The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis by Junchao Wu, Lisha Li, Tingrui Zhang, Jiaye Lu, Zongguang Tai, Quangang Zhu, Zhongjian Chen

“…Immune responses participate in lipid abnormalities within the EIME by downregulating barrier gene expression and are further cascade-amplified by microbial dysregulation which is instigated by barrier impairment. …”
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The effect of AKT inhibition in α-synuclein-dependent neurodegeneration by Bedri Ranxhi, Zoya R. Bangash, Zachary M. Chbihi, Sokol V. Todi, Sokol V. Todi, Peter A. LeWitt, Peter A. LeWitt, Peter A. LeWitt, Wei-Ling Tsou

“…These findings highlight the AKT cascade as a potential therapeutic target for synucleinopathies and provide insights into mechanisms that could be utilized to reduce α-Syn toxicity in PD and related disorders, such as multiple system atrophy.…”
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PPAR-γ Signaling Crosstalk in Mesenchymal Stem Cells by Ichiro Takada, Alexander P. Kouzmenko, Shigeaki Kato

“…We found that the TNF-α/IL-1-activated TAK1/TAB1/NIK (NFκB-inducible kinase) signaling cascade inhibited both the adipogenesis and Tro-induced transactivation by PPAR-γ by blocking the receptor binding to the cognate DNA response elements. …”
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A model‐based approach using GSK3772847, an anti‐interleukin‐33 receptor monoclonal antibody, as a showcase to predict SC administration PK and free target dynamics based on PK and... by Jan Berkhout, Dave Fairman, Martijn vanNoort, Tamara J. vanSteeg

“…Integration of free and/or total target measurements in a population TMDD model will allow quantification of target engagement which is the first step in the cascade leading to efficacy. However, the assays for determination of free target concentrations are analytically challenging and are inherently biased to overpredict the true concentrations in the presence of mAb:target complexes. …”
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Perbedaan Jumlah Perdarahan Saat Persalinan Pada Ibu Primigravida Yang Melakukan Dan Tidak Melakukan Senam Hamil Selama Kehamilan Trimester III by Febby Herayono, Vaulinne Basyir, Afriwardi Afriwardi

“…American College of Obstetricans and Gynecologist merekomendasikan senam selama kehamilan agar persalinan lancar dan mengurangi komplikasi saat persalinan. …”
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Evolving concepts in intracranial pressure monitoring - from traditional monitoring to precision medicine by Rohan Mathur, Lin Cheng, Josiah Lim, Tej D. Azad, Peter Dziedzic, Eleanor Belkin, Ivanna Joseph, Bhagyashri Bhende, Sudha Yellapantula, Niteesh Potu, Austen Lefebvre, Vishank Shah, Susanne Muehlschlegel, Julian Bosel, Tamas Budavari, Jose I. Suarez

“…A wide range of acute brain injuries, including both traumatic and non-traumatic causes, can result in elevated intracranial pressure (ICP), which in turn can cause further secondary injury to the brain, initiating a vicious cascade of propagating injury. Elevated ICP is therefore a neurological injury that requires intensive monitoring and time-sensitive interventions. …”
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Vitamin K and Bone Health: A Review on the Effects of Vitamin K Deficiency and Supplementation and the Effect of Non-Vitamin K Antagonist Oral Anticoagulants on Different Bone Para... by Celia Rodríguez-Olleros Rodríguez, Manuel Díaz Curiel

“…Although known for its importance in the coagulation cascade, vitamin K has other functions. It is an essential vitamin for bone health, taking part in the carboxylation of many bone-related proteins, regulating genetic transcription of osteoblastic markers, and regulating bone reabsorption. …”
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Hyperbaric oxygen therapy for the treatment of a crush injury of the hand: a case report by Pedro Henry Neto, Zamara Brandão Ribeiro, Adriano Bastos Pinho, Carlos Henrique Rodrigues de Almeida, Carlos Alberto de Albuquerque Maranhão, Joaquim da Cunha Campos Goncalves

“…Posttraumatic compartment syndrome responds well to HBOt, which reduces edema and contributes to angiogenesis, as well as promoting the cascade of healing events. High-energy trauma causes massive cell destruction, and the blood supply is usually not sufficient to meet the oxygen demands of viable tissues. …”
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Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer by Pietro Parcesepe, Guido Giordano, Carmelo Laudanna, Antonio Febbraro, Massimo Pancione

“…Recent works reveal that expression of immune antigens (PDL1, CD47, CD73, CD14, CD68, MAC387, CD163, DAP12, and CD15) by tumor cells “immune resistance,” combined with prometastatic function of nonmalignant infiltrating cells, may represent a strategy to overcome the rate-limiting steps of metastatic cascade through (a) enhanced interactions with protumorigenic myeloid cells and escape from T-dependent immune response mediated by CD8+ and natural killer (NK) cells; (b) production of immune mediators that establish a local and systemic tumor-supportive environment (premetastatic niche); (c) ability to survive either in the peripheral blood as circulating tumor cells (CTCs) or at the metastatic site forming a cooperative prometastatic loop with foreign “myeloid” cells, macrophages, and neutrophils, respectively. …”
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Parasitic Contamination of Commonly Consumed Fresh Leafy Vegetables in Benha, Egypt by Maysa Ahmad Eraky, Samia Mostafa Rashed, Mona El-Sayed Nasr, Azza Mohammed Salah El-Hamshary, Amera Salah El-Ghannam

“…Giardia lamblia cysts were the most prevalent parasite (8.8%) followed by Entamoeba spp. cysts (6.8%), Enterobius vermicularis eggs (4.9%), various helminth larvae (3.6%), Hymenolepis nana eggs (2.8%), Hymenolepis diminuta eggs (2.1%), and Ascaris lumbricoides eggs (0.6%). The highest contaminated vegetable was lettuce (45.5%) followed by watercress (41.3%), parsley (34.3%), green onion (16.5%), and leek (10.7%). …”
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Protective Effects of Tormentic Acid on Unilateral Ureteral Obstruction-Induced Renal Injury, Inflammation, and Fibrosis: A Comprehensive Approach to Reducing Oxidative Stress, Apo... by Ah Young Yang, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyun Hee Kwon, Jaechan Leem, Eon-Ju Jeon

“…It suppressed cytokine expression and reduced immune cell infiltration, inhibited the activation of the mitogen-activated protein kinase cascade, and alleviated endoplasmic reticulum stress. …”
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Comparative Study of the Prevalence of Intestinal Parasites in Low Socioeconomic Areas from South Chennai, India by Jeevitha Dhanabal, Pradeep Pushparaj Selvadoss, Kanchana Muthuswamy

“…Entamoeba coli (23%), Cyclospora sp. (22.2%), Entamoeba histolytica (21.8%), Giardia intestinalis (14.4%), Ascaris lumbricoides (6.2%), Trichuris trichiura (1.1%), and Hymenolepis nana (2.7%) were found in the dwellers of low socioeconomic areas. …”
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Para ser Colombianos por Siempre: esferas privadas y públicas para la génesis y construcción de un colectivo migrante en Temuco by Lucero Paz Burón Rodríguez, Gonzalo Rodrigo Diaz Crovetto

“…La creación de esta colectividad migrante surge como una forma de contestar y marcar presencia frente a problemáticas que los afectan y frente a las representaciones que otros generan sobre ellos. …”
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Revision of the thylacocephalan biota from the Upper Triassic Polzberg Konservat-Lagerstätte, Austria by Thomas Laville, Petra Lukeneder, Alexander Lukeneder

“…Known for over 140 years, the Upper Triassic Polzberg Konservat-Lagerstätte is an exceptional early Carnian marine assemblage discovered in the Northern Calcareous Alps of Lower Austria. The Polzberg biota is composed of a diverse marine fauna, including two species of thylacocephalans, an enigmatic group of fossil euarthropods that was highly diversified during the Triassic and thus representing a major component of many marine faunas throughout the Triassic. …”
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Parasitic contamination of soil and vegetable crops irrigated with raw wastewater: A case study from Al-Far’a, Palestine by Sameer Qorom, Taleb. M Abu-Sharar, Randa N Albdaiwi

“…The highest and lowest soil contamination with parasites eggs pertained to A. lumbricoides (30.0%) and T. trichiurid (19.2%).Conclusion Certain mitigation measures should be used to limit the danger of farmers becoming infected with common parasites, particularly Ascaris lumbricoides. Farmers' awareness of the manner of parasite transmission and adherence to safety regulations should be among them.…”
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Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer by Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki

“…PGE2 is induced in the arachidonate cascade by COX-2. PGE2 maintains high expression of COX-2 and induces angiogenic factors including VEGF and bFGF, causing carcinogenesis. …”
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Enhancing immunotherapy efficacy in colorectal cancer: targeting the FGR-AKT-SP1-DKK1 axis with DCC-2036 (Rebastinib) by Xiguang Chen, Qiting Zeng, Liyang Yin, Bingru Yan, Chen Wu, Jianbo Feng, Ying Wu, Jun He, Wenjun Ding, Jing Zhong, Yingying Shen, Xuyu Zu

“…Moreover, our findings identify FGR as a pivotal modulator that influences DKK1 expression via the PI3K-AKT-SP1 signaling cascade. Correlative analysis of clinical specimens supports the experimental data, showing that increased levels of FGR and DKK1 in CRC tissues are associated with inferior clinical outcomes and reduced efficacy of immunotherapeutic interventions. …”
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The involvement of CgCaspase-3 in regulating the expressions of proinflammatory cytokines through NF-κB/Rel signaling pathway in oysters by Zihan Wang, Xiaopeng Li, Jiejie Sun, Shuyi Mu, Wei Wu, Renle Chang, Lingling Wang, Linsheng Song

“…Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a prominent mediator of apoptosis and participates in the cell death signaling cascade. In our previous study, CgCaspase-3 identified from Crassostrea gigas was involved in CgGSDME-dependent pyroptosis. …”
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Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro by Divya S. Varghese, Shama Parween, Mustafa T. Ardah, Bright Starling Emerald, Suraiya A. Ansari

“…However, during directed differentiation towards neural and hepatic fate, significant cell death was noted through the activation of caspase cascade. Also, the expression of neural progenitor markers Pax6, Emx2, Otx2, and Pou3f2 was significantly reduced suggesting that gentamicin may adversely affect early embryonic neurogenesis whereas no effect was seen on the expression of endoderm or hepatic markers during differentiation. …”
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Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD by Fabrizio Termite, Sebastiano Archilei, Francesca D’Ambrosio, Lucrezia Petrucci, Nicholas Viceconti, Roberta Iaccarino, Antonio Liguori, Antonio Gasbarrini, Luca Miele

“…Gut microbiota plays a substantial role in modulating hepatic oxidative stress through multiple pathways: impairing the intestinal barrier, which results in bacterial translocation and chronic hepatic inflammation; modifying bile acid structure, which impacts signaling cascades involved in lipidic metabolism; influencing hepatocytes’ ferroptosis, a form of programmed cell death; regulating trimethylamine N-oxide (TMAO) metabolism; and activating platelet function, both recently identified as pathogenetic factors in MASH progression. …”
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