Understanding repeated non-attendance in health services: a pilot analysis of administrative data and full study protocol for a national retrospective cohort by Alex McConnachie, Philip Wilson, Ross McQueenie, David A Ellis, Andrea E Williamson

“…Serially (having a pattern of) missing general practice (GP) appointments may provide a risk marker for vulnerability and poorer health outcomes.Methods and analysis A proof of concept pilot using GP appointment data and a focus group with GPs informed the development of missed appointment categories: patients can be classified based on the number of appointments missed each year. …”
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Genome-wide association study for charcoal rot resistance in soybean harvested in Kazakhstan by A. Zatybekov, S. Abugalieva, S. Didorenko, A. Rsaliyev, A. Maulenbay, C. Fang, Y. Turuspekov

“…The GWAS was conducted using four different models (MLM, MLMM, FarmCPU, and BLINK) based on the GAPIT platform. As a result, SNP markers of 11 quantitative trait loci associated with CR resistance were identified. …”
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Fatty Liver as a Potential Surrogate for Waist Circumference in the Diagnosis of Metabolic Syndrome: A Population-Based Study among Chinese Adults by Boren Jiang, Ting Gu, Kun Zhou, Yanjun Zheng, Yuyu Guo, Yingli Lu

“…NAFLD could be used as a potential surrogate marker for the diagnosis of MetS in normal WC population.…”
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Predicting the Clinical Outcome of Triple-Negative Breast Cancer Based on the Gene Expression Characteristics of Necroptosis and Different Molecular Subtypes by Peng Luo, Zhaoqi Shi, Changshou He, Guojun Chen, Ji Feng, Linghua Zhu, Xiangyang Song

“…First, two stable molecular subtypes with different prognosis and immune characteristics were identified using necroptosis marker genes. Then, the key modules were identified, and 10 genes significantly related to the prognosis of necroptosis were selected. …”
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A Reduction in Selenoprotein S Amplifies the Inflammatory Profile of Fast-Twitch Skeletal Muscle in the mdx Dystrophic Mouse by Craig Robert Wright, Giselle Larissa Allsopp, Alex Bernard Addinsall, Natasha Lee McRae, Sofianos Andrikopoulos, Nicole Stupka

“…In the extensor digitorum longus (EDL) muscles, mRNA expression of monocyte chemoattractant protein 1 (Mcp-1) (P=0.034), macrophage marker F4/80 (P=0.030), and transforming growth factor-β1 (Tgf-β1) (P=0.056) were increased in mdx:Seps1−/+ mice. …”
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Comparison of Mean Platelet Volume (MPV) in Patients with Psoriasis and Healthy Individuals by Komal Shehzade, Saulat Zahra, Rabia Ishfaq, Kayinat Samreen, Maria Khalid, Fahad Usman

“…Mean Platelet Volume (MPV), a marker of platelet activation, may serve as a biomarker for systemic inflammation. …”
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Combining the Fibrinogen/Albumin Ratio and Systemic Inflammation Response Index Predicts Survival in Resectable Gastric Cancer by Junbin Zhang, Yongfeng Ding, Weibin Wang, Yimin Lu, Haiyong Wang, Haohao Wang, Lisong Teng

“…The present data demonstrated that FAR-SIRI scores predicted radical gastric cancer surgical outcomes and may serve as a blood marker for identifying high-risk patients.…”
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Impact of Obesity-Associated SARS-CoV-2 Mutations on COVID-19 Severity and Clinical Outcomes by Ana B. Martínez-Martinez, Alexander Tristancho-Baró, Beatriz Garcia-Rodriguez, Marina Clavel-Millan, Maria Pilar Palacian, Ana Milagro, Antonio Rezusta, Jose M. Arbones-Mainar

“…C313T showed a 428% increase in mortality risk, marking it as a possible poor-prognosis marker. Interestingly, all three mutations were synonymous, suggesting adaptive roles in obesity-driven environments despite not altering viral protein structures. …”
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Effects of Pioglitazone on Asymmetric Dimethylarginine and Components of the Metabolic Syndrome in Nondiabetic Patients (EPICAMP Study): A Double-Blind, Randomized Clinical Trial by Pedram Shokouh, Adel Joharimoghadam, Hamidreza Roohafza, Masoumeh Sadeghi, Allahyar Golabchi, Maryam Boshtam, Nizal Sarrafzadegan

“…The present trial aimed to investigate the effects of pioglitazone on the serum level of asymmetric dimethylarginine (ADMA), a marker of endothelial function, and some indices of inflammation and glucose and lipid metabolism in nondiabetic metabolic syndrome patients. 104 eligible participants (57% female; age between 20 and 70) were enrolled in a double-blind placebo-controlled trial and were randomized to receive either pioglitazone (uptitrated to 30 mg/day) or matching placebo for 24 weeks. …”
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Prevalence of diabetes and prediabetes in South Asian countries: a systematic review and meta-analysis by Masum Ali, Md Mahbub Alam, M. A. Rifat, Sonjida Mesket Simi, Sneha Sarwar, Md Ruhul Amin, Sanjib Saha

“…Abstract Introduction South Asia is observing an epidemiological transition from communicable to non-communicable diseases where diabetes is an important marker. In this study, we estimate the overall prevalence of diabetes and prediabetes in South Asian countries. …”
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PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma by Shunbin Shi, Guiping Yu, Bin Huang, Yedong Mi, Yan Kang, Julia Pia Simon

“…The partial mega-analysis showed a significant downregulated expression of PPARG in LSCC (LFC=−1.08, p value=0.00073). Twelve diagnostic markers and four prognostic markers were identified within multiple PPARG-LSCC regulatory pathways. …”
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Placental ischemia during pregnancy induces hypertension, cerebral inflammation, and oxidative stress in dams postpartum by Savanna Smith, Jonna Smith, Kylie Jones, Angie Castillo, Natalia Wiemann, Ahfiya Howard, Mark Cunningham

“…At 6 weeks PP (~3 human years), BP was measured via carotid catheterization, and cerebral oxidative stress and inflammation were assessed via ELISAs, biochemical assays, and Western blots.Results BP, cerebral pro-inflammatory cytokines (TNF-α and IL-6), and GFAP (a marker of astrocyte activity) were increased in PP RUPP dams. …”
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Osteopontin as a Biomarker for Coronary Artery Disease by Georgia R. Layton, Ibrahim Antoun, Alice Copperwheat, Zaidhan Latif Khan, Sanjay S. Bhandari, Riyaz Somani, André Ng, Mustafa Zakkar

“…Consequently, OPN is increasingly perceived as a marker of a poor prognosis rather than a tool for assessing the severity of coronary artery lesions.…”
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Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance by Marina Okuyama Kishima, Carlos Eduardo Coral de Oliveira, Bruna Karina Banin-Hirata, Roberta Losi-Guembarovski, Karen Brajão de Oliveira, Marla Karine Amarante, Maria Angelica Ehara Watanabe

“…Therefore, CXCR4 is being considered a prognostic marker in breast cancer. Within this context, this review summarizes established studies involving expression of CXCR4 on breast cancer, focusing on its clinical significance.…”
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A Novel Myosin Essential Light Chain Mutation Causes Hypertrophic Cardiomyopathy with Late Onset and Low Expressivity by Paal Skytt Andersen, Paula Louise Hedley, Stephen P. Page, Petros Syrris, Johanna Catharina Moolman-Smook, William John McKenna, Perry Mark Elliott, Michael Christiansen

“…We studied a large family with a 38-year-old asymptomatic HCM-affected male referred because of a murmur. The patient had HCM with left ventricular hypertrophy (max WT 21 mm), a resting left ventricular outflow gradient of 36 mm Hg, and left atrial dilation (54 mm). …”
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Serum Muscle Enzymes as Indicator for Gingival Wound Healing in Rabbits Orally Receiving Pomegranate Peel Extract by Bakhtiar Muhialdin Ahmed

“…Conclusions: Serum muscle enzymes activities may be used as a marker for the gingival wound healing process in rabbits supplemented with PPE. …”
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University proceedings. Volga region. Natural sciences by A.V. Kuzmin

“…It is necessary to start developing its own panel of microsatellite markers suitable for the identification of dogs of domestic cultural breeding.…”

Serum uric acid to creatinine ratio as a predictor of insulin resistance, β cell function, and metabolic syndrome in normal Korean adults: a cross-sectional study by Misuk Oh, Soo Hyun Cho

“…Conclusions The SUA/Cr may be a useful marker for predicting the insulin resistance, β cell function and incidence of MetS in normal Korean participants.…”
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The Role of Mean Platelet Volume as a Predictor of Mortality in Critically Ill Patients: A Systematic Review and Meta-Analysis by Pattraporn Tajarernmuang, Arintaya Phrommintikul, Atikun Limsukon, Chaicharn Pothirat, Kaweesak Chittawatanarat

“…Initial values of MPV might not be used as a prognostic marker of mortality in critically ill patients. Subsequent values of MPV after the 3rd day and the lower mortality rate unit might be useful. …”
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Biochemical Analysis of Pentraxin 3 and Fibrinogen Levels in Experimental Periodontitis Model by Gonca Cayir Keles, Umut Balli, Burcu Ozkan Cetinkaya, Bulent Ayas, Arzu Findik, Zeynep Pinar Keles, Ferda Pamuk

“…Pentraxin 3 (PTX3), newly discovered inflammation marker, is a member of acute-phase proteins. The hypothesis, synthesis of gingival tissue and serum PTX-3 increases in the experimental periodontitis model (with 10-day and 40-day periods), was tested by detecting gingival tissue and serum PTX-3 levels in rats with experimental periodontitis. …”
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