Protective Effects of Tormentic Acid on Unilateral Ureteral Obstruction-Induced Renal Injury, Inflammation, and Fibrosis: A Comprehensive Approach to Reducing Oxidative Stress, Apo... by Ah Young Yang, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyun Hee Kwon, Jaechan Leem, Eon-Ju Jeon

“…It suppressed cytokine expression and reduced immune cell infiltration, inhibited the activation of the mitogen-activated protein kinase cascade, and alleviated endoplasmic reticulum stress. …”
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Construção de HQs no ensino de Matemática: relato de experiência com alunos do Ensino Fundamental by Samira Santos Ferrugine, Marta Vieira da Silva, Dilson Henrique Ramos Evangelista, Cristiane Johann Evangelista

“… As histórias em quadrinhos (HQs) são ferramentas utilizadas para narrar histórias por meio de figuras e pequenos textos em forma de balões de forma prática e divertida. …”
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Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer by Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki

“…PGE2 is induced in the arachidonate cascade by COX-2. PGE2 maintains high expression of COX-2 and induces angiogenic factors including VEGF and bFGF, causing carcinogenesis. …”
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Enhancing immunotherapy efficacy in colorectal cancer: targeting the FGR-AKT-SP1-DKK1 axis with DCC-2036 (Rebastinib) by Xiguang Chen, Qiting Zeng, Liyang Yin, Bingru Yan, Chen Wu, Jianbo Feng, Ying Wu, Jun He, Wenjun Ding, Jing Zhong, Yingying Shen, Xuyu Zu

“…Moreover, our findings identify FGR as a pivotal modulator that influences DKK1 expression via the PI3K-AKT-SP1 signaling cascade. Correlative analysis of clinical specimens supports the experimental data, showing that increased levels of FGR and DKK1 in CRC tissues are associated with inferior clinical outcomes and reduced efficacy of immunotherapeutic interventions. …”
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The involvement of CgCaspase-3 in regulating the expressions of proinflammatory cytokines through NF-κB/Rel signaling pathway in oysters by Zihan Wang, Xiaopeng Li, Jiejie Sun, Shuyi Mu, Wei Wu, Renle Chang, Lingling Wang, Linsheng Song

“…Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a prominent mediator of apoptosis and participates in the cell death signaling cascade. In our previous study, CgCaspase-3 identified from Crassostrea gigas was involved in CgGSDME-dependent pyroptosis. …”
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Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro by Divya S. Varghese, Shama Parween, Mustafa T. Ardah, Bright Starling Emerald, Suraiya A. Ansari

“…However, during directed differentiation towards neural and hepatic fate, significant cell death was noted through the activation of caspase cascade. Also, the expression of neural progenitor markers Pax6, Emx2, Otx2, and Pou3f2 was significantly reduced suggesting that gentamicin may adversely affect early embryonic neurogenesis whereas no effect was seen on the expression of endoderm or hepatic markers during differentiation. …”
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Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD by Fabrizio Termite, Sebastiano Archilei, Francesca D’Ambrosio, Lucrezia Petrucci, Nicholas Viceconti, Roberta Iaccarino, Antonio Liguori, Antonio Gasbarrini, Luca Miele

“…Gut microbiota plays a substantial role in modulating hepatic oxidative stress through multiple pathways: impairing the intestinal barrier, which results in bacterial translocation and chronic hepatic inflammation; modifying bile acid structure, which impacts signaling cascades involved in lipidic metabolism; influencing hepatocytes’ ferroptosis, a form of programmed cell death; regulating trimethylamine N-oxide (TMAO) metabolism; and activating platelet function, both recently identified as pathogenetic factors in MASH progression. …”
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Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway by Yuqin Ye, Zhenyu Zhao, Hongyu Xu, Xin Zhang, Xinhong Su, Yongxiang Yang, Xinguang Yu, Xiaosheng He

“…More importantly, it was suggested that mitogen-activated protein kinase-Erk kinase (MEK)/Erk cascade was required for S1PR1-meidated neurogenesis and neurocognitive recovery following TBI. …”
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Ginkgo biloba Extract Improves Insulin Signaling and Attenuates Inflammation in Retroperitoneal Adipose Tissue Depot of Obese Rats by Bruna Kelly Sousa Hirata, Renata Mancini Banin, Ana Paula Segantine Dornellas, Iracema Senna de Andrade, Juliane Costa Silva Zemdegs, Luciana Chagas Caperuto, Lila Missae Oyama, Eliane Beraldi Ribeiro, Monica Marques Telles

“…In the present study we aimed to evaluate the effect of GbE on both inflammatory cascade and insulin signaling in retroperitoneal fat depot of diet-induced obese rats. …”
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Congenital cytomegalovirus - current state of knowledge on the treatment and prevention of fetuses and newborns by Katarzyna Miedzińska, Mateusz Grego, Łukasz Stojak, Dariusz Popiela, Karina Urbańska, Filip Kwiatkowski, Mateusz Baczewski, Witold Czyż

“…It is a component of the acronym TORCH describing pathogens which are a significant risk factor for miscarrings or serious damage to the fetus. Symptomatic congenital cytomegalovirus occurs in about 10% of infected newborns and, among of the other things, can cause hearing loosing, vision impairment or cognitive impairment in the children. …”
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The Effect of Periodontitis on Expression of Interleukin-21: A Systematic Review by Archana Mootha, Sankari Malaiappan, N. D. Jayakumar, Sheeja S. Varghese, Julie Toby Thomas

“…Interleukin-21 (IL-21) has been associated with systemic diseases like rheumatoid arthritis and Crohn’s disease that follow a chronic inflammatory cascade. Similarly recent studies have associated Interleukin-21 levels with periodontitis. …”
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Lung-specific CRBN knockout attenuates influenza a virus-induced acute lung injury in mice: a potential therapeutic approach by Lifang Zhang, Qingchao Zhang, Jiahui Chang, Yunyi Zhou, Wei Wang, Xiliang Wang, Chengyu Jiang, Yanli Zhang

“…PR8-infected Sftpc-Cre; Crbn flox/flox mice exhibited a marked reduction in lung inflammatory cell infiltration and suppression of MAPK pathway activation, highlighted by a significant downregulation of the MKK4-JNK-c-JUN signaling cascade. Collectively, these findings indicate that CRBN plays a pivotal role in the pathogenesis of influenza-induced lung injury by modulating MAPK pathway signaling, underscoring its therapeutic potential as a target for intervention.…”
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Criptografia em Funções Polinomiais: Um Processo de Ensino e Aprendizagem de Matemática na Educação Básica by Edel Alexandre Silva Pontes, Bruno Henrique Macêdo dos Santos Silva, Elinelson Gomes de Oliveira, Lidianne Leite e Lira

“…O conceito de criptografia nasceu precisamente dessa necessidade de se remeter mensagens, com total segurança, entre dois ou mais agentes. …”
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Peran Konselor dalam Meningkatkan Daya Ingat Belajar Siswa by Dini Fitriani, Ifdil Ifdil

“…Pada saat proses belajar individu menerima rangsangan dari stimulus-stimulus yang ada , dalam proses belajar belum ada faktor yang mendukung dan tidak mendukung berjalannya dengan lancar suatu proses belajar tersebut.Pada kenyataanya siswa tidak mampu dalam menjalankan dan mengembangkan potensi potensi yang ada pada dirinya , terkadang siswa tidak mampu mengimbangi faktor-faktor yang ada , salah satu nya adalah faktor yang sangat berpengaruh terhadap proses belajar sisswa adalah faktor daya ingta siswa tersebut. lemah atau kuatnya ssiswa dalam menginta pelajaran yanga da di tingkat pendidikannya.Bertolak dari permasalahn diatas, maka penulis akan membahas makalah ini dengan judul ‘Peran Koselor dalam Meningkatkan Daya Ingat Belajar Siswa’’ yang bertujuan untuk membantu dan mengarahkan siswa agar mampu meningkatkan dan mengingat pelajaran-pelajaran dengan baik.…”
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An improved DeepLabv3 + railway track extraction algorithm based on densely connected and attention mechanisms by Yanbin Weng, Jie Yang, Changfan Zhang, Jing He, Cheng Peng, Lin Jia, Hui Xiang

“…Secondly, the receptive field is enlarged by cascading atrous convolutions with different dilation rates in the ASPP (atrous spatial pyramid pooling) module, and other feature maps are concatenated using the multi-scale attention module to enhance the extraction accuracy of the model. …”
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Physical experimental simulation of unconventional reservoir formation process for carboniferous in Hudson Oilfield, Tarim Basin by Rujun Wang, Yongliang Tang, Wei Zhou, Daiyu Zhou, Zangyuan Wu, Guangqiang Shao

“…Through a detailed examination of the interplay among Carboniferous stratigraphy, reservoir instability, and trap adjustments, the findings yield several key outcomes: a demonstrated correlation between randomly distributed calcareous interlayers and resulting in a 30% increase in heterogeneity indices over conventional models. …”
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Biomimic Nanodrugs Overcome Tumor Immunosuppressive Microenvironment to Enhance Cuproptosis/Chemodynamic‐Induced Cancer Immunotherapy by Hangyi Wu, Xiaoyu Lu, Yuhan Hu, J. Baatarbolat, Zhihao Zhang, Yiping Liang, Youwen Zhang, Ye Liu, Huixia Lv, Xin Jin

“…Extra intracellular Cu induces cuproptosis and chemodynamic therapy (CDT), which further cascades immunogenic cell death (ICD) and activates antitumor immune responses. …”
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Key drivers of the TB epidemic in Suriname and priority actions to reduce incidence and mortality by E. Commiesie, D. Stijnberg, J. van den Boogaard, F. Gopie, S. Vreden, G. de Vries

“…CONCLUSION: The review identified the following areas of concern: no decline in TB rates, high proportion of TB-HIV co-infection, high rate of resistance to rifampicin, high case-fatality rates and suboptimal contact investigation care cascade . The review was used to inform interventions and key actions to reduce TB morbidity and mortality in Suriname.…”
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Progesterone induces meiosis through two obligate co-receptors with PLA2 activity by Nancy Nader, Lama Assaf, Lubna Zarif, Anna Halama, Sharan Yadav, Maya Dib, Nabeel Attarwala, Qiuying Chen, Karsten Suhre, Steven Gross, Khaled Machaca

“…Despite the established physiological importance of P4 nongenomic signaling, the details of its signal transduction cascade remain elusive. Here, using Xenopus oocyte maturation as a well-established physiological readout of nongenomic P4 signaling, we identify the lipid hydrolase ABHD2 (α/β hydrolase domain-containing protein 2) as an essential mPRβ co-receptor to trigger meiosis. …”
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Tenidap sodium inhibits secretory non-pancreatic phospholipase A2 synthesis by foetal rat calvarial osteoblasts by W. Pruzanski, B. P. Kennedy, H. van den Bosch, E. Stefanski, M. Wloch, P. Vadas

“…Therefore TD seems to inhibit the arachidonic acid cascade proximally to cyclooxygenase and lipoxygenase and its anti-inflammatory activity may be related at least in part to the inhibition of sPLA2 synthesis.…”
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