Evaluación del rol del equipo de coordinación de nefrología en la consulta externa específica de acceso vascular. ¿Qué podemos aportar de nuevo? by Néstor Fontseré, Gaspar Mestres, Xavi Yugueros, Daniel Gil, Carla Blanco, Valentín Lozano, Lidia María Rodas, Arantxa Gelabert, Paula Escarcena, Rosa Ramos, Francisco Maduell

“…Of the total number of procedures, nephrology obtained an adequate degree of agreement in 93.6% of the cases (kappa index: 0.886). The preoperative factors associated with greater discrepancies in assessments were age (P=.022) and arterial diameter (P =.032). …”
Get full text

Clinical evaluation of a multiplex droplet digital PCR for diagnosing suspected bloodstream infections: a prospective study by Yaqin Peng, Ruijie Xie, Yifeng Luo, Yifeng Luo, Yifeng Luo, Penghao Guo, Zhongwen Wu, Yili Chen, Pingjuan Liu, Jiankai Deng, Bin Huang, Kang Liao

“…Taking BC as the gold standard, receiver operating characteristic curve and Cohen’s kappa agreement were used to investigate whether the pathogen load could predict a corresponding culture-proven BSI for the top five microorganisms detected by ddPCR.ResultsOf the 173 blood samples collected, BC and ddPCR were positive in 48 (27.7%) and 92 (53.2%) cases, respectively. …”
Get full text

Performance of emergency triage prediction of an open access natural language processing based chatbot application (ChatGPT): A preliminary, scenario-based cross-sectional study by İbrahim Sarbay, Göksu Bozdereli Berikol, İbrahim Ulaş Özturan

“…Reliability analysis showed a fair agreement between EM specialists and ChatGPT (Cohen’s Kappa: 0.341). Eleven cases (22%) were over triaged and 9 (18%) cases were under triaged by ChatGPT. …”
Get full text

Investigation of the Mechanism Underlying Calcium Dobesilate-Mediated Improvement of Endothelial Dysfunction and Inflammation Caused by High Glucose by Yijun Zhou, Chaojun Qi, Shu Li, Xinghua Shao, Zhaohui Ni

“…Western blot and real-time PCR analyses were used to detect PTX3, p-IKBa/IKBa (I-kappa-B-alpha), and p-eNOS/eNOS (endothelial nitric oxide synthase) expression in mice and HUVECs. …”
Get full text

尿液中ErbB3蛋白在肾透明细胞癌早期诊断中的意义 by 莫承强, 王思豪, 潘金成, 丘少鹏

“…② 建立使用尿液ErbB3蛋白对肾透 明细胞癌进行早期诊断的ROC曲线，曲线下面积为0.802（P<0.001），当取诊断分界值为13.98 时，约登指数最大 为0.525，对应的诊断试验灵敏度为0.645，特异度0.880。诊断试验的Kappa值为0.542（P<0.001）。③ 实验组患 者尿液ErbB3蛋白含量与患者BMI、肿瘤病理直径、术前肌酐、血压及血糖无明显相关性。…”
Get full text

A novel ddPCR™ assay for eDNA detection and quantification of Greater Amberjack Seriola dumerilli and three congeners in US waters: challenges and application to fisheries independ... by P. Joana Dias, Ryan Lehman, Bryan L. Huerta-Beltrán, Ana Wheeler, Crystal L. Hightower, Jessica Heise, Theodore Switzer, Clint Rhode, J. Marcus Drymon, Lynne Stokes, Mark A. Albins, Sean Powers, Nicole Phillips

“…In order to groundtruth ddPCR™ data, and explore its capacity to provide abundance estimates, we compared ddPCR™ detections and quantifications to abundance data inferred from multiple camera (ROV, S-BRUV, chevron trap) and acoustic (VPS array) gears deployed during a fisheries research gear-calibration cruise. …”
Get full text

Inflammation and Immune Escape in Ovarian Cancer: Pathways and Therapeutic Opportunities by Liu C, Yin Q, Wu Z, Li W, Huang J, Chen B, Yang Y, Zheng X, Zeng L, Wang J

“…Inflammatory cytokines, including IL-6, TNF-α, and IL-8, as well as key signaling pathways such as nuclear factor kappa B (NF-kB) and signal transducer and activator of transcription 3 (STAT3), are upregulated in OC, promoting a tumor-promoting environment. …”
Get full text

Influencia de actividades agropecuarias sobre la deforestación en la Zona Norte del Paraguay by Antonio Anibal Benítez Cañiza, Alicia Raquel Eisenkölbl Closs

“…La clasificación del uso de la tierra en áreas deforestadas se realizó mediante técnicas de teledetección, utilizando imágenes de los satélites Landsat 5 TM y Landsat 8 OLI, y se complementó con el análisis geoestadístico índice Kappa. El período de estudio abarco desde 2005 hasta 2018, y las variables analizadas incluyeron a la soja como por ejemplo el principal rubro de agricultura empresarial, actividad ganadera y la agricultura familiar campesina (AFC) en áreas deforestadas. …”
Get full text

CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment by Yu Wang, Haiyan Xu, Li Cai, Yang Sun, Liwei Wang, Ming Yue, Xiaofei Zhang, Yanling Wang, Shumin Li, Shengbai Xue, Jingyu Ma, Tiebo Mao, Weiyu Ge, Daiyuan Shentu, Wenxin Lu, Yongchao Wang, Jiong Hu, Jiujie Cui

“…Then, we established gene-modified cells to determine whether CREB3L1 functions in cell proliferation and migration capacity. Besides, we constructed subcutaneously and orthotopically transplanted mice models to verify their progrowing function and pulmonary metastasis models to prove their proinvasion role. …”
Get full text

Safety, Tolerability, and Immunogenicity of the Invaplex_AR-Detox <i>Shigella</i> Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protoc... by Geert V. T. Roozen, Nsofwa Sukwa, Masuzyo Chirwa, Jessica A. White, Marcus Estrada, Nicole Maier, Kevin R. Turbyfill, Renee M. Laird, Akamol E. Suvarnapunya, Aicha Sayeh, Flavia D’Alessio, Candice Marion, Laura Pattacini, Marie-Astrid Hoogerwerf, Rajagopal Murugan, Manuela Terrinoni, Jan R. Holmgren, Sodiomon B. Sirima, Sophie Houard, Michelo Simuyandi, Meta Roestenberg

“…Besides strengthening the vaccine pipeline against a major diarrheal disease, another goal of the ShigaPlexIM project is to stimulate capacity building and strengthen global North-South relations in clinical research. …”
Get full text

Reliability and Measurement Error of the Qualitative Analysis of Single Leg Loading (QASLS) Tool For Unilateral Tasks by Gemma N Parry, Lee C Herrington, Allan G Munro

“…Intra-Class correlation coefficients (ICC~k,3~) were used to measure within and between session reliability, and Kappa coefficients and percentage of exact agreement (PEA%) were used to determine intra and inter-rater reliability. …”
Get full text

Spatiotemporal analysis of oil palm land clearing by M.K. Rosyidy, E. Frimawaty

“…Accuracy assessment of classification results uses a confusion matrix taking into account overall accuracy and Kappa Hat. Within the field observation, the validation class is the oil palm class, using documentation and plotting using the global positioning system, and other classes are validated using the Region of Interest collected through Google Earth. …”
Get full text

Dynamics of land use land cover change and its effect on urban heat island in Halaba Kulito Town by Begonet Dale, Mihret Dananto, Bisrat Kifle

“…For the years 1991, 2001, 2011, and 2021, the LULC change classification accuracy evaluation showed results of 70.81 %, 81.3 %, 81 %, 91 %, and 0.71, 0.81, 0.81, and 0.89, respectively, for overall classification accuracy and kappa coefficient. In 2001, 2011, and 2021, the built-up increased by 23.6 %, 31.6 %, and 43.13 %, respectively. …”
Get full text

CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma by Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Catrin Heim, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Philipp Wendel, Philipp Wendel, Philipp Wendel, Philipp Wendel, Süleyman Bozkurt, Sabine Harenkamp, Hermann Kreyenberg, Hermann Kreyenberg, Michael Merker, Michael Merker, Christian Münch, Christian Münch, Christian Münch, Elise Gradhand, Meike Vogler, Meike Vogler, Meike Vogler, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Halvard Bönig, Halvard Bönig, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger

“…CIK cells are a heterogenous population of predominantly T cells with a mixed natural killer (NK) phenotype and combine non-MHC-restricted cytotoxicity with potent anti-tumor capacity of the adaptive immune system. Here, we characterize and compare efficacy, phenotypic subpopulations and modes of action of CAR-CIK cells and conventional CAR-T cells from same-donor samples in ErbB2+ rhabdomyosarcoma (RMS).MethodsTo benchmark CAR-CIK against conventional CAR-T cells, effector cells were generated from same-donor samples and lentivirally transduced with a second generation CD28-CD3ζ CAR. …”
Get full text

Pink1/Parkin signaling mediates pineal mitochondrial autophagy dysfunction and its biological role in a comorbid rat model of depression and insomnia by Zirong Li, Yi Shu, Deguo Liu, Sheng Xie, Liangbo Xian, Jiaqi Luo, Xiuwen Huang, Haixing Jiang

“…The results showed that the levels of reactive oxygen species (ROS) in cerebrospinal fluid of CUMS+SD rats significantly increased along with the inflammatory factors Interleukin-1β (IL-1β) and nuclear factor kappa-B (NF-κB) in cerebrospinal fluid. In addition, the number of pineal gland cells significantly decreased, cell boundaries became blurred, cell volume shrank, and apoptotic bodies appeared in the pineal gland tissue under HE staining, indicating pineal gland inflammation. …”
Get full text

Factors associated with physical fitness and disparities in population segments among older adults: A cross-sectional study by Yuqin Rao, Jingjing Wang, Kai Li, Fanhui Zheng, Ying Chen, Bo Zhai, Jintao Hong, Chen Wang, Bao Liu, Dao Wang

“…Participants completed physical fitness assessments encompassing body fat percentage, lung capacity, high leg raise in place, grip strength, seated forward bending, 30-s sit-to-stand test, single-leg standing with eyes closed, and choice reaction time. …”
Get full text

Brucella suis ΔmapB outer membrane vesicles as an acellular vaccine against systemic and mucosal B. suis infection by Florencia Muñoz González, Florencia Muñoz González, Magali G. Bialer, Maria L. Cerutti, Silvia M. Estein, Lila Y. Ramis, Pablo C. Baldi, Pablo C. Baldi, Ángeles Zorreguieta, Ángeles Zorreguieta, Mariana C. Ferrero, Mariana C. Ferrero

“…Immunogenicity was assessed by intramuscular immunization of mice with wt OMVs or ΔmapB OMVs, followed by the measurement of antigen-specific antibody levels and functional assays to evaluate the protective capacity of the antibodies. Cellular immunity was assessed by characterizing cytokine secretion through ELISA after in vitro stimulation of spleen cells with heat-killed B. suis. …”
Get full text

The value-added model of the supply chain of petrochemical industries with a sustainable development approach by ali amiri, seyed abbas heydari, vahidreza Mirabi

“…The results of the investigations showed that the excessive increase in the sending capacity, the increase in the volume of orders, and the decrease in the time of sending the orders will have their own positive and negative results; which the creation of a favorable and optimal situation based on the various outputs of the model will be fruitful in the context of the organization's policy adopting. …”
Get full text

Designing a Digital Branding Pattern in Healthy Agricultural Products by Abolghasem Mohammadnezhad Ali Zamini, Arezo Ahmadi danyali, Mahmoud Ahmadi Sharif

“…In addition, agriculture plays a major role in shaping the country's export capacity and import substitution program. In recent years, agricultural trade has been developed in most industries in raw materials and feed production.  …”
Get full text

Overexpression of the <i>GmPM35</i> Gene Significantly Enhances Drought Tolerance in Transgenic Arabidopsis and Soybean by Xinyu Wang, Yao Sun, Rui Wang, Xinyang Li, Yongyi Li, Tianyu Wang, Zhaohao Guo, Yan Li, Wenxi Qiu, Shuyan Guan, Qi Zhang, Piwu Wang, Mingze Li, Siyan Liu, Xuhong Fan

“…In addition, we found that under drought stress, the MDA content was reduced by an average of 18.8%, and the Pro content was increased by an average of 60.14% in soybean plants overexpressing the <i>GmPM35</i> gene, and the changes in these indexes indicated that the plants had stronger antioxidant and osmoregulatory capacities in response to drought stress. In summary, this experiment demonstrated that the <i>GmPM35</i> gene plays an important role in soybean tolerance to drought stress, and by overexpressing the <i>GmPM35</i> gene, soybean plants can better tolerate drought stress and maintain normal physiological functions.…”
Get full text