A Randomized Trial of Insulin Glargine plus Oral Hypoglycemic Agents versus Continuous Subcutaneous Insulin Infusion to Treat Newly Diagnosed Type 2 Diabetes by Shuo Lin, Mu Chen, Wanling Chen, Keyi Lin, Panwei Mu, Bilian Zhu, Wen Xu, Manman Wang, Jianping Weng, Longyi Zeng

“…The primary outcome measure was the mean amplitude of glycemic excursions (MAGE), and secondary endpoints included time to reach glycemic control target (FPG < 7 mmol/L and 2-hour postprandial plasma glucose < 10 mmol/L), markers of β-cell function, and hypoglycemia. Results. …”
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Effects of celastrol on the heart and liver galaninergic system expression in a mouse model of Western-type diet-induced obesity and metabolic dysfunction-associated steatotic live... by Nikolina Canová, Jana Šípková, Mahak Arora, Zuzana Pavlíková, Zuzana Pavlíková, Tomáš Kučera, Ondřej Šeda, Tijana Šopin, Tomáš Vacík, Ondřej Slanař

“…Moreover, the inhibitor of sterol regulatory element-binding protein 1/2 (SREBP1/2), fatostatin, was also tested to compare its influence on the galaninergic system with celastrol.ResultsThe study demonstrates that celastrol treatment was safe and led to a reduction in food and energy intake, body fat and liver weights, and MASLD-to-MASH progression and improved glucose tolerance, serum biochemistry markers, and hepatic lipid peroxidation in mice. Quantitative gene expression originally showed significant regulation of galanin and all three of its receptors (GalR1/2/3) in the heart ventricles and only GalR2 in the liver of obese mice. …”
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Effect of ticagrelor combined with metoprolol extended-release tablets on cardiac function and clinical prognosis in elderly patients with acute coronary syndrome after percutaneou... by Lili Wang, Linlin Gao, Qin Chen, Li Chen, Hui Xu, Ling Sun, Youbin Hu

“…Additionally, it effectively increases myocardial injury markers and reduces serum inflammatory factor levels.…”
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Risk Factors Associated with Cardiac Autonomic Modulation in Obese Individuals by Camila Oliveira, Erika Aparecida Silveira, Lorena Rosa, Annelisa Santos, Ana Paula Rodrigues, Carolina Mendonça, Lucas Silva, Paulo Gentil, Ana Cristina Rebelo

“…To analyze the association between cardiovascular autonomic modulation and biochemical and anthropometric markers, food intake, and physical activity level in severely obese individuals. …”
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Identification of common and specific fibrosis-related genes in three common chronic kidney diseases by Zhangning Fu, Xiaodong Geng, Chao Liu, Wanjun Shen, Zheyi Dong, Guannan Sun, Guangyan Cai, Xiangmei Chen, Quan Hong

“…Quantitative real-time PCR (qRT-PCR) was performed to validate the expression of the selected genes.Results Protein tyrosine phosphatase receptor type C (PTPRC), intercellular cell adhesion molecule-1 (ICAM1), vascular cell adhesion molecule-1 (VCAM1), interleukin 10 receptor alpha (IL10RA) and CC chemokine receptor 2 (CCR2) were identified as the potential common genes for kidney fibrosis in different types of CKD, while peroxisome proliferator-activated receptor alpha (PPARA), lactate oxidase (LOX), secreted phosphoprotein 1 (SPP1) were identified as the specific fibrosis-associated genes for DN, IgAN and MN respectively. qRT-PCR demonstrated that the expression levels of these selected genes were consistent with the NanoString analysis.Conclusions There were both commonalities and differences in the mechanisms of fibrosis in different types of CKD, the commonalities might be used as the common therapeutic targets for kidney fibrosis in CKD, while the differences might be used as the diagnostic markers for DN, IgAN and MN respectively. Inflammation was highly relevant to the pathogenesis of fibrosis. …”
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Escherichia coli combination with PD-1 blockade synergistically enhances immunotherapy in glioblastoma multiforme by regulating the immune cells by Guochen Li, Haiyan Yang, Tengfei Ke, Na Tan, Xiaolan Du, Xirui Duan, Xinyan Zhou, Guangrong Zheng, Chengde Liao

“…H&E staining and immunofluorescence staining were used to observe the tumor inhibition markers. Results E.coli can specifically target into the tumor region, and activate the innate immune response in mice. …”
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Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway by Ji-Ji Dao, Ji-Ji Dao, Wei Zhang, Wei Zhang, Chong Liu, Chong Liu, Qian Li, Qian Li, Chen-Meng Qiao, Chen-Meng Qiao, Chun Cui, Chun Cui, Yan-Qin Shen, Yan-Qin Shen, Shuang-Xi Chen, Shuang-Xi Chen, Wei-Jiang Zhao, Wei-Jiang Zhao

“…In vitro studies further corroborated that D-gal treatment significantly and concurrently induced the expression of senescence markers and ferroptosis promoters. However, both E4A and melatonin were able to significantly reverse these changes. …”
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Mimosapudica L. aqueous extract protects mice against pilocarpine–picrotoxin kindling-induced temporal lobe epilepsy, oxidative stress, and alteration in GABAergic/cholinergic path... by Hart Mann Alain Youbi Mambou, Simon Pale, Orelien Sylvain Mtopi Bopda, Vanessa Tita Jugha, Nji Seraphin Ombel Musa, Tambong Ako Ojongnkpot, Bertrand Yuwong Wanyu, Raymond Bess Bila, Rashed N. Herqash, Abdelaaty A. Shahat, Germain Sotoing Taiwe

“…Finally, the mice were sacrificed, and the hippocampi were isolated to quantify some biochemical markers of oxidative/nitrosative stress, GABAergic/cholinergic signalling, and BDNF levels in the hippocampus. …”
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Radiological abnormalities persist following COVID-19 and correlate with impaired health-related quality of life: a prospective cohort study of hospitalised patients by Rhian M Touyz, Ninian N Lang, Kevin G Blyth, Naveed Sattar, Patrick B Mark, Stefan Siebert, Colin Berry, Iain McInnes, Giles Roditi, Neil Basu, David Corcoran, Kenneth Mangion, Alex McConnachie, David Carrick, Jaclyn Carberry, Stuart Watkins, Paul Welsh, Sabrina Nordin, Katherine Scott, Christian Delles, Bernard Kelly, Fraser Goldie, John GF Cleland, Sharon Kean, Peter Kellman, David J Lowe, Andrew J Morrow, Antonia Ho, Rosemary Woodward, Tracey Hopkins, Ryan Wereski, Massimo Palmarini, Alasdair McIntosh, Campbell Rogers, Ammani Brown, Catherine Bagot, Kathryn Scott, Robert Sykes, Colin Church, Claire Rooney, Nicola Ryan, Clare Orange, Dirk Husmeier, Xiaoyu Luo, PETER W MACFARLANE, Heerajnarain Bulluck, Iain Findlay, Evonne McLennan, Michael Briscoe, Oliver Peck, Alastair J Rankin, Gruschen Veldtman, Varun Sharma, Kathryn McLaren, Elaine Butler, Sarah Mullen, Andrew Morrow, Patrick Mark, Daniel Doherty, Alexander Payne, Jennifer S Lees, Kaitlin J Mayne, Louise Inglis, Anna Kamdar, Hannah Bayes, Vivienne B Gibson, Lynsey Gillespie, Douglas Grieve, Pauline Hall Barrientos, Christopher McGinley, Connor Mckee, Sarah Allwood-Spiers, Sarah Weeden, Laura Knox, Lynn Abel, David Stobo, Andrew Dougherty, Liam Peng, David Barrie Stobo, Sylvia Wright, Stephen Dobbin, Keith Gillis, Sarah A Spiers, Ian Fergus, Kirsty Fallon, Lesley Gilmour, Chloe Cowan, Jurgen Van-Melckebeke, Kim Moran-Jones, Debra Stuart, Maureen Travers, Laura Dymock, Fiona Savage, Nicola Tynan, Sau Lee Chang, Mhairi Dupre, Lindsey Norton, George Bruce, Rosario Gonzalez-Lopez, Rebecca Stace, Dionne Russell, Jean Watt, Shahid Latif, Nick Hill, Amy Collinsworth, Ross McGeoch Vera Lennie, Robin P Weir

“…Older age, premorbid performance status, typical acute COVID-19 radiological features, markers of severe acute COVID-19, convalescent ICAM-1 and P-selectin were associated with persisting lung abnormalities (all p&lt;0.05). …”
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The Autoimmune Profiles in the Etiopathogenesis of Granulomatous Lobular Mastitis by Lu Xie, Jiamei Feng, Qingqian Gao, Wenchao Qu, Shijun Shao, Jiaye Sun, Xueqing Wu, Hua Wan

“…M1 (CD86) and M2 (CD206) macrophage markers were significantly higher in GLM than controls in both immunohistochemical and immunofluorescent staining (P < 0.05). …”
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Clinical manifestations, para-clinical features and outcome of Iranian adults with respiratory syncytial virus (RSV) infection: a report from hospitalized patients by Maryam Shafaati, Abbas Shakoori Farahani, Mohammadreza Salehi, Mohammad Arabzadeh, Helya Bolouki Azari, Arman Soleimany, Maryam Edalatifard, Vahid Salimi, Alireza Abdollahi

“…Notably, biochemical and inflammatory markers such as CRP, ESR, and LDH were significantly elevated beyond the normal range. …”
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Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth by Hao Wang, Ruixue Huo, Kexin He, Weihan Li, Yuan Gao, Wei He, Minhao Yu, Shu-Heng Jiang, Junli Xue

“…Methods Tissue samples from 129 CRC patients were stained with immunofluorescent markers NF-L and S100B to detect nerves. Nerve diameter and density were measured and normalized. …”
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Machine learning-based plasma metabolomics for improved cirrhosis risk stratification by Jingru Song, Ziwei Gao, Liqun Lai, Jie Zhang, Binbin Liu, Yi Sang, Siqi Chen, Jiachen Qi, Yujun Zhang, Huang Kai, Wei Ye

“…Key metabolites, including branched-chain amino acids (BCAAs), lipids, and markers of oxidative stress, were identified as significant predictors. …”
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Advancing early detection of organ damage and cardiovascular risk prevention: the Suzhou cardiometabolic health study protocol - exploring the role of oral microbiome and metabolic... by Mengmeng Zhu, Mengmeng Zhu, Yiwen Li, Wenting Wang, Longkun Liu, Wenwu Liu, Jiayu Yu, Qian Xu, Jing Cui, Yanfei Liu, Keji Chen, Yue Liu, Yue Liu

“…This study introduces oral (tongue coating) microbiota as metabolic markers for the first time, in combination with multiple metabolic factors, to explore their potential in assessing subclinical target organ damage and optimizing cardiovascular risk stratification, in order to provide a new path for the early identification and intervention of CVD.MethodsThis study is a prospective cohort study aimed at assessing the association between tongue coating microbiota characteristics and multiple metabolic factors with subclinical target organ damage, and identifying high-risk groups suitable for cardiovascular 1.5-level prevention. …”
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Revealing the heterogeneity of treatment resistance in less‐defined subtype diffuse large B cell lymphoma patients by integrating programmed cell death patterns and liquid biopsy by Wei Hua, Jie Liu, Yue Li, Hua Yin, Hao‐Rui Shen, Jia‐Zhu Wu, Yi‐Lin Kong, Bi‐Hui Pan, Jun‐Heng Liang, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu

“…Programmed cell death (PCD) pathways are crucial in the advancement of lymphoma and serve as significant prognostic markers for individuals afflicted with lymphoid cancers. …”
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Combining genotyping approaches improves resolution for association mapping: a case study in tropical maize under water stress conditions by Fernanda Carla Ferreira de Pontes, Ingrid Pinheiro Machado, Maria Valnice de Souza Silveira, Antônio Lucas Aguiar Lobo, Felipe Sabadin, Roberto Fritsche-Neto, Júlio César DoVale

“…Genome-wide Association Studies (GWAS) identify genome variations related to specific phenotypes using Single Nucleotide Polymorphism (SNP) markers. Genotyping platforms like SNP-Array or sequencing-based techniques (GBS) can genotype samples with many SNPs. …”
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The In Vitro Immunomodulatory Effects of Gold Nanocomplex on THP-1-Derived Macrophages by Duaa Abuarqoub, Nouf N. Mahmoud, Rand Zaza, Rana Abu-Dahab, Enam A. Khalil, Dima A. Sabbah

“…THP-1 cells were differentiated into macrophages and characterized by measuring the expression of macrophage surface markers by flow cytometry. Then, differentiated cells were activated by lipopolysaccharide (LPS). …”
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Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumonia by Yong-tao Li, Yu-mei Ma, Fu-li Dai, Zhen Peng, Ya-ping Dai, Ke Zhi, Hai-hong Feng, Shu-jun Li

“…They also required longer azithromycin courses (median: 15 vs. 14 days, P = 0.026).ConclusionChildren with severe MP pneumonia and abnormal TEG profiles have more severe clinical manifestations, higher inflammatory markers, more extensive lung involvement, and a higher incidence of complications. …”
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Serological Evidence of Hepatitis B and E and Dengue Coinfection in Chadian Patients and Impact on Lipidemia Profile by Alexandre Kanga Djasrabe, Borris Rosnay Tietcheu Galani, Moussa Mahamat Ali, Fissou Henry Yandai, Bessimbaye Nadlaou, Mayann Habkreo, Nicolas Yanou Njintang

“…From February to May 2021, 179 subjects were recruited from the Department of Gastroenterology and Internal Medicine of the National Reference University Hospital of N’Djamena and tested for viral hepatitis markers, including HBsAg and IgM/IgG anti-HEV and dengue infection, using the NS1/IgM/IgG kit. …”
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Exosomes secreted by ATF3/Nrf2-mediated ferroptotic renal tubular epithelial cells promote M1/M2 ratio imbalance inducing renal interstitial fibrosis following ischemia and reperfu... by Qiao Tang, Jiatao Xie, Yifei Wang, Chong Dong, Chong Dong, Qian Sun

“…Moreover, there were higher levels of M2 markers (Arg1, TGF-β and IL-10 mRNA) in the IR group than those in the sham group, and lower levels in the IR+Fer-1 group or in the IR+ATF3KD group compared with the IR group. …”
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