Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation by Hiroto Nakano, Sadao Hikishima, Makoto Mori, Jota Minamikawa, Daiki Muramatsu, Yasuhiro Sakashita, Tokuhei Ikeda, Moeko Noguchi-Shinohara, David B. Teplow, Kenjiro Ono

“…However, the precise mechanisms of their molecular functions within the Aβ aggregation cascade have not been clarified so far. This research aimed to uncover the structural and functional characteristics of globular-shaped Aβ oligomers (gAβO) under in vitro conditions. …”
Get full text

Les limites de la cartographie des risques littoraux : des perspectives pour la compréhension de tous by Aurélie Arnaud

“…Moreover, coastal communities have the highest number of natural disaster order - Catnat (ONRS, 2011 and BD GASPAR). With this in mind we emit some recommendations in the adaptation maps areas to end users. …”
Get full text

Calves gastrointestinal nematodes and Eimeria prevalence and associated risk factors in dairy farms, southern Ethiopia by Maireg Hailu, Kassahun Asmare, Endrias Zewdu Gebremedhin, Vincenzo Di Marco Lo Presti, Maria Vitale, Desie Sheferaw

“…Based on their morphological appearance, Strongyle type (20.3%), Trichuris (4.2%) and Ascaris (16.3%) eggs, Eimeria oocysts (21.5%) were observed. …”
Get full text

Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…Mechanistically, the transcriptomic results showed that dietary protocatechuic acid inhibited acute inflammatory response and activated the signaling pathways of cytokine-cytokine receptor interaction, complement and coagulation cascades. Results of proteomic showed that protocatechuic acid inhibited the positive regulation of dendritic cell cytokine production and I-κB kinase/NF-κB signaling, as well as cytokine-cytokine receptor interaction and MAPK signaling pathways, and activated the mTOR signaling pathways. …”
Get full text

Threshold responses of freshwater fish community size spectra to invasive species by Bradley Novak, Brent A. Murry, Jeff S. Wesner, Vojsava Gjoni, Caroline C. Arantes, Erin Shepta, Justin P. F. Pomeranz, James R. Junker, Kathrine Zipfel, Andrew Stump, Levi E. Solomon, Kristopher A. Maxson, Jason A. DeBoer

“…Silver Carp are large‐bodied planktivores that compete with native planktivores, which can cause cascading effects throughout the food web. Our study tested the threshold of abundance beyond which Silver Carp alter fish assemblage structure. …”
Get full text

Effects of plant functional group removal on caterpillars (Gynaephora alpherakii) performance and plant production in an alpine meadow by Rui Cao, Han Chen, Jingran Cai, Chen Hang, Ziyu Zhang, Yingchun Miao, Peng Xie

“…Our findings suggest that forb removal disrupts trophic interactions, with potential cascading effects on herbivore populations, plant community structure, and ecosystem productivity. …”
Get full text

Rischi psicosociali nel lavoro degli infermieri di sala operatoria: studio osservazionale trasversale condotto con il copenhagen psychosocial questionnaire by Fortunato Durante, Loredana Pasquot

“…Principali effetti organizzativi negativi: la riduzione delle prestazioni, aumento dell'assenteismo e dei tassi di infortunio, burn out, intenzione di lasciare prematuramente la professione. SCOPO Misurare lo stress lavoro correlato dovuto a fattori psicosociali tra gli infermieri di sala operatoria usando il COPSOQ II short validato in italiano. …”
Get full text

A DNA-Methylated Sight on Autoimmune Inflammation Network across RA, pSS, and SLE by Xingqiang Wang, Dongyun Lei, Jie Ding, Shuang Liu, Li Tao, Fan Zhang, Jiangyun Peng, Jian Xu

“…Particularly, AZU1 and LTBR with hypomethylated TSS and first exon located in the promoter regions were able to trigger inflammation signaling cascades and play critical roles in autoimmune tautology. …”
Get full text

Decoding oral cancer: insights from miRNA expression profiles and their regulatory targets by Xin Wang, Xin Wang, Shuang Zhang, Shuang Zhang, Shuyi Wang, Tao Cao, Tao Cao, Hong Fan, Hong Fan

“…Furthermore, different signaling cascades such as IGF signaling, PDGF signaling and LKB1 signaling and PLK1 signaling pathways were also found associated with DEmiR-related regulation of OC progression. …”
Get full text

Parent-of-origin effects on nuclear chromatin organization and behavior in a Drosophila model for Williams–Beuren Syndrome by A. V. Medvedeva, E. V. Tokmatcheva, A. N. Kaminskaya, S. A. Vasileva, E. A. Nikitina, A. V. Zhuravlev, G. A. Zakharov, O. G. Zatsepina, E. V. Savvateeva-Popova

“…These processes are independent and controlled by different signal cascades: the first is cAMPdependent, the second relies on actin remodeling by small GTPase Rac1 – LIMK1 (LIM-kinase 1). …”
Get full text

Calves gastrointestinal nematodes and Eimeria prevalence and associated risk factors in dairy farms, southern Ethiopia by Maireg Hailu, Kassahun Asmare, Endrias Zewdu Gebremedhin, Vincenzo Di Marco Lo Presti, Maria Vitale, Desie Sheferaw

“…Based on their morphological appearance, Strongyle type (20.3%), Trichuris (4.2%) and Ascaris (16.3%) eggs, Eimeria oocysts (21.5%) were observed. …”
Get full text

A Seventeen Multilevel High-Power Application Inverter with Low Total Harmonic Distortion by Ajmal Farooq, Shanshan Tu, Fiaz Ahmad, Muhammad Zeeshan Malik, Obaid U. Rehman, Ghulam Hafeez, Sadaqat ur Rehman

“…The proposed MLI has the advantage of decreasing the output THD by using a modified form of the cascaded H-Bridge structure and sine pulse width modulation technique. …”
Get full text

Psychosocial risks and mental health of preschool care providers in Kuala Lumpur, Malaysia: a cross-sectional study by Sin Wan Tham, Min Fui Wong, Maslinor Binti Ismail, Noriklil Bukhary Binti Ismail Bukhary

“…Abstract Background Child maltreatment in daycare is a public health issue. As childcare is stressful, high care provider negativity independently predicts more internalizing behaviour problems, affecting children’s psycho-neurological development. …”
Get full text

Validation of the COTENP Code: A Steady-State Thermal-Hydraulic Analysis Code for Nuclear Reactors with Plate Type Fuel Assemblies by Duvan A. Castellanos-Gonzalez, João Manoel Losada Moreira, José Rubens Maiorino, Pedro Carajilescov

“…We consider the chain or cascade method in two steps to facilitate the analysis of whole core. …”
Get full text

Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma by Soo Yeon Kim, Miaolu Tang, Stephen Y. Chih, Jessica Sallavanti, Yan Gao, Zhiqiang Qiu, Hong-Gang Wang, Wei Li

“…MK2) signaling axis and the unfolded protein response signaling components activating transcription factor 4 (ATF4) and inositol-requiring enzyme 1 (IRE1α) in driving ischemic tumor cell death. This signaling cascade was further potentiated by RAS or PI3K activation under ischemic conditions, contributing to the inflammatory gene expression response. …”
Get full text

The role of Latin America medicinal plants in wound healing by Mariana Sánchez-Ramos, Andrea Ruiz-Betancourt, Stephany Abigail Tadeo-Cuenca, Angélica Román-Guerrero, María Crystal Columba-Palomares, Araceli Guerrero-Alonso, Antonio Bernabé-Antonio, Deyanira Ojeda-Ramírez, Francisco Cruz-Sosa

“…At a biological level, wound healing involves a complex mechanism in which the immune system and cellular biochemical cascades intervene in a coordinated manner, whose development occurs in stages such as inflammation, proliferation, and remodeling. …”
Get full text

A qualitative study to understand the facilitators of and barriers to retention in care to the national PMTCT Option B+ programme in Uganda. by Charity Kyomugisha-Nuwagaba, Rachel King, Rose Baryamutuma, Simon Muhumuza, Linda N Kisakye, William Bazeyo, Evelyn Akello

“…<h4>Introduction</h4>Effective prevention of mother to child transmission (PMTCT) programmes require women and their infants to have access to a cascade of HIV care and treatment interventions. Retention in care reduces the risk of vertical transmission and opportunistic infections among mothers living with HIV. …”
Get full text

Effect of schistosomiasis and soil-transmitted helminth infections on physical fitness of school children in Côte d'Ivoire. by Ivan Müller, Jean T Coulibaly, Thomas Fürst, Stefanie Knopp, Jan Hattendorf, Stefanie J Krauth, Katarina Stete, Aurélie A Righetti, Dominik Glinz, Adrien K Yao, Uwe Pühse, Eliézer K N'goran, Jürg Utzinger

“…., Schistosoma mansoni, hookworm and Ascaris lumbricoides infections was 85.3%, 71.2%, 53.8%, 13.5% and 1.3%, respectively. …”
Get full text

Anti-VEGF therapy for proliferative diabetic retinopathy: translating research evidence into clinical practice by E.A. Abdulaeva, E.L. Minkhuzina, A.N. Kuskov

“…DR pathogenesis is mediated by alterations in many metabolic cascades, production of pro-inflammatory cytokines and growth factors, increased vascular leakage resulting from the loss of blood-retinal barrier integrity, and pathological neovascularization (which indicates increasing severity of DR). …”
Get full text

Prevalence of intestinal parasites and associated factors among food handlers in food establishments in the Lideta subcity of Addis Ababa, Ethiopia: an institution-based, cross-sec... by Zemichael Gizaw, Woinishet Abera, Binyam Gintamo, Tewoderos Shitemaw, Zelalem Negash Mekuria

“…The most common intestinal parasites were Entamoeba histolytica/dispar (12.7%), Giardia duodenalis (11.2%) and Ascaris lumbricoides (8.3%). The presence of intestinal parasites among food handlers was associated with low monthly income (AOR: 2.83, 95% CI 1.50 to 8.84), untrimmed fingernails (AOR: 4.36, 95% CI 1.98 to 11.90), no food safety training (AOR: 2.51, 95% CI 1.20 to 5.58), low level of education (AOR: 3.13, 95% CI 1.34 to 7.44), poor handwashing practice (AOR: 2.16, 95% CI 1.03 to 4.22) and lack of medical check-up (AOR: 2.31, 95% CI 1.18 to 6.95).Conclusion The prevalence of intestinal parasites among food handlers in food establishments in the Lideta subcity of Addis Ababa was high. …”
Get full text