The Upregulation of IL-1β Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier by Yu M, Jiang WJ, Yu M, Zhou Z, Wang M, Li L

“…Both MMP9 and PI3K-AKT inhibitors abrogated IL-1β-induced changes.Conclusion: Our findings suggest that CDDP initiates a cascade of events starting with IL-1β release from endothelial cells. …”
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The impact on productivity costs of reducing unemployment in patients with advanced breast cancer: A model estimation based on a Portuguese nationwide observational study by Leonor Vasconcelos de Matos, Margarida Borges, Ana Teresa Oliveira, Carolina Bulhosa, Luís Silva Miguel, Tiago Fidalgo de Freitas, Renato Cunha, Ana Duarte Mendes, Ana Júlia Arede, Cristiana Marques, Diogo Alpuim Costa, Jorge Alves Correia, Margarida Brito, Mário Fontes e Sousa, Teresa Guimarães, Fatima Cardoso

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GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway by Chao Tang, Lin Li, Chongying Zhu, Qiang Xu, Zihao An, Shouying Xu, Chao Lin

“…Conclusions Collectively, this study depicts the role of GPR137-RAB8A-HH cascade in the development of OC, deepening our understanding of tumor biomechanics regarding OC progression and providing novel targets for OC therapy in future.…”
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Proceso del cuidado enfermero aplicado en un adulto con insuficiencia respiratoria por COVID-19 by Iris Villasante Montes, Lisbeth Jazmín Espejo Ávila, Mercedes Consuelo Guerra Pacheco

“…Caso clínico: Paciente mujer adulto de 39 años, no tiene antecedentes de enfermedades anteriores, obesa, con IMC 38, resultados de test rápido SARS-CoV-2: Positivo IgM (+) IgG (+), al examen físico presenta P/A: 145/84, FC: 118 X’, FR 38X’, T: 38,8 ºC, SpO2: 88 % (máscara de reservorio a 15 litros), consciente y orientada, deshidratada, con taquipnea y con hipoventilación a la auscultación. …”
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Maestros en zonas de conflicto by Mauricio Lizarralde J.

“…El que sus interacciones cotidianas se desarrollen en un contexto caracterizado por el miedo generado por las vivencias de acciones de guerra como combates, masacres, señalamientos y amenazas, además marcadas por la impunidad, la no reparación y la percepción de indefensión, hace que la identidad del maestro, que está constituida por su propia historia personal, por la conciencia de su rol público, por la valoración social de su profesión, y por su definición política, produzca diferentes formas de enunciación de sí mismo, y produzca a la vez determinantes del tipo de actitud que se asume como mecanismo de sobrevivencia. …”
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A Small-Area 2nd-Order Adder-Less Continuous-Time ΔΣ Modulator With Pulse Shaping FIR DAC for Magnetic Sensing by Manish Srivastava, Alessandro Ferro, Aleksandr Sidun, Jose M. De La Rosa, Kilian O'Donoghue, Padraig Cantillon-Murphy, Daniel O'Hare

“…The CT<inline-formula> <tex-math notation="LaTeX">$\Delta \Sigma \text{M}$ </tex-math></inline-formula> is used for digitising very low amplitude signals in applications such as magnetic tracking for image-guided and robotic surgery. A cascade of integrators in a feed-forward architecture implemented with an adder-less architecture has been proposed to minimise the silicon area. …”
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Risks of parasitic helminth disease outbreaks and influence of physico-chemical factors in flood prone areas of Yaoundé, Cameroon by Noura Efietngab Atembeh, Jean Patrick Molu, Jeanne Valerie Emvoutou Maboulou, Boris Fominyam, Rodrigue Nanfack Dongmo, Gabriel Bertrand Zambo, Emilie Tchinda Tiecheu, Jeannette Tombi, Lucia Nkengazong, Serge Hubert Zebaze Togouet, Jean Louis Essame Oyono

“…Strongyloides stercoralis was the most prevalent (33.3 %) and most abundant (1269) species followed by Toxocara canis (26.4 %), Ascaris lumbricoides (25 %), Toxocara leonina (20.8 %), Hookworm (15.3 %), Trichostrongylus sp. (11.1 %), Diphyllobothrium latum (8.3 %), Trichuris trichiura (2.8 %) and Schistosoma intercalatum (1.4 %). …”
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Adaptif Poly Frame PRMA pada Jaringan M2M Kognitif Kapiler by Eko Arifianto, Aghus Sofwan, Teguh Prakoso

“…Penelitian ini bertujuan membuat komunikasi M2M yang lancar walaupun perangkat bertambah banyak, dengan membuat struktur frame baru dan skenario komunikasi baru, berupa Adaptive Poly Frame (APF) serta Scheduler Update (SU). …”
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Anatomical and Functional Outcomes of Vitrectomy with/without Intravitreal Methotrexate Infusion for Management of Proliferative Vitreoretinopathy Secondary to Rhegmatogenous Retin... by Samir El Baha, Mahmoud Leila, Ahmed Amr, Mohamed M. A. Lolah

“…Methotrexate as an adjuvant therapy blocks essential drivers in the pathogenetic cascade leading to PVR. Intravitreal infusion has the advantage of blocking the pathology in its nascence and obviates the need for repeated intravitreal injections of the drug.…”
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Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma by Hua Dai, Xin Tao, Yuansen Shu, Fanrong Liu, Xiaoping Cheng, Xiushen Li, Bairui Shu, Hongcheng Luo, XuXiang Chen, Zhaorui Cheng

“…Elevated expression of PTGES3 was linked to immunosuppressive cascades, diminished responsiveness to immunotherapy, and inferior overall survival outcomes. …”
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Performance of RIS-Secured Short-Packet NOMA Systems With Discrete Phase-Shifter to Protect Digital Content and Copyright Against Untrusted User by Nguyen Quang Sang, Hye-Young Kim, Tan N. Nguyen, Minh Bui Vu, Phuong T. Tran, Tran Trung Duy, Byung-Seo Kim, Miroslav Voznak

“…In this strategy, untrustworthy users will be allocated higher power levels than trustworthy users, while the latter will be configured with sub-optimal phase shift criteria at RIS to maximize its cascaded channel gain. On this foundation, we derive closed-form expressions for the average block-error rate (BLER) to analyze the performance of trustworthy users as well as the average secure BLER to quantify the secure performance when untrustworthy users wiretap trustworthy users&#x2019; information using successive interference mechanisms. …”
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In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders by Stephen Tunmise Akanbi, Joshua Ayodele Yusuf, Thompson Oluwaferanmi Ayandele, Dayo Samson Oladipupo, Darasimi Racheal Olorunlowu, Blessing Dorcas Olawuyi, Joshua Oluwafisayo Adepoju, Dolapo Emmanuel Opasina, Elizabeth Kehinde Opoola, Uchenna Victor Ugwuanyi, Olufunto Omodele Adeleye

“…Also, we constructed transcription factor (TF)-hub gene expression networks, miRNA-hub gene expression networks, and disease hub gene association networks using the JASPAR database, Tarbase database, and DisGeNET via NetworkAnalyst platform, respectively. …”
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Group a Streptococcus remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination by Henry M. Vu, Thomas E. Moran, Zhong Liang, Yun-Juan Bao, Paulina G. Carles, Jessica C. Keane, Madelyn G. Cerney, Caitlyn N. Dahnke, Ana L. Flores-Mireles, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee

“…The host coagulation cascade initiates fibrin clots to sequester bacteria to prevent dissemination into deeper tissues. …”
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The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis by Haitao Mei, Qingshan Luo, Junyong Weng, Jialing Hao, Jinfeng Cai, Runkai Zhou, Ce Bian, Yingzi Ye, Shengzheng Luo, Yugang Wen

“…Protein mass spectrometry suggested an interaction between PCDHGA9 and HOXA1. JASPAR predicted that HOXA1 may act as a transcription factor of CXCR4. …”
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Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer by Siyue Zhang, Ning Zhang, Tong Wan, Yinqiao He, Jie Hao, Yiwei Liu, Yidong Liu, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Chao Gao, Qifeng Yang

“…As a secretory protein, ANGPTL4 subsequently activated the integrin-mediated JAK2/STAT3 signaling cascade in TNBC cells through autocrine signaling. …”
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Assessing the Future ODYSEA Satellite Mission for the Estimation of Ocean Surface Currents, Wind Stress, Energy Fluxes, and the Mechanical Coupling Between the Ocean and the Atmosp... by Marco Larrañaga, Lionel Renault, Alexander Wineteer, Marcela Contreras, Brian K. Arbic, Mark A. Bourassa, Ernesto Rodriguez

“…Our results indicate that ODYSEA would significantly improve the monitoring of eddy kinetic energy, the kinetic energy cascade, and air–sea kinetic energy flux in the Gulf Stream region. …”
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Is Intra-articular Platelet-rich Plasma Injection Safe and Effective in Osteoarthritis Knee? A Prospective Study: A Case Series by R Sahaya Jose, N Kattu Bava, M Syed Moosa

“…The release of platelet-derived factors directly at the site of cartilage disease, particularly with interest to knee OA, may stimulate the natural regenerative signaling cascade and enhance tissue healing with further mediation of the anti-inflammatory response. …”
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Investigating the Occurrence of Soil-Transmitted Parasites Contaminating Soil, Vegetables, and Green Fodder in the East of Nile Delta, Egypt by Samah H. Yahia, Samia E. Etewa, Abd Allah A. Al Hoot, Salwa Z. Arafa, Nesreen S. Saleh, Mohamed H. Sarhan, Suzan I. Rashad, Shimaa S. Hassan

“…Various parasitic life forms were significantly found in 249 out of 400 (62.25%) of the vegetable samples, with (65.1%) of them harboring one parasite species, whereas 9.2% significantly contained up to three parasites. Ascaris eggs, Trichuris eggs, and Giardia cysts were the most prevalent parasites, which were predominantly isolated from vegetables with uneven surfaces. 109 of 180 (60.0%) green fodder samples confirmed insignificantly positive for parasitic pollution. …”
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TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles by Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas

“…Conclusion Hence, we delineated a novel signaling cascade that leads to high rates of EV generation by cancer cells in response to TGF-β, with cholesterol being a key intermediate step in this mechanism. …”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…Furthermore, treatment with sp600125, a JNK inhibitor, resulted in the suppression of ULBP2 expression.Conclusions：RES potentiates ULBP2-mediated immune eradication of BC cells by NK cells through the downregulation of miR-17-5p and concurrent activation of the MINK1/JNK/c-Jun cascade. This finding identifies RES as a potentially effective therapeutic agent for inhibiting BC progression and optimizing NK cell-based cancer immunotherapy.…”
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