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4701
Anlotinib Inhibits Cisplatin Resistance in Non-Small-Cell Lung Cancer Cells by Inhibiting MCL-1 Expression via MET/STAT3/Akt Pathway
Published 2024-01-01“…Protein expression levels of MET, MCL-1, and STAT3/Akt pathway-related markers were examined using western blot analysis. …”
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4702
Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer’s Disease Mutations
Published 2021-01-01“…Alzheimer’s disease manifests itself in brain tissue by neuronal death, due to aggregation of β-amyloid, produced by senile plaques, and hyperphosphorylation of the tau protein, which produces neurofibrillary tangles. One of the genetic markers of the disease is the gene that translates the presenilin-2 protein, which has mutations that favor the appearance of the disease and has no reported crystallographic structure. …”
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4703
Efficacy of melatonin treatment in a cystic fibrosis mouse model of airway infection
Published 2025-01-01“…Melatonin-treated mice exhibited improved bacterial clearance, reduced inflammatory markers. Mice treated in drinking water for 1 week had improved bacterial clearance but no improvement in inflammation. …”
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4704
The Metabolomic Characterization of Different Types of Coronary Atherosclerotic Heart Disease in Male
Published 2022-01-01“…Compared with the stable coronary artery disease group, 15 specific metabolite markers were found in the acute coronary syndrome group. …”
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4705
The individual strategies of Internet users’ media activity
Published 2023-02-01“…The interaction of the individual and media ecosystem is analyzed with the help of a system of incoming and outcoming activity markers. The incoming activity is understood by the authors as a total of institutional and environmental factors of media activity practices realization, the outcoming one is understood as the characteristic of individual’s personal activity in realizing media practices. …”
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4706
Derivation of Pluripotent Cells from Mouse SSCs Seems to Be Age Dependent
Published 2016-01-01“…The generated ESC-like cells were similar to ESCs and express pluripotency markers. In vitro they differentiate into all three germ lineages; they form complex teratomas after transplantation in SCID mice and produce chimeric mice.…”
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4707
NGF-TrkA Axis Enhances PDGF-C-Mediated Angiogenesis in Osteosarcoma via miR-29b-3p Suppression: A Potential Therapeutic Strategy Using Larotrectinib
Published 2025-01-01“…Analysis of GEO (GSE16088) data identified five angiogenesis markers significantly upregulated in OS tissues. In vitro experiments demonstrated that NGF enhanced HUVEC tube formation by upregulating platelet-derived growth factor C (PDGF-C) expression and suppressing microRNA-29b-3p (miR-29b-3p). …”
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4708
Intermittent Fasting Protects Against the Progression from Acute Kidney Injury to Chronic Kidney Disease
Published 2025-01-01“…IF also reduced levels of TGF-β1, phosphorylated NF-κB p65, inflammatory cytokines, and F4/80-positive macrophages, along with markers of oxidative stress. These findings highlight IF’s ability to mitigate fibrosis and EMT through reductions in inflammation and oxidative stress during AKI-to-CKD progression. …”
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4709
White Mold: A Global Threat to Crops and Key Strategies for Its Sustainable Management
Published 2024-12-01“…Each stage of infection triggers a cascade of molecular and physiological events that underpin defense responses against <i>S. sclerotiorum</i>. Molecular markers can help rapid diagnosis of this disease in plants. …”
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4710
Diversity of Soil Filamentous Fungi Influenced by Marine Environment in São Luís, Maranhão, Brazil
Published 2020-01-01“…These fungi can be used as biological markers of pollution and as biodegraders and/or bioremediators to improve the area studied.…”
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4711
Demographic and historical processes influencing Cochliomyia hominivorax (Diptera: Calliphoridae) population structure across South America
Published 2025-01-01“…Methods Using microsatellite markers, we analyzed larvae collected from infested livestock across South America. …”
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4712
New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite
Published 2025-02-01“…These cells are typically identified by the expression of specific cell surface markers. A population of pancreatic cancer stem cells with aberrantly active developmental signaling pathways has been identified in recent studies of human pancreatic tumors. …”
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4713
Estimation and identification of parameters in a lumpedcerebrovascular model
Published 2008-11-01“…Thus, the method discussedin this study provides a new methodology to extract clinical markers thatcannot easily be assessed noninvasively.…”
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4714
Exploring the Anti-Osteoporotic Effects of <i>n</i>-Hexane Fraction from <i>Cotoneaster wilsonii</i> Nakai: Activation of Runx2 and Osteoblast Differentiation In Vivo
Published 2025-01-01“…Biochemical assays and histological analyses focused on the signaling activation of osteoblast differentiation and osteogenic markers, such as ALP, collagen, and osterix. The CWH significantly activated TGF-β and Wnt signaling, enhancing osteoblast differentiation and bone matrix formation. …”
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4715
Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen
Published 2014-01-01“…The present study attempted to investigate the protective effect of B. trimera against APAP-induced hepatic damage in rats. The liver-function markers ALT and AST, biomarkers of oxidative stress, antioxidant parameters, and histopathological changes were examined. …”
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4716
Structural brain basis of latent factors of executive functions in childhood
Published 2025-01-01“…Here, in a sample of 141 children aged 6–13 years, we administered a battery of 9 executive function tasks, derived latent factors of inhibition, working memory, and shifting and examined their associations with markers of brain structure (whole-brain cortical thickness). …”
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4717
Protective Role of Platelets in Myocardial Infarction and Ischemia/Reperfusion Injury
Published 2021-01-01“…Additionally, the use of platelet-derived microparticles as possible markers of MI, with and without comorbidities, and their role in cardioprotection are discussed. …”
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4718
Adrenal Hemangioma: A Case of Retroperitoneal Tumor
Published 2018-01-01“…Magnetic resonance imaging (MRI) and positron-emission tomography (PET)-CT were unable to confirm or deny malignancy, and tumor markers, including CEA and CA19-9, showed slight elevation. …”
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4719
Assessment of urine CCL2 as a potential diagnostic biomarker for acute kidney injury and septic acute kidney injury in intensive care unit patients
Published 2024-12-01“…In this study, we investigated the potential of plasma and urine CCL2 levels as diagnostic markers for AKI and SAKI in 216 ICU patients. Our findings revealed significant differences in plasma (p < 0.01) and urine CCL2 (p < 0.0001) levels between AKI and non-AKI patients in the ICU. …”
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4720
Prenatal Detection of Silver–Russell Syndrome: A First Trimester Suspicion and Diagnostic Approach
Published 2025-01-01“…The first-trimester biochemical markers, including PAPP-A and β-hCG, were within the normal range. …”
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