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4541
Ursodeoxycholic Acid Attenuates Endoplasmic Reticulum Stress-Related Retinal Pericyte Loss in Streptozotocin-Induced Diabetic Mice
Published 2017-01-01“…Fluorescein dye leakage during angiography and retinal capillary density were improved in UDCA-treated diabetic mice, compared to the nontreated diabetic group. Among the UPR markers, those involved in the protein kinase-like ER kinase (PERK) pathway were increased, while UDCA attenuated UPR in STZ-induced diabetic mice as well as AGE- or mLDL-exposed retinal pericytes in culture. …”
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4542
Current Molecular Targeted Therapy in Advanced Gastric Cancer: A Comprehensive Review of Therapeutic Mechanism, Clinical Trials, and Practical Application
Published 2016-01-01“…Many other clinical trials based on molecular markers are underway. This review will summarize targeted therapies for advanced gastric cancer.…”
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4543
Metadiscourse in Lithuanian linguistics research articles: A study of interactive and interactional features
Published 2024-01-01“…The most common interactive resources are transitions and evidentials, and the most frequent interactional devices include boosters, engagement markers, and hedges. The analysis offers a number of methodological steps necessary for applying the interpersonal model of metadiscourse to Lithuanian data, and complements numerous investigations into Lithuanian academic discourse by illustrating and discussing the writer-reader interaction in linguistics in a larger corpus. …”
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4544
Exploring the intricacies of politeness and impoliteness in Acehnese speech variations
Published 2024-06-01“…This study examines politeness and impoliteness in Acehnese speech variations conveyed through various linguistic features, including honorifics, politeness markers, and respectful forms of address. The research employed a descriptive qualitative method, commencing with observation in different social settings in Acehnese society to identify instances of polite and impolite speech. …”
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4545
Motor Recovery of the Affected Hand in Subacute Stroke Correlates with Changes of Contralesional Cortical Hand Motor Representation
Published 2017-01-01“…These measures may serve as surrogate markers for the outcome of hand motor rehabilitation after stroke.…”
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4546
Epigenetic Drug Interventions in Breast Cancer: A Narrative Review of Current Research and Future Directions
Published 2024-09-01“…While there is strong evidence that epigenetic alterations, consisting of changes in DNA methylation, histone modifications, and non-coding RNAs, play a crucial role in breast cancer initiation and development, additional research is warranted to elucidate the safety profile of long-term interventions involving epigenetic drugs and to validate the role of epigenetic markers in disease diagnosis, prognosis, and personalised treatment. …”
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4547
Lovastatin Decreases the Expression of CD133 and Influences the Differentiation Potential of Human Embryonic Stem Cells
Published 2016-01-01“…Likewise, expression of ectodermal (SOX1 and OTX2) and endodermal (GATA4 and FOXA2) markers was higher in treated cells. Exposure of hES cells to lovastatin led to a minor decrease in the expression of SSEA-3 and a significant reduction in CD133 expression. …”
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4548
Fagonia indica Repairs Hepatic Damage through Expression Regulation of Toll-Like Receptors in a Liver Injury Model
Published 2018-01-01“…In addition, altered expression of proinflammatory (IL-1β, IL-6, TNF-α, and TGF-β) and hepatic (krt-18 and albumin) markers further strengthens the liver injury reversal effects of Fagonia indica. …”
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4549
Allelic Frequencies of 20 Visible Phenotype Variants in the Korean Population
Published 2013-06-01“…Even though the usability of these SNPs should be verified by an association study in Koreans, this study provides 10 potential SNP markers for forensic science for externally visible characteristics in the Korean population.…”
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4550
An Alternative to the Human Hemoglobin Test in the Investigation of Bloodstains Treated with Active Oxygen: The Human Glycophorin A Test
Published 2011-01-01“…The need to determine the nature of the evidence is reflected in the latest bibliography, where the possibility of employing mRNA and miRNA markers for this purpose is proposed. While these new proposals are being investigated, the kits for determining human hemoglobin currently provide a simple solution for resolving this issue. …”
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4551
Update on Primary Biliary Cirrhosis
Published 2000-01-01“…There are no surrogate markers that predict outcome in asymptomatic patients, whose chance of survival is less than that of age- and sex-matched populations but much better than the median survival of eight years in patients with symptomatic PBC. …”
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4552
Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications
Published 2012-01-01“…Since certain epigenetic alterations precede histopathological changes, they can serve as excellent markers for the development of diagnostic, prognostic, and surveillance tools. …”
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4553
Environment as a Potential Key Determinant of the Continued Increase of Prostate Cancer Incidence in Martinique
Published 2011-01-01“…We also compared prostate cancer incidence rates, and lifestyle-related and socioeconomic markers such as life expectancy, dietary energy, and fat supply and consumption, with those in other Caribbean islands, France, UK, Sweden, and USA. …”
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4554
Classification of NSCLC subtypes using lung microbiome from resected tissue based on machine learning methods
Published 2025-01-01“…Differentially enriched taxa were identified using LEfSe, revealing ten potential microbial markers. Linear discriminant analysis (LDA) was subsequently applied to enhance inter-class separability. …”
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4555
Pituitary adenoma: important genetic factors and clinical diagnostic issues
Published 2021-06-01“…All of these studies are aimed at finding new molecular markers for the development of targets for the treatment of pituitary adenomas. …”
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4556
A New Case of Spontaneous Regression of Inflammatory Hepatic Pseudotumor
Published 2011-01-01“…Laboratory investigation showed normal blood counts, liver function test and tumoral markers. Another ultrasonography was interpretated as normal. …”
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4557
Neuronal heterogeneity in the ventral tegmental area: Distinct contributions to reward circuitry and motivated behavior
Published 2025-03-01“…This review aims to synthesize current knowledge of diverse neuronal populations in the VTA, including distinct subtypes of DA, glutamate (GLUT), and GABAergic neurons and combinatorial cells alongside well-characterized markers of these neuronal subclasses. Furthermore, this review highlights known projection targets and the role of diverse VTA cell types in motivated behavior. …”
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4558
An Analysis of the Outcomes of Language Contacts: with Specials Reference to Arabi-Malayalam
Published 2022-12-01“…The results of this study indicate that there are various borrowing patterns of grammar that occur in ARABI-MALAYALAM language contacts such as; Coordinating Conjunctions, Number Markers, Adjectives etc. …”
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4559
« The reality is, Mr. Speaker, that… » : de la modalité au positionnement énonciatif dans les structures projectives
Published 2021-12-01“…Drawing on previous research, we will present the general characteristics of these structures which make them ideal places where we can find stance markers. Regarding stancetaking, we will show that these structures can operate in two ways. …”
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4560
Human Gut Microbes Associated with Systolic Blood Pressure
Published 2022-01-01“…We examined associations between gut microbiome and blood pressure along with 14 other variables associated with lifestyle, dietary habits, disease conditions, and clinical blood markers in the three Assamese populations. Our analysis reveals a robust link between the gut microbiome diversity and composition and systolic blood pressure. …”
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