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2041
Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentum
Published 2025-01-01“…Mechanistic insights delve into molecular pathways elucidating the interactions of D. esculentum bioactives with cellular targets and signalling cascades. Furthermore pharmacokinetic considerations shed light on the absorption distribution metabolism and excretion ADME profiles of its constituents providing critical insights into their bioavailability and pharmacological efficacy. …”
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2042
Comportamiento de parasitismo intestinal en el área de salud de Potrerillo
Published 2015-12-01“…<br /><strong>Resultados:</strong> de los 286 análisis realizados 52 resultaron positivos, para un frecuencia parasitaria de 18, 1 %; entre los protozoarios predominó la Entamoeba histolytica con 8, 04 % fundamentalmente en adultos (6, 99 %), la Giardia lamblia (5,59 %) con predominio en los niños (3, 49 %), la frecuencia de presentación de los helmintos fue de 4, 53 % y predominó el Áscaris lumbricoides con 4, 19 % entre los infantes (ocho niños) y cuatro adultos 1,39 % y Trichuris trichiura (0, 34 %) en un niño.…”
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2043
Investigating Use of Crushed Glass as Partial Replacement of Sand to Improve Finish Mortar Strength.
Published 2025“…The high calcium oxide content and low magnesium oxide content probably mean that lime was provided from calcareous stones rather than dolomitic.…”
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2044
Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions
Published 2023-04-01“…Internalization of SARS‐CoV‐2 triggers ROS production and modulation of the immunological cascade which ultimately initiates the hypercoagulable state and vascular thrombosis. …”
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2045
Vitamin D Receptor, Retinoid X Receptor, Ki-67, Survivin, and Ezrin Expression in Canine Osteosarcoma
Published 2012-01-01“…Upon activation, vitamin D receptors (VDRs) combine with retinoid receptor (RXR) forming a heterodimer initiating a cascade of events. Vitamin D's antineoplastic activity and its mechanism of action in OS remain to be clearly established. …”
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2046
The Expanding Family of Bone Marrow Homing Factors for Hematopoietic Stem Cells: Stromal Derived Factor 1 Is Not the Only Player in the Game
Published 2012-01-01“…Moreover, the responsiveness of HSPCs to an SDF-1 gradient is enhanced by some elements of innate immunity (e.g., C3 complement cascade cleavage fragments and antimicrobial cationic peptides, such as cathelicidin/LL-37 or β2-defensin) as well as prostaglandin E2 (PGE2). …”
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2047
Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives
Published 2025-02-01“…Ferroptosis is a new form of regulatory cell death caused by iron-dependent lipid peroxidation, which has a dual role in PCa evolution and treatment due to the multi-omics cascade of interactions among pathways and environmental stimuli. …”
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2048
A Smart Nanomedicine Unleashes a Dual Assault of Glucose Starvation and Cuproptosis to Supercharge αPD‐L1 Therapy
Published 2025-01-01“…Such novel nanomedicine is able to induce lung cancer cell cuproptosis and PD‐L1 upregulation significantly via self‐amplified cascade reactions. Meanwhile, with a decent cancer cell membrane coating, CMGCL exhibited great biosafety, tumor‐targeted efficiency and anti‐tumor effects in LLC lung tumor‐bearing mice models. …”
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2049
Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque
Published 2017-01-01“…Pathway analyses indicated that the biological functions of differentially expressed proteins were related to glycolysis/gluconeogenesis, fatty acid metabolism, complements, and coagulation cascades. Expression change in tryptophan metabolism pathway was also found in this study which may be associations with diabetes. …”
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2050
Tumor microbiome: roles in tumor initiation, progression, and therapy
Published 2025-02-01“…We further propose the tumor microbiome may evade immunity and promote angiogenesis to support tumor progression, while uncovering specific microbial influences on each step of the metastatic cascade, such as invasion, circulation, and seeding in secondary sites. …”
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2051
Peroxiredoxin 6 Attenuates Alloxan-Induced Type 1 Diabetes Mellitus in Mice and Cytokine-Induced Cytotoxicity in RIN-m5F Beta Cells
Published 2020-01-01“…Signal transduction studies showed that PRDX6 prevented the activation of NF-κB and c-Jun N-terminal kinase signaling cascades in RIN-m5F β cells cultured with cytokines. …”
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2052
Method for improving voltage sag tolerance of dual power supply PET based on inter-port power coordination
Published 2025-01-01“…Dual power supply cascaded-type power electronic transformers (DPSC-PET) is connected to two power supplies with high operational reliability and flexible operation mode, and it can be widely used in medium and low voltage distribution networks. …”
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2053
Iddah dan ihdad sebagai pendidikan moral di era modern; issue emansipasi dan pemanfaatan media sosial
Published 2023-06-01“…Namun, perlu diketahui bahwa iddah akan berjalan lancar jika suami sudah memenuhi kewajiban nafkah dan hak untuk istri yang ditinggalkan yang diberikan selama menjalankan masa iddah. …”
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2054
Mathematical model of the 9th version Universal modeling method: features and results of identification
Published 2020-12-01“…Determining the non-incidence inlet in a blade cascade is an important part of calculating the compressor gas-dynamic characteristics. …”
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2055
The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood
Published 2019-01-01“…Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) contribute to the inflammatory cascade in the cerebrospinal fluid (CSF) during bacterial meningitis. …”
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2056
Effect of Antrodia camphorata on Inflammatory Arterial Thrombosis-Mediated Platelet Activation: The Pivotal Role of Protein Kinase C
Published 2014-01-01“…In conclusion, Antrodia camphorata may inhibit platelet activation by inhibiting of Ca2+ and PKC cascade and the Akt pathway. Our study suggests that Antrodia camphorata may be a potential therapeutic agent for preventing or treating thromboembolic disorders.…”
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2057
The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis
Published 2025-02-01“…Immune responses participate in lipid abnormalities within the EIME by downregulating barrier gene expression and are further cascade-amplified by microbial dysregulation which is instigated by barrier impairment. …”
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2058
The effect of AKT inhibition in α-synuclein-dependent neurodegeneration
Published 2025-02-01“…These findings highlight the AKT cascade as a potential therapeutic target for synucleinopathies and provide insights into mechanisms that could be utilized to reduce α-Syn toxicity in PD and related disorders, such as multiple system atrophy.…”
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2059
Perbedaan Jumlah Perdarahan Saat Persalinan Pada Ibu Primigravida Yang Melakukan Dan Tidak Melakukan Senam Hamil Selama Kehamilan Trimester III
Published 2019-05-01“…American College of Obstetricans and Gynecologist merekomendasikan senam selama kehamilan agar persalinan lancar dan mengurangi komplikasi saat persalinan. …”
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2060
Evolving concepts in intracranial pressure monitoring - from traditional monitoring to precision medicine
Published 2025-01-01“…A wide range of acute brain injuries, including both traumatic and non-traumatic causes, can result in elevated intracranial pressure (ICP), which in turn can cause further secondary injury to the brain, initiating a vicious cascade of propagating injury. Elevated ICP is therefore a neurological injury that requires intensive monitoring and time-sensitive interventions. …”
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