Blocking TNF-α Reduces <i>Leishmania major</i>-Induced Hyperalgesia and Changes the Cytokine Profile in the Paw Skin of BALB/c Mice with a Potential Positive Effect on Parasite Cle... by Muriel Tahtouh Zaatar, Sara Salman, Reem Hoblos, Rabih Roufayel, Ziad Fajloun, Jean-Marc Sabatier, Marc Karam

“…These and other cytokines also play a major role in <i>Leishmania</i>-induced hyperalgesia via two possible pathways, one involving prostaglandins and the other sympathetic amines as final mediators, preceded by a cascade of cytokines, among which TNF-α seems to play a pivotal role via a still unclear mechanism of action. …”
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Daytime F Region Echoes at Equatorial Ionization Anomaly Crest During Geomagnetic Quiet Period: Observations From Multi‐Instruments by Yi Liu, Zhongxin Deng, Tong Xu, Jian Kong, Chen Zhou, Yibin Yao, Qiong Tang, Zhengyu Zhao

“…Then the large‐scale ionospheric disturbance could further evolve into small‐scale irregularity producing radar echoes through the non‐linear cascade process.…”
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Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue by Jieun Shin, Kavita B. Hosur, Kalyani Pyaram, Ravi Jotwani, Shuang Liang, Triantafyllos Chavakis, George Hajishengallis

“…Treatment of human endothelial cells with Del-1 did not affect the expression of endothelial molecules involved in the leukocyte adhesion cascade (ICAM-1, VCAM-1, and E-selectin). Moreover, genetic or age-associated Del-1 deficiency did not significantly alter the expression of these adhesion molecules in the murine periodontium, further ruling out altered adhesion molecule expression as a mechanism whereby Del-1 regulates leukocyte recruitment. …”
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A Hybrid Transformer Architecture for Multiclass Mental Illness Prediction Using Social Media Text by Adnan Karamat, Muhammad Imran, Muhammad Usman Yaseen, Rasool Bukhsh, Sheraz Aslam, Nouman Ashraf

“…In this study, we propose a hybrid transformer architecture, comprising MentalBERT and MelBERT pretrained language models, cascaded with CNN models to generate and concatenate deep features. …”
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Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space by Maria Moreno-Villanueva, Maria Moreno-Villanueva, Luis E. Jimenez-Chavez, Luis E. Jimenez-Chavez, Stephanie Krieger, Liang-Hao Ding, Ye Zhang, Adriana Babiak-Vazquez, Mark Berres, Sandra Splinter, Kristen E. Pauken, Brian C. Schaefer, Brian E. Crucian, Honglu Wu

“…The dysregulated genes and pathways were mostly involved in energy and oxygen metabolism, immune responses, cell adhesion/migration and cell death/survival.DiscussionBased on the DEG and the associated pathways and functions, we propose that mitochondria dysfunction was caused by constant modulation of mechano-sensing receptors in microgravity, which triggered a signaling cascade that led to calcium overloading in mitochondria. …”
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Mechanistic Insights into the Anticancer Potential of Methoxyflavones Analogs: A Review by Mohammad Aidiel, Maisarah Abdul Mutalib, Rajesh Ramasamy, Nik Nasihah Nik Ramli, Shirley Gee Hoon Tang, Siti Hajar Adam

“…The methoxy group in naturally occurring flavones promotes cytotoxic activity in various cancer cell lines by targeting protein markers, in facilitating ligand–protein binding mechanisms and activating cascading downstream signaling pathways leading to cell death. …”
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Fufang E’jiao Jiang’s effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysis by Xiang Li, Xiao Xu, Ying Dong, Shusheng Fan, Xueyang Ren, Yuan Zheng, Jiamu Ma, Feng Zhang, Qingyue Deng, Xianxian Li, Yingyu He, Mengyu Sun, Wei Liu, Mengxia Li, Qing Xia, Yan Zhang, Gaimei She

“…Transcriptome data showed that several pathways such as complement and coagulation cascades, ECM-receptor interaction, and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ. 19 common targets were obtained through combined analysis of network pharmacology and transcriptomics, and 5 targets of them were verified by PCR. …”
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Sentidos otorgados a personas trans: una experiencia en San Luis, Argentina by Yael Guadalupe Calvo, Pia Torres Caiazzo, Roxana Vuanello

“…Los resultados expresan representaciones referidas a que las personas trans se adecúen a las normas desde un enfoque binario, que adapten su identidad al modelo heterosexual evitando su presencia en el espacio social por la incomodidad que despiertan y algunas personas manifiestan su aceptación y reconocen a las personas sin marcar diferencias por su sexualidad, valorizando su condición humana. …”
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Relative performance of various composts and NPK fertilizer on upgrowth and quality of fodder maize by Saleem Bhatti, Muhammad Afzal Kandhro, Zohaib Bughio, Inyatullah Rajpar, Javaid Shah, Muhammad Mithal Lund, Ali Akbar Maitlo, Hafeez ur Rehman Bughio

“…The experimental soil was fine textured (clayey), slightly alkaline in reaction, non-saline, poor in organic matter content, calcareous in nature, low in nitrogen, marginal in phosphorus and adequate in potassium.Results The supplementation of composts and NPK fertilizer significantly increased the growth and yield parameters (plant height up to 26%, number of leaves plant-1 up to 20%, stem girth up to 22%, and fresh weight of maize fodder up to 25%), and the concentrations of selected macronutrients (N up to 46%, P up to 27%, and K up to 38%) in maize leaves with respect to control. …”
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Experimental Study of Water Transfer and Ice Accumulation in Freezing Soils under Different Conditions by Sihao Liang, Xinyan Ma, Qiang Li, Xinyu Ye, Jianlong Liu, Jian Zhang

“…The water (or ice) accumulated in the soils of calcareous sand, silty soil in Lanzhou (SSL), red clay in Changsha, and silty soil in Hohhot (SSH) under the top plate is 34.5%, 21.0%, 11.33%, and 26.7%, respectively. …”
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Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines by Edismauro Garcia Freitas Filho, Elaine Zayas Marcelino da Silva, Camila Ziliotto Zanotto, Constance Oliver, Maria Célia Jamur

“…The effect of cross-linking these gangliosides on the activation of enzymes in the arachidonate cascade was then investigated. Ganglioside cross-linking resulted in phosphorylation of cytosolic phospholipase A2 and increased expression of cyclooxygenase-2. …”
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mTOR Inhibitor Everolimus Modulates Tumor Growth in Small-Cell Carcinoma of the Ovary, Hypercalcemic Type and Augments the Drug Sensitivity of Cancer Cells to Cisplatin by Kewei Zheng, Yi Gao, Jing Xu, Mingyi Kang, Ranran Chai, Guanqin Jin, Yu Kang

“…This indicates that everolimus enhances cisplatin efficacy by disrupting survival-promoting signaling cascades and inducing cell cycle arrest. Furthermore, it points to potential biomarkers for predicting therapeutic response.…”
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Personal glucose meter-based portable method for creatine kinase assay by Jinhwan Lee, Yejin Oh, Hyoyong Kim, Sangmo Lee, Hyun Gyu Park

“…This method relies on the target-induced consumption of glucose by the cascade enzymatic reaction (CER) promoted by the combined activities of CK and hexokinase (HK). …”
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Autoimmune and Neoplastic Thyroid Diseases Associated with Hepatitis C Chronic Infection by Poupak Fallahi, Silvia Martina Ferrari, Ugo Politti, Dilia Giuggioli, Clodoveo Ferri, Alessandro Antonelli

“…These cytokines might induce a further CXCL10 secretion by thyrocytes, thus perpetuating the immune cascade, which may lead to the appearance of autoimmune thyroid disorders in genetically predisposed subjects. …”
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Descriptive Investigation of Strongyloidiasis Infection and Characterization of Strongyloides stercoralis Using Morphological and Molecular-Based Methods by Nayana Gunathilaka, Nilmini Chandrasena, Tharaka Wijerathna, Yoshito Fuji, Deepa Gunasekara, Ruwan Prasanna Gunatilaka, Ranjan Premaratna

“…A multiplex polymerase chain reaction (PCR) assay was developed for the detection of S. stercoralis, Ascaris lumbricoides, and Enterobius vermicularis by designing primers specific for the ITS1 region of ribosomal DNA of S. stercoralis and A. lumbricoides and 18S region of rRNA of E. vermicularis. …”
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Construction of Multi-Scale Fusion Attention Unified Perceptual Parsing Networks for Semantic Segmentation of Mangrove Remote Sensing Images by Xin Wang, Yu Zhang, Wenquan Xu, Hanxi Wang, Jingye Cai, Qin Qin, Qin Wang, Jing Zeng

“…This network integrates Cascade Pyramid Fusion Modules, a Multi-scale Selective Kernel Attention Module, and an Auxiliary Edge Neck to process the unique characteristics of mangrove remote sensing images, particularly addressing issues of scale variation, complex backgrounds, and boundary accuracy. …”
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Nε-carboxyethyl-lysin influences atherosclerotic plaque stability through ZKSCAN3 acetylation-regulated macrophage autophagy via the RAGE/LKB1/AMPK1/SIRT1 pathway by Zhongwei Liu, Jing Liu, Xiqiang Wang, Yong Zhang, Yanpeng Ma, Gongchang Guan, Ya Yuwen, Ni He, Hanxiu Liu, Xingfeng Yu, Sen Ma, Junkui Wang, Jin Zhang, Ling Zhu, Yulian Zhang

“…Mechanistically, CEL disrupted macrophage autophagy and plaque stability by perturbing the Receptor for Advanced Glycation End products (RAGE)/Liver Kinase B1 (LKB1)/AMP-activated Protein Kinase 1 (AMPK1)/Sirtuin 1 (SIRT1) signaling cascade. This pathway further regulated autophagic activity through SIRT1-mediated acetylation of Zinc Finger with KRAB and SCAN Domains 3 (ZKSCAN3). …”
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Intestinal Schistosomiasis among Primary Schoolchildren in Two On-Shore Communities in Rorya District, Northwestern Tanzania: Prevalence, Intensity of Infection and Associated Risk... by David Z. Munisi, Joram Buza, Emmanuel A. Mpolya, Safari M. Kinung’hi

“…Other parasites detected were Ascaris lumbricoides (1.4%) and hookworms (1.4%). …”
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Liquid biopsy approaches to capture tumor evolution and clinical outcomes during cancer immunotherapy by Susan Scott, Mark Sausen, Valsamo Anagnostou, Jennifer Jackson, Vincent Lam, Joseph C Murray, Lavanya Sivapalan, Jenna Vanliere Canzoniero, Blair Landon, Benjamin P. Levy

“…Tracking the landscape of genomic alterations detected in ctDNA may reveal the clonal architecture of the metastatic cascade and thus improve our understanding of the molecular wiring of therapeutic responses. …”
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The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development by Jana Vcelakova, Radek Blatny, Zbynek Halbhuber, Michal Kolar, Ales Neuwirth, Lenka Petruzelkova, Tereza Ulmannova, Stanislava Kolouskova, Zdenek Sumnik, Pavlina Pithova, Maria Krivjanska, Dominik Filipp, Katerina Stechova

“…Genes involved in Th17 and TGF-beta cascades may represent novel, promising (pre)diabetes biomarkers.…”
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