Investigation of <i>ITGB3</i> Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer by Asiye Busra Boz Er

“…This study investigates the role of <i>ITGB3</i> heterogeneity in Trastuzumab resistance, focusing on its impact on TGF-β signalling and migration marker response. It also evaluates the potential of combining Trastuzumab with the integrin β3 inhibitor cilengitide to overcome resistance associated with <i>ITGB3</i> levels. …”
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Functional genomics implicates ebony in the black pupae phenotype of tephritid fruit flies by Daniel F. Paulo, Thu N. M. Nguyen, Chris M. Ward, Renee L. Corpuz, Angela N. Kauwe, Pedro Rendon, Rocio E. Y. Ruano, Amanda A. S. Cardoso, Georgia Gouvi, Elisabeth Fung, Peter Crisp, Anzu Okada, Amanda Choo, Christian Stauffer, Kostas Bourtzis, Sheina B. Sim, Simon W. Baxter, Scott M. Geib

“…Our findings offer key insights for molecular engineering of sexing strains based on the bp marker and for future evolutionary developmental biology studies in tephritids.…”
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Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male by Silvia Migliaccio, Davide Francomano, Roberto Bruzziches, Emanuela A. Greco, Rachele Fornari, Lorenzo M. Donini, Andrea Lenzi, Antonio Aversa

“…This new relationship with skeletal health has relevant implications for the aging male, suggesting OSCA as a novel marker of metabolic and gonadal health status.…”
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SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin by Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou

“…Downregulation of SHP2 also decreased the expression of mesenchymal markers but induced upregulation of the epithelial marker E-cadherin. …”
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Genetic context modulates aging and degeneration in the murine retina by Olivia J. Marola, Michael MacLean, Travis L. Cossette, Cory A. Diemler, Amanda A. Hewes, Alaina M. Reagan, Jonathan Nyandu Kanyinda, Daniel A. Skelly, Gareth R. Howell

“…Analysis of cell type-specific marker genes predicted age-related loss of photoreceptors and retinal ganglion cells (RGCs) in WSB and NZO, respectively. …”
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Triglyceride glucose index–body mass index as a predictor of coronary artery disease severity in patients with H-type hypertension across different glucose metabolic states by Lian Wang, Zijin Li, Rui Qiu, Li Luo, Xisheng Yan

“…Abstract Background The triglyceride glucose-body mass index (TyG-BMI) is considered to be a reliable surrogate marker of insulin resistance (IR). However, limited evidence exists regarding its association with the severity of coronary artery disease (CAD), particularly in hypertensive patients with different glucose metabolic states, including those with H-type hypertension. …”
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Increased Performances of the Biological Diagnosis of the Antiphospholipid Syndrome by the Use of a Multiplex Assay by M. Sénant, H. Rostane, F. Fernani-Oukil, F. Hosking, F. Bellery, A. Courchinoux, E. Tartour, L. Darnige, M-A. Dragon-Durey

“…The disease rate increased with the number of positive markers from 9% for 1 marker to 100% for 4 markers positive for patients with high risk scores. …”
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Analysis of Circulating MicroRNAs In Vivo following Administration of Dexamethasone and Adrenocorticotropin by Ivan Igaz, Gábor Nyírő, Zoltán Nagy, Henriett Butz, Zsolt Nagy, Pál Perge, Peter Sahin, Miklós Tóth, Károly Rácz, Peter Igaz, Attila Patócs

“…The expression of hsa-miR-483-5p proposed as diagnostic marker for adrenocortical malignancy was not affected by dexamethasone or tetracosactide administration. …”
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Relationship Between Perilesional Skin Condition and Survival in Terminally Ill Patients with Pressure Ulcers by María Isabel Pastor-Orduña, Federico Palomar-Llatas, David Palomar-Albert, María Teresa Murillo-Llorente, Ignacio Ventura, Francisco Tomás-Aguirre, Marcelino Pérez-Bermejo

“…On the other hand, the negative correlation between total lymphocyte count and survival suggests that lymphocytopenia may be a marker of adaptive immunosuppression. Perilesional tissue epithelialization, overall functionality and serum albumin levels are key factors in predicting survival, highlighting the need for a comprehensive palliative care approach to optimize quality of life and prolong survival in terminally ill patients with PUs.…”
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Aging Alters Olfactory Bulb Network Oscillations and Connectivity: Relevance for Aging-Related Neurodegeneration Studies by A. Ahnaou, D. Rodriguez-Manrique, S. Embrechts, R. Biermans, N. V. Manyakov, S. A. Youssef, W. H. I. M. Drinkenburg

“…Taken together, the results highlight the sensitivity and therefore potential use of LFP quantitative network oscillations and connectivity at the OB level as objective electrophysiological markers that will help reveal specific dysfunctional circuits in aging-related neurodegeneration studies.…”
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Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients by Dan Chen, Wenwu Sun, Jia Li, Bohua Wei, Wei Liu, Xiaopin Wang, Fan Song, Liangkai Chen, Junhui Yang, Li Yu

“…As a potential inflammatory marker, increasing baseline levels of serum cystatin C might independently predict adverse outcomes for COVID-19 patients. …”
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Food groups, macronutrient intake and objective measures of total carotenoids and fatty acids in 16-to-24-year-olds following different plant-based diets compared to an omnivorous... by Synne Groufh-Jacobsen, Christel Larsson, Isabelle Mulkerrins, Dagfinn Aune, Anine Christine Medin

“…For omega-3, lacto-ovo-vegetarians had intakes below recommendations. Blood marker of total carotenoids did not differ between groups, neither did the reported mean intake (g/MJ) of carotenoid-rich foods. …”
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IGJR issue 1/2018 by IF and FRFG

“…London: Intergenerational Foundation. Tepe, Markus / Vanhuysse, Pieter (2009): Are Aging OECD Welfare States on the Path to the Politics of Gerontocracy? …”
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A preliminary study on the prognostic significance of cysteine-rich EGF ligand domain 2 protein (CRELD2) in patients with triple negative breast cancer by Mehmet Zahid Kocak, Murat Araz, Siddika Findik, Aykut Demirkiran, Mustafa Korkmaz, Melek Karakurt Eryilmaz, Mehmet Artac

“…This is the first clinical study to determine the effect of CRELD2 on survival and as a prognostic marker in patients with triple metastatic breast cancer. …”
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Wnt signaling as a translational target in rheumatoid and psoriatic arthritis by Gloria Riitano, Francesca Spinelli, Valeria Manganelli, Daniela Caissutti, Antonella Capozzi, Cristina Garufi, Tina Garofalo, Roberta Misasi, Maurizio Sorice, Fabrizio Conti, Agostina Longo, Cristiano Alessandri

“…In particular, it indicates that DKK1 levels are correlated with CTX-1, a marker of bone resorption, and with disease activity in RA patients. …”
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THE SOLANUM TUBEROSUM KNOWLEDGE BASE: THE SECTION ON MOLECULAR-GENETIC REGULATION OF METABOLIC PATHWAYS by T. V. Ivanisenko, O. V. Saik, P. S. Demenkov, V. K. Khlestkin, E. K. Khlestkina, N A. Kolchanov, V. А. Ivanisenko

“…The reconstructed network is the basis for the search for target genes for directed mutagenesis and marker-oriented selection of potato varieties with specified starch properties. …”
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Oxidative Stress Induced Damage and Early Senescence in Preterm Placenta by Yudianto Budi Saroyo, Noroyono Wibowo, Rima Irwinda, Ani Retno Prijanti, Evy Yunihastuti, Saptawati Bardosono, Sofie Rifayani Krisnadi, Putri Indah Permata, Stephanie Wijaya, Victor Prana Andika Santawi

“…This research is aimed at demonstrating whether telomere shortening, proinflammatory HMGB1, and oxidative damage marker 8-OHdG play a role in the placenta of preterm birth in comparison to term birth. …”
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Molecular profiling of bladder cancer xenografts defines relevant molecular subtypes and provides a resource for biomarker discovery. by Sharada Mokkapati, Ganiraju Manyam, Alexis R. Steinmetz, Côme Tholomier, Alberto Martini, Woonyoung Choi, Bogdon Czerniak, Byron H Lee, Colin P Dinney, David J McConkey

“…SCaBER expressed high basal and EMT markers and low luminal markers, consistent with a true basal cell. …”
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Circulating MicroRNAs in Patients with Psoriasis Treated with Anti-IL-23: A Cohort Study by Federico Diotallevi, Giulia Matacchione, Anna Campanati, Elena Marinelli Busilacchi, Nadia Viola, Ilaria Pace, Beatrice Fontana, Roberta Roncarati, Massimiliano Bonafè, Manuela Ferracin, Jacopo Sabbatinelli, Fabiola Olivieri

“…Notably, miR-200a-3p showed a significant correlation with baseline Psoriasis Area Severity Index (PASI), indicating its potential as a severity marker. Risankizumab therapy also decreased peripheral blood levels of IL-23, IL-1β, and IL-8. …”
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The prognostic role of vasculoendothelial growth factor A in patients with ST-segment elevation acute myocardial infarction during 6-months follow-up period by N.P. Kopytsya, I.M. Кutya, I.V. Rodionova, Ya.V. Hilova

“…A decrease in the level of VEGF-A < 255.72 pg/ml is a sensitive prognostic marker for the adverse course of the post-infarction period. …”
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