Overexpression of MMP13 Is Associated with Clinical Outcomes and Poor Prognosis in Oral Squamous Cell Carcinoma by Vui King Vincent-Chong, Iman Salahshourifar, Lee Peng Karen-Ng, Ming Yhong Siow, Thomas George Kallarakkal, Anand Ramanathan, Yi-Hsin Yang, Goot Heah Khor, Zainal Ariff Abdul Rahman, Siti Mazlipah Ismail, Narayanan Prepageran, Wan Mahadzir Wan Mustafa, Mannil Thomas Abraham, Keng Kiong Tay, Sok Ching Cheong, Rosnah Binti Zain

“…Matrix metalloproteinase 13 (MMP13) plays a central role in the MMP activation cascade that enables degradation of the extracellular matrix and basement membranes, and it is identified as a potential driver in oral carcinogenesis. …”
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Molecular Mechanism of Macrophage Activation by Red Ginseng Acidic Polysaccharide from Korean Red Ginseng by Se Eun Byeon, Jaehwi Lee, Ji Hye Kim, Woo Seok Yang, Yi-Seong Kwak, Sun Young Kim, Eui Su Choung, Man Hee Rhee, Jae Youl Cho

“…According to pharmacological evaluation with specific enzyme inhibitors, Western blot analysis of intracellular signaling proteins and inhibitory pattern using blocking antibodies, ERK, and JNK were found to be the most important signaling enzymes compared to LPS signaling cascade. Further, TLR2 seems to be a target surface receptor of RGAP. …”
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Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer by Ayodeji Folorunsho Ajayi, Mega Obukohwo Oyovwi, Oyedayo Phillips Akano, Grace Bosede Akanbi, Florence Bukola Adisa

“…This review aims to provide an overview of the molecular pathways implicated in prostate and ovarian cancers, highlighting key genetic alterations, signaling cascades, and epigenetic modifications. A comprehensive literature search was conducted using databases such as PubMed, Web of Science, and Google Scholar. …”
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USP20 mediates malignant phenotypic changes in bladder cancer through direct interactions with YAP1 by Wensun Chen, Siqi Wu, Yifan Chen, Weijian Li, Yiqing Cao, Yingchun Liang, Xiyu Dai, Xinan Chen, Yilin Chen, Tian Chen, Shenghua Liu, Chen Yang, Haowen Jiang

“…Hippo pathway activity is controlled by the phosphorylation cascade in the MST1/2-LATS1/2-YAP1 axis, in addition to other modifications such as ubiquitination of the Hippo pathway proteins through the co-regulation of E3 ligases and deubiquitinases. …”
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Deep Vein Thrombosis and Pulmonary Embolism Secondary to Thrombophilic Disorder: A Case Report by Satbir Kaur Malik, Vineetha Naga Lakshmi Giduturi, Sindhuri Goud Nimmala, Vijayashree Gokhale

“…The most common inherited thrombophilias—such as Factor V Leiden mutation, prothrombin G20210A mutation and deficiencies in protein C, protein S and antithrombin III—are a group of genetic conditions that predispose individuals to thrombotic events by influencing various factors involved in the coagulation cascade. Deep Vein Thrombosis (DVT) is a common condition that is part of venous thromboembolism disorders and represents the third most common cause of death from cardiovascular disease, following heart attacks and strokes. …”
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Genetic Evidence of Killer Whale Predation on White Sharks in Australia by Isabella M. M. Reeves, Andrew R. Weeks, Alison V. Towner, Rachael Impey, Jessica J. Fish, Zach S. R. Clark, Paul A. Butcher, Lauren Meyer, David M. Donnelly, Charlie Huveneers, Nicky Hudson, Adam D. Miller

“…ABSTRACT Killer whales (Orcinus orca) have been documented to prey on white sharks (Carcharodon carcharias), in some cases causing localised shark displacement and triggering ecological cascades. Notably, a series of such predation events have been reported from South Africa over the last decade, with killer whales specifically targeting sharks' liver. …”
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Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability... by Garrick W. K. Spencer, Xu Li, Kenny W. L. Lam, George Mutch, Fiona H. Fry, Sally L. Gras

“…The enzyme codeine 3-O-demethylase can transform morphinan alkaloids by O-demethylation and has been applied in single step biotransformation reactions or as part of larger biosynthetic cascade, however, the productivity for these reactions remains low and suboptimal enzyme properties could be improved. …”
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A method of processing mechanical mixtures using vortex set of deep separation by V. I. Kuznetsov, O. A. Sharikov

“…The method involves processing mechanical mixtures using the new physical process of the vortex effect of the confuser, the series cascade connection of technological units in the main processing line and an additional line machines: separator-constrictors, cyclonesconstrictors, overpasses, separators exhaust air that drives the indivisible particles of the mixture of the overpass with the ejector, to reuse the exhaust air. …”
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Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage by Patrick Van Dreden, Guy Hue, Jean-François Dreyfus, Barry Woodhams, Marc Vasse

“…Brain contains large amounts of tissue factor, the major initiator of the coagulation cascade. Neuronal apoptosis after intracerebral haemorrhage (ICH) leads to the shedding of procoagulant phospholipids (PPLs). …”
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Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights by Akhil Hegde, Yung-Hua Koh, Shabbir M. Moochhala, Madhav Bhatia

“…We conclude that substance P acting via neurokinin-1 receptor in sepsis initiated signaling cascade mediated mainly by protein kinase C-α, led to NF-κB and activator protein-1 activation, and further modulated proinflammatory mediators.…”
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Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes by J. R. Thiele, J. Zeller, H. Bannasch, G. B. Stark, K. Peter, S. U. Eisenhardt

“…The chance to prevent the formation of proinflammatory mediators in ubiquitous inflammatory cascades has pushed therapeutic strategies by targeting pCRP dissociation in inflammation. …”
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Sophocarpine Attenuates LPS-Induced Liver Injury and Improves Survival of Mice through Suppressing Oxidative Stress, Inflammation, and Apoptosis by Zhengyu Jiang, Yan Meng, Lulong Bo, Changli Wang, Jinjun Bian, Xiaoming Deng

“…Mechanistic evidence was also investigated in the present study as sophocarpine inhibited hepatic expression of the CYP2E/Nrf2 pathway during oxidative stress, inactivated p38/JNK cascade and NF-κB pathway, and, meanwhile, suppressed PI3K/AKT signaling that reduced apoptosis. …”
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Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer by Pathea Shawnae Bruno, Aneeta Arshad, Maria-Raluca Gogu, Natalie Waterman, Rylie Flack, Kimberly Dunn, Costel C. Darie, Anca-Narcisa Neagu

“…In this review, we summarized and analyzed a wide spectrum of PTMs of proteins involved in all regulatory mechanisms that drive tumorigenesis, genetic instability, epigenetic reprogramming, all events of the metastatic cascade, cytoskeleton and extracellular matrix (ECM) remodeling, angiogenesis, immune response, tumor-associated microbiome, and metabolism rewiring as the most important hallmarks of cancer. …”
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The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis by Denis Grandgirard, Rahel Gäumann, Boubacar Coulibaly, Jean-Pierre Dangy, Ali Sie, Thomas Junghanss, Hans Schudel, Gerd Pluschke, Stephen L. Leib

“…The brain’s inflammatory response to the infecting pathogen determines the outcome of bacterial meningitis (BM), for example, the associated mortality and the extent of brain injury. The inflammatory cascade is initiated by the presence of bacteria in the cerebrospinal fluid (CSF) activating resident immune cells and leading to the influx of blood derived leukocytes. …”
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Identidades suspendidas por el silencio, la opacidad, la vergüenza y los tabúes. Narrativas sobre violencia sexual en la guerra irregular en el Caribe colombiano by Viridiana Molinares Hassan, Carlos Andrés Orozco Arcieri, Julia Sandra Bernal Crespo

“…En este artículo presentamos los primeros resultados del trabajo de campo realizado en el marco de la investigación Narrativas de la violencia sexual en la guerra irregular en el Caribe colombiano: voces de homosexua les, transexuales, intersexuales, bisexuales y lesbianas , cuyo objetivo es narrar literariamente casos de violencia sexual perpetrados por los grupos paramilitares arraigados en esta zona del país contra la población LGTBI del Caribe colombiano. …”
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Audio2DiffuGesture: Generating a diverse co-speech gesture based on a diffusion model by Hongze Yao, Yingting Xu, Weitao WU, Huabin He, Wen Ren, Zhiming Cai

“…Specifically, we employed cascaded 1D convolutions to extract features from the audio waveform and a two-stage attention mechanism to capture features from the Mel-spectrogram. …”
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The EGF Receptor and HER2 Participate in TNF-α-Dependent MAPK Activation and IL-8 Secretion in Intestinal Epithelial Cells by Humberto B. Jijon, Andre Buret, Christina L. Hirota, Morley D. Hollenberg, Paul L. Beck

“…TNF-α activates multiple mitogen-activated protein kinase (MAPK) cascades in intestinal epithelial cells (IECs) leading to the secretion of interleukin 8 (IL-8), a neutrophil chemoattractant and an angiogenic factor with tumor promoting properties. …”
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Soil-Transmitted Helminth Reinfection and Associated Risk Factors among School-Age Children in Chencha District, Southern Ethiopia: A Cross-Sectional Study by Zerihun Zerdo, Tsegaye Yohanes, Befikadu Tariku

“…The estimated prevalence of reinfection (95%CI) for Ascaris lumbricoides, Trichuris trichiura, and hookworms was 23.8% (21.1–28.2), 16.2% (12.7–20.1), and 1.0% (0.3–2.5), respectively. …”
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Second-generation anti-amyloid monoclonal antibodies for Alzheimer’s disease: current landscape and future perspectives by Byeong-Hyeon Kim, Sujin Kim, Yunkwon Nam, Yong Ho Park, Seong Min Shin, Minho Moon

“…Notably, lecanemab received traditional approval after demonstrating clinical benefit, supporting the Aβ cascade hypothesis. These MABs targeting Aβ are categorized based on their affinity to diverse conformational features of Aβ, including monomer, fibril, protofibril, and plaque forms of Aβ as well as pyroglutamate Aβ. …”
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Recognition of Blow Foraminifera Zones in the Tertiary Sediments in F- Well, Niger Delta by F.A. Lucas, O.E. Ononeme

“…A total of eighty (80) foraminiferal species were recorded, most of the species recorded are calcareous and arenaceous benthic  foraminiferal species. …”
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