Challenging Case of Ectopic ACTH Secretion from Prostate Adenocarcinoma by Wanling Zeng, Joan Khoo

“…ACTH-dependent Cushing’s syndrome was diagnosed with inappropriately normal ACTH 57.4 ng/L, significantly elevated 24-hour urine free cortisol and unsuppressed cortisol after 1 mg low-dose, 2-day low-dose, and 8 mg high-dose dexamethasone suppression tests. 68Ga-DOTANOC PET/CT showed an increase in DOTANOC avidity in the prostate gland, and his prostate biopsy specimen was stained positive for ACTH and markers for neuroendocrine differentiation. He was started on ketoconazole, which was switched to IV octreotide in view of liver dysfunction from hepatic metastases. …”
Get full text

Inflammatory biomarkers and therapeutic potential of milk exosome-mediated CCL7 siRNA in murine intestinal ischemia-reperfusion injury by WenDong Chen, WenPing Xu, Li Ma, Chun Bi, MeiXu Yang, Wei Yang

“…M-Exo/siCCL7 treatment effectively attenuated intestinal inflammation and injury, as evidenced by reduced histological damage, decreased serum markers of intestinal barrier dysfunction, and attenuated systemic inflammation.ConclusionOur findings provide new insights into the molecular mechanisms underlying IIRI, identify potential diagnostic biomarkers, and highlight the promise of exosome-based siRNA delivery as a novel therapeutic approach for IIRI.…”
Get full text

Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia by Alberto Tobón-Castaño, Esteban Mesa-Echeverry, Andrés Felipe Miranda-Arboleda

“…The utility of changes in leukocyte counts as markers of severity should be explored in depth. A better understanding of these hematological parameters will allow their use in prompt diagnosis of malaria complications and monitoring treatment response.…”
Get full text

Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis by Lei Liu, Jundi Wang, Peiyu Zhang, Wenjia Sun, Xiuliang Zhu, Xiujuan Sun, Jing Xue, Huaxiang Wu

“…This study is aimed at clarifying the role of neutrophil-associated biological markers in suggesting ASS and DM-associated respiratory infections and interstitial lung diseases. …”
Get full text

Linum usitatissimum Delivery over Chitosan Nanobiopolymer: Enhanced Effects on Polycystic Ovary Syndrome Condition by Abolfazl Bayrami, Maryam Sojoudi, Shima Rahim Pouran, Aziz Habibi-Yangjeh, Sanaz Sojoudi

“…Subsequently, the influence of CHIT-FSE, CHIT-TPP, and FSE supplementation was assessed on hormonal and biochemical markers of polycystic ovary syndrome (PCOS) in female rats and compared with untreated and healthy control groups. …”
Get full text

Flow Cytometric Bivariate Analysis of DNA and Cytokeratin in Colorectal Cancer by Carolin Post, Ib Jarle Christensen, Henrik Flyger, Jette Christiansen, Jørgen K. Larsen

“…Different opinions about flow cytometric estimates of DNA aneuploidy and/or S‐phase fraction (SPF) as supplementary prognostic markers in colorectal cancer are to some degree associated with methodology. …”
Get full text

Whole-Genome Sequencing Revealed a Late-Maturing Isogenic Rice Koshihikari Integrated with Hd16 Gene Derived from an Ise Shrine Mutant by Motonori Tomita, Ryotaro Tokuyama, Shosuke Matsumoto, Kazuo Ishii

“…Next, the linkage relationship of a single late-maturing gene with the SSR markers on the long arm of chromosome 3 was inferred by using late-maturing homozygous F2 segregants. …”
Get full text

Evaluation of biomarkers for clinical activity of systemic lupus erhythematodes by Valentina Reshkova, Dobroslav Kyurkchiev, Simeon Monov

“…Human IFN-alpha and human sVCAM-1 are sensitivity markers and play an important role in the activity of the disease in the Bulgarian population with SLE.…”
Get full text

Advances in adjuvant therapy for operable N2 non-small cell lung cancer: a narrative review by Lei Liu, Yilong Mao, Leilei Guo, Chencong Li, Yiqian Wang

“…Meanwhile, the booming development of adjuvant targeted therapy and adjuvant immunotherapy also provides newer therapeutic options for the prognosis of postoperative pN2 stage NSCLC, and some new markers will guide the adaptive application of immune drugs in the future. …”
Get full text

Dynamic conditioning of porcine kidney grafts with extracellular vesicles derived from urine progenitor cells: A proof‐of‐concept study by Perrine Burdeyron, Sébastien Giraud, Maryne Lepoittevin, Nina Jordan, Sonia Brishoual, Maïté Jacquard, Virginie Ameteau, Nadège Boildieu, Estelle Lemarie, Jonathan Daniel, Frédéric Martins, Nicolas Mélis, Marine Coué, Raphaël Thuillier, Henri Leuvenink, Luc Pellerin, Thierry Hauet, Clara Steichen

“…However, cell damage markers (LDH, ASAT) were decreased in G3 compared with G1, and G3 kidneys displayed a preserved tissue integrity with reduced tubular dilatation and inflammation notably. …”
Get full text

Anaplastic Thyroid Carcinoma: A ceRNA Analysis Pointed to a Crosstalk between SOX2, TP53, and microRNA Biogenesis by Walter Arancio, Valeria Carina, Giuseppe Pizzolanti, Laura Tomasello, Maria Pitrone, Concetta Baiamonte, Marco Calogero Amato, Carla Giordano

“…In detail, silencing SOX2 in SW1736 is able to suppress the expression of the stem markers analysed, strongly sensitizing the line to treatment with chemotherapeutic agents. …”
Get full text

Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research by Satoru Morikawa, Takehito Ouchi, Shinsuke Shibata, Takumi Fujimura, Hiromasa Kawana, Hideyuki Okano, Taneaki Nakagawa

“…Previous studies have identified mouse- and human-specific MSC subsets using cell surface markers. Additionally, some studies have shown that a subset of MSCs is closely related to neural crest derivatives and endothelial cells. …”
Get full text

Five New Indole Alkaloid Derivatives from Deep-Sea Fungus <i>Aspergillus fumigatus</i> AF1 by Lai-Hui Dai, Gao-Rong Zhang, Yang-Hui Ou, Xiao-Jing Liu, Hong-Liang Yao, Wen-Hao Hu, Hou-Jin Li, Wen-Jian Lan

“…Compounds <b>8</b> and <b>13</b> displayed significant downregulation of the mRNA expression levels of all three molecular markers (COL1A1, α-SMA and FN1), with compound <b>13</b> exhibiting the best performance among all the tested compounds.…”
Get full text

Th2 Regulation of Viral Myocarditis in Mice: Different Roles for TLR3 versus TRIF in Progression to Chronic Disease by Eric D. Abston, Michael J. Coronado, Adriana Bucek, Djahida Bedja, Jaewook Shin, Joseph B. Kim, Eunyong Kim, Kathleen L. Gabrielson, Dimitrios Georgakopoulos, Wayne Mitzner, DeLisa Fairweather

“…Interestingly, TLR3-deficient mice developed an interleukin (IL)-4-dominant T helper (Th)2 response during acute CVB3 myocarditis with elevated markers of alternative activation, while TRIF-deficient mice elevated the Th2-associated cytokine IL-33. …”
Get full text

Successful Treatment of Fungal Dermatitis in a Bottlenose Dolphin (<i>Tursiops truncatus</i>) by Takashi Kamio, Honoka Nojo, Rui Kano, Mami Murakami, Yukako Odani, Koji Kanda, Tomoko Mori, Yuichiro Akune, Masanori Kurita, Ayaka Okada, Yasuo Inoshima

“…Hematological examination revealed a reduction in inflammatory markers after antifungal treatment and surgical resection of necrotic tissue on the edge of the tail fin. …”
Get full text

The influence of vaginal microbiota on the pregnancy outcome of artificial insemination with husband's sperm based on microscope images combined with PCR fluorescence method by Yanling Xing, Wei Wang, Na Wan, Dongmei Zhang, Mei Shan, Guan Wang

“…Among women with successful pregnancy, the proportion of beneficial bacteria (such as lactic acid bacteria) is higher, while the abundance of pathogenic bacteria is significantly reduced. Specific microbial markers detected by PCR fluorescence method are positively correlated with pregnancy rate. …”
Get full text

Comparative In Vitro Immune Stimulation Analysis of Primary Human B Cells and B Cell Lines by Kristien Van Belle, Jean Herman, Louis Boon, Mark Waer, Ben Sprangers, Thierry Louat

“…As for the read-out for such screening assay, it is proposed that the expression of activation and costimulatory surface markers reliably reflects B lymphocyte activation.…”
Get full text

Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats by Srinivasa Rao Sirasanagandla, Sreedhara Ranganath Pai Karkala, Bhagath Kumar Potu, Kumar M.R. Bhat

“…Since PECQ improves the bone health in hyperglycemic conditions by enhancing the cortical and trabecular bone growth and altering the circulating bone markers, it could be used as an effective therapy against diabetes-associated bone disorders.…”
Get full text

The Role of the Liver in the Pathophysiology of PCOS: A Literature Review by Abrar Alhermi, Heather Perks, Varsha Nigi, Noor Altahoo, Stephen L. Atkin, Alexandra E. Butler

“…The purpose of this review is to discuss the current understanding regarding hepatic involvement in PCOS pathophysiology, the inflammatory markers and hepatokines involved in the development of PCOS, and the role of genetics in the occurrence of PCOS. …”
Get full text

HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia by Oscar Peralta-Zaragoza, Jessica Deas, Claudia Gómez-Cerón, Wendy Argelia García-Suastegui, Geny del Socorro Fierros-Zárate, Nadia Judith Jacobo-Herrera

“…Thus, the identification and subsequent functional evaluation of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis, identifying cervical cancer molecular markers, and developing specific targeting strategies against tumor cells. …”
Get full text