011 and linagliptin data from the manufacturer.Eligibility criteria for selecting studies Double-blind, randomised controlled clinical trials, ≥12 weeks’ duration, that analysed sitagliptin or linagliptin efficacies as changes in glycated haemoglobin (HbA1c) levels, in adults with T2DM and HbA1c >7%, irrespective of background medication.Model development and application A Bayesian model was fitted (Markov Chain Monte Carlo method). The final model described HbA1c levels as function of time, dose, baseline HbA1c, washout status/duration and ethnicity. …”
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Calidad nutritiva de láminas de festuca alta (Festuca arundinacea Schreb) en rebrotes de verano y otoño by J.R. INSUA, O.N. DI MARCO, M.G. AGNUSDEI

“…En las láminas se determinó el contenido de fibra detergente neutro (FDN), la digestibilidad de la FDN (DFDN) y la digestibilidad in vitro aparente de la materia seca (DAMS) (24 h de incubación, digestor DaisyII, ANKOM). Las variables de morfogénesis se evaluaron como medidas repetidas en el tiempo, y las de calidad ajustando funciones linea- les con la edad y largo foliar. …”
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Intention to use eLearning-based continuing professional development and its predictors among healthcare professionals in Amhara region referral hospitals, Ethiopia, 2023: using mo... by Jenberu Mekurianew Kelkay, Sisay Maru Wubante, Deje Sendek Anteneh, Mitiku Kassaw Takilo, Chernet Desalegn Gebeyehu, Temesgen Ayenew Alameraw, Kassahun Dessie Gashu

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Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma by Simin Li, Yang Wang, Rui Sun, Debora Franceschi, Hongying Pan, Chenxuan Wei, Anthony Chukwunonso Ogbuehi, Bernd Lethaus, Vuk Savkovic, Sebastian Gaus, Rüdiger Zimmerer, Dirk Ziebolz, Gerhard Schmalz, Xiao Jiang

“…Additionally, cell-cell communication patterns in key signal pathways were compared in different tissue groups. A hidden Markov model (HMM) was used to predict gene expression states (on or off) throughout pseudotime. …”
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Translation and Validation of the Edinburgh Postnatal Depression Scale for Eritrea: A Screening Tool for Postpartum Depression in Primary Health Care Facilities by Gebregziabher NK, Netsereab TB, Alazar FA, Fessaha YG, Sium AH, Ghebrehiwet NK

“…Nahom Kiros Gebregziabher,1,2 Tesfit Brhane Netsereab,1,3 Feven Andebrhan Alazar,4 Yerusalem Gebremeskel Fessaha,4 Aman Hadish Sium,4 Nardos Kidane Ghebrehiwet4 1Department of Community Medicine, Orotta College of Medicine and Health Sciences, Asmara, Eritrea; 2Department of Epidemiology & Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, People’s Republic of China; 3Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, People’s Republic of China; 4Ministry of Health, Asmara, EritreaCorrespondence: Nahom Kiros Gebregziabher, Department of Community Medicine, Orotta College of Medicine and Health Sciences, Asmara, Eritrea, Email nahomkiros21@gmail.comIntroduction: Postpartum depression (PPD) is a mood disorder characterized by symptoms such as changes in sleep and eating patterns, fatigue, sadness, crying, anxiety, and guilt. …”
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Modelling the potential clinical and economic impact of universal antenatal hepatitis C (HCV) screening and providing treatment for pregnant women with HCV and their infants in Egy... by Giuseppe Indolfi, Diana M Gibb, Aya Mostafa, Sarah Pett, Yazdan Yazdanpanah, Sylvie Deuffic-Burban, Anthony E Ades, Karen Scott, Ali Judd, Nadia Hachicha-Maalej, Clotilde Lepers, Intira Jeannie Collins, Manal H El Sayed

“…This study assesses the cost-effectiveness of several screening and treatment strategies for pregnant women and infants in Egypt.Design A Markov model was developed to simulate the cascade of care and HCV disease progression among pregnant women and their infants according to different screening and treatment strategies, which included: targeted versus universal antenatal screening; treatment of women in pregnancy or deferred till after breast feeding; treatment of infected children at 3 years vs 12 years. …”
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Age, frequency, and strategy optimization for organized colorectal cancer screening: a decision analysis conducted in China for the years 2023–2038 by Zixing Wang, Wei Han, Ran Fei, Yaoda Hu, Fang Xue, Wentao Gu, Cuihong Yang, Yubing Shen, Luwen Zhang, Jingmei Jiang

“…Methods We synthesized the most up-to-date data using a 12-state Markov model populated with a cohort of Chinese men and women born during 1949–1988, and evaluated 16 conventional and 40 risk-tailored schemes for colorectal cancer screening, considering possible combinations of age (starting at 40 + years and ending at 75 years), frequency, and strategy (standard colonoscopy, fecal immunochemical testing with colonoscopy if positive, or risk-tailored). …”
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Water cycle modelling strengthened by probabilistic integration of field data for groundwater management of a quite unknown tropical volcanic hydrosystem by Dumont, Marc, Plagnes, Valérie, Lachassagne, Patrick, Guérin, Roger, Nugraha, Bayu, Mohamad, Febriwan, Oudin, Ludovic, Fadillah, Arif, Valdès, Danièle, Brocard, Gilles, Bonjour, Jean-Luc, Saadi, Mohamed, Esneu, Anne-Sophie, Muhammad, Aswar, Hendarmawan, Dörfliger, Nathalie

“…The elevation of the recharge area was identified using isotopic analysis of spring water.After designing the hydrological model structure, we carried out a probabilistic parameters exploration using the multiple-try differential evolution adaptive Metropolis algorithm to calibrate aquifer discharge. Multiple Markov chains allow a better exploration of the parameter values. …”
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