Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome by Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D Galbraith, Joaquín M Espinosa, David Bentley, Mary Ann Allen, Robin D Dowell, Dylan J Taatjes

“…Hyperactive interferon (IFN) signaling is a hallmark of Down syndrome (DS), a condition caused by Trisomy 21 (T21); strategies that normalize IFN signaling could benefit this population. …”
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Out-of-Pocket Expenditure (OOPE) on Selected Surgeries in the Obstetrics and Gynaecology Department incurred by Ayushman Bharat Pradhan Mantri Jan Arogya  Yojana (AB-PMJAY), Privat... by Dr. Kumar Sumit, Reena Verma, Prajwal Salins, Helmut Brand, Siddhartha Sankar Acharya, Sagarika Kamath, rajesh kamath, Dr. Vidya Prabhu

“…Data was collected across AB-PMJAY, private health insurance, uninsured patients and analyzed using descriptive statistics (mean, median) and the Shapiro-Wilk test for data normality. Results The study analyzed OOPE across 905 OBG patients. …”
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A consort‐guided randomized, blinded, controlled clinical trial on the effects of 6 weeks training on heart rate variability in thoroughbred horses by Emma Santosuosso, Renaud Léguillette, Sierra Shoemaker, Ryan Baumwart, Sierra Temple, Kaneesha Hemmerling, Tessa Kell, Warwick Bayly

“…Methods Linear domain HRV variables were analyzed (high frequency [HF], low frequency [LF], their normalized units [Hfnu, Lfnu], root mean square of successive differences between beats [RMSSD], Poincaré plot features [SD1 and SD2]) while resting overnight before (baseline) and after 2, 4 and 6 weeks of training. …”
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Using remote sensing and machine learning to generate 100-cm soil moisture at 30-m resolution for the black soil region of China: Implication for agricultural water management by Liwen Chen, Boting Hu, Jingxuan Sun, Y. Jun Xu, Guangxin Zhang, Hongbo Ma, Jingquan Ren

“…Firstly, utilizing the Google Earth Engine (GEE) platform and Enhanced Spatial and Temporal Adaptive Reflectance Fusion Model (ESTARFM), we achieve the fusion of multi-source remote sensing data at large scales to obtain high spatiotemporal resolution Normalized Difference Vegetation Index (NDVI) and Land Surface Temperature (LST) data. …”
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Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach by Syntia Nusanti, Andhika Rachman, Brigitta Marcia Budihardja, Lourisa Ruth Eldinia, Nadia Delima Andini, Arief Kartasasmita, M Sidik, Seskoati Prayitnaningsih, Alida Roswita Harahap, Aria Kekalih, Tjahjono Darminto Gondhowiardjo

“…Prothrombin time and international normalized ratio (INR) were inversely correlated with both E-selectin and P-selectin in the hypercoagulation group (p = 0.032, p = 0.030 for E-selectin and p = 0.044, p = 0.036 for P-selectin). …”
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Unsupervised machine learning clustering approach for hospitalized COVID-19 pneumonia patients by Nuttinan Nalinthasnai, Ratchainant Thammasudjarit, Tanapat Tassaneyasin, Dararat Eksombatchai, Somnuek Sungkanuparph, Viboon Boonsarngsuk, Yuda Sutherasan, Detajin Junhasavasdikul, Pongdhep Theerawit, Tananchai Petnak

“…K-means clustering, an unsupervised machine learning method, was performed to identify clinical phenotypes based on clinical and laboratory variables collected within 24 hours of admission. Variables were normalized before clustering to ensure equal contribution to the analysis. …”
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Treatment of uterine fibroid: focus on endometrial receptivity. A pilot randomized prospective study by Yulia E. Dobrokhotova, Irina A. Lapina, Valeriia M. Gomzikova, Yury А. Sorokin, Eleonora T. Khatagova, Ayshan R. Allakhverdieva, Mariya A. Olkhovskaya

“…After 3 months of therapy, a more prominent improvement in the endometrium receptor status was noted in the mifepristone group due to a decrease in the ratio of progesterone to estrogen [2.21±0.47 vs 3.34 (1.42; 5.83) in group 1 and 2.35±0.35 vs 3.78 (3.11; 5.05) in group 2] and normalization of the level of leukemia inhibitory factor (mean value 9.4±3.51 vs 6.95±1.76). …”
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Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study by Mohamed A Baba, Ahmed Kharbach, Mohamed Lmejjati, Nawal Adali

“…The QLQ-C30 and QLQ-BN20 scales were used to assess QoL, while neurocognitive function was evaluated using the Mini-Mental State Examination (MMSE) test. Data normality were checked using the Shapiro-Wilk test, and non-parametric methods were used to compare scores. …”
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Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production by Michelle A.E. Brouwer, Zara Karami, Samuel T. Keating, Hedwig Vrijmoeth, Heidi L.M. Lemmers, Helga Dijkstra, Frank L. van de Veerdonk, Mihaela Lupse, Hadewych J.M. ter Hofstede, Mihai G. Netea, Leo A.B. Joosten

“…In primary human PBMCs and monocyte populations, B. burgdorferi s.l. also specifically interfered with CIITA isoforms normally expressed in antigen presenting dendritic cells. …”
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Diagnosis and treatment of the irritable bowel syndrome: clinical guidelines of the Russian gastroenterological association and Russian association of coloproctology by V. T. Ivashkin, Yu. A. Shelygin, Ye. K. Baranskaya, Ye. A. Belousova, A. G. Beniashvili, S. V. Vasilyev, A. O. Golovenko, O. V. Golovenko, Ye. G. Grigoryev, N. V. Kostenko, T. L. Lapina, I. D. Loranskaya, O. S. Lyashenko, I. V. Mayev, Ye. A. Poluektova, V. G. Rumyantsev, V. M. Timerbulatov, A. S. Trukhmanov, O. Yu. Fomenko, I. L. Khalif, E. Yu. Chashkova, A. A. Sheptulin, O. S. Shifrin, V. V. Yanovoy

“…Peripheral opioid agonists (trimebutine maleate) normalizing intestinal motor activity via action on different subtypes of peripheral opioid receptors, combined plant-derived medication STW 5 are applied as well. …”
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Fecal microbiome change in patients with ulcerative colitis after fecal microbiota transplantation by A. Y. Tikunov, V. V. Morozov, A. N. Shvalov, A. V. Bardasheva, E. V. Shrayner, O. A. Maksimova, I. O. Voloshina, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…Currently, this procedure is recognized as an efficacious method to normalize the intestinal microbiota mainly in inflammatory diseases of the gastrointestinal tract. …”
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Identification of the Transcriptional Networks and the Involvement in Angiotensin II-Induced Injury after CRISPR/Cas9-Mediated Knockdown of Cyr61 in HEK293T Cells by Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yan Jiang, Rentong Hu, Yanwu You

“…A total of 23184 lncRNAs and 28264 mRNAs were normalized. 26 lncRNAs and 212 mRNAs were upregulated, and 74 lncRNAs and 233 mRNAs were downregulated after Cyr61 knockdown. …”
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CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension by Lea Strohm, Henning Ubbens, Dominika Mihalikova, Alexander Czarnowski, Paul Stamm, Michael Molitor, Stefanie Finger, Matthias Oelze, Dorothee Atzler, Philip Wenzel, Philipp Lurz, Thomas Münzel, Christian Weber, Esther Lutgens, Andreas Daiber, Steffen Daub

“…The TRAF6 inhibitor treatment normalized endothelial dysfunction and reduced blood pressure in hypertensive wild type animals. …”
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Greenness and averted mortality in 390 cities in China (2000–2020)Research in context by John S. Ji, Zheng Tao, Hui Miao, Tom Cole-Hunter, Xuecao Li, David Rojas-Rueda, Wenjia Cai

“…Methods: In China, we mapped the urban human population distribution aged 20 and above with a 1 km grid (30 arc-second) and used satellite-based remote sensing to measure green space over time to create population-weighted normalized difference vegetation index (NDVI). We tracked changes in greenness in the urban area over time and created a spatial–temporal map. …”
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Seroprevalence of dengue, Zika, and chikungunya in São Sebastião, Brazil (2020–2021): a population-based survey by Tayane Nobre, Andre Luiz Dutra Fenner, Emerson Luiz Lima Araújo, Wildo Navegantes de Araújo, Emmanuel Roux, Pascal Handschumacher, Helen Gurgel, Bruno Dallago, Mariana Hecht, Luciana Hagström, Walter Massa Ramalho, Nadjar Nitz

“…Statistical analyses included tests for normality, associations, mean comparisons, and correlations. …”
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Evaluation of Airborne Particulate Matter and Volatile Organic Compounds Released by Three Types of Mosquito Repellents by Soyeon Lee, Jongmin Park, Myoungho Lee, Minjung Kim, Boowook Kim, Kiyoung Lee, Kyungduk Zoh, Chungsik Yoon

“…Coil types also lead in emission rates (1.94 × 1010 particles min–1 for 10–420 nm) releasing more particles per minute, followed by liquid (1.87 × 108 particles min‒1) and then mat types (6.34 × 107 particles min‒1), suggesting higher particulate emissions during use. When normalized by usage weight, Coil types again show the highest emission factors (6.59 × 1011 particles g‒1), implying they emit more particles per gram of product burned than liquid (1.82 × 1011 particles g‒1) and mat (4.81 × 1010 particles g‒1) types. …”
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Effect of a Vibration System on Pain Reduction during Injection of Dental Anesthesia in Children: A Randomized Clinical Trial by Muhanad AlHareky, Jehan AlHumaid, Sumit Bedi, Maha El Tantawi, Mazin AlGahtani, Yousef AlYousef

“…T-test or Mann–Whitney U-test was used for scale variables, paired sample T-test or Wilcoxon rank t-test was used for before and after data, and chi-square was used for categorical variable, based on the results of normality test. Results. The results showed a statistically significant reduction in pain after the injection for the test group compared with control using VAS scale (mean = 6.68 (1.09) and 8.42 (0.50); p=0.001) and FLACC scale (mean = 5.92 (1.05) and 8.16 (0.54); p=0.002), but not when using SEM scale (mean 3.22 (0.42) and 4.24 (2.74);p=0.08). …”
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Understanding basic and social emotions in Alzheimer's disease and frontotemporal dementia by Carlotta Sola, Vanessa Zanelli, Maria Angela Molinari, Claudia Casadio, Francesco Ricci, Omar Carpentiero, Manuela Tondelli, Fausta Lui, Paolo Frigio Nichelli, Francesca Benuzzi

“…Healthy control (HCs) subjects were recruited to obtain normative data for basic emotion recognition tests and social emotion recognition tasks. …”
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Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 by Charlotte Laurfelt Munch Rasmussen, Signe Frost Frederiksen, Christian Würtz Heegaard, Maj Schneider Thomsen, Eva Hede, Bartosz Laczek, Jakob Körbelin, Daniel Wüstner, Louiza Bohn Thomsen, Markus Schwaninger, Ole N. Jensen, Torben Moos, Annette Burkhart

“…AAV-BR1-NPC2 treatment partially normalized these ganglioside distributions in high responders, including restoration of lipid profiles towards those of Npc2+/+ controls. …”
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Maternal health risk factors dataset: Clinical parameters and insights from rural BangladeshMendeley Data by Mayen Uddin Mojumdar, Dhiman Sarker, Md Assaduzzaman, Hasin Arman Shifa, Md. Anisul Haque Sajeeb, Oahidul Islam, Md Shadikul Bari, Mohammad Jahangir Alam, Narayan Ranjan Chakraborty

“…The study's preprocessing methods, which included data cleaning, normalization, and encoding, ensured high-quality data for statistical analysis. …”
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