Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy by Julia Uffenorde, Mehran Hariri, Eleftherios Papalanis, Annika Staffas, Josefine Berg, Bo Stenerlöw, Hanna Berglund, Christer Malmberg, Diana Spiegelberg, Diana Spiegelberg

“…In this study, we investigated the effect of HSP90 inhibition in combination with radiotherapy in established and patient-derived glioblastoma cell lines.MethodsPotential radiosensitizing effects of the HSP90 inhibitor Onalespib were studied in XTT and clonogenic survival assays as well as in tumor-mimicking multicellular spheroid models. Further, migration capacity and effects on protein expression were studied after exposure to Onalespib and radiation using Proximity Extension Assay analysis.ResultsHSP90 inhibition with Onalespib synergistically enhanced the radiosensitivity of glioblastoma cells grown in 2D and 3D models, resulting in increased cell death, reduced migration capacity and activation of the apoptotic signaling pathway. …”
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Comparative Analysis of Antioxidant Potency and Phenolic Compounds in Fruit Peel of Opuntia robusta, Opuntia dillenii, and Opuntia ficus-indica Using HPLC-DAD Profiling by Ahmed Marhri, Youssef Rbah, Aymane Allay, Mehdi Boumediene, Aziz Tikent, Abdessamad Benmoumen, Reda Melhaoui, Ahmed Elamrani, Malika Abid, Mohamed Addi

“…In contrast, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and total antioxidant capacity (TAC) assays showed no significant difference between the examined species. …”
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Synthesis of Sustainable Dual-Function Aerogels from Water Hyacinth Cellulose and Shrimp Shell Nano-Chitosan for Heavy Metal Removal and Coliform Bacteria Filtration in Polluted Wa... by Al Husain Saddam, Febrian Lava, Ismail Muhammad, Anjani Putri Siti, Al Baihaqi Muhammad Fauzan, Ramadhan Wahyu

“…Gel precursors were characterized, and adsorption and filtration capacities were tested to identify the optimal formula. …”
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Power generation expansion planning with high penetration of geothermal energy – Potential, prospects and policy by Muhammad Amir Raza, Mahmoud Ahmad Al-Khasawneh, Yahya Z. Alharthi, Muhammad Faheem, Raza Haider, Laveet Kumar

“…Pakistan is blessed with 100 GW of geothermal capacity and it is exploited using the Low Emissions Analysis platform (LEAP) software for the study period 2024 to 2060 by taking the base year 2023. …”
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Evolution and importance of Molecular Microbiology in the Laboratory of the Provincial Center for Hygiene, Epidemiology and Microbiology by María de Lourdes Sánchez Alvarez, Rafael Abreu Duarte, Edenis García Alvarez, Adrian Fernández García, Ermis Alexander González Martínez, Maidelys Mendoza Acosta

“…In 2023, the pathogen detection capacity was strengthened and the community cocirculation of influenza A and B, parainfluenza virus type 4, the OC 43 coronavirus, SARS-CoV-2 and dengue was identified. …”
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Impact of Business Planning for Mini Oil Refineries to Enhance Socio-Economic Landscape by Violetta Roshchupkina, Natalia Dimurina, Viktoriya Manuylenko, Natalia Gryzunova, Elena Drannikova, Mukhamed Khamukov

“…The localized refining capacity significantly enhances regional economic resilience and sustainability by reducing costs, increasing market competition, and creating job opportunities. …”
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Identifying the Spatial Range of the Pearl River Delta Urban Agglomeration from a Differentiated Perspective of Population Distribution and Population Mobility by Yongwang Cao, Qingpu Li, Zaigao Yang

“…The results show that the spatial range identified by NTL_LS has an accuracy of 80.37% and a kappa coefficient of 0.5225, while NTL_HM achieves an accuracy of 89.17% with a kappa coefficient of 0.7342, indicating that the fusion of economic level with population mobility data more accurately reflects the spatial range of urban agglomerations in line with real development patterns. …”
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Integrated Spatiotemporal Hybrid Solar PV Generation Forecast Between Countries on Different Continents Using Transfer Learning Method by Bowoo Kim, Kaouther Belkilani, Gerd Heilscher, Marc-Oliver Otto, Jeung-Soo Huh, Dongjun Suh

“…Solar photovoltaic (PV) generation is a cornerstone of sustainable energy production, but predicting its capacity across countries remains challenging due to factors like climate, terrain, and population density. …”
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Quality assessment of clinical guidelines in the care of laryngitis and pharyngitis according to AGREE II by Lucas Mateus Rodrigues Carvalho, Ana Paula de Oliveira Barbosa, Nara Amanda Laismann, Débora Santos Lula Barros, Rodrigo Fonseca Lima, Rafael Santos Santana

“…To determine the agreement, a weighted Kappa square statistic calculation was performed. …”
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Solophenyl Navy Blue Dye Removal by Smectite Clay in a Porous Bed Column by Gilson L. da Silva, Valdinete L. Silva, Melissa G. A. Vieira, Meuris G. C. da Silva

“…The experimental data allowed an assessment of the kinetic behaviour of the dye, and of the removal capacity and removal efficiency of the examined clays. …”
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Transcriptomic and metabolomic analysis of recalcitrant phosphorus solubilization mechanisms in Trametes gibbosa by Yulan Chen, Akasha Farooq, XieLuyao Wei, Leitao Qin, Yong Wang, Lingzi Zhang, Quanju Xiang, Ke Zhao, Xiumei Yu, Qiang Chen, Xue Gao, Tashi Nyima, Petri Penttinen, Yunfu Gu

“…Compared with the Ca-P treatment, T-41 demonstrated a stronger alkaline phosphatase (ALP) production capacity under Phytin-P treatment (34.5 ± 1.2 μmol/L/h vs. 19.8 ± 0.8 μmol/L/h, p < 0.05). …”
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Metabolomics and Transcriptomics Reveal the Effects of Different Fermentation Times on Antioxidant Activities of <i>Ophiocordyceps sinensis</i> by Min He, Tao Wang, Chuyu Tang, Mengjun Xiao, Xiaojian Pu, Jianzhao Qi, Yuling Li, Xiuzhang Li

“…While studies have examined its metabolites, the evaluation of its antioxidant capacity remains to be conducted. The antioxidant results of <i>O. sinensis</i> indicate that the ferric ion-reducing antioxidant power (FRAP), antioxidant capacity (2.74 ± 0.12 μmol Trolox/g), 2,2-diphenyl-1-picrylhydrazyl (DPPH•) free radical scavenging rate (60.21 ± 0.51%), and the hydroxyl free radical scavenging rate (91.83 ± 0.68%) reached a maximum on day 30. …”
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Effect of SOCO–SAP on moisture of different graded coal gangue and Elymus Dahuricus growth in alpine mining area by Zhilong SUN, Jianying YANG, Changqing SHI, Cheng LI, Ruijie LI, Xiaozhan WANG, Chunyan YANG, Monan DENG, Xinrui YANG, Jiajing LI

“…The poor water-holding capacity of coal gangue is the main obstacle factor affecting plant growth. …”
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带有反向螺纹的同轴变速单螺杆三维流场分析 "Three dimensional flow field analysis of coaxial variable speed single screw with reverse thread" by 左晓甜，郭树国，金子云 ZUO Xiaotian，GUO Shuguo，JIN Ziyun

“…The results showed that in the same external situation, the new screw pressure building capacity was weaker than the traditional screw, i.e., the extrusion efficiency of the new screw was lower. …”
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Consecutive prediction of adverse maternal outcomes of preeclampsia, using the PIERS-ML and fullPIERS models: A multicountry prospective observational study. by Guiyou Yang, Tünde Montgomery-Csobán, Wessel Ganzevoort, Sanne J Gordijn, Kimberley Kavanagh, Paul Murray, Laura A Magee, Henk Groen, Peter von Dadelszen

“…When categorizing women into multiple risk groups, the PIERS-ML model generally showed good rule-in capacity for the "very high" risk group, with positive likelihood ratio values ranging from 70.99 to infinity, and good rule-out capacity for the "very low" risk group where most negative likelihood ratio values were 0. …”
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Comparing multi-texture fibrosis analysis versus binary opacity-based abnormality detection for quantitative assessment of idiopathic pulmonary fibrosis by Sebastian Nowak, Dominik Creuzberg, Maike Theis, Carmen Pizarro, Alexander Isaak, Claus C. Pieper, Julian A. Luetkens, Dirk Skowasch, Alois M. Sprinkart, Daniel Kütting

“…Also, correlation with spirometry parameters (percent predicted total lung capacity (TLC), percent predicted vital capacity (VC), percent predicted forced expiratory volume in 1 s (FEV1), diffusing capacity of the lungs for carbon monoxide (DLCO), partial pressure of oxygen (PO2) and carbon dioxide (PCO2)) were assessed by r. …”
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Time-frequency characterization of acoustic emission signals from bending damage of corroded reinforced concrete beams in high- temperature saline environment by Dazhong Zhang, Shiyi Zhang, SM Chayan, Yingfang Fan, Surendra P. Shah, Junjie Zheng

“…The yield load of the beam is advanced under high-temperature conditions and corrosion, and the ultimate bending capacity of the beam decreases, the ultimate bending capacity of the beam CRC-1 and GRC-1 under corrosion conditions decreases by 6.7 % and 14.4 %, respectively, compared with that of the beam RC-1 under non-corrosion condition. …”
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Evaluation of wheat products with high flavonoid content: justification of importance of marker-assisted development and production of flavonoid-rich wheat cultivars by E. K. Khlestkina, N. I. Usenko, E. I. Gordeeva, O. I. Stabrovskaya, I. B. Sharfunova, Y. S. Otmakhova

“…Adding bran to the flour as well as the backing process increased the antioxidant capacity of wheat products. The contribution of anthocyanins to increased antioxidant capacity is not significant. …”
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Diffusion des savoirs sur Internet et interactions citoyennes : de la « connaissance-produit » à la « connaissance-processus » by Chantal Aspe

“…In the 1980’s, the french environmental movement was established on its capacity to offer “counter-proposals”, especially in the field of development. …”
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Fix the Supply Side! Demand Stimulus Will Not Cure What Ails by Jan Philipp Fritsche, Patrick Christian Harms

“…The German Society for Epidemiology has warned that the number of cases could soon overshoot the capacity of the healthcare system. This may be true even if Germany follows the ‘flatten-the-curve’- approach to reduce infection rates. …”
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