Analysis of Inflammatory Mediator Profiles in Sepsis Patients Reveals That Extracellular Histones Are Strongly Elevated in Nonsurvivors by Tanja Eichhorn, Ingrid Linsberger, Lucia Lauková, Carla Tripisciano, Birgit Fendl, René Weiss, Franz König, Gerhard Valicek, Georg Miestinger, Christoph Hörmann, Viktoria Weber

“…Treatment strategies relying on a “one-fits-all” approach have failed to reduce mortality, suggesting that therapeutic targets differ between patient subgroups and highlighting the need for accurate analysis of the molecular cascades to assess the highly variable host response. …”
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Preoperative White Blood Cell Count and Risk of 30-Day Readmission after Cardiac Surgery by Jeremiah R. Brown, R. Clive Landis, Kristine Chaisson, Cathy S. Ross, Lawrence J. Dacey, Richard A. Boss, Robert E. Helm, Susan R. Horton, Patricia Hofmaster, Cheryl Jones, Helen Desaulniers, Benjamin M. Westbrook, Dennis Duquette, Kelly LeBlond, Reed D. Quinn, Patrick C. Magnus, David J. Malenka, Anthony W. DiScipio

“…Among the primary causes of readmission are infection and disease states susceptible to the inflammatory cascade, such as diabetes, chronic obstructive pulmonary disease, and gastrointestinal complications. …”
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Challenges and Solutions for Keeping Maternity and Gynecology Services Functioning Comprehensively in Secondary Level Health Care Facility in COVID-19 Pandemic Situation Using a Cl... by Jayanta Kumar Biswas, Pratistha Lall, Soumen Das Poddar, Vikas Srivastava, Ajith Nilakantan

“…RESULTS: Compared to figures for 2019, in-patient admissions, surgeries, and daycare procedures performed, and deliveries conducted were reduced in total but almost approached previous levels. …”
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Collapsing Pattern Class-IV Lupus Nephritis Presenting as Posterior Reversible Encephalopathy Syndrome and Cardiac Tamponade: A Rare COVID-19 Sequelae by K Harshitha Reddy, Pranjal Kashiv, Sunil Kumar, Sourya Acharya, Kapil Navin Sejpal

“…Patients infected with Coronavirus Disease-2019 (COVID-19) have an increased risk of acute renal injury as there is a systemic inflammatory cascade due to an acute infection, causing impairment of basic cellular activities in podocytes. …”
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Gene Expression Signatures of Peripheral Blood Mononuclear Cells during the Early Post-Transplant Period in Patients Developing Cardiac Allograft Vasculopathy by Khurram Shahzad, Martin Cadeiras, Sarfaraz Memon, Barry Zeeberg, Tod Klingler, Anshu Sinha, Esteban G. Tabak, Sreevalsa Unniachan, Mario C. Deng

“…Over 300 genes were differentially expressed (FDR < 5%), and 18 GO-categories including “macrophage activation”, “Interleukin-6 pathway”, “NF-KappaB cascade”, and “response to virus” were enriched by these genes (FDR < 5%). …”
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Lena River biogeochemistry captured by a 4.5-year high-frequency sampling program by B. Juhls, A. Morgenstern, J. Hölemann, A. Eulenburg, B. Heim, F. Miesner, F. Miesner, H. Grotheer, H. Grotheer, G. Mollenhauer, G. Mollenhauer, H. Meyer, E. Erkens, E. Erkens, F. Y. Gehde, S. Antonova, S. Chalov, S. Chalov, M. Tereshina, O. Erina, E. Fingert, E. Abramova, T. Sanders, L. Lebedeva, N. Torgovkin, G. Maksimov, V. Povazhnyi, R. Gonçalves-Araujo, U. Wünsch, A. Chetverova, A. Chetverova, S. Opfergelt, P. P. Overduin

“…<p>The Siberian Arctic is warming rapidly, causing permafrost to thaw and altering the biogeochemistry of aquatic environments, with cascading effects on the coastal and shelf ecosystems of the Arctic Ocean. …”
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Reconstruction of Araucaria araucana cone production reveals warming intensifies regionally synchronized masting by Andrew Hacket‐Pain, Fidel A. Roig, Davide Ascoli, Carlos LeQuesne, Martin Hadad

“…Masting is a key driver of plant regeneration dynamics and has cascading effects on food webs and carbon and nutrient fluxes through ecosystems. …”
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Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis by Heliang Liu, Jingjing Ma, Tian Jiang, Enhong Li, Xiaokun Zhao, Ying Wang, Jie Cui, Xiaohui Hao, Lingli Guo

“…Silicosis is a devastating disease caused by inhalation of silica dust that leads to inflammatory cascade and then scarring of the lung tissue. Increasing evidences indicate that soluble receptor for advanced glycation end products (sRAGE) is involved in inflammatory diseases. …”
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Chemical effects on ecological interactions within a model-experiment loop by Lamonica, Dominique, Charles, Sandrine, Clément, Bernard, Lopes, Christelle

“…For all parameters of our model, we obtained biologically realistic values and reasonable uncertainties. The cascade of cadmium effects, both direct and indirect, was identified. …”
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Preliminares al estudio de la huella en lingüística by Javier Arias

“…En sus orígenes, en lugar de ser un índice responsable de marcar la ubicación de una unidad antes de su movimiento sintáctico (que siempre toma la forma de fronting), la traza o huella era el resultado de un producto matricial entre funciones n-ádicas. …”
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Mechanistic insights into gut microbe derived siderophores and PHD2 interactions with implications for HIF-1α stabilization by Jainabbi Irshad Ahmed Patel, Jagadeesha Poyya, Apeksha Padakannaya, Namrata Manjunath Kurdekar, Ajay Sathayanarayan Khandagale, Chandrashekhar Gajanan Joshi, Santosh R. Kanade, Kapaettu Satyamoorthy

“…A key player in this process is the HIF-1α signaling cascade, meticulously regulated by Prolyl Hydroxylase Domain 2 (PHD2), which orchestrates cellular responses to varying oxygen levels. …”
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Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways by Mohamed El-Sherbiny, Hany A. Elkattawy, Shimaa Hadhoud, Ahmed N. Nasr, Ateya M. Ibrahim, Ateya M. Ibrahim, Omar Z. Ameer, Noorhan Alsaleebi, Joud Asfari, Madaniah O. Zakari, Moaz A. Mojaddidi, Ehab K. Ali, Hailah M. Almohaimeed, Ahmed Abdeen, Sahar K. Ali, Mamdouh Eldesoqui, Mamdouh Eldesoqui

“…Besides, LPS increased the malondialdehyde (MDA) and decreased the glutathione (GSH) levels, inducing an oxidative stress cascade. In addition, there are dramatic increases in the TLR4, MyD88, NF-κB, and PK2/PKR1 protein expression levels. …”
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Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition by Anastasiia Lozovska, Ana Casaca, Ana Novoa, Ying-Yi Kuo, Arnon D Jurberg, Gabriel G Martins, Anna-Katerina Hadjantonakis, Moises Mallo

“…Similar alterations in the LPM and vascular system were also observed in Isl1 null mutants, indicating that this factor acts in the regulatory cascade downstream of Tgfbr1 in LPM-derived tissues. …”
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Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons by Eduardo Pérez-Palma, Víctor Andrade, Mario O. Caracci, Bernabé I. Bustos, Camilo Villaman, Matías A. Medina, Miguel E. Ávila, Giorgia D. Ugarte, Giancarlo V. De Ferrari

“…Likewise, following activation of the signaling cascade, the expression of a significant number of genes with transcription factor activity (GO:0043565, p-adjusted = 4.1 × 10−6) was induced. …”
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Autoimmune Factor V Deficiency That Took 16 Years to Diagnose due to Pseudodeficiency of Multiple Coagulation Factors by Takaaki Kato, Takaya Hanawa, Mea Asou, Tomohiko Asakawa, Hisashi Sakamaki, Makoto Araki

“…When factor V, which is downstream of the coagulation cascade, is inhibited, coagulation test using the one-stage clotting method shows a pseudolow value. …”
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Association of polymorphism <i>TP53</i> Arg72Pro with radon-induced lung cancer in the Kazakh population by O. Bulgakova, A. Kussainova, A. Kakabayev, А. Kausbekova, R. Bersimbaev

“…The tumor suppressor gene TP53 is a key mediator of the DNA damage response cascade following cell exposure to ionizing radiation. …”
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Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma by Dandan Gao, Yang Lv, Fei Hong, Dong Wu, Ting Wang, Gongzhizi Gao, Zujie Lin, Ruoyu Yang, Jinsong Hu, Aili He, Pengyu Zhang

“…Then, the expression of BAX and Bcl2 was imbalance, and the cascade cleavage of PARP and caspase 3 was increased, ultimately triggering cell apoptosis. …”
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Application of new external cooling cycles in technological scheme of helium extraction and natural gas liquefaction by M. Mehrpooya, A. V. Zaitsev, A. O. Lisovtsov

“…The most common and effective way to ensure cooling capacity in the natural gas liquefaction process is to use a cascade cycle on mixed refrigerant (MFC) as external cooling. …”
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Intestinal Parasites Isolated from Some Vegetables Sold in Ado-Ekiti Market, Ekiti State, Nigeria by Chukwunonso Patrick Eya, Victoria Aikhomu, Frank Ebhodaghe, Moses Hamed, Obongama Edet, Monday Nwigube, Nichodemus Eze

“…Seven different types of parasites were isolated from 120 vegetables from 4 different markets; these parasites include Strongyloides stercoralis 34 (43.6%), Gardia lamblia 20 (25.6%), Ascaris lumbricoides 8 (10.3%), Hookworm 6 (7.7%), Entamoeba histolytica 4 (5.1%), Balantidium coli 4 (5.1%) and Trichuris trichuria 2 (2.6%). …”
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Analisis SWOT Pembinaan Prestasi Cabang Olahraga Pencak Silat Di Padepokan Tanpa Bayangan Magetan by Donny Firman Syah, Roy Januardi Irawan

“…Hasil. 1) Kekuatan yang paling menonjol yaitu pengurus memfasilitasi semua kebutuhan atlet serta pendanaan yang sudah lancar dan mampu dikelola dengan optimal. 2) Kelemahan terdapat pada tempat latihan di ruangan terbuka atau outdoor. 3) Peluang yang ada yaitu kejuaraan-kejuaraan yang mulai rutin dipertandingkan. 4) Ancaman yang mengkhawatirkan yaitu ada kekhawatiran regenerasi atlet terhambat. …”
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