TB prevention activities in the WHO European Region by A. Matteelli, Z. Mkrtchyan, T. Masini, A. Hovhannesyan, G. Kuchukhidze, S. Ahmedov, P. Kerndt, L. Rossi, A. Yedilbayev, D. Falzon, A. Dadu

“…This will require a massive scale-up of efforts and larger investments, as well as coordinated approaches and interventions across the ‘cascade’ of prevention, from the identification of target populations to the completion of treatment.…”
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IGF2BP3 curbed by miR-15c-3p restores disrupted lipid storage and progesterone secretion in chicken granulosa cells under oxidative stress through AKT-Raf1-ERK1/2 signaling pathway by Zhongzhen Lin, Yanrong Gong, Chunlin Yu, Chaowu Yang, Lingqian Yin, Donghao Zhang, Yuan Tang, Feng Xu, Ye Wang, Yiping Liu

“…These regulatory effects were mediated through the sequential downstream signaling cascade of AKT-Raf1-ERK1/2. In conclusion, IGF2BP3 curbed by miR-15c-3p restores disrupted lipid storage and progesterone secretion in chicken granulosa cells under oxidative stress through AKT-Raf1-ERK1/2 signaling pathway. …”
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A Novel Myosin Essential Light Chain Mutation Causes Hypertrophic Cardiomyopathy with Late Onset and Low Expressivity by Paal Skytt Andersen, Paula Louise Hedley, Stephen P. Page, Petros Syrris, Johanna Catharina Moolman-Smook, William John McKenna, Perry Mark Elliott, Michael Christiansen

“…The mutation was not found in 300 controls, and the patient had no mutations in 10 sarcomere genes. Cascade screening revealed a further nine heterozygote mutation carriers, three of whom had ECG and/or echocardiographic abnormalities but did not fulfil diagnostic criteria for HCM. …”
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Exploring <i>RNF213</i> in Ischemic Stroke and Moyamoya Disease: From Cellular Models to Clinical Insights by Benjamin Y. Q. Tan, Charlene H. P. Kok, Megan B. J. Ng, Shaun Loong, Eric Jou, Leonard L. L. Yeo, Weiping Han, Christopher D. Anderson, Chiea Chuen Khor, Poh San Lai

“…Additionally, we address the gene’s implications for disease prediction, risk assessment, and cascade screening. By integrating evidence across disciplines, this review identifies critical knowledge gaps, including the biological pathways underlying <i>RNF213</i>’s pathogenicity. …”
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Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Se... by Fatma Alzahraa Mokhtar, Mariam Ahmed, Aishah Saeed Al Dhanhani, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Ali A. Shati, Amal M. Fakhry

“…Extensive research on <i>S. grandiflora</i> has uncovered mechanisms such as the activation of caspase cascades and the induction of apoptosis, attributed to its rich content of flavonoids and alkaloids. …”
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PhpCNF-Y transcription factor infiltrates heterochromatin to generate cryptic intron-containing transcripts crucial for small RNA production by Manjit Kumar Srivastav, H. Diego Folco, Patroula Nathanailidou, Anupa T Anil, Drisya Vijayakumari, Shweta Jain, Jothy Dhakshnamoorthy, Maura O’Neill, Thorkell Andresson, David Wheeler, Shiv I. S. Grewal

“…This study reveals a mechanism by which heterochromatic repeats are transcribed, initiating their own silencing by triggering a primary cascade that produces siRNAs necessary for heterochromatin nucleation.…”
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Apontamentos sobre o conceito de classe social em Florestan Fernandes by Ana Rodrigues Cavalcanti Alves

“…O terceiro apontamento sugere 3) a afirmação do caráter complexo e multifacetado das lutas sociais, que envolvem diversos domínios da vida social e articulam diferentes formas de hierarquização e dominação social. A análise permite lançar luz sobre aspectos pouco explorados da compreensão do autor acerca da dinâmica das classes sociais e destacar as continuidades e reelaborações conceituais de Florestan Fernandes ao longo de sua trajetória. …”
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Parasitic contamination of lettuce: comparison between establishments located in areas with high and low economic values by Gustavo Trentini Barancelli, Larissa Kochenborger, Fernanda Gracieli Machado Brum, Fabiana Tonial, Cassiano Mateus Forcelini

“…Results: Parasitic forms were found in 80% of the samples, namely: ciliated cysts (probable Balantioides coli), larvae of nematode, Ascaris lumbricoides, cestode eggs, Giardia lamblia, Hymenolepis nana, Entamoeba coli, and Fasciola hepatica. …”
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SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection by Alexsia Richards, Andrew S. Khalil, Max Friesen, Troy W. Whitfield, Xinlei Gao, Tenzin Lungjangwa, Roger D. Kamm, Zhengpeng Wan, Lee Gehrke, David Mooney, Rudolf Jaenisch

“…We observe that infected SMCs shift to a pro-inflammatory state and increase the expression of key mediators of the coagulation cascade. Further, we show human ECs exposed to the secretome of infected SMCs produce hemostatic factors that contribute to vascular dysfunction despite not being susceptible to direct infection. …”
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High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells by Hong Feng, Junling Gu, Fang Gou, Wei Huang, Chenlin Gao, Guo Chen, Yang Long, Xueqin Zhou, Maojun Yang, Shuang Liu, Shishi Lü, Qiaoyan Luo, Yong Xu

“…The NLRP3 inflammasome responds to exogenous and endogenous danger signals, resulting in cleavage of procaspase-1 and activation of cytokines IL-1β, IL-18, and IL-33, ultimately triggering an inflammatory cascade reaction. This study observed the expression of NLRP3 inflammasome signaling stimulated by high glucose, lipopolysaccharide, and reactive oxygen species (ROS) inhibitor N-acetyl-L-cysteine in glomerular mesangial cells, aiming to elucidate the mechanism by which the NLRP3 inflammasome signaling pathway may contribute to diabetic nephropathy. …”
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An Integrating Approach for Genome-Wide Screening of MicroRNA Polymorphisms Mediated Drug Response Alterations by Xianyue Wang, Hong Jiang, Wei Wu, Rongxin Zhang, Lingxiang Wu, Huan Chen, Pengping Li, Yumin Nie, Jiaofang Shao, Yan Li, Xue Lin, Sali Lv, Qh Wang, Jie Hu

“…In addition, harnessing the abundant high quality biological network/pathways, we evaluated the cascade distribution of tarSNP impacts. We showed that the predictions can uncover most of the known experimentally supported cases as well as provide informative candidates complementary to existing methods/tools. …”
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Everyday and Exotic Foodborne Parasites by Marilyn B Lee

“…However, these parasites are most frequently acquired through unfiltered drinking water, homosexual activity or close personal contact such as in daycare centres and occasionally via a food vehicle. …”
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Global Sensitivity Analysis and Uncertainty Quantification for Background Solar Wind Using the Alfvén Wave Solar Atmosphere Model by Aniket Jivani, Nishtha Sachdeva, Zhenguang Huang, Yang Chen, Bart van derHolst, Ward Manchester, Daniel Iong, Hongfan Chen, Shasha Zou, Xun Huan, Gabor Toth

“…Overall, we identify three important model parameters: the multiplicative factor applied to the magnetogram, Poynting flux per magnetic field strength constant used at the inner boundary, and the coefficient of the perpendicular correlation length in the turbulent cascade model in AWSoM.…”
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Functional Metaplasticity of Hippocampal Schaffer Collateral-CA1 Synapses Is Reversed in Chronically Epileptic Rats by Mirko Rehberg, Timo Kirschstein, Xiati Guli, Steffen Müller, Marco Rohde, Denise Franz, Tursonjan Tokay, Rüdiger Köhling

“…Hence, studying the cellular and molecular cascades involved in the key mechanism of information storage in the brain, synaptic plasticity, has led to enormous knowledge in this field. …”
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Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation by Yin Zhang, Tinglian Zhou, Kai Wang, Chenqi Luo, Dan Chen, Zeen Lv, Haijie Han, Ke Yao

“…Specifically, CF@SNPs attenuate dry eye pathology by suppressing p53‐SLC7A11‐GSH‐dependent ferroptosis and TNF‐α‐associated inflammatory cascades, accompanied by favorable biocompatibility in vivo. …”
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The Role of E-Cadherin in Maintaining the Barrier Function of Corneal Epithelium after Treatment with Cultured Autologous Oral Mucosa Epithelial Cell Sheet Grafts for Limbal Stem D... by Fawzia Bardag-Gorce, Richard H. Hoft, Andrew Wood, Joan Oliva, Hope Niihara, Andrew Makalinao, Jacquelyn Thropay, Derek Pan, Imara Meepe, Kumar Tiger, Julio Garcia, Amanda Laporte, Samuel W. French, Yutaka Niihara

“…LSCD corneas did not show continuous staining for ZO-1 or for Cnx43, while CAOMECS-grafted corneas showed a positive expression of ZO-1 and Cnx43. Cascade Blue® hydrazide did not pass through CAOMECS. …”
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MicroRNA Expression Profiling in Behçet’s Disease by Antonio Puccetti, Andrea Pelosi, Piera Filomena Fiore, Giuseppe Patuzzo, Claudio Lunardi, Marzia Dolcino

“…These miRNAs target pathways relevant in BD, such as TNF, IFN gamma, and VEGF-VEGFR signaling cascades. Network analysis revealed several miRNAs regulating highly connected genes within the BD transcriptoma. …”
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Single-cell RNA sequencing reveals intrahepatic signature related to pathobiology of duck hepatitis A virus type 3 (DHAV-3) infection by Yunsheng Zhang, Dingbang Ding, Shaofei Li, Qiong Pan, Jinlong Ru, Haonan Zhao, Guang Yao, Jie Wei, Shuaiqin Wang, Shuisheng Hou, Xia Wang

“…We identified significant dysregulation of various genes in complement and coagulation cascades in hepatocytes2 exclusive to S ducks, together with over-secretion of ANGPTL4 from endothelial cells in S ducks which is confirmed to promote cellular migration, suggesting etiology of coagulopathic complications in ducks with severe DVH. …”
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The spatiotemporal and paradoxical roles of NRF2 in renal toxicity and kidney diseases by Yiying Bian, Jize Dong, Zhengsheng Zhou, Hua Zhou, Yuanyuan Xu, Qiang Zhang, Chengjie Chen, Jingbo Pi

“…However, if persistently activated, NRF2-induced transcriptional cascade may disrupt normal cell signaling and contribute to numerous chronic pathogenic processes such as fibrosis. …”
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Metasurface higher-order poincaré sphere polarization detection clock by Hui Yang, Kai Ou, Qiang Liu, Meiyu Peng, Zhenwei Xie, Yuting Jiang, Honghui Jia, Xinbin Cheng, Hui Jing, Yueqiang Hu, Huigao Duan

“…Conventional strategies for detecting SoP, which typically involves a sequence of cascaded optical elements, are bulky, complex, and run counter to miniaturization and integration. …”
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