Simulation investigation of a Ka-band phase-locked klystron-type coaxial relativistic Cherenkov generator by Yunxiao Zhou, Jinchuan Ju, Wei Zhang, Dian Zhang, Ying Li, Tengfang Wang, Fugui Zhou, Zhuang Yu, Hongtao Yao, Jun Zhang

“…Specially designed reflectors and cascaded single-gap bunching cavities with active suppression of asymmetric TM mode are employed in the pre-modulation region to suppress energy coupling and achieve a lower input power ratio. …”
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Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism by Hong Gong, Yao Lu, Shi-Long Deng, Ke-Yi Lv, Jing Luo, Yi Luo, Zhu-Lin Du, Ling-Feng Wu, Tian-Yao Liu, Xia-Qing Wang, Jing-Hui Zhao, Lian Wang, Mei-Ling Xia, Dong-Mei Zhu, Li-Wei Wang, Xiao-Tang Fan

“…Our findings indicate that microglia-derived S100A9 triggers the neuroinflammation cascade, myelination deficits, and social dysfunction. …”
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Macrophages facilitate tumor cell PD‐L1 expression via an IL‐1β‐centered loop to attenuate immune checkpoint blockade by Cheng Xu, Yu Xia, Bai‐Wei Zhang, Emmanuel Kwateng Drokow, Hua‐Yi Li, Sen Xu, Zhen Wang, Si‐Yuan Wang, Ping Jin, Tian Fang, Xiao‐Ming Xiong, Pu Huang, Ning Jin, Jia‐Hong Tan, Qing Zhong, Yu‐Xin Chen, Qi Zhang, Yong Fang, Fei Ye, Qing‐Lei Gao

“…Mechanistically, we demonstrated that IL‐1β significantly boosted programmed death‐ligand 1 (PD‐L1) expression in tumor cells via the activation of the nuclear factor‐κb signaling cascade. Specifically, IL‐1β released from TAMs was triggered by lactate, the anaerobic metabolite of tumor cells, in an inflammasome activation‐dependent manner. …”
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Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines by Elizabeth Curtiss, Youde Jiang, Li Liu, Claire Hawthorne, Jessica Zhang, Jena J. Steinle

“…Whole retinal lysates from Epac1 floxed and endothelial cell-specific Epac1 knockout mice were used to investigate proteins involved in the insulin signaling cascade. Primary human REC were cultured in normal and high glucose followed by Epac1 agonist treatment or transfection with IL-1β or TNFα siRNA for protein analyses of insulin signaling proteins. …”
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CRENTES SEM RELIGIÃO E ATEÍSMO HERMENÊUTICO: PESQUISA EM PROGRAMAS DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA RELIGIÃO by Omar Lucas Perrout Fortes de Sales, Clóvis Ecco

“…A partir daí, compete lançar luzes acerca do material obtido e estabelecer conexões que possibilitem emergir intertextualidades e horizontes novos de aproximação ao universo dos crentes sem religião em sintonia com os eixos interpretativos configurados pelo ateísmo hermenêutico. …”
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Targeted allele-specific FGFR2 knockdown via human recombinant ferritin nanoparticles for personalized treatment of Crouzon syndrome by Federica Tiberio, Martina Salvati, Luca Polito, Giada Tisci, Alessia Vita, Ornella Parolini, Luca Massimi, Lorena Di Pietro, Pierpaolo Ceci, Gianpiero Tamburrini, Alessandro Arcovito, Elisabetta Falvo, Wanda Lattanzi

“…The selected therapeutic siRNA mitigated FGFR2 cascade downregulating phosphorylation of FGFR2 (48%) and of its key effector ERK1/2 (77%) as RUNX2 protein levels (34%). …”
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The Effect of Laminin-1-Doped Nanoroughened Implant Surfaces: Gene Expression and Morphological Evaluation by Humberto Osvaldo Schwartz-Filho, Kostas Bougas, Paulo G. Coelho, Ying Xue, Mariko Hayashi, Rafael Silveira Faeda, Rosemary Adriana Chiérici Marcantonio, Daisuke Ono, Fumio Kobayashi, Kamal Mustafa, Ann Wennerberg, Ryo Jimbo

“…The protein-doped surface showed higher gene expression of typical genes involved in the osseointegration cascade than the control surface.…”
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Application of Cart Method in Analyzing Factors Affecting Nutritional Status of Children Aged 6-23 Months by Izzati Rahmi, Yozza Hazmira, Husna Radhiatul, Rahmy Hafifatul Auliya

“…The data used were acquired from a survey conducted at mother and child health services (‘posyandu’), daycares, and households in four districts in Padang City, West Sumatera. …”
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Application of Cart Method in Analyzing Factors Affecting Nutritional Status of Children Aged 6-23 Months by Izzati Rahmi, Yozza Hazmira, Husna Radhiatul, Rahmy Hafifatul Auliya

“…The data used were acquired from a survey conducted at mother and child health services (‘posyandu’), daycares, and households in four districts in Padang City, West Sumatera. …”
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Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban by Qianxing Zhou, Florian Bea, Michael Preusch, Hongjie Wang, Berend Isermann, Khurrum Shahzad, Hugo A. Katus, Erwin Blessing

“…Activated factor X (FXa) is traditionally known as an important player in the coagulation cascade responsible for thrombin generation. We assessed the hypothesis that rivaroxaban, a direct FXa inhibitor, attenuates plaque progression and promotes stability of advanced atherosclerotic lesions in an in vivo model. …”
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Neonatal Screening for Congenital Hypothyroidism: A Study Conducted in a Tertiary Care Hospital of Gujarat by Shubhangi Rathod, Ramesh Pradhan, Rosy Lekharu, Jaydip Vala, Mehak Kulshrestha

“…Background: Growth and differentiation of the fetal brain largely depend on the thyroidal biochemical cascade. The most common cause of congenital hypothyroidism (CH) is thyroid dysgenesis. …”
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MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways by Xueting Guo, Wenqi Wang, Liting Lin, Jie Shan, Junyao Zhu, Shipeng Ning, Hanmei Li, Xianwen Wang, Decheng Lu

“…Specifically, MnGA scavenges superoxide anions and produces H2O2 via SOD-like activity and then consumes H2O2 to convert it to nontoxic H2O and O2 via CAT-like activity, resulting in a cascade of catalytic reactions to scavenge reactive oxygen species (ROS). …”
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Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation by Wancheng Liu, Xuejiao Yang, Ning Wang, Shijun Fan, Yuanfeng Zhu, Xinchuan Zheng, Yan Li

“…These results suggest that CpG-c41 acts as an upstream of signaling cascades, perhaps on the processes of ligand internalization and transfer. …”
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Assessing the ecological consequences of crude oil spills on bird communities in an Afrotropical landscape by Iniunam Aniefiok Iniunam, Talatu Tende, Adams Adamanyiwa Chaskda

“…Our study highlights the cascading effects of oil spills on ecosystem services provided by birds, which are vital for human well-being. …”
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Two Cysteines in Raf Kinase Inhibitor Protein Make Differential Contributions to Structural Dynamics In Vitro by Hyun Sang Cho, Mohammad Faysal Al Mazid, Eun-Young Lee, Md Abu Rayhan, Hyoun Sook Kim, Byung Il Lee, Hye Jin You

“…As a scaffolding protein, Raf kinase binding protein (RKIP) is involved in a variety of cellular pathways, including the Raf–MEK–ERK-cascade. It acts as a negative regulator by binding to its partners, making it an attractive target in the development of therapeutic strategies for cancer. …”
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Experiências memoráveis na vivência acadêmica em cursos de administração: um estudo à luz das “experiências em serviços” by Eduardo Cechinel, Aline Regina Santos

“… Ao recorrer à abordagem das experiências no contexto dos serviços educacionais, especificamente no ensino superior, este estudo teve o propósito de lançar um novo olhar sobre o segmento, tendo como objetivo propor um framework conceitual para caracterizar as experiências memoráveis vivenciadas por egressos de cursos de graduação em administração, considerando as principais interações na vivência acadêmica. …”
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Parasitic contamination of lettuce: comparison between establishments located in areas with high and low economic values by Gustavo Trentini Barancelli, Larissa Kochenborger, Fernanda Gracieli Machado Brum, Fabiana Tonial, Cassiano Mateus Forcelini

“…Results: Parasitic forms were found in 80% of the samples, namely: ciliated cysts (probable Balantioides coli), larvae of nematode, Ascaris lumbricoides, cestode eggs, Giardia lamblia, Hymenolepis nana, Entamoeba coli, and Fasciola hepatica. …”
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The role of the interleukin family in liver fibrosis by Zixin Zhang, Zixin Zhang, Jiahui Wang, Hui Li, Qun Niu, Qun Niu, Yujing Tao, Yujing Tao, Xin Zhao, Xin Zhao, Zijian Zeng, Zijian Zeng, Haijian Dong, Haijian Dong

“…Among these, the interleukin family activates a complex cascade of responses, including cytokines, chemokines, adhesion molecules, and lipid mediators, playing a key role in the initiation and regulation of inflammation, as well as innate and adaptive immunity. …”
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Modeling and robust control of a parallel robotic mechanism driven by linear actuators based on shape memory alloys by Alejandro Guarneros-Sandoval, Mariana Ballesteros, Rita Q. Fuentes-Aguilar, Isaac Chairez

“…Based on the estimated model, a cascade control (backstepping-like) is implemented on the individual actuator and the parallel device to track a desired path. …”
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As redes de colaboração no turismo de base comunitária: implicações para a gestão participativa by Andrés Burgos, Frédéric Mertens

“…O principal objetivo é contribuir com a reflexão teórico-metodológica sobre como os padrões relacionais dentro de uma comunidade podem lançar luz sobre a gestão participativa no turismo local, atendendo à complexidade que caracteriza as relações sociais e o sistema turístico. …”
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