Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway by Yuqin Ye, Zhenyu Zhao, Hongyu Xu, Xin Zhang, Xinhong Su, Yongxiang Yang, Xinguang Yu, Xiaosheng He

“…More importantly, it was suggested that mitogen-activated protein kinase-Erk kinase (MEK)/Erk cascade was required for S1PR1-meidated neurogenesis and neurocognitive recovery following TBI. …”
Get full text

Recycling Marble Waste from Afghan Mining Sites as a Replacement for Cement and Sand by Mohammad Rafi Rafi, Safiullah Omary, Amanullah Faqiri, Elhem Ghorbel

“…A comparative study replaced marble waste with a calcareous filler from Omya SAS. The marble waste, collected from a mining site in Nangarhar, Afghanistan, consisted of 29% particles smaller than 63 μm and 71% sand particles. …”
Get full text

Ginkgo biloba Extract Improves Insulin Signaling and Attenuates Inflammation in Retroperitoneal Adipose Tissue Depot of Obese Rats by Bruna Kelly Sousa Hirata, Renata Mancini Banin, Ana Paula Segantine Dornellas, Iracema Senna de Andrade, Juliane Costa Silva Zemdegs, Luciana Chagas Caperuto, Lila Missae Oyama, Eliane Beraldi Ribeiro, Monica Marques Telles

“…In the present study we aimed to evaluate the effect of GbE on both inflammatory cascade and insulin signaling in retroperitoneal fat depot of diet-induced obese rats. …”
Get full text

The Effect of Periodontitis on Expression of Interleukin-21: A Systematic Review by Archana Mootha, Sankari Malaiappan, N. D. Jayakumar, Sheeja S. Varghese, Julie Toby Thomas

“…Interleukin-21 (IL-21) has been associated with systemic diseases like rheumatoid arthritis and Crohn’s disease that follow a chronic inflammatory cascade. Similarly recent studies have associated Interleukin-21 levels with periodontitis. …”
Get full text

Lung-specific CRBN knockout attenuates influenza a virus-induced acute lung injury in mice: a potential therapeutic approach by Lifang Zhang, Qingchao Zhang, Jiahui Chang, Yunyi Zhou, Wei Wang, Xiliang Wang, Chengyu Jiang, Yanli Zhang

“…PR8-infected Sftpc-Cre; Crbn flox/flox mice exhibited a marked reduction in lung inflammatory cell infiltration and suppression of MAPK pathway activation, highlighted by a significant downregulation of the MKK4-JNK-c-JUN signaling cascade. Collectively, these findings indicate that CRBN plays a pivotal role in the pathogenesis of influenza-induced lung injury by modulating MAPK pathway signaling, underscoring its therapeutic potential as a target for intervention.…”
Get full text

A Bi‐level stacked LSTM‐DNN‐based decoder network for AGC dispatch under regulation market framework in presence of VPP and EV aggregators by Kingshuk Roy, Sanjoy Debbarma, Siddhartha Deb Roy, Liza Debbarma

“…The proposed decoder network is comprised of stacked LSTM and DNN, wherein the cascaded LSTM layers are introduced to accurately capture temporal information from time series input. …”
Get full text

Peran Konselor dalam Meningkatkan Daya Ingat Belajar Siswa by Dini Fitriani, Ifdil Ifdil

“…Pada saat proses belajar individu menerima rangsangan dari stimulus-stimulus yang ada , dalam proses belajar belum ada faktor yang mendukung dan tidak mendukung berjalannya dengan lancar suatu proses belajar tersebut.Pada kenyataanya siswa tidak mampu dalam menjalankan dan mengembangkan potensi potensi yang ada pada dirinya , terkadang siswa tidak mampu mengimbangi faktor-faktor yang ada , salah satu nya adalah faktor yang sangat berpengaruh terhadap proses belajar sisswa adalah faktor daya ingta siswa tersebut. lemah atau kuatnya ssiswa dalam menginta pelajaran yanga da di tingkat pendidikannya.Bertolak dari permasalahn diatas, maka penulis akan membahas makalah ini dengan judul ‘Peran Koselor dalam Meningkatkan Daya Ingat Belajar Siswa’’ yang bertujuan untuk membantu dan mengarahkan siswa agar mampu meningkatkan dan mengingat pelajaran-pelajaran dengan baik.…”
Get full text

An improved DeepLabv3 + railway track extraction algorithm based on densely connected and attention mechanisms by Yanbin Weng, Jie Yang, Changfan Zhang, Jing He, Cheng Peng, Lin Jia, Hui Xiang

“…Secondly, the receptive field is enlarged by cascading atrous convolutions with different dilation rates in the ASPP (atrous spatial pyramid pooling) module, and other feature maps are concatenated using the multi-scale attention module to enhance the extraction accuracy of the model. …”
Get full text

Physical experimental simulation of unconventional reservoir formation process for carboniferous in Hudson Oilfield, Tarim Basin by Rujun Wang, Yongliang Tang, Wei Zhou, Daiyu Zhou, Zangyuan Wu, Guangqiang Shao

“…Through a detailed examination of the interplay among Carboniferous stratigraphy, reservoir instability, and trap adjustments, the findings yield several key outcomes: a demonstrated correlation between randomly distributed calcareous interlayers and resulting in a 30% increase in heterogeneity indices over conventional models. …”
Get full text

Biomimic Nanodrugs Overcome Tumor Immunosuppressive Microenvironment to Enhance Cuproptosis/Chemodynamic‐Induced Cancer Immunotherapy by Hangyi Wu, Xiaoyu Lu, Yuhan Hu, J. Baatarbolat, Zhihao Zhang, Yiping Liang, Youwen Zhang, Ye Liu, Huixia Lv, Xin Jin

“…Extra intracellular Cu induces cuproptosis and chemodynamic therapy (CDT), which further cascades immunogenic cell death (ICD) and activates antitumor immune responses. …”
Get full text

The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation? by Catherine Gebhard, Catherine Gebhard, Susan Bengs, Susan Bengs, Achi Haider, Achi Haider, Michael Fiechter, Michael Fiechter, Michael Fiechter

“…This newly suggested sex-dependent brain-heart interrelation was further supported by the discovery that bone marrow activity, a surrogate parameter of inflammation, represents a potential bridging link between amygdalar activity and cardiovascular pathology by fueling inflammatory processes that promote atherosclerotic disease. Such malignant cascade of events might account, at least in part, for the excess female mortality seen in women with coronary artery disease and calls for sex-specific research toward pharmacologic or behavioral modulators to improve cardiovascular outcomes, particularly in women. …”
Get full text

Ionospheric Disturbances Over the Indian Sector During 8 September 2017 Geomagnetic Storm: Plasma Structuring and Propagation by L. Alfonsi, C. Cesaroni, L. Spogli, M. Regi, A. Paul, S. Ray, S. Lepidi, D. Di Mauro, H. Haralambous, C. Oikonomou, P. R. Shreedevi, A. K. Sinha

“…The occurrence of severe post‐sunset scintillations in the northeastern sector suggests a possible cascade process forming small‐scale irregularities from the migrating EPB.…”
Get full text

Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs by Kitra Cates, Luorongxin Yuan, Yan Yang, Andrew S. Yoo

“…This study extends miR-9/9∗-124 reprogramming to alternate somatic cells, reveals the pan-somatic gene network fate erasure logic of miR-9/9∗-124, and shows a neurogenic role for p53 inhibition in the miR-9/9∗-124 signaling cascade.…”
Get full text

Key drivers of the TB epidemic in Suriname and priority actions to reduce incidence and mortality by E. Commiesie, D. Stijnberg, J. van den Boogaard, F. Gopie, S. Vreden, G. de Vries

“…CONCLUSION: The review identified the following areas of concern: no decline in TB rates, high proportion of TB-HIV co-infection, high rate of resistance to rifampicin, high case-fatality rates and suboptimal contact investigation care cascade . The review was used to inform interventions and key actions to reduce TB morbidity and mortality in Suriname.…”
Get full text

Potential of nutraceutical products for irritable bowel syndrome remission maintenance by A. I. Ulyanin, Ye. A. Poluektova, Ch. S. Pavlov, V. T. Ivashkin

“…Therefore, according to the results of available studies, intestinal microbiota changes in IBS is a key factor for the cascade of events including intestinal wall inflammation, changes of gastrointestinal motility, decreased threshold of gastrointestinal receptor sensitivity, as well as emotional disorders resulting in development of disease symptoms. …”
Get full text

Progesterone induces meiosis through two obligate co-receptors with PLA2 activity by Nancy Nader, Lama Assaf, Lubna Zarif, Anna Halama, Sharan Yadav, Maya Dib, Nabeel Attarwala, Qiuying Chen, Karsten Suhre, Steven Gross, Khaled Machaca

“…Despite the established physiological importance of P4 nongenomic signaling, the details of its signal transduction cascade remain elusive. Here, using Xenopus oocyte maturation as a well-established physiological readout of nongenomic P4 signaling, we identify the lipid hydrolase ABHD2 (α/β hydrolase domain-containing protein 2) as an essential mPRβ co-receptor to trigger meiosis. …”
Get full text

Tenidap sodium inhibits secretory non-pancreatic phospholipase A2 synthesis by foetal rat calvarial osteoblasts by W. Pruzanski, B. P. Kennedy, H. van den Bosch, E. Stefanski, M. Wloch, P. Vadas

“…Therefore TD seems to inhibit the arachidonic acid cascade proximally to cyclooxygenase and lipoxygenase and its anti-inflammatory activity may be related at least in part to the inhibition of sPLA2 synthesis.…”
Get full text

Overexpression of MMP13 Is Associated with Clinical Outcomes and Poor Prognosis in Oral Squamous Cell Carcinoma by Vui King Vincent-Chong, Iman Salahshourifar, Lee Peng Karen-Ng, Ming Yhong Siow, Thomas George Kallarakkal, Anand Ramanathan, Yi-Hsin Yang, Goot Heah Khor, Zainal Ariff Abdul Rahman, Siti Mazlipah Ismail, Narayanan Prepageran, Wan Mahadzir Wan Mustafa, Mannil Thomas Abraham, Keng Kiong Tay, Sok Ching Cheong, Rosnah Binti Zain

“…Matrix metalloproteinase 13 (MMP13) plays a central role in the MMP activation cascade that enables degradation of the extracellular matrix and basement membranes, and it is identified as a potential driver in oral carcinogenesis. …”
Get full text

Molecular Mechanism of Macrophage Activation by Red Ginseng Acidic Polysaccharide from Korean Red Ginseng by Se Eun Byeon, Jaehwi Lee, Ji Hye Kim, Woo Seok Yang, Yi-Seong Kwak, Sun Young Kim, Eui Su Choung, Man Hee Rhee, Jae Youl Cho

“…According to pharmacological evaluation with specific enzyme inhibitors, Western blot analysis of intracellular signaling proteins and inhibitory pattern using blocking antibodies, ERK, and JNK were found to be the most important signaling enzymes compared to LPS signaling cascade. Further, TLR2 seems to be a target surface receptor of RGAP. …”
Get full text

Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer by Ayodeji Folorunsho Ajayi, Mega Obukohwo Oyovwi, Oyedayo Phillips Akano, Grace Bosede Akanbi, Florence Bukola Adisa

“…This review aims to provide an overview of the molecular pathways implicated in prostate and ovarian cancers, highlighting key genetic alterations, signaling cascades, and epigenetic modifications. A comprehensive literature search was conducted using databases such as PubMed, Web of Science, and Google Scholar. …”
Get full text